WO2019126992A1 - 一种制剂注射器一体化结构 - Google Patents

一种制剂注射器一体化结构 Download PDF

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Publication number
WO2019126992A1
WO2019126992A1 PCT/CN2017/118535 CN2017118535W WO2019126992A1 WO 2019126992 A1 WO2019126992 A1 WO 2019126992A1 CN 2017118535 W CN2017118535 W CN 2017118535W WO 2019126992 A1 WO2019126992 A1 WO 2019126992A1
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WIPO (PCT)
Prior art keywords
syringe
rubber plug
hollow
integrated structure
needle
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Application number
PCT/CN2017/118535
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English (en)
French (fr)
Inventor
邱玉宇
王骏
夏淑芳
蒋玉宇
Original Assignee
江南大学
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Publication date
Application filed by 江南大学 filed Critical 江南大学
Priority to US16/303,656 priority Critical patent/US11110033B2/en
Publication of WO2019126992A1 publication Critical patent/WO2019126992A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/22—Arrangements for transferring or mixing fluids, e.g. from vial to syringe with means for metering the amount of fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2041—Separating means having removable plugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
    • A61M5/345—Adaptors positioned between needle hub and syringe nozzle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/50—General identification or selection means using icons or symbolic figures, e.g. by a graphical representation symbolising the type of pathology or the organ by an image
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members

Definitions

  • the invention belongs to the technical field of syringes, and in particular relates to a preparation syringe with an integrated structure.
  • the waste of the liquid medicine is mainly caused by the following factors: the extravasation of the liquid medicine, when the liquid medicine is sucked, due to the sealed bottle When the pressure is increased, the liquid can overflow from the needle, and the extravasated liquid can form a toxic particulate aerosol or aerosol that is invisible to the naked eye, thereby causing injury to the medical staff and environmental pollution through the skin, respiratory tract, etc.; Insufficient, due to the special structure of the sealed bottle, the liquid drop and the liquid remaining in the sealing ring of the bottle can not be sucked out; the injection of the liquid is not enough, and some of the liquid remains in the needle when the conventional syringe is used.
  • Powder injection usually requires two syringes to in and out to dissolve the drug and aspirate the drug. In this process, the possibility of contamination of the drug solution and the syringe is greatly increased. 3.
  • Intrusion of infusion particles due to the sealed bottle The sealing ring is made of rubber-like material. Repeated puncture may cause particles to enter the liquid medicine, which may bring potential harm to the patient.
  • Fourth, in the process of dispensing the pharmaceutical liquid it takes time and manpower to dissolve and pump the liquid repeatedly. .
  • the invention relates to an integrated structure of a preparation syringe, comprising a stretchable piston, a syringe, a needle, an exposed rubber stopper, a sealing sheet, a built-in rubber stopper, a sealing rubber plug and a connecting rubber plug, wherein one end of the syringe is provided with a stretchable piston And the other end of the barrel is provided with a post, the side of the stretchable piston away from the barrel is provided with an exposed rubber plug, and the inside of the barrel is provided with a built-in rubber plug, the circumferential surface of the barrel a tick line is disposed, the stud sleeve is provided with a sealing rubber plug, a side of the exposed rubber plug away from the syringe is provided with a sealing piece, and an end of the needle away from the needle tip is provided with a blunt end, the blunt end An adapter rubber plug is provided on the outer side.
  • the stretchable piston comprises a plurality of hollow hollow sleeves
  • the multi-layer hollow hollow sleeve is composed of a plurality of hollow hollow sleeves of decreasing diameter, and adjacent hollow hollow sleeves are passed between The card slot and the protrusion are engaged, and the inner hollow hollow sleeve is pulled out from the outer hollow hollow sleeve and the protrusion is placed in the card slot, the inner hollow hollow sleeve and the outer hollow sleeve
  • the tubes are relatively fixed.
  • the exposed rubber plug passes through the connecting rod between the plug and the built-in rubber plug, and the inside of the connecting rod has a hollow structure.
  • the cross section of the connecting rubber plug is a "mountain" shape structure.
  • the needle is mounted on the post by a glue plug insert.
  • the outer side of the exposed rubber plug and the sealing rubber plug are provided with a sealing sheet.
  • the inside of the post is provided with a through hole.
  • the invention designs the drug storage bottle and the syringe into an integrated structure, is a brand-new design, has novel structure, reduces the intermediate link during use, thereby reducing waste of liquid medicine and waste of liquid medicine caused by overflow of the liquid medicine, and also Reduce the occupational risk of medical staff, and reduce the potential damage to the patient due to repeated puncture formation of particles; match the design of the stretchable piston structure, reduce the overall length, and facilitate the puncture operation; the needle with the cross-section of the mountain-shaped structure is also Effectively avoid the waste of liquid medicine.
  • Figure 1 is a schematic view of the structure of the present invention
  • FIG. 2 is a schematic structural view of a needle of the present invention
  • Figure 3 is a schematic view showing the structure of the tip end of the syringe of the present invention.
  • FIG. 4 is a partial enlarged view of A of FIG. 1.
  • a preparation syringe integrated structure including a stretchable piston 1, a syringe 2, a needle 3, an exposed rubber stopper 7, a sealing sheet 8, a built-in rubber stopper 9, a sealing rubber plug 12 and a connecting rubber plug 14, one end of the barrel 2 is provided with a stretchable piston 1, and the other end of the barrel 2 is provided with a stud 11 comprising a multi-layer hollow sleeve 4 and a card
  • the groove 5 wherein the multi-layer hollow sleeve 4 is composed of a plurality of hollow sleeves whose diameters are sequentially reduced, and the adjacent pairs of hollow sleeves are connected by a card slot 5 and an elastic protrusion 15 to form an elastic protrusion.
  • the side of the stretchable piston 1 away from the syringe 2 is provided with an exposed rubber plug 7, and the inside of the syringe 2 is provided with a built-in rubber plug 9, that is, the lower end of the outermost hollow sleeve is connected with the built-in rubber plug 9, most The upper end of the inner hollow sleeve is connected with the exposed rubber plug 7; the circumference of the cylinder 2 is provided with a scale line 10, and the sleeve 11 is provided with a sealant
  • the plug 12 seals the opening of the post 11 through the sealing rubber plug 12, and the sealing plug 8 is disposed on the outer side of the exposed rubber plug 7 and the sealing rubber plug 12, and the sealing strip is disposed on the side of the exposed rubber plug 7 away from the
  • the end of the needle 3 away from the tip of the needle is provided with a blunt end 13 , and the outer side of the blunt end 13 is provided with a connecting rubber plug 14 , the cross section of the connecting rubber plug 14 is a “mountain”-shaped structure, and the needle 3 is mounted on the insert by the connecting rubber plug 14 On the post 11, the inside of the post 11 is provided with a through hole 6.
  • the syringe 2 and the stretchable piston 1 have a combined structure to form a sealing device, and the inside can accommodate a liquid medicine or a powder injection medicine. If it is a liquid drug, in use, the cartridge 11 of the syringe 2 is facing upward, the sealing sheet 8 is uncovered, the sealing rubber plug 12 is removed, the blunt end 13 of the needle 3 is embedded in the cartridge 11, and the stretchable piston 1 is pulled apart.
  • the fixed piston (the inner and outer hollow sleeves are relatively fixed, the multi-layer hollow sleeve is elongated and the push rod relative to the built-in rubber plug 9), and the piston is gently pushed.
  • the injection operation is carried out in a conventional manner, so that the built-in rubber stopper 9 is completely adhered to the bottom of the injection syringe 2 to complete the injection.
  • the positioning buckle structure between the inner and outer adjacent hollow sleeves is not limited to the card slot 5 and the protrusion 15 in the above embodiment, and the other can achieve the relative fixing effect after the inner and outer sleeves are stretched.
  • the structure can be.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

一种制剂注射器一体化结构，包括可拉伸活塞（1）、针筒（2）、针头（3）、外露胶塞（7）、密封片（8）、内置胶塞（9）、密封胶塞（12）及衔接胶塞（14）。针筒（2）的一端设置有可拉伸活塞（1），另一端设置有卡柱（11），可拉伸活塞（1）远离针筒（2）的一侧设置有外露胶塞（7）；针筒（2）的内部设置有内置胶塞（9）；针筒（2）的圆周面上设置有刻度线（10）。将储药瓶和注射器设计成一体化结构能够减少中间环节，从而减少药液抽吸不尽和药液溢出导致的药液浪费，同时降低医务人员的职业风险，从而减少由于反复穿刺形成微粒造成对患者的潜在损伤；匹配设计的可拉伸活塞结构能够减小整体长度，方便刺穿操作；采用截面为山字形结构的针头能够避免药液的浪费。

Description

一种制剂注射器一体化结构 技术领域
本发明属于注射器技术领域，具体涉及一种一体化结构的制剂注射器。
 背景技术
通过密封瓶配制药液后进行各种注射治疗是临床常见医疗行为。密封瓶内药物常见有液体剂或粉针剂两种，其中以粉针剂更为多见，需通过溶媒溶解成液体状，经注射器抽吸后使用。
 技术问题
在使用传统的注射器抽吸药液和注射的过程中，主要存在以下问题：一、药液浪费，主要有以下几种因素造成：药液外渗，在抽吸药液时，由于密封瓶内压力增加，药液可从针头处溢出，同时外渗药液可形成肉眼看不见的毒性微粒气溶胶或气雾，进而通过皮肤、呼吸道等途径对医护人员造成伤害以及环境污染；药液抽吸不尽，由于密封瓶的特殊结构，挂壁液滴和残留于瓶口密封圈内的药液无法吸出；药液注射不尽，使用传统注射器时部分药液残留于针栓中。二、细菌污染可能性增加，粉针剂通常需要注射器两次进出以溶解药物和抽吸药物，在此过程中大大增加了药液和注射器污染的可能性；三、输液微粒的侵入，由于密封瓶的密封圈由橡胶类材料制成，反复穿刺可能导致微粒进入药液，从而给患者带来潜在的危害；四、在配制药液过程中，重复性的溶解、抽吸药液耗费时间和人力。
 技术解决方案
一种制剂注射器一体化结构，包括可拉伸活塞、针筒、针头、外露胶塞、密封片、内置胶塞、密封胶塞及衔接胶塞，所述针筒的一端设置有可拉伸活塞，且针筒的另一端设置有卡柱，所述可拉伸活塞远离针筒的一侧设置有外露胶塞，所述针筒的内部设置有内置胶塞，所述针筒的圆周面上设置有刻度线，所述卡柱上镶套设置有密封胶塞，所述外露胶塞远离针筒的一侧设置有密封片，所述针头远离针尖的一端设置有钝端，所述钝端的外侧设置有衔接胶塞。
优选的，所述可拉伸活塞包括多层空心空心套管，所述多层空心空心套管由若干个直径依次减小的空心空心套管组成，相邻对的空心空心套管之间通过卡槽及凸起进行卡接，内层空心空心套管从外层空心空心套管中拉出且所述凸起置于所述卡槽中后，内层空心空心套管与外层空心套管之间相对固定。
优选的，所述外露胶塞与内置胶塞之间通过连接杆，且连接杆的内部为中空结构。
优选的，所述衔接胶塞的截面为“山”字形结构。
优选的，所述针头通过衔接胶塞镶套安装在卡柱上。
优选的，所述外露胶塞和密封胶塞的外侧均设置有密封片。
优选的，所述卡柱的内部设置有通孔。
 有益效果
本发明将储药瓶和注射器设计成一体化结构，是一种全新的设计，结构新颖，使用时减少中间环节，从而减少药液抽吸不尽和药液溢出导致的药液浪费，同时也降低医务人员的职业风险，并且减少由于反复穿刺形成微粒造成对患者的潜在损伤；匹配设计的可拉伸活塞结构，减小整体长度，方便刺穿操作；采用截面为山字形结构的针头同样也有效避免了药液的浪费。
 附图说明
图1为本发明的结构示意图；
图2为本发明针头的结构示意图；
图3为本发明针筒头端的结构示意图；
图4为图1的A处局部放大图。
 本发明的实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
请参阅图1-4，本发明提供以下技术方案：一种制剂注射器一体化结构，包括可拉伸活塞1、针筒2、针头3、外露胶塞7、密封片8、内置胶塞9、密封胶塞12及衔接胶塞14，针筒2的一端设置有可拉伸活塞1，且针筒2的另一端设置有卡柱11，可拉伸活塞1包括多层空心套管4和卡槽5，其中，多层空心套管4由若干个直径依次减小的空心套管组成，相邻对的空心套管之间通过卡槽5和具有弹性的凸起15进行连接，弹性凸起15还起到密封圈的作用；将多层空心套管4拉开后，卡槽5与凸起15卡合，对多层空心套管进行固定，弹性凸起15卡扣于卡槽5中后，可拉伸活塞1远离针筒2的一侧设置有外露胶塞7，针筒2的内部设置有内置胶塞9，即最外层空心套管的下端与内置胶塞9相连，最内层空心套管的上端与外露胶塞7相连；针筒2的圆周面上设置有刻度线10，卡柱11上镶套设置有密封胶塞12，通过密封胶塞12对卡柱11的开口进行密封，外露胶塞7和密封胶塞12的外侧均设置有密封片8，外露胶塞7远离针筒2的一侧设置有密封片8，针头3远离针尖的一端设置有钝端13，钝端13的外侧设置有衔接胶塞14，衔接胶塞14的截面为“山”字形结构，针头3通过衔接胶塞14镶套安装在卡柱11上，卡柱11的内部设置有通孔6。
本发明的工作原理及使用流程：本发明使用时，针筒2与可拉伸活塞1为组合结构，形成密封装置，内部可容纳液体状药物或粉针剂药物。若是液体状药物，使用时，使针筒2的卡柱11朝上，揭开密封片8，拔除密封胶塞12，将针头3钝端13嵌入卡柱11，拉开可拉伸活塞1，听到卡扣声音（卡槽5与凸起15匹配），固定活塞（内外空心套管之间相对固定，多层空心套管拉长后相对于内置胶塞9的推杆），轻推活塞，排气，按常规方法进行注射操作，使内置胶塞9完全紧贴于注射针筒2底部，完成注射。若是粉针剂药物，使用时，先揭开活塞外露一端胶塞密封片8，消毒，将抽吸好的溶媒经另一常规注射器针头刺入外露活塞，针头经活塞空心套管中空处抵达内置活塞，并穿透内置活塞，将溶媒注入针筒2内，拔除常规注射器针头，充分溶解药物成溶液状。使针筒2卡柱11朝上，揭开密封片8，拔除密封胶塞12，将针头钝端13嵌入卡柱11，拉开可拉伸活塞1，听到卡扣声音，固定活塞，轻推活塞，排气，按常规方法进行注射操作，使内置胶塞9完全紧贴于注射针筒2底部，完成注射。
本发明中，内外相邻的空心套管之间配合的定位卡扣结构不局限于上述实施例中的卡槽5与凸起15，还可以是其他能达到内外套管拉伸后相对固定效果的结构均可。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。

Claims (6)

  1. 一种制剂注射器一体化结构，其特征在于：包括可拉伸活塞（1）、针筒（2）、针头（3）、外露胶塞（7）、密封片（8）、内置胶塞（9）、密封胶塞（12）及衔接胶塞（14），所述针筒（2）的一端设置有可拉伸活塞（1），且针筒（2）的另一端设置有卡柱（11），所述可拉伸活塞（1）远离针筒（2）的一侧设置有外露胶塞（7），所述针筒（2）的内部设置有内置胶塞（9），所述针筒（2）的圆周面上设置有刻度线（10），所述卡柱（11）上镶套设置有密封胶塞（12），所述外露胶塞（7）远离针筒（2）的一侧设置有密封片（8），所述针头（3）远离针尖的一端设置有钝端（13），所述钝端（13）的外侧设置有衔接胶塞（14）。
  2. 根据权利要求1所述的制剂注射器一体化结构，其特征在于：所述可拉伸活塞（1）包括多层空心空心套管（4），所述多层空心空心套管（4）由若干个直径依次减小的空心空心套管组成，相邻对的空心空心套管之间通过卡槽（5）及凸起（15）进行卡接，内层空心空心套管从外层空心空心套管中拉出且所述凸起（15）置于所述卡槽（5）中后，内层空心空心套管与外层空心空心套管之间相对固定。
  3. 根据权利要求1所述的制剂注射器一体化结构，其特征在于：所述衔接胶塞（14）的截面为“山”字形结构。
  4. 根据权利要求1所述的制剂注射器一体化结构，其特征在于：所述针头（3）通过衔接胶塞（14）镶套安装在卡柱（11）上。
  5. 根据权利要求1所述的制剂注射器一体化结构，其特征在于：所述外露胶塞（7）和密封胶塞（12）的外侧均设置有密封片（8）。
  6. 根据权利要求1所述的制剂注射器一体化结构，其特征在于：所述卡柱（11）的内部设置有通孔（6）。
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Publication number Priority date Publication date Assignee Title
CN109172362B (zh) * 2018-07-09 2021-01-26 杨洪伟 一种医护用碘酊容器
CN111939072B (zh) * 2020-08-17 2023-09-19 遵义医科大学附属医院 一种针头保护装置
TWI806182B (zh) * 2020-11-18 2023-06-21 潔霺生醫科技股份有限公司 多段式氣體致動供藥裝置及方法
CN112933344B (zh) * 2021-01-27 2023-04-25 桂林市中西医结合医院 一种注射装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3498295A (en) * 1967-05-17 1970-03-03 Bio Neering Inc Cartridge for use in multiple injection device
US3916893A (en) * 1973-03-28 1975-11-04 Hoechst Ag Single-injection device
CN2899809Y (zh) * 2006-01-05 2007-05-16 陈庆强 一种防污染注射器的密封结构
CN200984372Y (zh) * 2006-12-26 2007-12-05 马海军 新型防污染注射器
US20090259195A1 (en) * 2008-04-14 2009-10-15 Bencha International Group. Inc. Prepacked automatic retractable safety syringe
CN104132038A (zh) * 2013-04-30 2014-11-05 麦迪莫普医疗工程有限公司 伸缩组件和组装伸缩螺纹件的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545607A (en) * 1968-08-29 1970-12-08 Becton Dickinson Co Self-contained packaged needle assembly
US20060161105A1 (en) * 2003-06-27 2006-07-20 Akihide Mori Disposable injector
US9345836B2 (en) * 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
DE102011013792A1 (de) * 2011-03-03 2012-09-06 Vetter Pharma-Fertigung GmbH & Co. KG Verschluss für eine Pulverspritze und Pulverspritze
US10653844B2 (en) * 2015-11-27 2020-05-19 Sanofi-Aventis Deutschland Gmbh Auto-injector

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3498295A (en) * 1967-05-17 1970-03-03 Bio Neering Inc Cartridge for use in multiple injection device
US3916893A (en) * 1973-03-28 1975-11-04 Hoechst Ag Single-injection device
CN2899809Y (zh) * 2006-01-05 2007-05-16 陈庆强 一种防污染注射器的密封结构
CN200984372Y (zh) * 2006-12-26 2007-12-05 马海军 新型防污染注射器
US20090259195A1 (en) * 2008-04-14 2009-10-15 Bencha International Group. Inc. Prepacked automatic retractable safety syringe
CN104132038A (zh) * 2013-04-30 2014-11-05 麦迪莫普医疗工程有限公司 伸缩组件和组装伸缩螺纹件的方法

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