Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
  • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
  • A61K31/716—Glucans
  • A61K31/722—Chitin, chitosan
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
  • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
  • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/06—Fungi, e.g. yeasts
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
  • A61K36/234—Cnidium (snowparsley)
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
  • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Definitions

• the present invention relates to a dietary supplement useful for the prevention and/or the treatment of erectile dysfunction.
• 5-phosphodiesterase inhibitors which improve the erectile function, have been marketed relatively recently, and have had some commercial success.
• the present invention relates to a dietary supplement stimulating the male sexual function comprising:
• the invention also concerns the use of the dietary supplement in the prevention and/or the treatment of erectile dysfunction.
• the present invention relates to a dietary supplement stimulating the male sexual function.
• the supplement comprises (as active ingredients):
• Tribulas terrestris has preferably a 40% saponin content; it naturally stimulates testosterone production, increases the libido and the trophism of the testosterone-dependent organs and improves fertility.
• the glucosamine oligosaccharide is marketed for example under the trademark BIOVIS® and comprises polymers of D-glucosamine and N-acetyl-D-glucosamine.
• BIOVIS® The glucosamine oligosaccharide stimulates the release of NO (nitrous oxide).
• Alga Ecklonia may be selected from the group consisting of Ecklonia bicyclis Kjellman, Ecklonia biruncinata (Bory de Saint-Vincent) Papenfuss, Ecklonia brevipes J. Agardh, Ecklonia huccinalis (Linnaeus) Hornemann, Ecklonia caepaestipes (Montagne) End Anlagen, Ecklonia cava Kjellman, Ecklonia exasperata (Turner) J.
• alga Ecklonia which comprises fat-soluble polyphenols, is selected from alga Ecklonia Cava , alga Ecklonia Bicyclis (also known as Eisenia Bicyclis ).
• Alga Ecklonia Cava is marketed for example under the trademark SEANOL®.
• the fat-soluble polyphenols improves the erectile function.
• ingredients present in the supplement are:
• the ingredients of the dietary supplement may vary as follows:
• a reduction in the number of dosage units to be taken by the patient can be obtained, for example, with the following quantities of ingredients:
• the supplement further comprises Cnidium Monnieri.
• Cnidium Monnieri has a muscle-relaxant effect on the corpora cavernosa by releasing NO.
• Cnidium Monnieri is usually added at a dose ranging between 50 mg and 300 mg per dosage unit.
• the supplement further comprises Anentopaegma Mirandum Mart. ex DC ( Catuaba ), in particular Catuaba bark.
• Catuaba is usually added at a dose ranging between 50 mg and 300 mg per dosage unit.
• the dietary supplements may be formulated by conventional methods.
• Preferred dosage forms are capsules, sachets.
• the dietary supplement according to the invention does not present the drawbacks of the medicaments currently on the market, and in particular has the following advantages, compared to the conventional medicaments:
• the supplement according to the invention includes substances which improve both the libido and the erectile function.
• the supplement comprises:
• the supplement comprises:
• pts patients with erectile dysfunction (ED), without previous treatment for the ED were enrolled for study inclusion.
• the mean age of the pts was 53.1 years.
• the IIEF questionnaire was administered to each patient and the serum level of baseline testosterone was checked.
• the Mann-Whitney test has been used to determine the statistical significance of responses to global efficacy question, with the paired Student t test with significance considered at p ⁇ 0.01.
• the IIEF scores were significantly improved in all the pts with an increase of 78% in mild ED group, while in the moderate ED group there was an improvement of 80% and in the severe ED group of 108% from the baseline.
• Group A showed an improvement in all domains of IIEF questionnaire scores, with a significant improvement after 8 weeks of treatment (from baseline 22.1+/ ⁇ 1.6 to 39.3+/ ⁇ 5.1 p ⁇ 0.01).
• Group B showed an improvement in all domains of IIEF questionnaire, with a significant improvement after 8 weeks of treatment (from baseline 14.1+/ ⁇ 1.5 to 25.4+/ ⁇ 1.8 p ⁇ 0.01).
• the third group (C) showed an improvement in all domains of IIEF questionnaire. Mean IIEF scores showed significant improvement after 8 weeks of treatment (from baseline 6.7+/ ⁇ 1.4 to 13.9+/ ⁇ 2.0 p ⁇ 0.01).
• Table 1 shows IIEF scores in three groups (A, B, C) before and after the treatment.
• Group A a 17% increase of the number of spontaneous erections and a 11% increase of the mean percentage of rigidity; in Group B; 39% and 6% respectively and 75% and 38% respectively in the Group C.
• testosterone serum level was 5.0+/ ⁇ 1.1 ng/ml; and in the group C was 5.0+/1.0 ng/ml.
• Table 3 shows the changes in mean testosterone serum: an increase of 28% in the Group A, 20% in the Group B and 24% in the Group C has been noted.
• patient's mean baseline of serum level of total PSA was 1.8+/ ⁇ 0.6 (normal range: 0 to 4 ng/ml) in group A, 1.9+/ ⁇ 0.2 in group B and 1.8+/ ⁇ 0.1 in Group C.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Natural Medicines & Medicinal Plants (AREA)
• Chemical & Material Sciences (AREA)
• Engineering & Computer Science (AREA)
• Mycology (AREA)
• Veterinary Medicine (AREA)
• Animal Behavior & Ethology (AREA)
• Medicinal Chemistry (AREA)
• Public Health (AREA)
• General Health & Medical Sciences (AREA)
• Pharmacology & Pharmacy (AREA)
• Epidemiology (AREA)
• Botany (AREA)
• Alternative & Traditional Medicine (AREA)
• Microbiology (AREA)
• Medical Informatics (AREA)
• Biotechnology (AREA)
• Polymers & Plastics (AREA)
• Nutrition Science (AREA)
• Food Science & Technology (AREA)
• General Chemical & Material Sciences (AREA)
• Reproductive Health (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Organic Chemistry (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Endocrinology (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Molecular Biology (AREA)
• Gynecology & Obstetrics (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
• Coloring Foods And Improving Nutritive Qualities (AREA)
• Medicines Containing Plant Substances (AREA)

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Citations (6)

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• 2010
  • 2010-09-16 SI SI201030380T patent/SI2477633T1/sl unknown
  • 2010-09-16 US US13/496,360 patent/US8609155B2/en not_active Expired - Fee Related
  • 2010-09-16 DK DK10760252.6T patent/DK2477633T3/da active
  • 2010-09-16 RS RS20130406A patent/RS52957B/sr unknown
  • 2010-09-16 EP EP10760252.6A patent/EP2477633B1/en active Active
  • 2010-09-16 CN CN201080041364.4A patent/CN102612370B/zh active Active
  • 2010-09-16 WO PCT/EP2010/005689 patent/WO2011032697A1/en not_active Ceased
  • 2010-09-16 ME MEP-2013-107A patent/ME01540B/me unknown
  • 2010-09-16 HR HRP20130925AT patent/HRP20130925T1/hr unknown
  • 2010-09-16 ES ES10760252T patent/ES2430226T3/es active Active
  • 2010-09-16 CA CA2774451A patent/CA2774451C/en active Active
  • 2010-09-16 PT PT107602526T patent/PT2477633E/pt unknown
  • 2010-09-16 PL PL10760252T patent/PL2477633T3/pl unknown

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