US3916893A - Single-injection device - Google Patents

Single-injection device Download PDF

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Publication number
US3916893A
US3916893A US455014A US45501474A US3916893A US 3916893 A US3916893 A US 3916893A US 455014 A US455014 A US 455014A US 45501474 A US45501474 A US 45501474A US 3916893 A US3916893 A US 3916893A
Authority
US
United States
Prior art keywords
needle
container
end portion
syringe body
sleeve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US455014A
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English (en)
Inventor
Felice Wilfried De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of US3916893A publication Critical patent/US3916893A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase

Definitions

  • the present invention relates to a single-injection de vice consisting of a liquid container of special shape to be filled with a liquid medicament.
  • the sealed lower end of the container holds a syringe body which, however, may also cover the liquid container over its full length.
  • the interior of the syringe body is provided with a movable needle support and forms a sterile chamber together with a piston rod.
  • injection devices in which the medicament to be injected is stored in a liquid container, shaped as an ampoule which is pushed into a syringe body.
  • the ampoule placed in the syringe body will be pushed in only to such a point that the assembled injection cannula which reaches into the interior of the syringe body does not pierce the seal at the front end of the ampoule.
  • An essential disadvantage of that syringe is the injection needle fixed in the syringe body, since the needle portion which projects into the syringe body and the portion of the ampoule facing it have to be kept sterile. Because of the resulting space between the liquid container and the syringe body, however, micro-organisms can penetrate into the sterile zone within a certain length of time in storage.
  • the present invention makesit a point to provide a sterile zone for the injection needle not in the syringe body but in a sealed and separate part of the device. This is achieved by mechanically deforming the syringe body proper into engagement with the liquid container, thus providing a sealed sterile chamber.
  • FIG. 1 is a side view of the syringe
  • FIG. 2 is a longitudinal cross sectional view of the sy ringe with the syringe body shortened;
  • FIG. 3 is a longitudinal cross sectional view of the syringe with the syringe body covering the liquid container;
  • FIG. 3a is a top view of the upper end of the syringe as shown in FIG. 3.
  • FIG. 2, A and FIG. 3, B show the syringe body in its shortened form and in its long form respectively, the finger support 5 in the first case being part of the liquid container, whereas in the second case it is part of the syringe body.
  • the preferred method for securely fastening the container according to the invention is provided by thermically and megchanically deforming a projecting portion of the rim 4 (FIG. 3) of the syring body made of a suitable plastic material by means of a punch moved in the direction of the container axis so as to form beads (FIGS. 3 and 3a) to retain the container.
  • FIG. 1 A container 1 to be filled with a liquid medicament, a shortened and/or a long syringe body 2 and a piston rod 3 mounted on the syringe body.
  • the liquid container is sealed in a familiar manner at its rear end by means of a movable piston stopper 6 and at its lower end by means of an aluminium cap 7 having a central aperture, under which a rubber disk or a rubber stopper 8 is inserted.
  • the sealing plug of the rubber stopper is advantageously provided with a conical cavity, through which air bubbles, which frequently form in the interior of the container filled with the liquid medicament prior to the application, can simply be removed by pressing the piston rod.
  • the liquid container 1 may be separated from a bore 9 holding the needle support 10, with a cannula ll passing through, by means of a plastic membrane 12, which may be injection-molded onto the syringe body 2, which is made of a plastic material.
  • the surface of the needle support 10 is provided with an annular projection 13 which engages an annular groove 14 cut in the bore 9, thus securing the needle support 10 in its initial position. This prevents premature perforation of the membrane 12 and the piercing of the rubber disk or stopper 8 placed under the aluminium cap 7.
  • the lower end of the needle support 10 is frustroconical, preferably shaped as a record frustrum l6, and has a shoulder 17, so that a plastic socket 18 projecting in the interior of the piston rod 3 can engage the needle support 10.
  • a long cannula which,
  • the syringe body 2 with the piston rod 3 screwed on and the needle support 10 located inside it may be sterilized in ways already known, for example by using gamma rays.
  • the device is secured against inadvertent twisting of the piston rod 3 by spot welding, which also presents the advantage of tamper-proof sealing.
  • the piston rod 3 is turned until retained by a stop 21.
  • the injection needle is then placed on the record frustrum 16 of the needle support 10. It is also possible to use the injection cannula 11, which projects beyond the frustrum and is firmly connected to the needle support 10, as an injection needle.
  • the injection device of of the invention has the advantage that the whole can'- nula is located in a sterile chamber, that fractionation of the rubber disk or stopper and thus clogging of the cannula are avoided to a large extent and that, in the case of a long syringe body, provision of retaining beads ensures a locking effect which is superior to conventional types and, inter alia, ensures perfect aspira tion.
  • the retaining beads provide a reliable means of preventing the liquid container from falling out of the syringe or being exchanged unintentionally.
  • a single-injection syringe comprising a container for a medicament; said container having first and second open end positions; said first end portion of the container having a penetrable seal mounted therein for sealing said first end portion, and said second end portion having a piston inserted therein to define with said seal a chamber for containing the medicament; a sy ringe body mounted on and surrounding said first end portion of the container; said syringe body having a penetrable end wall extending across said first end portion of the container and an elongated generally cylindrical sleeve integrally formed with and extending from said wall; said sleeve having an elongated bore formed therein extending from said end wall to an open end located in spaced relation from said end wall and a threaded external periphery; a needle support mounted in said bore for movement between first and second positions therein; said needle support having a diameter which is slightly less than the diameter of said bore and including an annular projection formed thereon and at least four stabilizing fins

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US455014A 1973-03-28 1974-03-26 Single-injection device Expired - Lifetime US3916893A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2315367A DE2315367A1 (de) 1973-03-28 1973-03-28 Injektionsspritze zur einmaligen verwendung

Publications (1)

Publication Number Publication Date
US3916893A true US3916893A (en) 1975-11-04

Family

ID=5876145

Family Applications (1)

Application Number Title Priority Date Filing Date
US455014A Expired - Lifetime US3916893A (en) 1973-03-28 1974-03-26 Single-injection device

Country Status (16)

Country Link
US (1) US3916893A (es)
JP (1) JPS49127494A (es)
AR (1) AR208661A1 (es)
AT (1) AT355192B (es)
BE (1) BE812955A (es)
BR (1) BR7402416D0 (es)
CA (1) CA1044104A (es)
CH (1) CH575765A5 (es)
DE (1) DE2315367A1 (es)
FR (1) FR2223051B1 (es)
GB (1) GB1465281A (es)
IN (1) IN139269B (es)
IT (1) IT1010829B (es)
LU (1) LU69713A1 (es)
NL (1) NL7403938A (es)
SE (1) SE409077B (es)

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4067333A (en) * 1975-08-07 1978-01-10 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Syringe for storage and application of at least two injection media
US5250037A (en) * 1992-12-18 1993-10-05 Becton, Dickinson And Company Syringe having needle isolation features
US5324272A (en) * 1990-07-27 1994-06-28 Sterling Winthrop Inc. Multiple-celled safety package, needle guard and safe disposal module for prefilled medication cartridge
US5372590A (en) * 1990-07-27 1994-12-13 Habley Medical Technology Corporation Multi-celled safety package, needle guard and safety disposal module with sleeve for prefilled medication cartridges
US5693027A (en) * 1990-09-21 1997-12-02 Novo Nordisk A/S Adaptor top
US5718690A (en) * 1996-06-10 1998-02-17 Gettig Technologies, Incorporated Hypodermic injector system and method for maintaining the sterility thereof prior to use
FR2784033A1 (fr) * 1998-10-01 2000-04-07 Marc Brunel Dispositif d'injection a usage unique destine a etre pre-rempli
US20030078195A1 (en) * 2001-08-27 2003-04-24 Kristensen Lars Thougaard Cartridge and medical delivery system accommodating such cartridge
US20030109845A1 (en) * 2001-12-06 2003-06-12 Dca Design International Limited Medicament cartridge assembly
US20050065476A1 (en) * 2001-11-30 2005-03-24 Karsten Jensen Safety needle assembly
US20050171485A1 (en) * 2000-05-31 2005-08-04 Larsen Carsten G. Disposable double pointed injection needle, and an insulin injection system comprising a disposable double pointed injection needle
WO2008098860A1 (en) * 2007-02-14 2008-08-21 Shl Medical Ab Container for a medical device
US20090259197A1 (en) * 2006-07-15 2009-10-15 Novo Nordisk A/S Medical Delivery System with Flexible Blocking Element
US20090281505A1 (en) * 2006-07-15 2009-11-12 Novo Nordisk A/S Medical Delivery System with Asymmetrical Coding Means
US20090312715A1 (en) * 2006-07-11 2009-12-17 Rodney Hal Monson Needle mounting assembly for a medication injection device
WO2009150078A1 (en) * 2008-06-10 2009-12-17 Shl Group Ab Injection needle assembly
US20100010472A1 (en) * 2004-12-24 2010-01-14 Ian Marshall Moore Safety syringe
US20100010455A1 (en) * 2006-08-28 2010-01-14 Novo Nordisk A/S Medical Delivery System Adapted to be Locked Axially and Unlocked Rotationally
US20100042054A1 (en) * 2006-11-17 2010-02-18 Novo Nordisk A/S Medical Delivery System Comprising a Coding Mechanism Between Dosing Assembly and Medicament Container
US20100106099A1 (en) * 2006-12-21 2010-04-29 Novo Nordisk A/S Syringe Device
US20100324498A1 (en) * 2006-12-15 2010-12-23 Novo Nordisk A/S Medical delivery system comprising a container and a dosing assembly with radially moving fastening means
US20110046566A1 (en) * 2006-11-21 2011-02-24 Novo Nordisk A/S Medical Delivery System Comprising Locking Ring with L-Shaped Grooves
US20120179115A1 (en) * 2009-09-18 2012-07-12 Horvath Joshua Separable hub post of pen needle
US20130256166A1 (en) * 2010-12-14 2013-10-03 Becton Dickinson France Compact injection device
US8632506B2 (en) 2006-06-30 2014-01-21 Novo Nordisk A/S Medical delivery system comprising a coding mechanism
US20160136637A1 (en) * 2013-06-13 2016-05-19 Hamilton Bonaduz Ag Syringe having a mechanical coupling piece
US20160166765A1 (en) * 2011-10-14 2016-06-16 Amgen Inc. Injector and method of assembly
CN107929881A (zh) * 2017-12-25 2018-04-20 江南大学 一种制剂注射器一体化结构
CN108495671A (zh) * 2015-11-27 2018-09-04 赛诺菲-安万特德国有限公司 药物注射装置
CN108601903A (zh) * 2015-11-27 2018-09-28 赛诺菲-安万特德国有限公司 药物注射装置
US10850037B2 (en) 2013-03-22 2020-12-01 Amgen Inc. Injector and method of assembly
US10898658B2 (en) 2016-07-06 2021-01-26 LynJohnston, LLC Compact injection device with telescoping components
US11097055B2 (en) 2013-10-24 2021-08-24 Amgen Inc. Injector and method of assembly
US11607502B2 (en) 2018-01-10 2023-03-21 LynJohnston, LLC Compact injector systems and methods

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH591866A5 (es) * 1975-11-05 1977-09-30 Lezard Sa
CH591867A5 (es) * 1975-11-05 1977-09-30 Lezard Sa
US4078565A (en) * 1976-10-04 1978-03-14 Abbott Laboratories Readily activated hypodermic syringe
JPS5731870A (en) * 1980-08-05 1982-02-20 Korupo Kk Injector
WO1985004590A1 (en) * 1984-04-04 1985-10-24 Sigma Company Limited Syringes
DE3924830A1 (de) * 1989-07-27 1991-02-07 Vetter & Co Apotheker Spritzenzylinder fuer medizinische zwecke
DE9400867U1 (de) * 1994-01-17 1994-03-03 Christian Dunkel Gmbh Werkzeugbau, 12459 Berlin Einwegspritze mit Spritzampulle
GB9506087D0 (en) * 1995-03-24 1995-05-10 Owen Mumford Ltd Improvements relating to medical injection devices
DE102008025023A1 (de) * 2008-05-24 2009-11-26 Tecpharma Licensing Ag Nadeleinheit mit drehbarem Stechmittel
KR101533378B1 (ko) * 2013-09-13 2015-07-02 (주)연우 주사기형 화장품 용기

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US2542814A (en) * 1946-10-17 1951-02-20 Sterling Drug Inc Hypodermic syringe
US3084688A (en) * 1959-07-15 1963-04-09 Robert K Mcconnaughey Disposable hypodermic syringe
US3500830A (en) * 1966-08-10 1970-03-17 Philips Corp Injection syringe
US3721241A (en) * 1970-04-08 1973-03-20 Sherwood Medical Ind Inc Rigid container assembly for syringe
US3820652A (en) * 1972-11-14 1974-06-28 T Thackston Packaged syringe construction

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DE1917739A1 (de) * 1969-04-05 1970-10-08 Bayer Ag Neue Derivate der Thiocarbamidsaeure

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2542814A (en) * 1946-10-17 1951-02-20 Sterling Drug Inc Hypodermic syringe
US3084688A (en) * 1959-07-15 1963-04-09 Robert K Mcconnaughey Disposable hypodermic syringe
US3500830A (en) * 1966-08-10 1970-03-17 Philips Corp Injection syringe
US3721241A (en) * 1970-04-08 1973-03-20 Sherwood Medical Ind Inc Rigid container assembly for syringe
US3820652A (en) * 1972-11-14 1974-06-28 T Thackston Packaged syringe construction

Cited By (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4067333A (en) * 1975-08-07 1978-01-10 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Syringe for storage and application of at least two injection media
US5324272A (en) * 1990-07-27 1994-06-28 Sterling Winthrop Inc. Multiple-celled safety package, needle guard and safe disposal module for prefilled medication cartridge
US5372590A (en) * 1990-07-27 1994-12-13 Habley Medical Technology Corporation Multi-celled safety package, needle guard and safety disposal module with sleeve for prefilled medication cartridges
US5380296A (en) * 1990-07-27 1995-01-10 Sterling Winthrop Inc. Multi-celled safety package, needle guard and safe disposal module for pre-filled medication cartridges
US5693027A (en) * 1990-09-21 1997-12-02 Novo Nordisk A/S Adaptor top
US5250037A (en) * 1992-12-18 1993-10-05 Becton, Dickinson And Company Syringe having needle isolation features
US5718690A (en) * 1996-06-10 1998-02-17 Gettig Technologies, Incorporated Hypodermic injector system and method for maintaining the sterility thereof prior to use
US5860961A (en) * 1996-06-10 1999-01-19 Gettig Technologies, Incorporated Hypodermic injector system and method for maintaining the sterility thereof prior to use
FR2784033A1 (fr) * 1998-10-01 2000-04-07 Marc Brunel Dispositif d'injection a usage unique destine a etre pre-rempli
WO2000020059A1 (fr) * 1998-10-01 2000-04-13 Sanofi-Synthelabo Dispositif d'injection a usage unique destine a etre pre-rempli
US6447480B1 (en) 1998-10-01 2002-09-10 Sanofi-Synthelabo Disposable injection device designed to be pre-filled
US8075522B2 (en) 2000-05-31 2011-12-13 Novo Nordisk A/S Disposable double pointed injection needle, and an insulin injection system comprising a disposable double pointed injection needle
US20050171485A1 (en) * 2000-05-31 2005-08-04 Larsen Carsten G. Disposable double pointed injection needle, and an insulin injection system comprising a disposable double pointed injection needle
US9095660B2 (en) 2000-05-31 2015-08-04 Novo Nordisk A/S Disposable double point injection needle and an insulin injection system comprising a disposable double point injection needle
US20030078195A1 (en) * 2001-08-27 2003-04-24 Kristensen Lars Thougaard Cartridge and medical delivery system accommodating such cartridge
US8177767B2 (en) 2001-08-27 2012-05-15 Novo Nordisk A/S Cartridge and medical delivery system accommodating such cartridge
US20070233008A1 (en) * 2001-08-27 2007-10-04 Novo Nordisk A/S Cartridge and medical delivery system accommodating such cartridge
US7553293B2 (en) 2001-11-30 2009-06-30 Novo Nordisk A/S Safety needle assembly
US8728027B2 (en) 2001-11-30 2014-05-20 Novo Nordisk A/S Safety needle assembly
US20050065476A1 (en) * 2001-11-30 2005-03-24 Karsten Jensen Safety needle assembly
US9636276B2 (en) 2001-12-06 2017-05-02 Sanofi-Aventis Deutschland Gmbh Medicament cartridge assembly
US20060207959A1 (en) * 2001-12-06 2006-09-21 Dca Design International Limited Medicament cartridge assembly
US8387809B2 (en) 2001-12-06 2013-03-05 Dca Design International Limited Medicament cartridge assembly
US20100004617A1 (en) * 2001-12-06 2010-01-07 Dca Design International Limited Medicament cartridge assembly
US20030109845A1 (en) * 2001-12-06 2003-06-12 Dca Design International Limited Medicament cartridge assembly
US20100010472A1 (en) * 2004-12-24 2010-01-14 Ian Marshall Moore Safety syringe
US8632506B2 (en) 2006-06-30 2014-01-21 Novo Nordisk A/S Medical delivery system comprising a coding mechanism
US20090312715A1 (en) * 2006-07-11 2009-12-17 Rodney Hal Monson Needle mounting assembly for a medication injection device
US7988678B2 (en) 2006-07-11 2011-08-02 Eli Lilly And Company Needle mounting assembly for a medication injection device
US20090281505A1 (en) * 2006-07-15 2009-11-12 Novo Nordisk A/S Medical Delivery System with Asymmetrical Coding Means
US8708972B2 (en) 2006-07-15 2014-04-29 Novo Nordisk A/S Medical delivery system with a rotatable coding element
US20090312717A1 (en) * 2006-07-15 2009-12-17 Asger Voss Christiansen Medical Delivery System with a Rotatable Coding Element
US9050397B2 (en) 2006-07-15 2015-06-09 Novo Nordisk A/S Medical delivery system with a rotatable coding element
US20090259197A1 (en) * 2006-07-15 2009-10-15 Novo Nordisk A/S Medical Delivery System with Flexible Blocking Element
US8579868B2 (en) 2006-07-15 2013-11-12 Novo Nordisk A/S Medical delivery system with flexible blocking element
US8613731B2 (en) 2006-07-15 2013-12-24 Novo Nordisk A/S Medical delivery system with asymmetrical coding means
US20100010455A1 (en) * 2006-08-28 2010-01-14 Novo Nordisk A/S Medical Delivery System Adapted to be Locked Axially and Unlocked Rotationally
US20100042054A1 (en) * 2006-11-17 2010-02-18 Novo Nordisk A/S Medical Delivery System Comprising a Coding Mechanism Between Dosing Assembly and Medicament Container
US8672897B2 (en) 2006-11-21 2014-03-18 Novo Nordisk A/S Medical delivery system comprising locking ring with L-shaped grooves
US20110046566A1 (en) * 2006-11-21 2011-02-24 Novo Nordisk A/S Medical Delivery System Comprising Locking Ring with L-Shaped Grooves
US9289558B2 (en) 2006-11-21 2016-03-22 Novo Nordisk A/S Medical delivery system comprising locking ring with L-shaped grooves
US8617125B2 (en) 2006-12-15 2013-12-31 Novo Nordisk A/S Medical delivery system comprising a container and a dosing assembly with radially moving fastening means
US20100324498A1 (en) * 2006-12-15 2010-12-23 Novo Nordisk A/S Medical delivery system comprising a container and a dosing assembly with radially moving fastening means
US20100106099A1 (en) * 2006-12-21 2010-04-29 Novo Nordisk A/S Syringe Device
US8740857B2 (en) 2006-12-21 2014-06-03 Novo Nordisk A/S Syringe device
WO2008098860A1 (en) * 2007-02-14 2008-08-21 Shl Medical Ab Container for a medical device
CN102119037B (zh) * 2008-06-10 2013-07-31 Shl集团有限责任公司 注射针组件
US10463805B2 (en) 2008-06-10 2019-11-05 Shl Medical Ag Injection needle assembly
US20110125106A1 (en) * 2008-06-10 2011-05-26 Shl Group Ab Injection Needle Assembly
US11793941B2 (en) 2008-06-10 2023-10-24 Shl Medical Ag Injection needle assembly
AU2009256717B2 (en) * 2008-06-10 2013-05-16 Shl Medical Ag Injection needle assembly
WO2009150078A1 (en) * 2008-06-10 2009-12-17 Shl Group Ab Injection needle assembly
AU2009256717B9 (en) * 2008-06-10 2013-05-23 Shl Medical Ag Injection needle assembly
EP3263161A1 (en) 2008-06-10 2018-01-03 SHL Group AB Injection needle assembly
US9687615B2 (en) 2008-06-10 2017-06-27 Shl Group Ab Injection needle assembly
US11007326B2 (en) 2008-06-10 2021-05-18 Shl Medical Ag Injection needle assembly
US8708970B2 (en) 2008-06-10 2014-04-29 Shl Group Ab Injection needle assembly
US10166344B2 (en) 2008-06-10 2019-01-01 Shl Group Ab Injection needle assembly
US10022504B2 (en) * 2009-09-18 2018-07-17 Becton, Dickinson And Company Separable hub post of pen needle
US20120179115A1 (en) * 2009-09-18 2012-07-12 Horvath Joshua Separable hub post of pen needle
US20130256166A1 (en) * 2010-12-14 2013-10-03 Becton Dickinson France Compact injection device
US9333146B2 (en) * 2010-12-14 2016-05-10 Becton Dickinson France S.A.S. Compact injection device
US10314976B2 (en) 2011-10-14 2019-06-11 Amgen Inc. Method of assembling and filling a drug delivery device
US10537682B2 (en) * 2011-10-14 2020-01-21 Amgen Inc. Injector and method of assembly
US11298463B2 (en) 2011-10-14 2022-04-12 Amgen Inc. Method of assembling and filling a drug delivery device
US11129941B2 (en) 2011-10-14 2021-09-28 Amgen Inc. Method of assembling and filling a drug delivery device
US11110225B2 (en) 2011-10-14 2021-09-07 Amgen Inc. Injector and method of assembly
US11273260B2 (en) 2011-10-14 2022-03-15 Amgen Inc. Injector and method of assembly
US20160199578A1 (en) * 2011-10-14 2016-07-14 Amgen Inc. Injector and method of assembly
US11058821B2 (en) 2011-10-14 2021-07-13 Amgen Inc. Injector and method of assembly
US10537681B2 (en) * 2011-10-14 2020-01-21 Amgen Inc. Injector and method of assembly
US20160166765A1 (en) * 2011-10-14 2016-06-16 Amgen Inc. Injector and method of assembly
US11160931B2 (en) 2011-10-14 2021-11-02 Amgen Inc. Method of assembling and filling a drug delivery device
US10850037B2 (en) 2013-03-22 2020-12-01 Amgen Inc. Injector and method of assembly
US11759571B2 (en) 2013-03-22 2023-09-19 Amgen Inc. Injector and method of assembly
US20160136637A1 (en) * 2013-06-13 2016-05-19 Hamilton Bonaduz Ag Syringe having a mechanical coupling piece
US9517463B2 (en) * 2013-06-13 2016-12-13 Hamilton Bonaduz Ag Syringe having a mechanical coupling piece
US11097055B2 (en) 2013-10-24 2021-08-24 Amgen Inc. Injector and method of assembly
CN108601903B (zh) * 2015-11-27 2021-10-08 赛诺菲-安万特德国有限公司 药物注射装置
US11213627B2 (en) 2015-11-27 2022-01-04 Sanofi-Aventis Deutschland Gmbh Medicament injection device
CN108601903A (zh) * 2015-11-27 2018-09-28 赛诺菲-安万特德国有限公司 药物注射装置
CN108495671A (zh) * 2015-11-27 2018-09-04 赛诺菲-安万特德国有限公司 药物注射装置
US11865308B2 (en) 2015-11-27 2024-01-09 Sanofi-Aventis Deutschland Gmbh Medicament injection device
US11865307B2 (en) 2015-11-27 2024-01-09 Sanofi-Aventis Deutschland Gmbh Medicament injection device
US10898658B2 (en) 2016-07-06 2021-01-26 LynJohnston, LLC Compact injection device with telescoping components
US11110033B2 (en) 2017-12-25 2021-09-07 Jiangnan University Integrated structure of preparation syringe
WO2019126992A1 (zh) * 2017-12-25 2019-07-04 江南大学 一种制剂注射器一体化结构
CN107929881B (zh) * 2017-12-25 2023-08-25 江南大学 一种制剂注射器一体化结构
CN107929881A (zh) * 2017-12-25 2018-04-20 江南大学 一种制剂注射器一体化结构
US11607502B2 (en) 2018-01-10 2023-03-21 LynJohnston, LLC Compact injector systems and methods

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Publication number Publication date
CA1044104A (en) 1978-12-12
FR2223051B1 (es) 1977-10-07
AR208661A1 (es) 1977-02-28
AU6713274A (en) 1975-10-02
NL7403938A (es) 1974-10-01
IT1010829B (it) 1977-01-20
AT355192B (de) 1980-02-25
ATA253774A (de) 1979-07-15
DE2315367A1 (de) 1974-10-17
GB1465281A (en) 1977-02-23
BR7402416D0 (pt) 1974-12-03
BE812955A (fr) 1974-09-30
LU69713A1 (es) 1976-02-04
FR2223051A1 (es) 1974-10-25
SE409077B (sv) 1979-07-30
JPS49127494A (es) 1974-12-06
CH575765A5 (es) 1976-05-31
IN139269B (es) 1976-05-29

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