US4084588A - Parenteral drug storage device with closure piercing coupling member - Google Patents

Parenteral drug storage device with closure piercing coupling member Download PDF

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Publication number
US4084588A
US4084588A US05/668,388 US66838876A US4084588A US 4084588 A US4084588 A US 4084588A US 66838876 A US66838876 A US 66838876A US 4084588 A US4084588 A US 4084588A
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US
United States
Prior art keywords
cap
syringe
coupling member
barrel
seal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US05/668,388
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English (en)
Inventor
Elmer A. Koenig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sherwood Medical Co
Original Assignee
Sherwood Medical Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sherwood Medical Industries Inc filed Critical Sherwood Medical Industries Inc
Priority to US05/668,388 priority Critical patent/US4084588A/en
Priority to CA272,606A priority patent/CA1091526A/fr
Priority to GB9058/77A priority patent/GB1572866A/en
Priority to DE19772711732 priority patent/DE2711732A1/de
Priority to JP3025077A priority patent/JPS52113593A/ja
Priority to BR7701696A priority patent/BR7701696A/pt
Priority to FR7708306A priority patent/FR2344279A1/fr
Priority to BE175932A priority patent/BE852650A/fr
Application granted granted Critical
Publication of US4084588A publication Critical patent/US4084588A/en
Assigned to SHERWOOD MEDICAL COMPANY reassignment SHERWOOD MEDICAL COMPANY MERGER (SEE DOCUMENT FOR DETAILS). Assignors: SHERWOOD MEDICAL INDUSTRIES INC. (INTO)
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents

Definitions

  • This invention relates to containers for parenteral drugs and, more particularly, to parenteral drug storage devices of the type that can be prefilled with a drug for storage and which has means for arming the device prior to administration of the drug.
  • Parenteral drugs are often packaged and stored in glass ampoules or vials. Ampoules are used by breaking the necked portion and inserting the needle of a syringe into the main body portion to draw the desired quantity of drug into the syringe. Vials are used by inserting the needle of a syringe through the rubber stopper on the vial.
  • both a syringe and an ampoule or vial are required.
  • the additional handling of the parts in order to fill the syringe increases the danger of contamination.
  • the time required to fill the syringe, particularly where the dosage is of relatively large volume can be highly undesirable, especially in emergency cases.
  • Prefilled syringes generally have a double-ended needle cannula which is shifted relative to the barrel containing the drug to arm the syringe for use. While the drug may be conveniently stored in the syringe barrel, these devices usually employ a glass barrel having a generally relatively expensive necked-down portion with a flange, and a cap clamping a pierceable seal to the barrel end and being fitted over the flange, for example, as disclosed in U.S. Pat. No. 3,406,686 and 3,375,825.
  • Both of the above-mentioned systems are also generally limited in use to applications where direct infusion of the drug is accomplished through the needle connected to the barrel.
  • Neither system is generally suitable for use with other drug administration devices such as catheters, intravenous administration or infusion devices employing catheters, or other conventional fluid couplers.
  • Another object is to provide a parenteral drug storage device which can be prefilled with a parenteral drug for long term storage, preserves the potency and sterility of the drug during storage, and which has a safe means for transferring the drug to the patient with a minimum chance of contaminating the drug.
  • a container for a drug is provided with an opeing at one end, a seal closing the opening, a cap member secured to the container, and a coupling member disposed for sliding movement relative to the cap member which has a seal piercing portion at one end and a coupling portion at the other end for receiving a fluid coupling element for administering the drug.
  • FIG. 1 is an elevational cross-sectional view of a syringe in accordance with a preferred embodiment of the present invention
  • FIG. 2 is an elevational view, on a reduced scale, of the coupling member of the syringe of FIG. 1, and a fragmentary sectional view of a coupling element connectable with the coupling member;
  • FIG. 3 is a fragmentary cross-sectional view, on an enlarged scale, of portions of the cap and coupling members 26 and 40 of FIG. 1;
  • FIG. 4 is a top end view of the coupling member of FIG. 2.
  • a syringe 10 capable of storing a parenteral drug 11, such as a drug in liquid form.
  • the syringe includes a cylindrical syringe barrel 12, preferably of glass, having an open proximal or lower end 13 receiving a plunger 14 having a sealing piston 16, such as of rubber, and a piston rod 18 connected, such as by threads (not shown), to the piston 16.
  • the upper or distal end 17 of the barrel 12 has a radially inwardly extending, substantially flat, end portion 20 with a central opening 22 therein.
  • the opening 22 is closed by a seal member 24.
  • the seal member 24 is formed of a suitable elastomer such as silicone or natural rubber.
  • the seal member may be formed, for example, of a silicone rubber with a coating of polytetrafluoroethylene, such as Teflon or the like, on the interior side of it so that the drug which may be stored within the barrel 12 is not affected or contaminated by the rubber seal member.
  • the seal member 24 is clamped against the exterior side of the barrel end portion 20 by a cap 26 with the seal member covering and closing the opening 22.
  • the cap 26 has a lower cylindrical portion 28 integral with a radially inwardly extending shoulder portion 30 which is integrally connected with a distally extending cylindrical sleeve 32 at the upper portion of the cap.
  • a pair of circular ribs or rings 34 and 36 extend downwardly from the inner surface of portion 30 which engage and extend into the seal member 24.
  • the cap 26 may be made by the injection molding of a suitable plastic, for example, polypropylene. It is formed such that the lower cylindrical portion 28 has an inside diameter slightly less than the outside diameter of the glass barrel 12.
  • the cap 26 When applying the cap 26, it is preferable to heat the cap to slightly soften it and then apply it by moving it down onto the upper end of the barrel 12 with the seal 24 between the barrel end portion 20 and radial shoulder portion 30 of the cap. As the cap 26 cools, it shrinks so that upon cooling, the cap provides a good tight fit with the barrel and the seal 24 is sealingly clamped between the cap and barrel to provide a liquid-tight seal for the distal end of the barrel.
  • the rings 34 and 36 provide higher pressure areas for better sealing and reduce the tendency of the seal to slide toward its center during needle penetration.
  • the cap 26 supports a movable syringe arming and fluid coupling member 40, the member 40 being connected to the cap for sliding movement relative to the cap.
  • Member 40 is preferably a single-piece member having a needle or pointed portion 42 at the proximal or lower end, and a fluid coupling portion 44 at the distal or upper end.
  • the coupling portion 44 is shown as a luer lock coupler of conventional configuration which has a luer tapered central portion 46 and a concentric, radially outer, internally threaded luer locking portion 48.
  • Coupler 44 is generally referred to as a male luer lock connector and is adapted to receive a complementary coupling element such as a female luer lock connector, partially shown in FIG.
  • the luer lock coupling element 50 which is of conventional construction, has a luer tapered bore portion 52, and a pair of diametrically opposed radial lugs 54 and 56 which serve as threads.
  • the lugs cooperate with the internal threads on locking portion 48 of the coupling member 40 to cause the bore 52 to be drawn into fluid tight engagement with the lure tapered portion 46 when rotated.
  • a hypodermic needle having a female lure lock connector like connector 50 may be connected to coupling portion 44, or medical tubing or a catheter, such as an intravenous catheter that is provided with a luer lock coupling element like element 50 may be connected to the coupling portion 44.
  • coupling portion 44 may be a simple slip fit type connector without internal threads.
  • the coupling member 40 has a central lumen 58 extending through the luer tapered portion 46 and needle 42.
  • the needle is provided with a pair of opposed side openings or holes 60 and 62 which connect with lumen 58.
  • Coupling member 40 is a single-piece molded member of a suitable plastic, such as a relatively hard polycarbonate.
  • the arming and coupling member 40 is sized to slide on the cylindrical portion 32 of cap 26.
  • the member 40 is slidable within the cap from an initial or normal unarmed position, the position shown in the drawing, to an armed position wherein an end portion of the needle 42 and the holes 60 and 62 are disposed within the barrel 12 so that the drug 11 within the barrel 12 is in fluid communication with lumen 58, the lower end of the needle shown in phantom in its armed position.
  • the coupling member 40 has a generally cylindrical outer surface with a pair of diametrically opposed axially extending keys or ribs 64 and 66 which are slidable in a pair of diametrically opposed, axially extending, grooves or keyways 68 (one shown) in the cylindrical portion 32 of cap 26.
  • This key and keyway arrangement prevents the member 40 from rotating on its axis when a female luer coupling element, such as element 50, is rotated into sealing engagement with the member 46.
  • annular rib or skirt 72 which has an outer diameter slightly greater than the inner diameter of cap portion 32 but which is resilient enough to allow the insertion and movement of member 40 in the cylindrical portion 32.
  • the skirt 72 snaps into an annular groove 74 formed in the side wall of the cylindrical portion 32 intermediate its ends, as best seen in FIG. 3, to hold and maintain the member 40 in the unarmed position.
  • a protective arming cap or end closure 76 preferably of a suitable plastic such as polypropylene, is shown having a cylindrical portion 78 with an inner diameter such that it slides over the outer surface of the cylindrical portion 32 of cap 26, and an upper integral radial end wall 80.
  • the end closure cap 76 is preferably heat staked or spot-welded to cap 26, such as indicated at 82.
  • the cap 26 is merely rotated to break the spot-weld 82 and then moved axially toward the barrel 12.
  • the upper end of the central luer tapered portion 46 of the member 40 extends above the upper end of the threaded portion 48 and engages the inner side of the wall 80 of closure cap 76.
  • the cap 76 When the cap 76 is moved axially, it causes the member 40 to move downwardly with the skirt 72 being forced out of groove 74 (FIG. 3) and to slide along the inner wall of the cylindrical portion 32 until it engages the seal member 24. During this downward movement, the needle 42 pierces the seal member to place the lumen 58 in fluid communication with the fluid 11 in the barrel 12.
  • the skirt 72 enters a lower undercut or groove 84 in cap portion 32 to ensure that the coupling member 40 remains in the armed position during use of the syringe.
  • the end closure cap 76 After the end closure cap 76 has been used to arm the syringe, it is removed and a coupling element, such as element 50, of the device to which the luer lock coupling member 44 is to be connected, is attached.
  • the syringe plunger 14 may then be moved distally relative to the barrel 12 to cause the liquid drug 11 within the cylindrical barrel 12 to flow into the holes 60 and 62 of the needle 42, through lumen 58, to coupling portion 44 and to the apparatus connected to element 50.
  • the coupling member 40 provides a simple and effective member which is capable of arming the syringe and which permits different types of medicament applying, infusion devices or coupling elements, such as 50, to be quickly and readily coupled in fluid communication with the fluid in the syringe barrel. No transfer of fluid from a container to the syringe at the time of use is required and the medicament can be directly stored in the syringe 10. This avoids the disadvantages previously mentioned in connection with systems requiring the transfer of fluid.
  • the needle 42 can be formed so that it does not tend to core the seal member since it is not subsequently inserted into a patient.
  • cap 26 and seal member 24, and the heat staking of it to the barrel 12 provide a highly effective puncturable seal assembly for the syringe 10.
  • the end wall 20 of the barrel is substantially flat so that it is more economically made than the necked type.
  • the hole 22 can be post-formed in the wall 20.
  • the parenteral drug storage device of the present invention is especially well suited in the form of a syringe, as is shown and described in the preferred embodiment herein.
  • other devices such as vials can be advantageously provided with closures and arming parts similar to those of syringe 10.
  • a vial container having an integrally closed bottom can be advantageously provided at the open end with closure and arming members like members 24, 26, 40, and 76.
  • the vial is armed in the same manner as described with syringe 10.
  • the luer slip portion of the coupling member in such case may be of the female type so as to receive a male luer slip member such as commonly provided on the end of a syringe barrel. After such syringe barrel is filled, a hypodermic needle may be attached for injection purposes.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US05/668,388 1976-03-19 1976-03-19 Parenteral drug storage device with closure piercing coupling member Expired - Lifetime US4084588A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US05/668,388 US4084588A (en) 1976-03-19 1976-03-19 Parenteral drug storage device with closure piercing coupling member
CA272,606A CA1091526A (fr) 1976-03-19 1977-02-24 Contenant scelle pour medicament administre par voie parenterale
GB9058/77A GB1572866A (en) 1976-03-19 1977-03-03 Parenteral drug storage device with closure piercing coupling member
DE19772711732 DE2711732A1 (de) 1976-03-19 1977-03-17 Arzneimittel-lagervorrichtung
JP3025077A JPS52113593A (en) 1976-03-19 1977-03-18 Nonnperoral medicine stock injector
BR7701696A BR7701696A (pt) 1976-03-19 1977-03-18 Dispositivo e seringa de armazenagem de droga parenteral
FR7708306A FR2344279A1 (fr) 1976-03-19 1977-03-18 Reservoir de medicament a administration parenterale
BE175932A BE852650A (fr) 1976-03-19 1977-03-18 Recipients et seringues pour medicaments a administration par voie parenterale

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/668,388 US4084588A (en) 1976-03-19 1976-03-19 Parenteral drug storage device with closure piercing coupling member

Publications (1)

Publication Number Publication Date
US4084588A true US4084588A (en) 1978-04-18

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Family Applications (1)

Application Number Title Priority Date Filing Date
US05/668,388 Expired - Lifetime US4084588A (en) 1976-03-19 1976-03-19 Parenteral drug storage device with closure piercing coupling member

Country Status (8)

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US (1) US4084588A (fr)
JP (1) JPS52113593A (fr)
BE (1) BE852650A (fr)
BR (1) BR7701696A (fr)
CA (1) CA1091526A (fr)
DE (1) DE2711732A1 (fr)
FR (1) FR2344279A1 (fr)
GB (1) GB1572866A (fr)

Cited By (31)

* Cited by examiner, † Cited by third party
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US4221218A (en) * 1979-01-18 1980-09-09 Pfleger Frederick W Disposable hypodermic syringe
WO1988001881A1 (fr) * 1986-09-18 1988-03-24 Aktiebolaget Leo Raccord et unite jetable utilisant ledit raccord
US5230427A (en) * 1991-06-12 1993-07-27 Ppg Industries, Inc. Sterilizable hermetically-sealed substantially glass container
US5249391A (en) * 1991-08-19 1993-10-05 Omala Inc. Tree injection device
US5401253A (en) * 1993-01-12 1995-03-28 Reynolds; David L. Intravenous infusion of pharmaceuticals
US5611785A (en) * 1993-08-06 1997-03-18 Nihon Medi-Physics Co., Ltd. Luer needle unit and injector
WO1998032411A1 (fr) * 1997-01-24 1998-07-30 Smithkline Beecham Biologicals S.A. Nouveau dispositif
WO2000025852A1 (fr) * 1998-10-29 2000-05-11 Minimed Inc. Raccord pour reservoir
US6068614A (en) * 1994-11-03 2000-05-30 Astra Pharmaceuticals Pty, Ltd. Plastic syringe with overcap
US6132402A (en) * 1999-02-02 2000-10-17 Bioform Inc. Storage and delivery device for a catheter or needle
US6210372B1 (en) 1999-06-17 2001-04-03 Bioform, Inc. Storage and delivery device for a catheter or needle
US6209738B1 (en) * 1998-04-20 2001-04-03 Becton, Dickinson And Company Transfer set for vials and medical containers
US6248093B1 (en) 1998-10-29 2001-06-19 Minimed Inc. Compact pump drive system
US6342061B1 (en) 1996-09-13 2002-01-29 Barry J. Kauker Surgical tool with integrated channel for irrigation
US6398031B1 (en) * 1999-03-25 2002-06-04 Pierre Frezza Vial for packaging a liquid for medical use
US20030167039A1 (en) * 1999-10-28 2003-09-04 Medtronic Minimed, Inc. Drive system seal
US20030187406A1 (en) * 2000-06-15 2003-10-02 Spofforth Leonard Morris Hypodermic syringe with passive aspiration feature
US20040085215A1 (en) * 1998-10-29 2004-05-06 Medtronic Minimed, Inc. Method and apparatus for detecting errors, fluid pressure, and occlusions in an ambulatory infusion pump
US20040092873A1 (en) * 1998-10-29 2004-05-13 Medtronic Minimed Inc. External infusion device with a vented housing
US20050124941A1 (en) * 2003-11-14 2005-06-09 Martin Panchula Package for pharmaceutical formulation
US20060136049A1 (en) * 2004-12-20 2006-06-22 Rojo Nicholas A Implantable systems and stents containing cells for therapeutic uses
US20080281264A1 (en) * 2007-05-08 2008-11-13 Alan Reid Methods and apparatus for syringe adapter
US7628772B2 (en) 1998-10-29 2009-12-08 Medtronic Minimed, Inc. Reservoir connector
US20100168712A1 (en) * 2006-05-25 2010-07-01 Bayer Healthcare Llc Reconstitution device
US20100179473A1 (en) * 2006-12-29 2010-07-15 Amir Genosar Hypodermic drug delivery reservoir and apparatus
WO2012044565A1 (fr) * 2010-09-28 2012-04-05 Tyco Healthcare Group Lp Système d'aiguille de transfert de flacon à deux composants
CN102458538A (zh) * 2009-06-03 2012-05-16 贝克顿迪金森法国公司 改进型鲁尔锁适配器
US8663188B2 (en) 2007-12-28 2014-03-04 Aktivpak, Inc. Dispenser and therapeutic package suitable for administering a therapeutic substance to a subject, along with method relating to same
WO2014159213A1 (fr) * 2013-03-29 2014-10-02 Animas Corporation Cartouche de fluide pour un dispositif médical de perfusion
US10611048B1 (en) * 2016-05-27 2020-04-07 SmartFume Co. Wood treatment device
US20200209270A1 (en) * 2017-09-13 2020-07-02 Roche Diagnostics Operations, Inc. Sample container carrier, laboratory sample distribution system and laboratory automation system

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US4465472A (en) * 1982-11-22 1984-08-14 American Hospital Supply Corp. Syringe cartridge and method
JPS5985237U (ja) * 1982-11-29 1984-06-08 株式会社トツプ 予め薬液を充填した注射筒
JPS59100433U (ja) * 1982-12-24 1984-07-06 株式会社トツプ カ−トリツジを内挿した注射器
EP0126718A3 (fr) * 1983-05-20 1985-10-23 Bengt Gustavsson Dispositif pour transmettre une substance d'un récipient à un autre récipient, ainsi que l'application proposée
DE3531071A1 (de) * 1985-08-30 1987-03-05 Merck Patent Gmbh Oeffnungshilfe fuer ampullen
JPS647045A (en) * 1987-06-30 1989-01-11 Fuji Electric Co Ltd Electrophotographic sensitive body
NO891734L (no) * 1989-04-26 1990-10-29 Ken Heimreid Anordning ved lukke for beholdere for eventuelt infisertevaesker.
JP3385645B2 (ja) * 1993-03-12 2003-03-10 ニプロ株式会社 薬液充填型注射器
ATE173638T1 (de) * 1993-06-17 1998-12-15 Farco Gmbh Verfahren zur herstellung einer sterilen bereitschaftspackung und behältnis für eine solche bereitschaftspackung
JP3385598B2 (ja) * 1993-07-16 2003-03-10 ニプロ株式会社 自動注射器
DE19603632C2 (de) * 1996-02-01 1999-06-02 Claus H Dr Ing Backes Adapter für ein Fluidentnahmesystem
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US3405712A (en) * 1966-02-07 1968-10-15 Richard L. Pierick Desiccative syringe
US3406686A (en) * 1965-01-15 1968-10-22 Becton Dickinson Co Prefilled syringe
US3739779A (en) * 1970-04-28 1973-06-19 Medical Electroscience & Pharm Hypodermic syringe and needle construction
US3884229A (en) * 1973-11-29 1975-05-20 Burron Medical Prod Inc Hypodermic syringe and needle assembly
DE2442856A1 (de) * 1974-05-07 1975-11-13 Roger Roy Larson Sicherheitskappe

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Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
US2661740A (en) * 1952-02-07 1953-12-08 Bishop & Co Platinum Works J Disposable syringe
US3336924A (en) * 1964-02-20 1967-08-22 Sarnoff Two compartment syringe package
US3406686A (en) * 1965-01-15 1968-10-22 Becton Dickinson Co Prefilled syringe
US3375825A (en) * 1965-09-02 1968-04-02 Becton Dickinson Co Prefilled syringe
US3405712A (en) * 1966-02-07 1968-10-15 Richard L. Pierick Desiccative syringe
US3739779A (en) * 1970-04-28 1973-06-19 Medical Electroscience & Pharm Hypodermic syringe and needle construction
US3884229A (en) * 1973-11-29 1975-05-20 Burron Medical Prod Inc Hypodermic syringe and needle assembly
DE2442856A1 (de) * 1974-05-07 1975-11-13 Roger Roy Larson Sicherheitskappe

Cited By (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4221218A (en) * 1979-01-18 1980-09-09 Pfleger Frederick W Disposable hypodermic syringe
WO1988001881A1 (fr) * 1986-09-18 1988-03-24 Aktiebolaget Leo Raccord et unite jetable utilisant ledit raccord
US4927423A (en) * 1986-09-18 1990-05-22 Aktiebolaget Leo Connector and a disposable assembly utilizing said connector
US5230427A (en) * 1991-06-12 1993-07-27 Ppg Industries, Inc. Sterilizable hermetically-sealed substantially glass container
US5249391A (en) * 1991-08-19 1993-10-05 Omala Inc. Tree injection device
US5401253A (en) * 1993-01-12 1995-03-28 Reynolds; David L. Intravenous infusion of pharmaceuticals
US5611785A (en) * 1993-08-06 1997-03-18 Nihon Medi-Physics Co., Ltd. Luer needle unit and injector
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Also Published As

Publication number Publication date
FR2344279A1 (fr) 1977-10-14
FR2344279B1 (fr) 1982-03-05
JPS52113593A (en) 1977-09-22
BE852650A (fr) 1977-07-18
DE2711732A1 (de) 1977-09-22
CA1091526A (fr) 1980-12-16
GB1572866A (en) 1980-08-06
BR7701696A (pt) 1978-01-24

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