US3921630A - Thermoplastic bottle with controlled lateral collapse and method of dispensing liquid therefrom - Google Patents

Thermoplastic bottle with controlled lateral collapse and method of dispensing liquid therefrom Download PDF

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Publication number
US3921630A
US3921630A US445836A US44583674A US3921630A US 3921630 A US3921630 A US 3921630A US 445836 A US445836 A US 445836A US 44583674 A US44583674 A US 44583674A US 3921630 A US3921630 A US 3921630A
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United States
Prior art keywords
bottle
liquid
base
shoulder
oval
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US445836A
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English (en)
Inventor
Charles J Mcphee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kendall Mcgraw Laboratories Inc
General Electric Co
Original Assignee
American Hospital Supply Corp
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Publication date
Application filed by American Hospital Supply Corp filed Critical American Hospital Supply Corp
Priority to US445836A priority Critical patent/US3921630A/en
Priority to IN2874/CAL/74A priority patent/IN143639B/en
Priority to CA217,210A priority patent/CA1046013A/en
Priority to AU77060/74A priority patent/AU481401B2/en
Priority to FR7500005A priority patent/FR2261781B1/fr
Priority to ZA00750035A priority patent/ZA7535B/xx
Priority to PH16716A priority patent/PH11706A/en
Priority to TR19086A priority patent/TR19086A/xx
Priority to ES433993A priority patent/ES433993A1/es
Priority to DE19752502310 priority patent/DE2502310A1/de
Priority to IT7547775A priority patent/IT1026409B/it
Priority to EG45/75A priority patent/EG11580A/xx
Priority to BE153000A priority patent/BE825117A/xx
Priority to BR745/75A priority patent/BR7500745A/pt
Priority to CH181975A priority patent/CH582093A5/xx
Priority to AR257642A priority patent/AR201642A1/es
Priority to JP50021433A priority patent/JPS50118888A/ja
Priority to GB7395/75A priority patent/GB1483553A/en
Application granted granted Critical
Publication of US3921630A publication Critical patent/US3921630A/en
Assigned to KENDALL MCGAW LABORATORIES, INC., A CORP OF OH reassignment KENDALL MCGAW LABORATORIES, INC., A CORP OF OH ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: AMERICAN HOSPITAL SUPPLY CORPORATION, A CORP OF IL
Assigned to WELLS FARGO BANK, N.A. reassignment WELLS FARGO BANK, N.A. SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MCGAW, INC., A CORP. OF OH
Assigned to KENDALL MCGAW LABORATORIES, INC. AN OH CORPORATION reassignment KENDALL MCGAW LABORATORIES, INC. AN OH CORPORATION RELEASED BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: MANUFACTURERS HANOVER TRUST COMPANY
Assigned to KENDALL MCGAW LABORATORIES, INC. reassignment KENDALL MCGAW LABORATORIES, INC. RELEASED BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: MANUFACTURERS HANOVER TRUST COMPANY
Assigned to MCGAW, INC., MORAINE, MONTGOMERY COUNTY, A CORP. OF OH reassignment MCGAW, INC., MORAINE, MONTGOMERY COUNTY, A CORP. OF OH MERGER (SEE DOCUMENT FOR DETAILS). EFFECTIVE ON 10/22/1990 MAINE Assignors: MG ACQUISITION CORP. A CORP. OF DE (MERGED TO) KENDALL MCGAW LABORATORIES, INC., A CORP. OF OHIO
Assigned to GENERAL ELECTRIC CAPITAL CORPORATION, A NEW YORK CORP. reassignment GENERAL ELECTRIC CAPITAL CORPORATION, A NEW YORK CORP. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: MCGAW, INC., A DELAWARE CORP.
Assigned to MCGAW, INC. A CORP. OF DELAWARE reassignment MCGAW, INC. A CORP. OF DELAWARE SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WELLS FARGO BANK, N.A.
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Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/70—Device provided with specific sensor or indicating means
    • A61J2200/76—Device provided with specific sensor or indicating means for fluid level
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/24—Medical-surgical bags
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/03—Medical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/90—Collapsible wall structure

Definitions

  • a 1 liter collapsible bottle has an accuracy of 130 ml., which accuracy is equivalent to that of a rigid glass bottle of the same size.
  • Sterile medical liquid such as a parenteral solution or blood
  • a parenteral solution or blood is commonly infused into a patients vein from a container hanging above the patient.
  • the sterile liquid flows by gravity through a tubular administration set connected at one end to the container and at an opposite end to a venous needle in the patient.
  • Sterile parenteral solutions such as dextrose, normal saline, etc. are frequently supplied to the hospitals in sealed, sterilized containers.
  • These containers are basically of two types rigid glass bottles, or flexible bags.
  • Such containers come in various sizes such as A, /2, l and 2 liters, with the 1 liter size being the most commonly used for intravenous therapy. Both types of containers have disadvantages because of their particular structure.
  • a volumetrically calibrated glass bottle gives an accurate volumeric reading of :30 ml. of the actual volume of liquid in a 1 liter bottle because a rigid glass bottle retains its shape and maintains an upper surface of the liquid that can be easily read against the calibrations.
  • Typical air inletting systems include an air tube extending into the bottle or a filtered air vent that bubbles air into the bottle through its liquid contents. Because of the air inletting requirements these systems are called open systems.
  • a flexible bag does not require an air-inletting system because its walls can collapseas liquid is dispensed. Such a system is called a closed system.
  • a closed system is much preferred over an open system because there is no requirement for air tubes, filters, etc.
  • the flexible bag has other serious disadvantages.
  • First the flexible bag is limp making it difficult to handle. Also the bag will not effectively support itself upright on its own base.
  • Another disadvantage with a flexible bag is its inaccurate volume measurements.
  • a flexible bag has an .uncontrolled collapse and when volumetrically calibrated can give a volumetric reading that it is in error as much as :200 ml. from the actual volume of liquid in a 1 liter flexible bag.
  • a factor contributing to these inaccurate volumetric readings are the variable tear- .drop shapes the bags form as they collapse. When the flexible bags are all printed with the same calibrations but collapse differently, this causes great errors in volumetric readings from the calibrations.
  • the rigid glass bottle has the disadvantage of requiring an open-air inletting system to replace a dispensed liquid.
  • the flexible bag has disadvantages of being limp and difficult to handle, and also has an uncontrolled collapse which makes for inaccurate volumetric readings of the dispensed liquid.
  • thermoplastic bottle of this invention has a structure that (l supports the bottle upright on its rigid base, (2) causes a controlled lateral collapse of the bottle when dispensing to give volumetric accuracy equivalent to that of a rigid glass bottle, and (3) dispenses its entire liquid contents through a closed system, while a gas within the bottle is redistributed throughout the bottle to occupy pockets that form at upper and lower ends of the bottle.
  • the applicants bottle is of a thermoplastic material and an oval base at one end, an oval shoulder with a dispensing outlet at an opposite end, and a thin flexible oval side wall extending between the base and shoulder.
  • This thin flexible oval side wall extending between the base and shoulder has a major axis and a minor axis.
  • the base and shoulder are substantially more rigid than the flexible side wall and the bottle can be suspended from its rigid base without collapse of this base.
  • a sterile liquid occupying 50 to 95% of the bottles volume with a sterile air space above the liquid.
  • the rigid oval shoulder and base prevent opposed portions of the side wall from contacting each other at the liquids upper surface. This maintains the liquids upper surface in a level condition and readily visible'for accurately reading againstthe volumetric calibrations through its entire descent as-the bottle empties. As the bottle partially collapses to dispense its entire liquid contents, the sterile air occupies pockets tht form at the base and shoulder portions of the bottle.
  • FIG. 1A is a side elevational view of the flexible bag of the prior art shown in its storing position
  • FIGS. 1B, 1C, and ID are side elevational views of the prior art flexible bag showing it suspended for dispensing
  • FIG. 2A is a side elevational view of a prior art rigid glass bottle showing it in storing position
  • FIGS. 2B, 2C, and 2D are side elevational views of the rigid glass bottle of the prior art showing it suspended for dispensing;
  • FIG. 3A is a side elevational view of the applicants thermoplastic bottle in storing position:
  • FIG. 3B is a side elevational view of applicants bottle suspended for dispensing
  • FIG. 3C is applicants bottle with approximately onehalf of its contents dispensed
  • FIG. 3D is a side elevational view of applicants bottle with approximately three-fourths of its contents dispensed;
  • FIG. 3E is a side elevational view of applicants bottle connected with an administration set forming a closed system
  • FIG. 4 is a front elevational view of a first embodiment of applicants bottle as it is supplied to the hospital;
  • FIG. 5 is a side elevational view of the bottle of FIG.
  • FIG. 6 is a sectional view taken along line 6-6 of FIG. 4;
  • FIG. 7 is a sectional view taken along line FIG. 4;
  • FIG. 8 is a sectional view taken along line 88 of FIG. 4;
  • FIG. 9 is a top plan view of the bottle of FIG. 4;
  • FIG. 10 is a bottom plan view of the bottle of FIG. 4;
  • FIG. 11 is a front elevational view of a second embodiment of applicants bottle which has a more sloping shoulder configuration than the first embodiment;
  • FIG. 12 is a side elevational view of the bottle of FIG.
  • FIG. 13 is a front elevational view of the bottle of FIG. 11 suspended for dispensing and showing the slope ing shoulder feature;
  • FIG. 14 is a side elevational view of the bottle of FIG. 4 showing a pouring container outlet opening
  • FIG. 15 is an enlarged sectional view of the bottle of FIG. 12 with an outlet system for connecting to a parenteral liquid administration set;
  • FIG. 16 is an. enlarged sectional side elevational view of the bottle of FIG. 15 showing it suspended from its rigid base and connected to a parenteral liquid administration set;
  • FIG. 17 is an enlarged sectional view of the FIG. 16 bottle showing it with approximately one-half of its contents dispensed;
  • FIG. 18 is an enlarged sectional view of FIG. 16 hottle showing it with approximately three-fourths of its contents dispensed;
  • FIG. 19 is an enlarged fragmentary view of the upper and lower lefthand corners of the bottle shown in FIG. 16;
  • FIG. 20 is an enlarged exploded view of a closure system designed for connection with a parenteral liquid administration set.
  • FIG. 21 is an enlarged exploded view of a closure system for dispensing liquid from the applicants thermoplastic bottle by pouring.
  • FIGS. 1A through 1D. represent the prior art of flexible thermoplastic bags used for dispensing either intravenous solutions or blood.
  • the flexible bag 1 has a dispensing spout 2 at one end and a base 3 at an opposite end.
  • One of the main disadvantages of the flexible bag is that it has no definite shape. The bag is limp and difficult to handle and will not support itself upright on its own base.
  • the flexible bag shown in dispensing position in FIGS. 1B through 1D have been used primarily for dispensing blood.
  • the bag With blood, the bag is normally filled with one pint'( approximately one-half liter) and the entire contents of the blood bag dispensed at one time to a patient.
  • the accuracy of the blood bags liquid contents is usually controlled by weighing the blood bag when collecting blood from a donor. Thus, blood bags do not need to be accurately calibrated.
  • intravenous solutions such as 5% dextrose, normal saline, etc.
  • the physician often desires to administer less than the full contents of the container or to know how much has been administered. For instance, from a 1 liter bottle a physician might want to administer 350 ml. This is why volumetric accuracy is extremely important in intravenous solution therapy.
  • FIG. 2A shows the second type of prior art medical liquid container which is a rigid glass bottle.
  • rigid glass bottle 4 has a dispensing closure system 5 at one end and a supporting base 6 at an opposite end.
  • the rigid glass bottle supports itself upright on its base and retains its shape.
  • the rigid glass bottle is hung from a bail 7, for dispensing liquid to a patient through a tube 8.
  • the liquid from bottle 4 is approximately one-third administered. In FIG. 2D the liquid is nearly two-thirds administered.
  • thermoplastic bottle shown in FIG. 3A isa blow;
  • thermoplastic bottle with a rigid shoulder 10 at one end and a rigid base 11 at an opposite end.
  • rigid shoulder has a dispensing outlet therethrough. Integrally connected to this rigid shoulder and base, and extending therebetween is a thin, flexible, generally oval side wall 12.
  • a thin, flexible, generally oval side wall 12 Integrally connected to this rigid shoulder and base, and extending therebetween is a thin, flexible, generally oval side wall 12.
  • the bottle maintains its shape and supports itself upright on rigid base 11. It will support itself as shown in FIG. 3A whether the bottle contains liquid or is empty.
  • a a container When applicants bottle is supplied to a hospital it contains more than 50% liquid, and the bottles oval wall is sufficiently transparent for observation of an upper surface of liquid within the bottle.
  • the a a container has between 50 and of its total internal capacity filled with liquid, and a constant mass of sterile air occupies the remaining volume. This air phase is large enough to provide a liquid upper surface 14 for volumetric readings when dispensing begins. As liquid is dispensed from this collapsible bottle it flows.
  • Protrusion 16 shown in FIG. 3B is not an air-inletting system as in FIG. 2C
  • protrusion 16 has a passage sealed by a I puncturable, resealable resilient rubber pad through which additive medication can be injected with a hypodermic. syringe into the closed system for administering to the patient. As soon as the hypodermic syringe or other additive device is withdrawn the rubber padreseals so that no atmospheric air can enterthe bottle. I
  • portions 17 and 18 of the oval wall deflect inwardly. These portions 17 and 18 always remain spaced apart until the upper surface 14 of the liquid has descended below these portions. When wall portions 17 and. 18 do contact, as in FIG. 3D, the liquid level 14 is below such.
  • an administration set for dispensing through a closed system from the bottle through the set and to the patient.
  • an administration set includes a flexible tube which has a tubular rigid spike at an upper end and a rigid adapter with a venous needle at a lower end of the tube.
  • the administration set also includes an enlarged drip chamber and a roller clamp.
  • the upper surface of the liquid in the bottle is 7 to' 72 inches (17.8 to 193 cm) above the lower end of the administration set to establish a liquid head.
  • a very important feature of applicants controlled collapse bottle is the extreme accuracy that was unexpectedly found which can be maintained from one bottle to the next in the manufacture of these bottles. It has been found that the volumetric accuracy in a 1 liter bottle with controlled collapse gives a repeatable reading of i30 ml. from one bottle to the next. This is equivalent to the repeatable volumetric accuracy of :30 ml. in rigid glass bottles.
  • the reason glass bottles have this variance in volume accuracy is because of the thickness of the glass bottle wall which is approximately 0.125 inch (3.3 mm) thick. A 10% increase or decrease in the wall thickness changes the internal diameter 0.025 inch (0.67 mm) and it is the internal dimensions that control the bottles volumetric accuracy.
  • the glass bottle is internally expanded by pressure against a mold contacting its outer surface. There is no mold forming its inner surface and hence the variance. Also, internal glass bumps or thickened portions that sometimes are found in a glass bottle affect its volumetric accuracy.
  • the applicants bottle is an extremely thin walled thermoplastic bottle with an oval wall with a thickness of from 0.010.to 0.035 inch (0.25 to 0.94 mm).
  • a 10% variance in applicants wall thickness has a much lesser effect on its internal volume than the glass bottle above.
  • Numerous bottles have been tested and show very reliable repeatability in the volumetric accuracy. This accuracy in applicant s bottle has been within 0 ml. for a series of 1 liter bottles. In some cases it has been even more accurate and in the range of 120 ml. readings for a series of 1 liter bottles.
  • FIG. 4 shows a front elevational view of a first embodiment of the applicants bottle which has a generally oval side wall 12 integrally connected to a rigid shoulder 10 and a rigid base 11. At an upper end of the bottle is a neck flange to which is secured a removable cap 21.
  • Cap 21 can be either a vented cap as described in my co-pending application entitled Three Barrier Closure System for Medical Liquid Container Ser. No. 445,834, filed Feb. 26, 1974, or a non-vented cap as described in a co-pending application entitled, Frangible Closure System for Medical Liquid Con- .tainer and Method of Making Same Ser. No. 338,685,
  • a series of supporting feet represented by numerals 22 and 23.
  • a hinged hanger 25 integrally formed with the bottle.
  • an external rib 26 on one side of the bottle and an external rib 27 on an opposite side. These ribs help strengthen the rigidity of the bottle is this area and also provide finger grips to keep the bottle from slipping out of the hand of the nurse or physician.
  • volumetric calibrations 30a and 30b are shown in FIGS. 4 and 5 along the wall section of the oval bottle.
  • Calibration 30a is a fill mark for measurement when filling the bottle in its upright position. If desired, calibration 300 could be replaced with a full scale calibration along the bottle so the amount of liquid in the less-than-full bottle can be determined with the bottle upright.
  • Calibrations 30b are for measurement when the 6 bottle is inverted and liquid is dispensed. It is these calibrations 30b that are critical for the accurate volume measurement during dispensing.
  • Located between calibrations 30a and 30b is a flexible label 28 with the bottles contents and directions for use.
  • FIGS. 6, 7 and 8 are cross-sectional views taken through the bottles oval wall along lines 66, 7-7, and 88 of FIG. 4.
  • the oval wall has marginal zones at the left and right sides of FIG. 4 that merge at relatively sharp transverse cross-sectional curvatures predisposing the body for folding along said zones as the bottle collapses.
  • the bottle has a major axis 31 that is approximately twice the length of minor axis 32.
  • a cross-section of the bottle is these figures shows the bottle of FIGS. 4 and 5 to have generally parallel sides at ends of the major axis 31 but a generally decreasing length of minor axis 32 from a top portion of the oval side wall to a bottom portion.
  • the bottle appears to have parallel sides and in FIG.
  • the sides converge inwardly from top to bottom causing the bottle to have a more flattened oval configuration adjacent its bottom end.
  • opposed thin flex ribs 33 and 34 that extend across ends of the minor axis along only a portion of the bottles periphery. Adjacent ends of the flex ribs 33 and 34 and extending above the flex ribs are columar support sections of the oval wall that are generally parallel to the bottles longitudinal axis and prevent the longitu" dinal collapse of the bottle at the flex ribs when the bottle is sitting upright as in FIG. 4. The flex ribs do not extend across these columnar support sections.
  • FIG. 9 there is a top plan view of FIG. 4 showing the cap 21 and flange 20. From this view of the rigid shoulder 10 is shown to be generally oval in shape.
  • FIG. 10 is a bottom plan view of the bottle of FIG. 4 which illustrates the hinged hanger 25 integrally formed with the bottle and being held within recess 24 that extends along the bottles minor axis.
  • Four feet are shown here, but a different number could be used if desired. Representative feet are indicated at 22 and 23.
  • FIGS. 1 l and 12 show respectively a front elevational view and a side elevational view of a second embodiment of the bottle.
  • the bottle has a generally oval side wall 40 which is connected to a rigid shoulder 41 and a rigid base 42.
  • a cap 43 As in the first embodiment there is a cap 43, a hinged hanger 44, and supporting feet represented by 45 and 46.
  • the main difference between the first and second embodiments of the bottle is in the shoulder structure.
  • shoulder 10 is substantially crowned along the major axis to slope relative to the longitudinal axis as shoulder 10 extends outwardly from the bottle.
  • the shoulder 10 in the first embodiment is not substantially crowned along the minor axis but is generally perpendicular to the bottles longitudinal axis. See FIGS. 4 and 5.
  • the bottle shoulder 41 slopes away from the neck at a steep slope of approximately 45 from the longitudinal axis at both its major and minor axis to give a generally conical shoulder as shown in FIGS. 11 and 12.
  • the purpose for this sloping neck is shown in FIG. 13.
  • the bottle of the second embodiment is canted as much as 30 from the vertical it willstill dispense its entire liquid content. No liquid is retained in an outer portion of the shoulder.
  • the bottle of the second embodiment has a slightly more converging taper along its minor axis as shown in FIG. 12.
  • the bottle of the second embodiment functions in a controlled. collapse in the same manner as in the 7 first embodiment.
  • FIG. 13 illustrates the bottle of the second embodiment used for dispensing intervenous solution in a closed system".
  • FIG. 14 shows how the bottle designed for a "closed system has a structure of its shoulder, base and oval wall that can be used as a pouring container with a different outlet. Despite its collapsibility the bottle has very fine handling characteristics. When the bottle is used as a pouring container a threaded screw cap can be provided beneath cap 21. Both caps would be removed for pouring. While either the first or second embodiment bottle could be modified at its outlet structure for use as a pouring container, only the first embodiment bottle is illustrated in FIG. 14.
  • FIGS. 15, 16, 17 and 18 Substantially enlarged sectional views of the bottle of the second embodiment used for administering parenteral liquids in a closed system are shown in FIGS. 15, 16, 17 and 18.
  • the outer cap 21 has been removed to expose two tubular ports 50 and 51.
  • Port 50 is adapted to receive and form a liquid tight joint with a spike of parenteral solution administration set.
  • Port 51 has a punctural resealable rubber diaphragm 52 through which additive medication can be injected. Sealing off both of these ports is a peelable, metal-thermoplastic laminate foil that protect their sterility.
  • This foil designated as 53 is peeled off immediately before use. In the drawings foil 53 is shown with a cut between the two tubular ports 50 and 51.
  • each portion of the foil can be easily peeled from its perpendicular tubular port without damaging the foil seal with the other tubular port.
  • the hinged hanger 44 is shown tucked into a recess.
  • the container of FIG. 15 When the container of FIG. 15 is supplied to the hospital it has an upper liquid surface of 54 of liquid 55. It is important that there is a gas, such as air within the bottle to establish the liquid measuring level.
  • This gas could also be an inert gas or mixtures of inert gases.
  • the air occupies between and 50% of the container capacity. Exceptionally fine results have been obtained in volumetric accuracy with air occupying approximately 30% of the containers volume when dispensing begins.
  • This air space can be partially filled with additive liquid medication injected into tubular port 51 immediately before dispensing, however, there must be a volume of gas, such as air in the container when dispensing begins. This air will be redistributed within the container so thatthe readings on calibrations shown most clearly in FIGS. 4 and 11 are accurate. Since air is neither added nor removed from the container after dispensing begins, there is a constant mass of air in the container during dispensing and collapse of the bottle of this invention.
  • FIG. the outer closure 43 has been removed and foil 53 is ready to be peeled back from tubular outlet 50 for connecting to an administration set.
  • administration set shown as 57, has been connected in FIG. 16 and the bottle inverted and hung from its hanger 44 on support 56. At this point the volumetric reading will indicate that the 1 liter bottle has 1,000 ml. (:30 ml.).
  • uid level 54 has descended below a contact area of* these wall portions. This is so that a level, readable liquid surface 54 is maintained throughout the entire descent path of the liquid. If the walls had uncontrolled collapse it would be possible to have them pinch together below the liquid surface 54 causing serious volumetric reading errors. 1
  • the liquid head causes a slight vacuum to form in the bottle, and this slight vacuum is 0.2 to 2.0 psi (0.014 to 14 Kg/cm below the atmospheric pressure outside the bottle,and this causes the side wall to deflect inwardly.
  • This slight vacuum causes the gas in the bottle to expand slightly (about 2 /z%).
  • Tempera atures normally does not affect the volume;of the gas because the temperature inside and outside the bottle.
  • the side wall portions 58 and 59 havecome in contact with each other in FIG. 18. However, the liquid level 54 is below this contact area and a pocket formed atthe bottle shoulder is large enough to hold the bot.- I
  • thermoplastic bottle requires no vacuum for completely emptying.
  • the sequence of draining as shown through FIGS. l6, l7 and 18 occurs with a conventional gravity dispensing administration set.
  • the slight vacuum within the bottle created by gravity dispensing is opposed by a flexure resistance of the tubular side wall.
  • this flexure resistance is in equilibrium withthe slight vacuum within the bottle.
  • the volume of gas in the bottle at this slight vacuum is equal to or exceeds the combined volumes of the two pockets so that liquid cancompletely empty from the bottle.
  • the administration set can be disconnected, which provides an opening into the bottle.
  • the administration set is ,disconnected, the side walls will remain partially collapsed,
  • the gas in the bottle at the vacuum created during gravity dispensing of the liquid through a closed system" of the bottle and administration set has a volume less than the combined internal volume of the closed system.
  • the gas volume tends to hold some liquid in the 9 air into a patient. This air volume will even hold liquid in the set after a venous needle has been removed from such patient, and there is no longer a venous back pressure into the set.
  • FIG. 19 shows a greatly enlarged sectional fragmentary view of the junctures of the flexible oval sidewall with rigid base 42 and with the rigid shoulder 41. These fragmentary sections are taken from the upper lefthand area and the lower left-hand area of FIG. 16.
  • the flexible oval side wall indicated as 70 is integrally connected to rigid base 42 through a thin flex rib 71.
  • This flex rib 71 appears on the external surface of the bottle as a laterally extending bulged rib adjacent the indented recess for hanger 44.
  • This thinned rib section 71 protrudes outwardly from collapsible wall 70 and it is thinner than wall 70.
  • flex rib 71 and the like rib on an opposite side of the bottle, is to aid in flexing wall 70 relative to rigid base 42. This helps to cause additional flex adjacent to base 42 to diminish the capacity of air pocket 60 as the liquid drains.
  • the flex ribs in a 1 liter bottle can be from 0.008 to 0.015 inch (0.21 to 0.40 mm) thick.
  • the oval wall can be from 0.010 to 0.035 inch (0.35 inch (0.25 to 0.94 mm) thick. Although there is an overlap of thickness ranges the flex rib will be always have a thinner portion than remaining portions of the oval wall of a particular bottle.
  • an oval wall of 0.012 inch (0.32 mm) might have a flex rib of 0.009 inch (0.23 mm) thick.
  • the arcuate cross sectional shape of the flex rib also aids in its increased flexibility.
  • the rigid shoulder 41 is joined to flexible wall 70 at a juncture 72.
  • the bottle has a structure which encourages the bottle to collapse adjacent rigid base 42 and permits the air in the bottle to be redistributed in the bottle for lowering the upper surface of the liquid below a contact point of the walls as liquid is dispensed. Despite this controlled lateral collapse during a gravity liquid drain this laterally flexible bottle structure shown in FIG. 19 is sufficiently rigid to support the bottle upright on a flat surface.
  • FIGS. 20 and 21 Two dispensing outlets for the bottle are shown in FIGS. 20 and 21.
  • the dispensing outlet includes tubular ports 50 and 51.
  • Tubular port 51 is closed off by a puncturable resealable rubber pad 52.
  • a @peelable foil 53 is sealed across the outer end of both of these tubular sections, and the foil 53 is preferably severed between tubular ports 50 and 51 for convenient independent removal from each tubular section.
  • Fitting over the tubular ports 51 and 52 is a removable closure 43. This closure can have a frangible portion 86 that is sealed to flange 76 of the bottle.
  • the outlet structure beneath outer cap 42 of FIG. 20 is specifically for administering parenteral solutions through a closed system that includes an administration set.
  • the same bottle of this invention has sufficient rigidity for use as a pouring container.
  • an alternate outlet system is provided on the bottle.
  • the bottle (FIG. 21) includes a flange 80 surrounded by a threading dispensing outlet 81. Fitting over this outlet is a threaded inner cap 82.
  • the container of applicants invention could be used for a pouring container as shown in FIG. 14.
  • the bottle of this invention can be made of a propylene-ethylene copolymer thermoplastic material.
  • the bottle is blowmolded as a homogenous unit that includes the rigid base, rigid shoulder and collapsible oval sidewall.
  • the rigid shoulder is between 0.040 and 0.060 inch (1.0 to 1.5 mm) thick and the rigid base is between 0.060 and 0.090 inch (1.5 to 2.3
  • the flexible side wall is from 0.010 to 0.35
  • a closed system for administering medical liquid comprising the combination of a substantially transparent thermoplastic bottle with controlled lateral collapse for accurately measuring the volume of liquid dispensed without inletting air into the bottle, which bottle includes a rigid oval base adapted to support the bottle in a longitudinally upright position on a flat surface during storage; a rigid oval shoulder with a nonair-inletting dispensing outlet therethrough at an opposite end of the bottle; a laterally flexible generally oval side wall integrally connected to the base and shoulder and having a cross-section with a transverse major axis and transverse minor axis, said transverse major axis remaining generally constant in length at various locations along the bottles length, and said transverse minor axis becoming progressively shorter as the minor axis proceeds from the oval shoulder to the oval base along the bottle s length; volumetric calibrations on the side wall; a sterile medical liquid initially filling the bottle between 50 and of its internal capacity, and sterile air occupying the remaining portion of the internal capacity of the bottle immediately prior to dispensing from the bottle to provide
  • thermoplastic bottle is of 1 liter size and calibrated between and 1000 ml. and the collapse is carried out to provide a volumetric accuracy in a closed system of 0 ml.
  • a liquid administration bottle having a substantially rigid base at one end thereof and a substantially rigid shoulder with a dispensing outlet at the other end thereof, wherein the improvement comprises said dispensing outlet including tubular port means defining an inner surface sealingly engagable with the outer surface of a hollow spike of a medical ad ministration set for forming an airtight seal therewith and for placing said bottle and set in flow communication; a removable bacteria-tight sealing member secured to said tubular port means; said bottle having a tubular wall extending longitudinally between said base and shoulder, which wall has longitudinally columnar rigidity for supporting the bottle upright on its base and has limited lateral flexibility permitting partial, but not total, collapse of the bottle when the same is inverted and gravity drained to a reduced volume capacity; said bottle containing a measured amount of liquid, which liquid has an upper surface, and an amount of sterile gas above said liquid, which has has a volume at 12 dispensing pressures and temperatures that is equal to or greater than said reduced volume capacity of said bottle, whereby, substantially all of
  • tubular wall of said bottle has portions that contact each other only above the upper surface of said liquid and substantially below said rigid base of the bottle when said bottle is inverted and gravity drained.
  • tubular wall is calibrated from O to 1,000 ml; said rigid base andshou lder coacting with said flexible tubular wall to control the collapse of said bottle from its uncollapsed condition to said partially collapsed conditionto provide a calibration accuracy within i 30 ml over the 0 to 1,000 ml range.
  • tubular wall has a thickness between 0.010 and 0.035 inches (0.25 i
  • tubular wall has longitudinally-extending portions at the ends of its minor transverse axis that converge in a direction from said shoulder towards said base.
  • a closed system for administering liquid which includes a bottle having a substantially rigid base and a substantially rigid shoulder with a dispensing outlet,l
  • a closed system for administering liquid which includes a bottle having a substantially rigid base and a substantially rigid shoulder with a dispensing outlet, wherein the improvement comprises said bottle having a tubular wall extending longitudinally between said base and said shoulder; said wall having longitudinal columnar rigidity for supporting the bottle upright on its base and having limited lateral flexibility permitting partial, but not total, collapse of the bottle to a reduced volume capacity; said bottle containing a measured amount of liquid having an upper surface intermediate the base and shoulder and also containing above said surface an amount of sterile gas having a volume at dispensing pressures and temperatures that is equal to or greater than said reduced volume capacity of said bottle, whereby, substantially all of said liquid can drain by gravity from said bottle when the same is inverted without inletting any additional gas into said bottle; and a tubular administration set connected to said outlet, with said combined bottle and administration set forming the closed system; said gas having a volume at dispensing pressures and temperatures less than the total of the volume of said administration set plus said reduced volume capacity of said bottle, whereby, said administration set is
  • a liquid administration bottle having a substantially rigid base and a substantially rigid shoulder with a portions of the tubular wall contacting each other; said bottle containing a measured amount of liquid occupying 50 to 95% of the bottles uncollapsed volume; said liquid having an upper surface and a sterile gas occupying the remaining volume of the bottle above said surface; said gas having a volume at dispensing pressures and temperatures that is equal to or greater than said reduced volume capacity of said bottle; said rigidity and oval configurations of said base, shoulder, and tubular wall, combined with the proportions of liquid and gas in said bottle, controlling the collapse of the bottle when the same is inverted and gravity drained so that said opposed portions of said tubular wall contact each other only above the upper surface of said liquid; whereby, said bottle may be gravity drained of substantially all of the liquid therein without inletting any additional gas into said bottle.
  • a medical liquid administration bottle having a substantially rigid base at one end thereof and a substantially rigid shoulder with a dispensing outlet at the other end thereof, wherein the improvement comprises said dispensing outlet including tubular port means defining an inner surface sealingly engagable with the outer surface of a hollow spike of a medical administration set for forming an air-tight seal therewith and for placing said bottle and set in flow communication; a substantially transparent body extending longitudinally between said base and shoulder; said outlet in said shoulder being capable of dispensing liquid from said bottle under the influence of gravity, without the concurrent entry of air, when the bottle is supported and drained in inverted position; said bottle being filled completely with a sterile gas and an infusable sterile liquid, which liquid has an upper surface visible through said transparent body; said body having opposite wall portions is filled and capable of flexing inwardly to engage each other at a point of initial contact intermediate said base and shoulder as said bottle is inverted and drained; the volume of gas in said bottle exceeding the'volume of the space in said bottle between said

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  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
US445836A 1974-02-26 1974-02-26 Thermoplastic bottle with controlled lateral collapse and method of dispensing liquid therefrom Expired - Lifetime US3921630A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
US445836A US3921630A (en) 1974-02-26 1974-02-26 Thermoplastic bottle with controlled lateral collapse and method of dispensing liquid therefrom
IN2874/CAL/74A IN143639B (xx) 1974-02-26 1974-12-28
AU77060/74A AU481401B2 (en) 1974-02-26 1974-12-31 Thermoplastic bottle with controlled lateral collapse and method of dispensing liquid therefrom
CA217,210A CA1046013A (en) 1974-02-26 1974-12-31 Thermoplastic bottle with controlled lateral collapse and method of dispensing liquid therefrom
FR7500005A FR2261781B1 (xx) 1974-02-26 1975-01-02
ZA00750035A ZA7535B (en) 1974-02-26 1975-01-02 Thermoplastic bottle with controlled lateral collapse and method of dispensing liquid therefrom
PH16716A PH11706A (en) 1974-02-26 1975-01-16 Thermoplastic bottle with controlled lateral collapse and method of dispensing liquid therefrom
TR19086A TR19086A (tr) 1974-02-26 1975-01-17 Kontrol edilen yanal iceri coekmeli termoplastik kap ve bu kaptan sivi vermeye mahsus metod
ES433993A ES433993A1 (es) 1974-02-26 1975-01-21 Perfeccionamientos introducidos en una botella para entregade liquido.
DE19752502310 DE2502310A1 (de) 1974-02-26 1975-01-21 Thermoplastische kunststofflasche mit gesteuerter seitlicher zusammenfaltung
IT7547775A IT1026409B (it) 1974-02-26 1975-01-21 Perfezionamento nei contenitori per soluzioni sterili
EG45/75A EG11580A (en) 1974-02-26 1975-02-01 Thermoplastic bottle with controlled lateral collapse and method of dispensing liquid therefrom
BE153000A BE825117A (fr) 1974-02-26 1975-02-03 Bouteille en matiere thermoplastique a usage medical
BR745/75A BR7500745A (pt) 1974-02-26 1975-02-05 Garrafa ministradora de liquidos aperfeicoada
CH181975A CH582093A5 (xx) 1974-02-26 1975-02-14
AR257642A AR201642A1 (es) 1974-02-26 1975-02-14 Botella suministradora de liquido
JP50021433A JPS50118888A (xx) 1974-02-26 1975-02-20
GB7395/75A GB1483553A (en) 1974-02-26 1975-02-21 Liquid dispensing pack

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US445836A US3921630A (en) 1974-02-26 1974-02-26 Thermoplastic bottle with controlled lateral collapse and method of dispensing liquid therefrom

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US3921630A true US3921630A (en) 1975-11-25

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US (1) US3921630A (xx)
JP (1) JPS50118888A (xx)
AR (1) AR201642A1 (xx)
BE (1) BE825117A (xx)
BR (1) BR7500745A (xx)
CA (1) CA1046013A (xx)
CH (1) CH582093A5 (xx)
DE (1) DE2502310A1 (xx)
EG (1) EG11580A (xx)
ES (1) ES433993A1 (xx)
FR (1) FR2261781B1 (xx)
GB (1) GB1483553A (xx)
IN (1) IN143639B (xx)
IT (1) IT1026409B (xx)
PH (1) PH11706A (xx)
TR (1) TR19086A (xx)
ZA (1) ZA7535B (xx)

Cited By (42)

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US4049033A (en) * 1974-11-21 1977-09-20 Baxter Travenol Laboratories, Inc. Molded collapsible solution container
US4096897A (en) * 1976-03-25 1978-06-27 Baxter Travenol Laboratories, Inc. Molded collapsible solution container having transverse fold lines
US4125186A (en) * 1977-02-01 1978-11-14 Warner-Lambert Company Pharmaceutical delivery system
US4253458A (en) * 1979-03-08 1981-03-03 Baxter Travenol Laboratories, Inc. Method and apparatus for collecting blood plasma
US4308904A (en) * 1979-04-09 1982-01-05 Baxter Travenol Laboratories, Inc. Collapsible solution container having reduced collapse rate at the end of the collapsing process
US4334640A (en) * 1977-08-08 1982-06-15 Douwe Egberts Koninklijke Tabaksfabriek-Koffiebranderijen-Theehandel B.V. Exchangeable concentrate container for beverage dispensing machines
US4336802A (en) * 1980-07-28 1982-06-29 Baxter Travenol Laboratories, Inc. Parenteral solution container for aseptic mixing
US4479989A (en) * 1982-12-02 1984-10-30 Cutter Laboratories, Inc. Flexible container material
EP0144543A1 (en) * 1983-08-24 1985-06-19 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Medical solution transfusion circuit
US4527703A (en) * 1982-06-07 1985-07-09 U.S. Clinical Products, Inc. Flexible sterile closure system for containers
US4553970A (en) * 1983-12-28 1985-11-19 Miles Laboratories, Inc. Collapsible molded container
USRE32065E (en) * 1974-11-21 1986-01-14 Baxter Travenol Laboratories, Inc. Molded collapsible solution container
US4598834A (en) * 1985-02-06 1986-07-08 U.S. Clinical Products, Inc. Flexible sterile closure system for a container with a side injection port
US4700871A (en) * 1984-10-30 1987-10-20 Toyo Seikan Kaisha, Ltd. Liquid transfusing bottle
US4715279A (en) * 1987-02-06 1987-12-29 Albanese Rocco J Supplementary liquid dispensing device
US4754891A (en) * 1986-02-20 1988-07-05 Sherwood Medical Company Bottle for an enteral nutrition delivery system
US4886504A (en) * 1987-11-19 1989-12-12 Abbott Laboratories Reservoir/dispensing container
AU596825B2 (en) * 1986-02-20 1990-05-17 Sherwood Services Ag Enteral feeding apparatus
US5006118A (en) * 1988-01-09 1991-04-09 Bruce Yule Liquid transfer assemblies
US5083678A (en) * 1990-08-27 1992-01-28 James River Corporation Collapsible dispenser bottle
US5222615A (en) * 1985-07-30 1993-06-29 Yoshino Kogyosho Co., Ltd. Container having support structure in its bottom section
US5377877A (en) * 1991-12-06 1995-01-03 Liquid Molding Systems, Inc. Dispensing valve for packaging
US5403538A (en) * 1989-11-16 1995-04-04 Mitsui Petrochemical Industries, Ltd. Container with a suspension grip and method of manufacturing the same
WO1996006959A1 (en) * 1994-08-26 1996-03-07 Medical Discoveries, Inc. System for electrolyzing fluids for in vivo administration to humans and other warm blooded mammals
US5776109A (en) * 1996-08-23 1998-07-07 Urrutia; Hector Drip chamber for intravenous fluid delivery system
US5839614A (en) * 1991-12-06 1998-11-24 Aptar Group, Inc. Dispensing package
US5950878A (en) * 1997-08-04 1999-09-14 Steris Corporation Dispensing tube valve assembly
US6106504A (en) * 1998-07-15 2000-08-22 Urrutia; Hector Drip chamber for medical fluid delivery system
US6116457A (en) * 1995-09-01 2000-09-12 Haberman; Mandy Nicola Drinks containers
US6117285A (en) * 1994-08-26 2000-09-12 Medical Discoveries, Inc. System for carrying out sterilization of equipment
US6422415B1 (en) 1998-02-06 2002-07-23 Playtex Products, Inc. Leak-proof cup assembly with flow control element
US6578723B1 (en) 1997-05-30 2003-06-17 Pharmacy, Inc. Flexible sealing cover with seal break indicator
US20040195253A1 (en) * 2003-04-03 2004-10-07 Boucher Richard A. Valve for non-spill cup
US6997337B1 (en) * 2003-05-19 2006-02-14 Graham Packaging Pet Technologies Inc. Molded plastic flask
US20060111681A1 (en) * 2004-11-08 2006-05-25 Vernon Robert D Free-standing urine collection bag and urine bag system
US20070092858A1 (en) * 2005-10-20 2007-04-26 Qaisar Usmani Personal medication dispensing system
US7357267B1 (en) * 1998-03-20 2008-04-15 Yoshino Kogyosho Co., Ltd. Plastic bottle with handle
US20110240673A1 (en) * 2010-04-01 2011-10-06 Graham Packaging Company, L.P. Collapsible container and method of making
US20120132609A1 (en) * 2006-06-30 2012-05-31 H. J. Heinz Company Condiment bottle
WO2013120341A1 (zh) * 2012-02-17 2013-08-22 重庆莱美药业股份有限公司 双头输液容器
US20180064383A1 (en) * 2016-09-06 2018-03-08 Shih-Hua HUANG Multi-functional specimen collector
WO2023117067A1 (en) * 2021-12-21 2023-06-29 Sintetica Sa A semi-rigid multilayer bag for a premixed pharmaceutical fluid

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US4153173A (en) * 1978-03-13 1979-05-08 Baxter Travenol Laboratories, Inc. Cap closure and method of producing same
JPS6125792Y2 (xx) * 1979-07-20 1986-08-04
JPS5745944U (xx) * 1980-08-28 1982-03-13
JPS5924041U (ja) * 1982-08-05 1984-02-15 株式会社大塚製薬工場 プラスチツク製輸液容器
FR2579102B1 (fr) * 1985-03-25 1989-03-31 Nal Transfusion Sanguine Centr Flacon notamment destine a la conservation du plasma sanguin
AU606685B2 (en) * 1987-05-18 1991-02-14 Otsuka Pharmaceutical Factory, Inc. Self-supportable parenteral bottle of synthetic resin
WO1989003697A1 (en) * 1987-10-22 1989-05-05 Leonard Barry French Collapsible solution container
DE4003041A1 (de) * 1990-02-02 1991-08-08 Fresenius Ag Einweg-haemodilutionsset fuer die beutelplasmapherese
DE4003040A1 (de) * 1990-02-02 1991-08-08 Fresenius Ag Wegwerfbares haemodilutionsset
GB2335900A (en) * 1998-03-31 1999-10-06 Britvic Soft Drinks Limited Containers for dispensing beverages
CN106214480B (zh) * 2016-08-11 2023-07-25 重庆医科大学附属永川医院 一种医用雾化液储存瓶

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US2261065A (en) * 1940-06-05 1941-10-28 Kirchner Ricardo Apparatus for and method of blood infusion
US2335799A (en) * 1940-12-17 1943-11-30 Martin C Schwab Apparatus for liquid dispensing and method of manufacture thereof
US3171412A (en) * 1956-06-15 1965-03-02 Brann Bernd Container for biological liquids
US3081002A (en) * 1957-09-24 1963-03-12 Pfrimmer & Co J Containers for medicinal liquids
US3215299A (en) * 1961-09-11 1965-11-02 Baxter Don Inc Parenteral solution container
US3202324A (en) * 1961-10-06 1965-08-24 Fr Des Lab Labaz Sa Soc Plastic bags for injectable solutions

Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE32065E (en) * 1974-11-21 1986-01-14 Baxter Travenol Laboratories, Inc. Molded collapsible solution container
US4049033A (en) * 1974-11-21 1977-09-20 Baxter Travenol Laboratories, Inc. Molded collapsible solution container
US4096897A (en) * 1976-03-25 1978-06-27 Baxter Travenol Laboratories, Inc. Molded collapsible solution container having transverse fold lines
US4125186A (en) * 1977-02-01 1978-11-14 Warner-Lambert Company Pharmaceutical delivery system
US4717047A (en) * 1977-08-08 1988-01-05 Douwe Egberts Koninklijke Tabaksfabriek-Koffiebranderijen-Theehandel B.V. Disposable coffee concentrate storing and transporting apparatus
US4334640A (en) * 1977-08-08 1982-06-15 Douwe Egberts Koninklijke Tabaksfabriek-Koffiebranderijen-Theehandel B.V. Exchangeable concentrate container for beverage dispensing machines
US4253458A (en) * 1979-03-08 1981-03-03 Baxter Travenol Laboratories, Inc. Method and apparatus for collecting blood plasma
US4308904A (en) * 1979-04-09 1982-01-05 Baxter Travenol Laboratories, Inc. Collapsible solution container having reduced collapse rate at the end of the collapsing process
US4336802A (en) * 1980-07-28 1982-06-29 Baxter Travenol Laboratories, Inc. Parenteral solution container for aseptic mixing
US4527703A (en) * 1982-06-07 1985-07-09 U.S. Clinical Products, Inc. Flexible sterile closure system for containers
US4479989A (en) * 1982-12-02 1984-10-30 Cutter Laboratories, Inc. Flexible container material
EP0144543A1 (en) * 1983-08-24 1985-06-19 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Medical solution transfusion circuit
US4553970A (en) * 1983-12-28 1985-11-19 Miles Laboratories, Inc. Collapsible molded container
US4700871A (en) * 1984-10-30 1987-10-20 Toyo Seikan Kaisha, Ltd. Liquid transfusing bottle
US4598834A (en) * 1985-02-06 1986-07-08 U.S. Clinical Products, Inc. Flexible sterile closure system for a container with a side injection port
US5222615A (en) * 1985-07-30 1993-06-29 Yoshino Kogyosho Co., Ltd. Container having support structure in its bottom section
US4754891A (en) * 1986-02-20 1988-07-05 Sherwood Medical Company Bottle for an enteral nutrition delivery system
AU596825B2 (en) * 1986-02-20 1990-05-17 Sherwood Services Ag Enteral feeding apparatus
US4715279A (en) * 1987-02-06 1987-12-29 Albanese Rocco J Supplementary liquid dispensing device
US4886504A (en) * 1987-11-19 1989-12-12 Abbott Laboratories Reservoir/dispensing container
US5006118A (en) * 1988-01-09 1991-04-09 Bruce Yule Liquid transfer assemblies
US5403538A (en) * 1989-11-16 1995-04-04 Mitsui Petrochemical Industries, Ltd. Container with a suspension grip and method of manufacturing the same
US5083678A (en) * 1990-08-27 1992-01-28 James River Corporation Collapsible dispenser bottle
US5377877A (en) * 1991-12-06 1995-01-03 Liquid Molding Systems, Inc. Dispensing valve for packaging
US5839614A (en) * 1991-12-06 1998-11-24 Aptar Group, Inc. Dispensing package
US6007686A (en) * 1994-08-26 1999-12-28 Medical Discoveries, Inc. System for elctrolyzing fluids for use as antimicrobial agents
WO1996006959A1 (en) * 1994-08-26 1996-03-07 Medical Discoveries, Inc. System for electrolyzing fluids for in vivo administration to humans and other warm blooded mammals
US6117285A (en) * 1994-08-26 2000-09-12 Medical Discoveries, Inc. System for carrying out sterilization of equipment
US6116457A (en) * 1995-09-01 2000-09-12 Haberman; Mandy Nicola Drinks containers
US5776109A (en) * 1996-08-23 1998-07-07 Urrutia; Hector Drip chamber for intravenous fluid delivery system
US6578723B1 (en) 1997-05-30 2003-06-17 Pharmacy, Inc. Flexible sealing cover with seal break indicator
US5950878A (en) * 1997-08-04 1999-09-14 Steris Corporation Dispensing tube valve assembly
US6422415B1 (en) 1998-02-06 2002-07-23 Playtex Products, Inc. Leak-proof cup assembly with flow control element
US7357267B1 (en) * 1998-03-20 2008-04-15 Yoshino Kogyosho Co., Ltd. Plastic bottle with handle
US6106504A (en) * 1998-07-15 2000-08-22 Urrutia; Hector Drip chamber for medical fluid delivery system
US7147121B2 (en) 2003-04-03 2006-12-12 Abc Development Inc. Valve for non-spill cup
US20040195253A1 (en) * 2003-04-03 2004-10-07 Boucher Richard A. Valve for non-spill cup
US6997337B1 (en) * 2003-05-19 2006-02-14 Graham Packaging Pet Technologies Inc. Molded plastic flask
US20060111681A1 (en) * 2004-11-08 2006-05-25 Vernon Robert D Free-standing urine collection bag and urine bag system
US20070092858A1 (en) * 2005-10-20 2007-04-26 Qaisar Usmani Personal medication dispensing system
US20120132609A1 (en) * 2006-06-30 2012-05-31 H. J. Heinz Company Condiment bottle
US8863991B2 (en) * 2006-06-30 2014-10-21 H.J. Heinz Company Condiment bottle
US20110240673A1 (en) * 2010-04-01 2011-10-06 Graham Packaging Company, L.P. Collapsible container and method of making
WO2013120341A1 (zh) * 2012-02-17 2013-08-22 重庆莱美药业股份有限公司 双头输液容器
US20180064383A1 (en) * 2016-09-06 2018-03-08 Shih-Hua HUANG Multi-functional specimen collector
US10575768B2 (en) * 2016-09-06 2020-03-03 Shih-Hua HUANG Multi-functional specimen collector
WO2023117067A1 (en) * 2021-12-21 2023-06-29 Sintetica Sa A semi-rigid multilayer bag for a premixed pharmaceutical fluid

Also Published As

Publication number Publication date
BR7500745A (pt) 1975-12-02
IT1026409B (it) 1978-09-20
FR2261781B1 (xx) 1981-11-27
CA1046013A (en) 1979-01-09
AU7706074A (en) 1976-07-01
PH11706A (en) 1978-05-24
ES433993A1 (es) 1976-11-16
TR19086A (tr) 1978-05-01
FR2261781A1 (xx) 1975-09-19
GB1483553A (en) 1977-08-24
DE2502310A1 (de) 1975-08-28
IN143639B (xx) 1978-01-07
EG11580A (en) 1977-08-15
AR201642A1 (es) 1975-03-31
ZA7535B (en) 1976-01-28
BE825117A (fr) 1975-05-29
CH582093A5 (xx) 1976-11-30
JPS50118888A (xx) 1975-09-17

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STCF Information on status: patent grant

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AS Assignment

Owner name: KENDALL MCGAW LABORATORIES, INC., 2525 MCGAW AVENU

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST. EFFECTIVE NOVEMBER 26, 1985.;ASSIGNOR:AMERICAN HOSPITAL SUPPLY CORPORATION, A CORP OF IL;REEL/FRAME:004600/0460

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