US7284474B2 - Piston-pumping system having o-ring seal properties - Google Patents

Piston-pumping system having o-ring seal properties Download PDF

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Publication number
US7284474B2
US7284474B2 US10/727,286 US72728603A US7284474B2 US 7284474 B2 US7284474 B2 US 7284474B2 US 72728603 A US72728603 A US 72728603A US 7284474 B2 US7284474 B2 US 7284474B2
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piston
pumping system
liquid
pumping
chamber
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US20040134495A1 (en
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Jutta Eigemann
Johannes Geser
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Priority to US10/727,286 priority Critical patent/US7284474B2/en
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Assigned to BOEHRINGER INGELHEIM INTERNATIONAL GMBH reassignment BOEHRINGER INGELHEIM INTERNATIONAL GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: EIGEMANN, JUTTA, GESER, JOHANNES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
    • F04B53/14—Pistons, piston-rods or piston-rod connections
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
    • F04B53/16—Casings; Cylinders; Cylinder liners or heads; Fluid connections
    • F04B53/162—Adaptations of cylinders
    • F04B53/164—Stoffing boxes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16J—PISTONS; CYLINDERS; SEALINGS
    • F16J15/00—Sealings
    • F16J15/16—Sealings between relatively-moving surfaces
    • F16J15/32—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0272—Electro-active or magneto-active materials
    • A61M2205/0294—Piezoelectric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14216—Reciprocating piston type

Definitions

  • the present invention relates to a piston pumping system for substantially gas-free measurement and/or pumping of predetermined quantities of liquids, preferably pharmaceutical liquids containing oxidation-prone ingredients.
  • the system is used as a mini- or micropump or as a component thereof in medical devices such as for example transdermal therapeutic systems.
  • the gas which has entered the measuring chamber can falsify the measuring process and thus alter the quantity of liquid to be delivered.
  • the liquid to be delivered must not of itself contain any appreciable amounts of gas, so as not to endanger the health of the patient.
  • transdermal therapeutic systems as disclosed in EP 0840634.
  • Such systems consist essentially of a reservoir for the medicament and at least one—typically several—micro-pins with capillary openings which are connected to the reservoir so that the pharmaceutical composition in the form of a solution containing an active substance travels from the reservoir into the micro-pins.
  • the pins pass through the stratum corneum and possibly the epidermis so that the pharmaceutical composition gains direct access to the innervated layer of the skin.
  • the pharmaceutical composition can flow from the reservoir through the capillary openings of the micro-pins into vascularised parts of the skin in order to be absorbed from there into the blood stream through the capillary system.
  • the active substance is usually in the form of a solution to ensure satisfactory transportation through the capillary openings of the micro-pins of the transcorneal system.
  • the medicament may be transported “actively”—e.g. by means of excess pressure stored in the reservoir or by electrostatic or capillary forces, or using a pump integrated in the system.
  • An active system of this kind is described in EP 0840634 B1.
  • the aim of the present invention is to provide a piston-operated pumping system which guarantees that during the measuring and/or pumping of liquids by means of a piston pumping system, substantially no gas can pass along the piston from outside and enter the filling or pumping chamber.
  • a further objective is to provide a pumping system for medical devices which prevents the pharmaceutical liquid from being mixed with oxygen, air or any other gas as a result of the measuring or pumping process.
  • a further objective is to overcome the disadvantages of pumping systems in medical devices known from the prior art.
  • the present invention now relates to a piston pumping system which can be used as or in a small pump, e.g. a mini- or micropump, in medical devices for the direct administration of pharmaceutical formulations.
  • the device according to the invention is used in medical devices which require or may require a pump for delivering liquids.
  • the invention may be used in any other piston pumping system, not restricted to medical devices, in which it is of advantage.
  • the invention is also not restricted to mini-pumps or micropumps but may also be applied to larger pumping systems.
  • the term medical device preferably denotes application devices for liquids such as transdermal therapeutic systems with active transportation of the active substance, devices for the intravenous administration of liquid formulations in small amounts, atomisers for liquids such as inhalers, particularly propellant-free inhalers, needleless injectors, eye sprays, etc.
  • Medical devices of this kind also serve to some extent as primary packaging for pharmaceutical preparations or may be regarded as such, as the pharmaceutical preparation is initially stored in these devices before the device is used on or for the patient. Therefore, the concept also includes medical devices which serve as primary packaging.
  • a piston pumping system which, using sealing materials suitable for food or drug use, improves the sealing of the piston in the pumping system against the diffusion of air or other gases from the outer environment into the liquid which is to be drawn up or measured and thus reduces the penetration of air or other gases into this liquid.
  • the pumping system according to the invention overcomes the above mentioned disadvantages of current pumping systems.
  • a pumping and measuring system suitable for the invention may consist of a chamber having a liquid inlet and a liquid outlet, a piston being connected to the chamber in such a way that by a stroke-like movement of the piston along its longitudinal axis liquid can be taken in from a storage system in a predetermined quantity through the liquid inlet and from there can be delivered, optionally under pressure, through the liquid outlet.
  • the storage system is constructed as a flexible container which collapses as liquid is removed.
  • a static underpressure or static vacuum may be produced in the chamber in the resting phase. This means that the underpressure in the storage system is passed on to the pumping chamber.
  • the pumping system according to the invention is therefore designed both for dynamic high pressure loading and also for dynamic and/or static underpressure loading.
  • high pressure is meant pressures of more than 1 bar.
  • the system is preferably designed for a pressure of up to 600 bar, more preferably up to 250 bar. This pressure may be maintained for up to about 10 seconds, preferably up to 5 seconds, more preferably up to 2 seconds.
  • underpressure is meant a pressure difference of preferably less than 0.5 bar, preferably less than 100 mbar and most preferably less than 50 mbar.
  • a static underpressure is meant that this is maintained for a period of more than 5 minutes, preferably more than 1 hour, more preferably more than 10 hours and most preferably about 24 hours.
  • the above mentioned chamber is also referred to as a pumping chamber or measuring chamber.
  • the chamber has a fill volume of from 1 microliter to 1 ml, more preferably from 1 microliter to 500 microliters, most preferably from 5 microliters to 100 microliters. Volumes of 5 microliters to 30 microliters are most preferred.
  • the liquid inlet or the supply system connected to the liquid inlet, which brings the liquid from the storage system into the chamber, is preferably formed by pipes or tubes.
  • the cross section of the tube opening is preferably less than 1 mm, more preferably less than 0.5 mm.
  • the supply system preferably has a non-return valve which prevents the liquid sucked in from running back into the storage container.
  • the system comprising the liquid inlet and/or the supply system is also referred to as the intake system within the scope of the present description of the invention.
  • the intake system may optionally be integrated in the pump piston.
  • the pump piston is a hollow piston.
  • the hollow interior of the piston then constitutes the feed for the liquid from the storage system into the chamber or is connected to such a feed.
  • the intake system contains a non-return valve, preferably as an integral part of the piston.
  • the liquid outlet or the release system for the liquid connected to the liquid outlet which supplies the liquid from the pumping or measuring chamber to its intended destination, may have a non-return valve of this kind, but this is not essential.
  • the liquid outlet will always have a non-return valve when the filling system is such that it is possible or undesirable for the liquid forced out of the measuring chamber to flow back from the destination through the liquid outlet and back into the pumping or measuring chamber.
  • the system of fluid inlet and/or the above-mentioned release system is also referred to as the release system within the scope of the present description.
  • the moveable piston projecting into the pumping or measuring chamber is guided within a cylindrical bore of a solid element, for example a block or a wall.
  • a block or a wall of this kind may be an independent element in the pumping system or may be an integral part of the chamber.
  • the piston may be inserted into the chamber or extracted from it by means of a predetermined stroke movement. This stroke movement fills and empties the chamber.
  • the dimensions of the piston and the chamber should be matched to each other accordingly.
  • the piston preferably has a length of 5 mm to 10 cm, preferably from 1 cm to 7.5 cm.
  • the diameter of the piston is preferably 0.25 to 4 mm, more preferably 0.5 to 3 mm and most preferably 0.75 to 2.25 mm.
  • the stroke movement of the piston along its longitudinal axis preferably covers a length of from 1 mm to 5 cm, particularly from 0.25 cm to 3 cm. Stroke movements of from 0.5 cm to 2 cm are most preferred.
  • a seal on the piston seals off the space between the piston and the chamber, independently of the movement of the piston, thus preventing liquid from escaping.
  • the piston is guided within the pumping system such that in normal operation it cannot escape from the cylindrical guide and always performs its sealing function.
  • the sealing materials like all other materials of systems for dosing pharmaceutical liquids, are subject to particular requirements. Thus, they may be of such a nature that there is no impairment of the pharmaceutical quality of the liquid and no contamination which could endanger the health of the end consumer. These requirements apply particularly to the sealing material as well, which is generally an elastic polymer, from which constituents can continue to escape during use, which are undesirable in the liquids being dosed, for the reasons stated above.
  • the sealing systems used for the piston must be selected primarily so that they do not affect the quality of the liquid.
  • the outline conditions relating to function must be subordinate to this criterion.
  • Such secondary properties of the sealing material include the density of the material and/or its permeation coefficient for air or other gases.
  • the guiding of the piston within the pumping system is preferably effected by means of silicon seals as silicon has the properties which make it acceptable for use with food or pharmaceuticals as referred to above.
  • silicon seals As silicon has the properties which make it acceptable for use with food or pharmaceuticals as referred to above.
  • One disadvantage of this sealing material and other sealing materials which are suitable under food or drug regulations is the fact that these materials have a relatively high permeation coefficient for air, with the result that air and oxygen can diffuse through the sealing material into the liquid being dispensed.
  • Current sealing materials such as NBR or PU, for example, cannot be used in every case for pharmaceutical reasons.
  • the seal is in the form of an O-ring seal.
  • an O-ring is meant an annular seal, irrespective of the shape of its cross section.
  • O-ring seals with a circular cross section are preferred.
  • the piston may be sealed off by one or more O-rings.
  • Butyl rubber, epichlorohydrin, fluorocarbon rubber and nitrile rubber with a high acrylonitrile content are butyl rubber, epichlorohydrin, fluorocarbon rubber and nitrile rubber with a high acrylonitrile content.
  • Silicon rubbers are regarded as totally unsuitable as they have particularly high gas permeabilities.
  • the O-ring seal is subjected to a radial and possibly axial compression of up to 30%, preferably up to 20%.
  • radial compression is meant the compression exerted on the sealing ring along the annular plane.
  • an O-ring seal with a gas permeation of 100 to 500 N*cm 3 *mm/(m 2 *h*bar) and a cord thickness of 0.3 to 3 mm, preferably 0.5 to 2 mm, more preferably 0.75 to 1.5 mm, is proposed which seals off a piston reciprocating along its longitudinal axis in a guide tube and is held in a groove, the seal having a radial and possibly axial compression of up to 30%, preferably up to 20% and having a groove filling level of 90 to 100%.
  • a groove filling level of 90% is meant that 90% of the volume of the groove is filled by the seal.
  • the preferred sealing material is silicon.
  • the pump according to the invention can be operated mechanically or electrically. Details may be found in the prior art. These embodiments may be controlled electronically, preferably using a microchip.
  • the piston may be operated for example by coupling to a piezoelectric element.
  • This coupling may be direct, via one or more lever arms or a diaphragm.
  • the piston is moved directly by the piezoelectric element.
  • the piezoelectric element itself is actuated by the microchip, for example, in such a case.
  • the piston may also be operated by means of a spring, e.g. a helical spring, which is mechanically or electrically biased and connected to the piston via a flange.
  • a spring e.g. a helical spring, which is mechanically or electrically biased and connected to the piston via a flange. Details may be found from the prior art relating to medical devices, particularly the fields of transdermal therapeutic systems, atomisers, propellant-free inhalers, needleless injectors, etc.
  • any physiologically acceptable solvents or mixtures of solvents in which the active substance dissolves sufficiently may be used with the medical devices according to the invention and the pumping system described.
  • “sufficiently” is meant concentrations of active substance in the solvent such as to allow a therapeutically active quantity of active substance to be administered.
  • Preferred solvents are water and pharmacologically acceptable alcohols such as ethanol. If it should prove necessary, solubilisers and complexing agents may be used to increase the solubility of the active substance in the solvent. Sensitive or unstable active substances may contain additives to extend their shelf life.
  • the medical device according to the invention contains a reservoir for storing the active substance solution, a liquid-conveying connection between the reservoir and the pump according to the invention, and a liquid-conveying connection to at least one device which delivers the liquid.
  • the latter may be a nozzle, a micro-pin or a microcutter along which the liquid is passed, a canula or an outlet.
  • Microcutters and micro-pins are described in detail in EP 0840634 and in FIG. 6 therein, while nozzle systems may be inferred from EP 1017469.
  • Such nozzle systems may comprise a single nozzle opening or a plurality of nozzle openings.
  • Such a nozzle may be a body with at least two or more continuous bores extending parallel to one another or inclined relative to one another. In the case of bores which are inclined relative to one another the end with the acute angle is the nozzle outlet end and the other end is the nozzle inlet end.
  • the devices according to the invention are preferably used to measure out small volumes of liquids, e.g. less than 1 ml or even less than 100 microliters, from a storage system through the pumping and/or measuring system into a pumping chamber from where the liquid is conveyed to the device which delivers it.
  • Such systems comprise, for example, transcorneal therapeutic systems (TTS, “patch” systems), atomisers, particularly pumping systems in nasal sprays, inhalers, eye washes, infusion systems, needleless injectors, etc, provided that they measure out and deliver propellant-free liquids in order to administer them to a patient.
  • TTS transcorneal therapeutic systems
  • atomisers particularly pumping systems in nasal sprays, inhalers, eye washes, infusion systems, needleless injectors, etc, provided that they measure out and deliver propellant-free liquids in order to administer them to a patient.
  • Transcorneal therapeutic systems continuously or discontinuously transfer pharmaceutical formulations from a storage container through the skin into a patient.
  • the pumping system according to the invention may be incorporated, for example, in a TTS as described in EP 0840634, to which reference is hereby expressly made.
  • a system of this kind may consist of a storage system, into which the pump piston of the pumping system according to the invention projects, which is preferably in the form of a hollow piston with an integrated non-return valve.
  • the hollow piston opens into the measuring chamber from which a release system leads into one or more pin-like projections.
  • the pin-like projection or projections is or are also hollow and constructed so as to penetrate into the corneum of the patient when the patch system is attached to the patient's skin ready for use, so that the liquid can be pumped in.
  • the release system which consists of at least one tube preferably has one or more non-return valves.
  • FIG. 1 shows a pumping system of this kind with a piston 1 having a diameter of 1.5 mm.
  • the piston opens into the pumping chamber 5 .
  • the piston is guided within a guide tube 2 and sealed off by means of an O-ring seal 3 in a groove 4 .
  • the piston travels into the pumping and measuring chamber 5 . Opening into the chamber is a feed tube 6 with a non-return valve 7 through which liquid is sucked in.
  • a release tube 8 with a non-return valve 9 draws liquid out of the chamber.
  • the storage chamber is generally designed 6 b.
  • the piston may also be operated by means of a spring 30 , e.g. a helical spring, which is mechanically or electrically biased and connected to the piston via a flange.
  • a spring 30 e.g. a helical spring, which is mechanically or electrically biased and connected to the piston via a flange. Details may be found from the prior art relating to medical devices, particularly the fields of transdermal therapeutic systems, atomisers, propellant-free inhalers, needleless injectors, etc.
  • the piston may be operated for example by coupling to a piezoelectric element 32 .
  • This coupling may be direct, via one or more lever arms or a diaphragm.
  • the piston is moved directly by the piezoelectric element 32 .
  • the piezoelectric element 32 itself is actuated by a microchip, for example, in such a case.
  • FIG. 2 shows the system according to FIG. 1 in which the feed tube 6 is integrated in the piston 1 .
  • FIG. 3 shows a transdermal therapeutic system with the pump according to the invention.
  • the drawing shows a section through a transcorneal system 10 with an active substance reservoir sealed off at the top by a bellows 13 .
  • the active substance reservoir is the active substance solution 14 which is conveyed outwards at the lower end of the active substance reservoir through a system 15 according to FIG. 2 to the micro-pins with capillary openings 12 provided on the underside of the housing.
  • the side parts 16 of the housing and the underside of the housing together with the micro-pins form a structural unit, preferably of thermoplastic plastics.
  • the lid of the housing contains the energy supply in the form of a battery 17 for operating the pumping system and an electronic control 18 , e.g. a microchip. Venting means 19 allow the bellows to adapt to the decreased volume as active substance solution is delivered through the micro-pins.
  • a pin protector 20 for example in the form of a cap.
  • the micro-pins may contain microvalves 21 as shown in FIG. 4 .

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  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Medical Informatics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Details Of Reciprocating Pumps (AREA)
  • Sealing Devices (AREA)
US10/727,286 2002-12-06 2003-12-03 Piston-pumping system having o-ring seal properties Expired - Lifetime US7284474B2 (en)

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US43164002P 2002-12-06 2002-12-06
EP02027243 2002-12-06
EP02027243A EP1426662A1 (de) 2002-12-06 2002-12-06 Kolbenpumpsystem
US10/727,286 US7284474B2 (en) 2002-12-06 2003-12-03 Piston-pumping system having o-ring seal properties

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US20040134495A1 US20040134495A1 (en) 2004-07-15
US7284474B2 true US7284474B2 (en) 2007-10-23

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US (1) US7284474B2 (enrdf_load_stackoverflow)
EP (2) EP1426662A1 (enrdf_load_stackoverflow)
JP (1) JP2006509153A (enrdf_load_stackoverflow)
AU (1) AU2003293736A1 (enrdf_load_stackoverflow)
CA (1) CA2508673C (enrdf_load_stackoverflow)
DK (1) DK1579130T3 (enrdf_load_stackoverflow)
ES (1) ES2410157T3 (enrdf_load_stackoverflow)
WO (1) WO2004053362A1 (enrdf_load_stackoverflow)

Cited By (5)

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US20080086086A1 (en) * 2006-10-10 2008-04-10 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
EP2601928A1 (en) * 2011-12-08 2013-06-12 King Saud University Apparatus and method for transdermal delivery of bioactive solution
EP4015819A1 (en) 2020-12-18 2022-06-22 Merxin Ltd Micropump having a sealing ring
WO2024241286A1 (en) 2023-05-25 2024-11-28 Merxin Ltd Micropump having a polyolefin sealing element
US12370566B2 (en) 2020-03-18 2025-07-29 Boehringer Ingelheim Microparts Gmbh Method for assembling dispensing devices, and dispensing device

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JP4981660B2 (ja) 2004-04-12 2012-07-25 アラーガン、インコーポレイテッド マルチサイト注射システム
US20150025459A1 (en) * 2009-07-29 2015-01-22 Allergan, Inc. Multi-site injection system
DE102005052898A1 (de) * 2005-11-03 2007-05-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren und Vorrichtung zum Dosieren von Arzneimitteln
US8061350B2 (en) * 2006-06-02 2011-11-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process and device for dosing pharmaceutical agents
FR2933872B1 (fr) * 2008-07-18 2012-09-28 Bernard Perriere Dispositif d'injection miniaturise a usage medical a cartouche amovible
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
JP6276204B2 (ja) 2012-03-13 2018-02-07 ベクトン ディキンソン フランス 小型化された薬物送達デバイスのための製造方法
WO2013150025A1 (en) 2012-04-05 2013-10-10 Tecpharma Licensing Ag Infusion pump device with venting feature
DK3110475T3 (da) 2014-02-26 2019-09-23 Tecpharma Licensing Ag Indretning til administration af et fluidprodukt
US11079022B2 (en) * 2018-03-02 2021-08-03 Gojo Industries, Inc. Outlet valve arrangements for enhanced pump efficiency
US20220134072A1 (en) * 2019-03-19 2022-05-05 King Abdullah University Of Science And Technology Miniaturized delivery system and method
KR102644287B1 (ko) * 2021-11-11 2024-03-05 윤인수 기포제거가 가능하고 입자가 있는 약액의 농도를 일정하게 유지하며, 여러 약액을 일정 비율로 혼합 할 때 정밀하게 혼합 할 수 있는 약액공급용 리버스펌프

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US4246833A (en) 1978-12-29 1981-01-27 The United States Of America As Represented By The Secretary Of The Navy High pressure spherical piston
US4468221A (en) * 1981-04-10 1984-08-28 Parker-Hannifin Corporation Medication infusion pump
US4813932A (en) * 1984-09-11 1989-03-21 Hobbs Michael A Single-handed breast pump
US4961726A (en) * 1987-11-11 1990-10-09 Siegfried Richter Breast milk pump
EP0361260A2 (de) 1988-09-17 1990-04-04 Ophardt Product Hermann Ophardt Kolbenpumpe zum Dosieren fliessfähiger Substanzen
US6132755A (en) 1995-07-14 2000-10-17 Boehringer Ingelheim Kg Transcorneal drug-release system
DE19921951A1 (de) 1998-05-14 1999-11-18 Univ Dresden Tech Piezobetätigte Kolbenpumpe
US6389955B1 (en) 1999-02-06 2002-05-21 Robert Bosch Gmbh Pump assembly for a slip-controlled hydraulic brake system for a vehicle
US6409175B1 (en) * 1999-07-13 2002-06-25 Grant Prideco, Inc. Expandable joint connector
US6547756B1 (en) * 1999-12-10 2003-04-15 Medela Holding Ag Programmable breastpump
US6916159B2 (en) * 2002-10-09 2005-07-12 Therasense, Inc. Device and method employing shape memory alloy

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080086086A1 (en) * 2006-10-10 2008-04-10 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
US8202267B2 (en) * 2006-10-10 2012-06-19 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
EP2601928A1 (en) * 2011-12-08 2013-06-12 King Saud University Apparatus and method for transdermal delivery of bioactive solution
US9517297B2 (en) 2011-12-08 2016-12-13 King Saud University Apparatus and method for transdermal delivery of bioactive solution
US12370566B2 (en) 2020-03-18 2025-07-29 Boehringer Ingelheim Microparts Gmbh Method for assembling dispensing devices, and dispensing device
EP4015819A1 (en) 2020-12-18 2022-06-22 Merxin Ltd Micropump having a sealing ring
WO2024241286A1 (en) 2023-05-25 2024-11-28 Merxin Ltd Micropump having a polyolefin sealing element

Also Published As

Publication number Publication date
ES2410157T3 (es) 2013-07-01
CA2508673C (en) 2012-10-09
CA2508673A1 (en) 2004-06-24
AU2003293736A1 (en) 2004-06-30
WO2004053362A1 (de) 2004-06-24
JP2006509153A (ja) 2006-03-16
EP1579130A1 (de) 2005-09-28
US20040134495A1 (en) 2004-07-15
DK1579130T3 (da) 2013-06-10
EP1426662A1 (de) 2004-06-09
EP1579130B1 (de) 2013-03-06

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