CA1044104A - Single-injection device - Google Patents

Single-injection device

Info

Publication number
CA1044104A
CA1044104A CA196,175A CA196175A CA1044104A CA 1044104 A CA1044104 A CA 1044104A CA 196175 A CA196175 A CA 196175A CA 1044104 A CA1044104 A CA 1044104A
Authority
CA
Canada
Prior art keywords
needle
syringe
container
support
stopper
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA196,175A
Other languages
French (fr)
Other versions
CA196175S (en
Inventor
Wilfried De Felice
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of CA1044104A publication Critical patent/CA1044104A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

ABSTRACT OF THE DISCLOSURE

The present invention provides a single-injection syringe having a liquid container filled with the medicament.
The container is coupled to a syringe body which contains a moveable needle support hauing a needle for penetrating the container. The needle support and needle are contained in a cavity defined in part hy the syringe body and by a piston rad coupled to the syringe body. The piston rod is arranged so that it can be used to moue the needle support such that the needle penetrates the container and then the piston rod is removed and used to move a stopper associated with the container for forcing the medicament out of the syringe.

Description

The present invention relates to a single-injection ; device for use in administering liquid medicament.
So-called "ready-to-use" syringes are available for a single lnjection and,are widely employed in the administration.:of li~uid.medicament. Prio~ art syringes , ., include many individual.parts which are both expensive .~ to manufacture,and to assemble,.under.sterile conditions.
. ~ Because a xeady~to-use syringe is intended for one.injection ,! only, it.is advantageous to provide syringes which are , . , of minimal cost. ., ~, .
.i In prior.art devices, the liquid medicament is ~', ':', stored in a liquid container shaped like an ampoule. This ampoule is pushed into a syringe body. In the final assembly, ~'' i! the ampoule is placed in the syringe body such tha~ the ~ injection cannula which reaches.into.. the.interior of the . :~
.. ,j -~, ..syringe body doqs not pierce.the seal at the front end of ,~ the ampoule. An essential.disadvantage of.such.a syringe '., ,,1 : -: . .. .
~ s that the injection'needle,fixed in the syringe body . .
;
'1land the portion of the ampoule facing it have to be kept ,,~: .
! .: . . ' ~: sterile...The resulting.space between the.liquid container '~
and the syringe body is.sometimes.penetrated.~.by micro-organisms , ~' :during ~storage..
It would be advantageous. to provide~a sterile zone ~' :~",i for~the injection needle in a sealed and separate part of '.
:the syrlnge to.prevent the intoduction of micro-organisms ~; .

during lengthy storage.
In one o~ its aspects the present invention provides a single-injec,tion syringe having a liquid container filled with the medicament. The container is coupled to a syringe bbdy which..contains a moveable needle support having a needle,for penetrating the container~ The needle support.and.needle are contained.i~.a.cavity defined in part by the syringe body and by a piston rod coupled to the syringe body. The piston.rod..is.!.arranged so that it can be used to move the.needle.support.such tha.t the needle penetrates the container..and then the piston rod,is removed and,used to move a stopper associated wi~h the container for forcing the medicament out of the syringe.
Syri~ges constructed.in accordance with the present invention will now.be desaribed in detail by way o~ example only.with.reference:.to.the:accompanying drawings, in which: . ' ' , Fig. 1 is a side,view of a syringe ready for use;
I
¦~ Fig. 2 is.. a.longitudinal cross-sectional view .
:1:
of the syringe shown in Fig. 1 with the syringe in use;

.Fig. 3 is a longitudi~al,.cross-sectional view of ''l ~ : :
another:embadiment of.the syringe with the syringe in aondition prior prior.to use; and ::: .... ,. Fig~ 3a is a top view o~ the syringe on line.IIIa-IIIa.

ff; ~
3 ~ : 3 - ' :

, . - .. ~ . , ,:. . ,, ,, ,. :,: . , . . - - . . . , , . ., , . , ; . : : .

3f~
As seen in Fig. 1, a syringe is provided having ' a container 1, a syringe body 2 and a piston rod 3 which ~ is detachable for operating the syringe. Such operation ;' is indicated in Fig. 2 where the piston rod 3 has been e~gaged in tke container 1 as will be described. ', The piston rod 3 is normally threadably engaged .
. on the syringe.body.2 and..spaced from.the,body to permit . movement of the rod.3.towards the.. body. This movement forces.a needl.e support 10 and associated.needle towards ... .
`.! the container 1 until.the needle.pit~r.ces.a ~opper 8 at .
an end of the container 1. The stopper B is.conventional , and is held.in.this end of. ~he container.. by, an aluminum . .
'.' r.ap 7. ~s seen in Fig. 2,.the. syringe body 2 is deormed -.~.' .~ . about an annulax.depr.ess.ion.. in.. the.. container.l to retain . ::
I the contaîner.in the body 2. ':
. . .
,~1 . Fig. 2 also.illustrates the operation of the :' , syringe. This operation.will be descri~ed and then the transitional steps neceesary to convert the syringe from .;
the Fig. 1 condition to the Fig.. 2 condition will be '1, described with referenc~ o.parts of another embodiment `~ : shown in Fig. 3. ~. :
~ A stopper 6 is normally located in the container 1 .. . .
~ .: adjacent a finger support 5 for sealing liquid in the container. ':
, ~ , .
: The stopper is retained in position,by any suitable means ,' -such as by a plurality of beads 20 shown in the Fig. 3 ,"

., :
~ 4 ~
.. 1 .

embodiment. These retaining beads prevent the liquid container from being removed while compensating for differences in the.total length of the liquid ~ontainer.
Various other securing means of injection devices give similar results. For example,..stoppers with annular sealing lamellae, or threads, or so-called..bayonet-type seals.
. In use the piston rod 3.. is threadably engaged in the stopper 6 and pushed axially to force liquid through .. . .
the needle and ~upport 10. As seen.in Fig. 2 the support ..
. 10 is attached to a cannula ll.which extends from a record ;1 ~rustrum 16. The frustro-conical shape of frustrum 16 depends from a shoulder 17 so that.a plastic socket 18 l projecting in the interior of the piston rod 3 could engage the needle.support 10 as will.be descrihed. In the case of a.long cannula.which.is used as the injection needle, the frustrum 16 is not required.
l As previously mentioned,.~the-intermediate steps I between the Fig. 1 and Fig. 2 positlons will.be described .~ with reference to Fig. 3 in.which primed numerals correspond -~
I to parts already described with reference to Figs. 1 and 2.
In Fig. 3 the syringe is ready for use. The needle ,, - .
nd needle sup.por* 10, and.cannula ll.are contained in a sealed.cavity defined by the hollow piston rod 3' and bore 9. ~ .:

:.1 , i~ .

A plastic membrane 12 separates this cavity from the stopper , , 81.
As seen in Fig. 2, an annular projection 13 is provided on the needle support 10 for normal.engagement in i an outer annular grQove 14 defined.. in .the threaded portion ,of the.syringe body 2. ,Such an engagement is shown in I Fig. 3. ~n inner,annular.. grooYe.is also provided on body 2 ,., I (Fig. 2).. and corresponding to groove 22.in body 2~., The ~, .
~', support 10 is,located,in,.,this.. inner groove , as seen iD Fig.. 2. The needle suppor,t,,l.O.,preferably also includ~s stabilizing fins 15.
-I ,, ... ,. It.will now be.appar.ent:.. that.the embodiment B
.1l ... .
hown in Fig. 3 is s.imilar.to the embodiment A shown in Figs. 1 and 2.. The embodiment..B,differs,..primarily in that j the body 2''has finger.support 5.' and receiv,es.a separate . -:j .... . container.l' which.. is held.. in.place by heads.. 20 which also . ' .~ contain the stopper 6'. By~contrast.. the container 1 of :
.~ , , embodiment A forms.an.integral,.par.t of,the structure and :. ha~s the.finger s,upport,5.formed directly on it. :, . , . The use~of both embodiments will...be.described .,with,.reference initially to Fig. 3 which is typical of : both embodiments.,in their normal,.positions,..and.then with i-,~ ~ :,:
reference~to Fig. 2 which is typical of both embodiments ,, '~;,: ~ : in~positions..which they would occupy during use.
.: . .During assembly, the piston.rod,3' is threaded 'i. ~ ~ : : ' ", ,~L~

onto the syringe body 2' until a socket corresponding to a socket 18 shown in Fig. 2 engages the needle support 10. In this condition the needle support is located in a first position where the needle is out of engayement with the container 1'. The needle support 10' is then in a cavity which 1s sterilized.and defi~ed.partially by the body 2' and partiall~ by the hollow piston rod 3'.
When the~syringe is to be used, the piston rod 3' is ro~ated to cause it.to move up the threads of the body 2' .
thereby forcing the...annular projec~ion 13 7 out of its location in.the outer.annular.groove.of the body 2l and towards.the container..l'. The movement continues to force the needle.through the.rubber stopper 8' and to engage the annular projection 13' in the inner annular groove of the : .
body 2'. At this point the leading end of the piston rod 3' engaqes a stop 21 on the body 2'.

The piston rod 3' i.s now removed to expose the ,; .
l.;` cannula 11' and the externally threaded.end of the rod 3' :: ,: . .
.~ is èngaged in the stopper 6' associated.with the container . .
. ~, .
,;,~~ 1 ' , ~" . - ' ' .
~: .
Operation.of the syringe is indicated in Fig. 2 which, as mentioned,.is typical of both embodiments.A and B.

In Fig. 2 the piston rod has been.mo~ed.towards the needle ~ support 10 to expel liquid through the associated needle -:!~- ~ .-and out through the cannula 11. Once the medicament has ."~
~ - 7 ~
,.. , :~ . :

been administered..the syringe can be discarded.
; . The bodies 2 and 2' of the respective embodiments A and.B are.preferably of a material which allows deformation to.enga~e the body with the respective containers 1 and 1'. Further, the body 2' permi~s the creation of beads 20 from a rim 4 by means of a punch moved in the direction of the container axis. The piston rods and containers 1, 1' are also preferably of any suitable plastic material capable o~ being sterilized and containing the liquid.medicament.
. An injection needle, the size of which depends : . . ..
on:the intended injection, can.be.placed on the record ; frustrum 16 of the needle support 10. .However, it is ,~ also possible to use the injection cannula 11 since this cannula projects beyond the.frustrum and is firmly connected to the needle support 10 for such use.
:l It will be evident.from the aforegoing description ,:
~:l that the device of the present invention has the a~vantage that the whole cannula is located in a.sterile cavity -.
and that fractionation of the rubber disc or stopper :; , . . .
;l and thus clogging of the cannula.. are avoided to a large : -I extent.
.,j ~ . .
. .: The rubber stopper 8.is.pre~erably provided with a conical cavity,. through which air bubbles, which ~requently ., '" : ~ .
~ 8 - :
, ` . .
;, ~: . , . : .. .,: .. ...

form in the interior of the container filled with the liquid medicament prior to the application, can simply be removed by pressing the pi~ton rod.

, ; , 1 , .

, . . .
:i, ' .
;~ :
~;, . : :.
. .
~ . :
,:
1' : . ` : `.
.
.j . ..
,, ~ . .
, , , - .
!
'1 ' '':
j: :
,, :: '.
;!
! :
~ ` ' . ~ , . . .

:L~
JI; . . .

( . ~ ' .

,,' ~: ~::,, : . :: : ;. -- . ~ i:: : : ' I . , - : : .

Claims (8)

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A single-injection syringe comprising:
a container for receiving a liquid medica-ment and having a first stopper at one end adapted to be pierced by a needle;
a second stopper engageable in the con-tainer to trap the liquid medicament in the container;
a syringe body positively coupled to the container and defining a bore, the syringe body including a membrane at an end of the bore nearer the end of the container adapted to be pierced by a needle, and the body further defining an externally threaded portion concentric with the bore and remote from the membrane;
a needle support engaged in the bore in a first position for axial movement in the bore towards a second position and including a short needle extending in said bore towards said diaphragm and having sufficient length with the support in the second position to penetrate both the diaphragm and said first stopper, the needle being hollow for communicating with a cannula attached to the needle support to dispense the medicament;
said needle support and the bore defining co-operating means for releasably locating the needle sup-port in said first and second position;

a piston rod threadably engaged on said threaded portion of the syringe body at one end of the rod and being hollow for containing the cannula, the rod including a portion in engagement with said needle support so that rotation of the piston rod relative to the syringe body in a first direction will cause said portion of the rod to push the needle support from the first to the second position and rotation in the oppo-site direction will disconnect the rod from the syringe body, the rod further including means adapted to con-nect the rod to the second stopper to permit the user to push this stopper axially with the needle support in the second position to thereby dispense the medica-ment through the needle and catheter.
2. A single-injection syringe as claimed in claim 1 in which the first stopper defines a conical cavity through which the needle will emerge in penetrating this stopper.
3. A single-injection syringe as claimed in claim 1 in which said co-operating means comprises a radial annular projection on the needle support and a pair of spaced annular grooves in the bore.
4. A syringe as claimed in claim 1, 2 or 3 wherein the needle support includes stabilizing fins for better location of the support in the bore.
5. A syringe as claimed in claim 1, 2 or 3 in which an injection cannula is firmly engaged in the needle support and projects in a direction opposite to that of the needle.
6. A syringe as claimed in claim 1, 2 or 3 in which the piston rod has an externally threaded end for en-gagement in the second stopper of the container to facili-tate moving this stopper axially for dispensing the medica-ment.
7. A syringe as claimed in claim 1, 2 or 3 in which the container has a finger support defined at an end of the container remote from the syringe body.
8. A syringe as claimed in claim 1, 2 or 3 in which the syringe body substantially encloses the container and defines a finger support at an end of the body remote from the piston rod.
CA196,175A 1973-03-28 1974-03-27 Single-injection device Expired CA1044104A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2315367A DE2315367A1 (en) 1973-03-28 1973-03-28 SINGLE USE INJECTION SYRINGE

Publications (1)

Publication Number Publication Date
CA1044104A true CA1044104A (en) 1978-12-12

Family

ID=5876145

Family Applications (1)

Application Number Title Priority Date Filing Date
CA196,175A Expired CA1044104A (en) 1973-03-28 1974-03-27 Single-injection device

Country Status (16)

Country Link
US (1) US3916893A (en)
JP (1) JPS49127494A (en)
AR (1) AR208661A1 (en)
AT (1) AT355192B (en)
BE (1) BE812955A (en)
BR (1) BR7402416D0 (en)
CA (1) CA1044104A (en)
CH (1) CH575765A5 (en)
DE (1) DE2315367A1 (en)
FR (1) FR2223051B1 (en)
GB (1) GB1465281A (en)
IN (1) IN139269B (en)
IT (1) IT1010829B (en)
LU (1) LU69713A1 (en)
NL (1) NL7403938A (en)
SE (1) SE409077B (en)

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CN102119037B (en) 2008-06-10 2013-07-31 Shl集团有限责任公司 Injection needle assembly
CN103977485B (en) * 2009-09-18 2017-04-12 贝克顿·迪金森公司 Separable hub post of pen needle
ES2572656T3 (en) * 2010-12-14 2016-06-01 Becton Dickinson France Compact injection device
CA2851521C (en) 2011-10-14 2020-09-22 Amgen Inc. Injector and method of assembly
LT2976117T (en) 2013-03-22 2021-02-25 Amgen Inc. Injector and method of assembly
DE102013210998A1 (en) * 2013-06-13 2014-12-18 Hamilton Bonaduz Ag Syringe with mechanical coupling
KR101533378B1 (en) * 2013-09-13 2015-07-02 (주)연우 Syringe type cosmetic case
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JP6987056B2 (en) 2015-11-27 2021-12-22 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Drug injection device
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Also Published As

Publication number Publication date
FR2223051B1 (en) 1977-10-07
AR208661A1 (en) 1977-02-28
AU6713274A (en) 1975-10-02
NL7403938A (en) 1974-10-01
IT1010829B (en) 1977-01-20
AT355192B (en) 1980-02-25
ATA253774A (en) 1979-07-15
DE2315367A1 (en) 1974-10-17
GB1465281A (en) 1977-02-23
BR7402416D0 (en) 1974-12-03
BE812955A (en) 1974-09-30
LU69713A1 (en) 1976-02-04
FR2223051A1 (en) 1974-10-25
SE409077B (en) 1979-07-30
US3916893A (en) 1975-11-04
JPS49127494A (en) 1974-12-06
CH575765A5 (en) 1976-05-31
IN139269B (en) 1976-05-29

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