UY23672A1 - Procedimiento para la preparacion de derivados de cefalosporina - Google Patents
Procedimiento para la preparacion de derivados de cefalosporinaInfo
- Publication number
- UY23672A1 UY23672A1 UY23672A UY23672A UY23672A1 UY 23672 A1 UY23672 A1 UY 23672A1 UY 23672 A UY23672 A UY 23672A UY 23672 A UY23672 A UY 23672A UY 23672 A1 UY23672 A1 UY 23672A1
- Authority
- UY
- Uruguay
- Prior art keywords
- preparation
- hydrate
- salt
- pharmaceutically acceptable
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para la preparación de derivados de cefalosporina de fórmula general (I) (figura 1), y ésteres fácilmente hidrolizables y farmacéuticamente aceptables correspondientes así como sales e hidratos de estos compuestos, donde R representa uno de los grupos representados en la figura 2; el procedimiento comprende: a- acilar un compuesto de fórmula general (II) (figura 3), donde R' es un grupo correspondiente a R que comporta un grupo amino insustituido en posición 7 del núcleo cefalosporínico, o una sal de adición de ácido respectiva; b- o bien convertir un compuesto de fórmula (I) en una sal o hidrato o hidrato de dicha sal farmacéuticamente aceptable. Ejemplo no limitante: ácido (6R-trans)-3-hidroximetil-7-[[(1,1-dimetil-etoxi-carbonil]amino]-8-oxo-5-tia-1-azabiciclo[4.2.0]oct-2-en-2-carboxílico. Los productos finales conforme al procedimiento son de utilidad en la preparación de un medicamento para el tratamiento y profilaxis de enfermedades infecciosas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97625092A | 1992-11-12 | 1992-11-12 | |
| US97624892A | 1992-11-12 | 1992-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY23672A1 true UY23672A1 (es) | 1994-05-06 |
Family
ID=27130586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY23672A UY23672A1 (es) | 1992-11-12 | 1993-11-12 | Procedimiento para la preparacion de derivados de cefalosporina |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0597303A2 (es) |
| JP (1) | JPH06199868A (es) |
| KR (1) | KR940011470A (es) |
| CN (1) | CN1141922A (es) |
| AU (1) | AU5051793A (es) |
| BG (1) | BG98208A (es) |
| BR (1) | BR9304699A (es) |
| CA (1) | CA2108609A1 (es) |
| CZ (1) | CZ239893A3 (es) |
| FI (1) | FI935025A (es) |
| HU (1) | HUT65717A (es) |
| IS (1) | IS4093A (es) |
| LV (1) | LV10277A (es) |
| MX (1) | MX9306985A (es) |
| NO (1) | NO934078D0 (es) |
| PL (1) | PL301024A1 (es) |
| SI (1) | SI9300555A (es) |
| SK (1) | SK125693A3 (es) |
| UY (1) | UY23672A1 (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT49889A (en) * | 1988-03-31 | 1989-11-28 | Hoffmann La Roche | Process for producing acyl derivatives |
| EP0997466A1 (en) * | 1988-10-24 | 2000-05-03 | PROCTER & GAMBLE PHARMACEUTICALS, INC. | Novel antimicrobial lactam-quinolones |
-
1993
- 1993-10-18 CA CA002108609A patent/CA2108609A1/en not_active Abandoned
- 1993-10-21 SI SI9300555A patent/SI9300555A/sl unknown
- 1993-10-23 EP EP93117216A patent/EP0597303A2/en not_active Withdrawn
- 1993-11-08 HU HU9303155A patent/HUT65717A/hu unknown
- 1993-11-08 AU AU50517/93A patent/AU5051793A/en not_active Abandoned
- 1993-11-09 MX MX9306985A patent/MX9306985A/es unknown
- 1993-11-10 JP JP5304824A patent/JPH06199868A/ja active Pending
- 1993-11-10 BG BG98208A patent/BG98208A/xx unknown
- 1993-11-10 CZ CZ932398A patent/CZ239893A3/cs unknown
- 1993-11-10 SK SK1256-93A patent/SK125693A3/sk unknown
- 1993-11-10 PL PL93301024A patent/PL301024A1/xx unknown
- 1993-11-11 KR KR1019930023861A patent/KR940011470A/ko not_active Application Discontinuation
- 1993-11-11 IS IS4093A patent/IS4093A/is unknown
- 1993-11-11 NO NO934078A patent/NO934078D0/no unknown
- 1993-11-11 BR BR9304699A patent/BR9304699A/pt not_active Application Discontinuation
- 1993-11-11 LV LV931189A patent/LV10277A/xx unknown
- 1993-11-11 CN CN93114373A patent/CN1141922A/zh active Pending
- 1993-11-12 FI FI935025A patent/FI935025A/fi not_active Application Discontinuation
- 1993-11-12 UY UY23672A patent/UY23672A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06199868A (ja) | 1994-07-19 |
| HUT65717A (en) | 1994-07-28 |
| NO934078L (es) | 1994-05-13 |
| IS4093A (is) | 1994-05-13 |
| CN1141922A (zh) | 1997-02-05 |
| KR940011470A (ko) | 1994-06-21 |
| BR9304699A (pt) | 1994-06-14 |
| NO934078D0 (no) | 1993-11-11 |
| FI935025A (fi) | 1994-05-13 |
| LV10277A (lv) | 1994-10-20 |
| BG98208A (en) | 1994-05-27 |
| AU5051793A (en) | 1994-05-26 |
| SK125693A3 (en) | 1994-09-07 |
| MX9306985A (es) | 1995-01-31 |
| CZ239893A3 (en) | 1994-06-15 |
| FI935025A0 (fi) | 1993-11-12 |
| CA2108609A1 (en) | 1994-05-13 |
| PL301024A1 (en) | 1994-05-16 |
| SI9300555A (en) | 1994-06-30 |
| EP0597303A2 (en) | 1994-05-18 |
| EP0597303A3 (es) | 1994-08-03 |
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