Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
  • A61K8/738—Cyclodextrins
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/0208—Tissues; Wipes; Patches
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q13/00—Formulations or additives for perfume preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q15/00—Anti-perspirants or body deodorants

Definitions

• Zeolites such as those marketed under the trade name Abscents® by the Union Carbide Corporation and UOP are known odor absorbers.
• these commonly known solid odor absorbers in addition to known activated charcoal odor absorbers, lose functionality when wet. Therefore, when wetted by body fluids or when carried in an aqueous solution, these odor absorbers are not preferred as they substantially lose their desired odor absorbent characteristics.
• zeolites can cause a "harsh" feel if too much is deposited onto the skin.
• the white zeolite powder and the black activated charcoal can also be rather visible and unsightly when applied to surfaces such as skin.
• the present invention encompasses a method of controlling environmental malodors on skin comprising the application to the skin of a composition comprising from about 0.1% to about 5%, by weight of the composition, of solubilized, water-soluble, uncomplexed cyclodextrin; from about 0.1% to about 36%, by weight of the composition, of an oil phase selected from the group consisting of emollients, moisturizers, and skin protectants; one or more surfactants; from about 0.004% to about 2%, by weight of the composition, of a hydrophilic, volatile perfume composition; and an aqueous carrier.
• a composition comprising from about 0.1% to about 5%, by weight of the composition, of solubilized, water-soluble, uncomplexed cyclodextrin; from about 0.1% to about 36%, by weight of the composition, of an oil phase selected from the group consisting of emollients, moisturizers, and skin protectants; one or more surfactants; from about 0.004% to about
• body fluids includes eccrine sweat, apocrine sweat, sebum, build up of sensible moisture from transepidermal water loss, vaginal discharge, urine, and mixtures thereof.
• body odor means odors which are generated as a result of the natural functioning of a human or mammalian body. Such odors include, but are not limited to odors produced by microorganisms of the human or mammalian skin (i.e. bacterial decomposition of skin secretions), urine, or vaginal discharge, and mixtures thereof.
• the term “entire body” means the entire external surface of human or mammalian skin.
• skin means human or mammalian skin.
• compositions of the present invention are topically applied directly to the skin or hair.
• the compositions can be delivered by placing the composition into a dispensing means and applying an effective amount via spraying or rubbing the composition onto the desired skin surface; typically the entire body.
• the dispensing means is a wipe or a spray dispenser.
• Distribution of the composition of the present invention can also be achieved by using a pre-formed applicator such as a roller, pad, sponge, tissue, cotton ball, hand, etc.
• the user may combine the composition of the present invention with a wipe substance of his or her own choosing.
• a wipe substance such as a commercial paper towel, tissue, sponge, cotton, pad, washcloth, or the like; and pours, from a bottle or other suitable container, a solution of the composition of the present invention over the chosen wipe substance and applies the composition to the desired area of the body.
• the user may use as much or as little of the composition of the present invention as he/she desires, depending upon their intended use and degree of odor control necessary.
• the cyclodextrins used in the present invention are highly water-soluble such as, alpha-cyclodextrin and/or derivatives thereof, gamma-cyclodextrin and/or derivatives thereof, derivatised beta-cyclodextrins, and/or mixtures thereof.
• the derivatives of cyclodextrin consist mainly of molecules wherein some of the OH groups are converted to OR groups.
• Highly water-soluble cyclodextrins are those having water solubility of at least about 10 g in 100 ml of water at room temperature, preferably at least about 20 g in 100 ml of water, more preferably at least about 25 g in 100 ml of water at room temperature.
• the preferred highly water-soluble cylcodextrins are hydroxy propyl beta-cyclodextrin and methylated beta-cyclodextrin.
• the present invention method also includes compositions comprising an oil phase.
• the oil phase is chosen from the following ingredients: skin protectants, emollients, and/or moisturizers. Saturated or hydrogenated oils are preferred. These ingredients enhance the skin feel characteristics and/or skin care benefits of the present invention. Additionally, the oil phase provides a medium in which hydrophobic antibacterials, if present, may be dissolved.
• preferred surfactants optimize both the odor absorbing characteristic of cyclodextrin and the blending ability of the surfactant.
• Such surfactants when added to an aqueous cyclodextrin solution, provide a surfactant/cyclodextrin solution which demonstrate odor absorption similar to the same cyclodextrin solution without the surfactant.
• surfactants which, when added to an aqueous cyclodextrin solution, provide a surfactant/cyclodextrin solution which demonstrate odor absorption similar to pure water.
• the preferred surfactants for use herein include block copolymers of ethylene oxide and/or propylene oxide and polyalkyleneoxide polysiloxanes. Most preferred are mixtures of at least one of each of block copolymers of ethylene oxide and/or propylene oxide and polyalkyleneoxide polysiloxanes.
• Block polyoxyethylene-polyoxypropylene polymeric compounds which are compatible with most cyclodextrins include those based on ethylene glycol, propylene glycol, glycerol, trimethylolpropane and ethylenediamine as the initial reactive hydrogen compound. Polymeric compounds made from a sequential ethoxylation and propoxylation of initial compounds with a single reactive hydrogen atom, such as C 12-18 aliphatic alcohols, are not generally compatible with the cyclodextrin.
• Block polymer surfactant compounds designated Pluronic® and Tetronic® are commercially available from the BASF-Wyandotte Corp.
• Pluronic® surfactants H(EO) n (PO) m (EO) n H;
• Reverse Pluronic® surfactants H(PO) n (EO) m (PO) n H;
• Tetronic® surfactants ##STR1## and/or
• Reverse Tetronic® surfactants ##STR2## wherein EO is an ethylene oxide group, PO is a propylene oxide group, and n and m are numbers that indicate the average number of the groups in the surfactants.
• the average molecular weight of the polyoxypropylene polymers in the mixture is between about 900 to about 25,000 and the oxyethylene groups constitute between about 10 to about 90 weight percent of the oxyethylene/oxypropylene mixture.
• Non-limiting examples of surfactants useful herein having an HLB of about 8 to 18 include: Pluronic® surfactants L10, L43, L44, L63, L64, L65, P75, P84, P85, P103, P104, P105, P123, and mixtures thereof; Reverse Pluronic® surfactants 10R5, 17R4,17R8, 22R4,25R4, 25R5, 25R8, and mixtures thereof; Tetronic® surfactants: 304, 504, 704, 707, 904, 1104, 1304, 1504, and mixtures thereof; and Reverse Tetronic® surfactants 50R4, 50R8, 70R4, 90R8, 110R7150R8, and mixtures thereof; and mixtures thereof.
• Polyalkyleneoxide polysiloxanes are defined by the general formula: ##STR3## wherein a+b are from about 1 to about 50, preferably from about 3 to about 30, more preferably from about 10 to about 25, and R 1 is mainly one or more random or block poly(ethyleneoxide/propyleneoxide) copolymer groups having the general formula:
• n is 3 or 4, preferably 3; total c (for all polyalkyleneoxy side groups) has a value of from 1 to about 100, preferably from about 6 to about 100; total d is from 0 to about 14, preferably from 0 to about 3; and more preferably d is 0; c+d has a value of from about 5 to about 150, preferably from about 9 to about 100 and each R 2 is the same or different and is selected from the group consisting of hydrogen, an alkyl having 1 to 4 carbon atoms, and an acetyl group, preferably hydrogen and methyl group.
• Examples of such compounds suitable herein include: Silwet® L-7600, L-7602, L-7604, L-7605, L-7657, and mixtures thereof; all commercially available from OSi Specialties, Endicott, N.Y.
• the molecular weight of the oxyalkylene group (R 1 ) is less than or equal to 10000.
• the molecular weight of the oxyalkylene group is less than or equal to about 8000, and most preferably ranges from about 300 to 5000.
• the values of c and d can be those numbers which provide molecular weights within these ranges.
• the number of oxyethylene units (--C 2 H 4 O) in the polyoxyalkylene groups (R 1 ) must be sufficient to render the polyalkyleneoxide polysiloxane water dispersible or water soluble.
• the oxyethylene and oxypropylene units can be distributed randomly throughout the polysiloxane chain or in respective blocks of oxyethylene and oxypropylene units or a combination of random and block distributions.
• the preparation of polyalkyleneoxide polysiloxanes is well known in the art. Such compounds can be prepared according to the procedure set forth in U.S. Pat. No. 3,299,112, incorporated herein by reference.
• the total surfactant level used in the present compositions is from about 0.05% to about 15%, more preferably from about 0.1 % to about 12%, by weight of the composition. If a hydrophobic antimicrobial agent is included, more surfactant(s) should be included, typically from about 0.5% to about 10%, by weight of the composition.
• the present invention contains a hydrophilic, volatile perfume composition comprising perfume ingredients.
• the hydrophilic perfume composition is volatile and fleeting such that the perfume is effusive and noticeable when the product is first used, but its odor impact is substantially diminished when the treated surface, e.g., skin, is dry.
• Non-limiting examples of preferred hydrophilic, volatile perfume ingredients are allyl caproate, amyl acetate, amyl propionate, anisic aldehyde, anisole, benzaldehyde, benzyl acetate, benzyl acetone, benzyl alcohol, benzyl formate, benzyl isovalerate, benzyl propionate, beta gamma hexenol, camphor gum, laevo-carveol, d-carvone, laevo-carvone, cinnamyl formate, cis-jasmone, cis-3-hexenyl acetate, cuminic alcohol, cuminic aldehyde, Cyclal C, dimethyl benzyl carbinol, dimethyl benzyl carbinyl acetate, ethyl acetate, ethyl acetoacetate, ethyl amyl ketone, ethyl
• hydrophilic, volatile perfume ingredients useful herein are allyl heptoate, anethol, carvacrol, cinnamic alcohol, citral, citronellol, citronellyl nitrile, cyclohexyl ethyl acetate, dihydro myrcenol, ethyl methyl phenyl glycidate,eugenol, fenchyl acetate, gamma-nonalactone, geranyl acetate, geranyl formate, geranyl nitrile, hexenyl isobutyrate, indole, alpha-ionone, isobornyl acetate, isobutyl benzoate, isononyl alcohol, isomenthol, isopulegol, linalyl acetate, methyl chavicol, methyl-N-methyl anthranilate, neral, neryl acetate, nonyl alde
• the hydrophilic, volatile perfume composition contains at least about 50 wt. % of hydrophilic, volatile perfume ingredients, preferably at least about 55 wt. % of hydrophilic, volatile perfume ingredients, more preferably at least about 60 wt. % of hydrophilic, volatile perfume ingredients, and even more preferably at least about 70 wt.% of hydrophilic, volatile perfume ingredients.
• Most common perfume ingredients which are derived from natural sources are composed of a multitude of components. When each such material is used in the formulation of hydrophilic, volatile perfume compositions of the present invention, it is counted as one ingredient, for the purpose of defining the invention. Synthetic reproductions of such natural perfume ingredients are also often comprised of a multitude of components and are counted as one ingredient for the purpose of defining the invention.
• the weight ratio of hydrophilic, volatile perfume ingredients to hydrophilic, residual perfume ingredients is typically greater than about 1, preferably greater than about 1.3, more preferably greater than about 1.5, and even more preferably greater than about 2.
• the perfume compositions contain at least about 50 wt. % of the combined hydrophilic, volatile perfume ingredients and hydrophilic, residual perfume ingredients, preferably at least about 55 wt. % of the combined perfume ingredients, more preferably at least about 60 wt. % of the combined perfume ingredients, and even more preferably at least about 70 wt. % of the combined perfume ingredients.
• auxiliary materials having no odor, or a low odor are used, e.g., as solvents, diluents, extenders or fixatives.
• these materials are ethyl alcohol, carbitol, dipropylene glycol, diethyl phthalate, triethyl citrate, isopropyl myristate, and benzyl benzoate. These materials may be used for solubilizing or diluting some solid or viscous perfume ingredients to improve handling and/or formulating. These materials are useful in the hydrophilic, volatile perfume compositions, but are not counted in the calculation of the limits for the definition/formulation of the hydrophilic, volatile perfume compositions of the present invention.
• Hydrophobic perfume ingredients which should be minimized in odor controlling compositions of the present invention, are those having a ClogP. of more than about 3.5. Normally, some hydrophobic perfume ingredients can be used in small amounts, e.g., to improve product odor.
• the aqueous carrier of the present invention will typically comprise from about 80% to about 98% of the present invention's composition.
• the compositions comprise the aqueous carrier at from about 85% to about 95%, by weight of the composition.
• compositions may optionally but preferably contain solubilized, mild, water-soluble, antimicrobial preservatives which are effective for inhibiting and/or regulating microbial growth in the composition.
• Contamination of the compositions by microorganisms and subsequent microbial growth can result in unsightly or malodorous compositions.
• microorganisms are typically found in cyclodextrin supplies and their growth in aqueous solutions is possible.
• the inclusion of the antimicrobial preservatives aids in increasing storage stability of the present invention. When included for preservative action, the water-soluble antimicrobials are present in an effective amount.
• the zinc salt, zinc phenolsulfonate is preferred for use in the skin composition of the present invention; although others may also fall within the scope of the present invention. However, care must be taken in selecting zinc salts, as well as their levels, since some may be irritants to the skin and therefore are not preferred for use in the present invention.
• the carbon material suitable for use in the present invention is the material well known in commercial practice as an absorbent for organic molecules and/or for air purification purposes. Often, such carbon material is referred to as "activated” carbon or "activated” charcoal. Such carbon is available from commercial sources under such trade names as; Calgon-Type CPG®; Type PCB®; Type SGL®; Type CAL®; and Type OL®.
• the process of making the mixture in the first step additionally comprises adding a premix with mixing to the surfactant(s) and the oil phase until homogenous, wherein the premix is prepared by mixing a hydrophobic antimicrobial with a surfactant(s) until the premix is homogenous.
• homogenous means a uniformly dispersed solution. Homogeneity is indicated by a substantially smooth, lump-free and uniform appearing composition. A stable emulsion remains homogeneous over a given period which is determined by the required shelf life of the composition.
• Equipment suitable for forming the mixtures and emulsion may be selected from those which are known or become known in the art.
• suitable apparatii include dual propeller blade mixers and sonifers.
• a turbine mixer and an in-line homogenizer using tandem rotor-stators, as described in the above-referenced U.S. Pat. No. 5,043,155, may also be used.
• the wipe comprises a flexible dispensing means.
• flexible dispensing means includes papers, cloths, non-wovens, films, foams, foam sheets, sponges, rollers, pads, tissues, cotton balls, and the like.
• Preferred wipe substrates comprise a porous material, such as the non-woven substrates, foams, or sponges, which are capable of holding the composition within the pores of the substrates. Examples of cellulosic non-wovens particularly useful and economic in the present invention are described in U.S. Pat. No. 4,191,609, Trokhan, issued Mar. 4, 1980. Further description of useful wipes and methods of making said wipes are found in World Patent 95/17175, to Mitra et. al, publication date of Jun. 29, 1995. Both references are incorporated herein by reference in their entireties.
• the hydroxy propyl beta cyclodextrin in the above examples could be substituted with other beta cyclodextrins, alpha-cyclodextrins, gamma-cyclodextrins, or mixtures of these cyclodextrins and/or their derivatives.
• the examples could comprise other hydrophobic antimicrobials.
• Example II Prepare Examples I-III as follows: Prepare a premix by mixing triclosan with about 1/6, by weight, of total Pluronic® L and/or Silwet® L (Example III only). Prepare a first mixture by mixing about 1% of water, by total formula weight, with a perfume and surfactant(s). For Example III, preparing the first mixture also includes a final step of adding the premix with mixing. Using a sonifier, prepare a second mixture by adding dimethicone to the first mixture, then slowly adding about 1%-2% of water, by total formula weight.
• premix (a) by mixing hydroxypropyl beta cyclodextrin and about 1.5%-3% of water, by total formula weight; premix (b) by mixing zinc phenolsulfonate and about 2% of water, by total formula weight; premix (c) by mixing the ascorbic acid and about 2% of water by total formula weight; and premix (d) by mixing Glydant® Plus (and Suttocide® A) and propylene glycol.
• a homogenizer add remaining water to the second mixture to create a third mixture. Add premixes (a), (b), (c), and (d) to the third mixture using the homogenizer.
• solutions of the present invention such as those formed from the examples may be loaded onto a wipe or poured into a spray device or poured directly onto the skin or cloth of the user's choosing for convenient application to the skin and/or hair.
• To prepare spray Pour the composition into the selected spray package. Close the package for storage until consumer use.
• a man is cooking fish and a spicy sauce requiring the dicing of garlic, onions, and various peppers. He is told that his hands and hair smell of these food odors and he wants to remove these odors from his body. The man rubs his hands and hair with wipes containing the composition in Example I. Each wipe deposits about 0.05 grams of environmental odor-absorbing composition on the skin and hair. The man notices less odor after using the wipes.
• a man on his way to an important meeting, stops to buy gasoline for his car. As he is filing the gas tank, gasoline splashes on his hands. The man wipes his hands on a paper towel but the gasoline odor remains on his hands. The man removes a small bottle from his gym bag which contains the composition of Example III. He opens the bottle and pours some of the composition on his hands, delivering roughly about 0.5 grams of the environmental odor-absorbing composition. He then smells his hands and notices that the gasoline odor is no longer present.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Epidemiology (AREA)
• Birds (AREA)
• Engineering & Computer Science (AREA)
• Biomedical Technology (AREA)
• Cosmetics (AREA)
• Fats And Perfumes (AREA)
• Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
• Compositions Of Macromolecular Compounds (AREA)
• Polysaccharides And Polysaccharide Derivatives (AREA)

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Cited By (31)

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• 1997
  • 1997-06-09 US US08/871,166 patent/US5942214A/en not_active Expired - Fee Related
• 1998
  • 1998-06-08 HU HU0004525A patent/HUP0004525A3/hu unknown
  • 1998-06-08 AU AU78257/98A patent/AU7825798A/en not_active Abandoned
  • 1998-06-08 TR TR1999/03041T patent/TR199903041T2/xx unknown
  • 1998-06-08 KR KR19997011622A patent/KR20010013612A/ko not_active Application Discontinuation
  • 1998-06-08 CN CN98806859A patent/CN1261785A/zh active Pending
  • 1998-06-08 ID IDW991561A patent/ID27862A/id unknown
  • 1998-06-08 WO PCT/US1998/011812 patent/WO1998056341A1/en not_active Application Discontinuation
  • 1998-06-08 BR BR9809995-7A patent/BR9809995A/pt not_active IP Right Cessation
  • 1998-06-08 EP EP98926413A patent/EP0991401A1/en not_active Withdrawn
  • 1998-06-08 JP JP50303199A patent/JP2001506276A/ja not_active Ceased
  • 1998-06-08 CA CA002293417A patent/CA2293417A1/en not_active Abandoned
  • 1998-06-09 CO CO98032877A patent/CO4940387A1/es unknown
  • 1998-06-09 PE PE1998000481A patent/PE98399A1/es not_active Application Discontinuation
• 1999
  • 1999-12-08 NO NO996055A patent/NO996055L/no not_active Application Discontinuation

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