US3888377A - Closure cap for an infusion flask - Google Patents

Closure cap for an infusion flask Download PDF

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Publication number
US3888377A
US3888377A US46988374A US3888377A US 3888377 A US3888377 A US 3888377A US 46988374 A US46988374 A US 46988374A US 3888377 A US3888377 A US 3888377A
Authority
US
United States
Prior art keywords
cap
flask
sealing disc
closure cap
closure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
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English (en)
Inventor
Reinhard Stadler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
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Filing date
Publication date
Priority claimed from DE19732327553 external-priority patent/DE2327553C3/de
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of US3888377A publication Critical patent/US3888377A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1425—Snap-fit type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1431—Permanent type, e.g. welded or glued
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties

Definitions

  • the closure cap can be fixedly connected to the neck of the flask, and locat- [561 References Cited ing means may be provided on the cap and the flask to UNITED STATES PATENTS determine a preset rotational position of alignment of 2,387,955 10/1945 Tilson 215/249 the cap and fl k 3,047,178 7/1962 Poitras et al. 2l5/249 14 Claims, 2 Drawing Figures PATENTEB JUN 10 I975 Fig.1
  • Fig-Z CLOSURE CAP FOR AN INFUSION FLASK FIELD OF THE INVENTION This invention relates generally to infusion flasks, and more particularly to closure caps for infusion flasks. It is to be understood that the term infusion flasks" as used throughout this specification and the appended claims is intended to embrace any medical or pharmaceutical container containing an injectant that can be drawn out through the canule of a syringe, and that the closure caps of the invention are applicable to the closure of all such containers.
  • the cap contains a sealing disc and has an integral cap portion which can be torn open or torn off to uncover the sealing disc when the infusion flask is to be used. After the removal of this tear-off portion of the cap the underlying surface of the sealing disc is exposed.
  • the sealing disc is capable of being perforated after it has been uncovered and exposed in this fashion.
  • the disc is provided with a prepared point in the form of an indentation where perforation is to take place.
  • a closure cap for application to the closed neck of an infusion flask to provide a sterile seal therefor, the cap comprising a skirt adapted to embrace the neck of the flask and an end closure wall, a sealing disc cast or moulded in engagement with the inner face of the end closure wall, a tear-off cover portion integrally formed in the end closure wall whereby the sealing disc is exposed through the end closure wall when said cover portion is removed, and at least one projection on the inner face of said cover portion which locally reduces the thickness of the sealing disc for perforation.
  • the above form of construction of the closure cap provides a number of important advantages.
  • the pro duction of the closure cap can be considerably simplified by injection moulding or casting the sealing disc into the cap.
  • the indentation in the sealing disc which identifies the prepared point of perforation and is produced by the at least one projection in the tear-off cover portion which locally reduces the thickness of the sealing disc, is in a predetermined position in relation to the closure cap.
  • the material forming the sealing disc can be sterilised in production, so that a sterile surface for perforation is exposed when the cover portion is removed.
  • the indentation identifying the point of perforation is automatically produced when the sealing disc is moulded or cast.
  • closure cap may be made in a plastics material, or in a metal such as aluminium.
  • a plastics material appears to offer advantages in convenience and cheapness of production costs.
  • Suitable materials for forming the sealing disc include a large number of rubber-elastic compositions which can be formed by a moulding or casting process.
  • a particularly suitable material is an unvulcanised calendered natural rubber, a disc of which can be moulded by vulcanisation in situ in the cap.
  • moulding temperature is usually sufficiently high to sterilise the surfaces of the resultant sealing disc, so that no separate sterilisation procedures are required.
  • a temperature of C would appear to be possible and would give rise to a sealing disc having sterile surfaces after the moulding process.
  • plastics materials for the closure cap include polyethylene, polyvinyl chloride and polypropylene, which can also be satisfactorily heat sealed. It is desirable that the materials chosen for the closure cap and the sealing disc should be such that the tear-off cover portion will detach from the surface of the sealing disc without sticking thereto.
  • the infusion flask is formed with a peripheral collar on the neck of the flask, it may be useful to attach the closure cap to the collar, Suitable the closure cap may be bonded to the collar as by the employment of suitable adhesives or by welding, or the cap may be attached to the collar by use of an additional metal or plastics coated flanging ring.
  • the closure cap may be a snap-fit onto the neck of the collar. This may be achieved, for example, by forming the skirt of the closure cap in a manner such that it is adapted to snap onto the neck of the flask.
  • the neck of the flask may be formed with an undercut shoulder and an internal peripheral rib on the skirt of the cap may be engaged beneath the shoulder. This arrangement could, of course, be reversed by providing a rib on the neck of the flask and a shoulder on the skirt of the cap.
  • a convenient method of producing a closure cap of the abovedescribed kind comprises filling a mouldable sealing disc material into the cap and moulding the sealing disc offset material in situ in the cap at a temperature high enough to sterilise the surfaces of the sealing disc.
  • such a closure cap can be very conveniently located in relation to the parting seam of a plastics flask by providing means on the flask and on the cap for locating the flask and cap in a predetermined relative rotational position, thus permitting the closure cap to be applied to the flask in a production machine and the prepared point of perforation to be automatically located away from the parting seam and/or any other undesirable surface regions of the infusion flask.
  • Such locating means may with advantage comprise flat surfaces on at least one side of the cap and the flask respectively adapted when aligned or registered to determine the rotational position of the cap relative to the flask.
  • FIG. 1 is a section of a closure cap according to the invention applied to the neck of an infusion flask
  • FIG. 2 is a top plan view of the cap in FIG. 1.
  • FIG. 1 of the accompanying drawings there is shown an infusion flask made of a synthetic plastics material.
  • the infusion flask has a neck 2 on which is formed a peripheral collar 12.
  • the parting seam of the flask, whereat the material is thickest, is indicated by the line 13.
  • the neck 2 of the infusion flask is embraced by the skirt 3a of a closure cap 3 which also comprises an integral end closure wall 4. having a tear-off cover portion 4a integrally formed therein. Tearoff cover portion 4a is defined by an annular groove 16 extending into closure wall 4 from the inner face 4b thereof. With cover portion 4a in place, the cap 3 is sealed. A ring-shaped finger grip 5 is provided on cap 3. By gripping grip S and pulling the cover portion 4a is torn off around groove 16 which constitutes a predetermined line of weakening in the end closure wall 4. In order to facilitate tearing off the cover portion 4a the end wall 4 may further be provided with a point of preferential initial fracture, such as a triangular nib adjoining groove 16 at a selected point.
  • a point of preferential initial fracture such as a triangular nib adjoining groove 16 at a selected point.
  • the mouth 7 of the infusion flask 1 is sealed by a sealing disc 6 which has been formed by moulding or casting a compounded rubber material into the cap 3 in engagement with the inner face 4b of the end closure wall 4.
  • a sealing disc 6 which has been formed by moulding or casting a compounded rubber material into the cap 3 in engagement with the inner face 4b of the end closure wall 4.
  • At least one protuberance or projection 8 on the un derside of the cover portion 4a projects into the sealing disc 6.
  • Projection 8 is suitably in the form ofa boss integral with the cover portion 4a.
  • the projection 8 locally reduces the thickness of the sealing disc and provides a prepared location for effecting perforation of the sealing disc 6 by the canule of a syringe (not shown) once the cover portion 4a has been torn off.
  • Cap 3 is an injection moulded plastics material which does not stick to the surface of the material constituting the sealing disc 6.
  • the inner surface of the skirt 3a of the closure cap 3 is formed with projecting peripheral rib or flange 9 which by snap-action engages beneath an undercut shoulder 10 encircling the neck 2 of the flask.
  • the rim of the closure cap 3 is further formed with a flange 11 which can be bonded to the peripheral collar 12 on the neck of the flask by hot sealing, with an adhesive or by like means or with the aid of a flanging ring (not shown) to firmly attach the closure cap 3 to the flask l.
  • Locating means are preferably provided on the closure cap 3 and on the neck 2 of the flask for locating these parts in a predetermined rotational position when the cap is being fitted onto the flask, for example to ensure that the prepared point of perforation is not near the parting seam 13 of the flask or near some other undesirable part of the surface of the flask.
  • the locating means suitably comprise flat surfaces on at least one side of the closure cap 3 and the flask 1.
  • the locating means comprise diametrically opposed pairs of flats 14 on the closure cap 3 and flats 15 on the collar 12 of the neck 2 of the flask l which permit corresponding parts of the circumference of the cap 3 and of the neck 2 to be mechanically aligned in a bottle closing machine.
  • the moulding process carried out in situ in the cap is preferably carried out at a temperature which is high enough to sterilise the surfaces of the sealing disc.
  • an unvulcanised cal endered natural rubber disc may be vulcanised in situ in the cap and sterilised automatically in the course of the vulcanisation.
  • the temperature of the material will normally be high enough to ensure sterilisation of the material in producing the disc.
  • a sterile surface of the sealing disc is thus exposed when the cover portion 4a is torn off.
  • a closure cap for application to the closed neck of an infusion flask to provide a sterile seal therefor, the cap comprising a skirt adapted to embrace the neck of the flask and an end closure wall, a sealing disc cast or moulded in engagement with the inner face of the end closure wall, a tear-off cover portion integrally formed in the end closure wall whereby the sealing disc is exposed through the end closure wall when said cover portion is removed, and at least one projection on the inner face of said cover portion which locally reduces the thickness of the sealing disc for perforation.
  • a closure cap according to claim I wherein the at least one projection comprises a boss integral with said cover portion.
  • a closure cap according to claim 1, wherein the sealing disc comprises an injection moulded elastomer.
  • a closure cap according to claim 1 which comprises a synthetic plastics material.
  • a closure cap according to claim 1, wherein said tear-off cover portion is defined by an annular groove which constitutes a predetermined line of weakening in said end closure wall and said wall further comprises a point of preferential initial fracture adjoining said groove.
  • An infusion flask comprising the closure cap as claimed in claim 1 and a peripheral collar on the neck of the flask to which said closure cap is attached.
  • An infusion flask comprising the closure cap as claimed in claim 1 and the skirt of the cap is adapted to snap onto the neck of said flask.
  • An infusion flask comprising the closure cap as claimed in claim 1 and means on said flask and said cap for locating said cap and flask in predetermined relative rotational position.
  • said locating means comprise flat surfaces on at least one side of said cap and said flask respectively adapted when aligned to determine the rotational position of said cap relative to said flask.
  • a method of manufacturing a closure cap as claimed in claim 1 which comprises filling a mouldable sealing disc material into the cap and moulding the sealing disc of said material in situ in the cap at a temperature high enough to sterilise the surfaces of the sealing disc.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
US46988374 1973-05-30 1974-05-14 Closure cap for an infusion flask Expired - Lifetime US3888377A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732327553 DE2327553C3 (de) 1973-05-30 Verschlußkappe, mit dieser verschließbare Infusionsflasche und Herstellu ngsverf ahren

Publications (1)

Publication Number Publication Date
US3888377A true US3888377A (en) 1975-06-10

Family

ID=5882583

Family Applications (1)

Application Number Title Priority Date Filing Date
US46988374 Expired - Lifetime US3888377A (en) 1973-05-30 1974-05-14 Closure cap for an infusion flask

Country Status (7)

Country Link
US (1) US3888377A (enrdf_load_stackoverflow)
JP (1) JPS5733225B2 (enrdf_load_stackoverflow)
ES (1) ES226235Y (enrdf_load_stackoverflow)
FR (1) FR2231361B1 (enrdf_load_stackoverflow)
GB (1) GB1465326A (enrdf_load_stackoverflow)
IT (1) IT1013302B (enrdf_load_stackoverflow)
SE (1) SE397267B (enrdf_load_stackoverflow)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211333A (en) * 1978-06-05 1980-07-08 Merck & Co., Inc. Tamperproof container
US4227617A (en) * 1979-08-30 1980-10-14 Aluminum Company Of America Container closure
US4286640A (en) * 1980-01-21 1981-09-01 Abbott Laboratories Tamperproof port cover
US4320861A (en) * 1980-05-12 1982-03-23 Rieke Corporation Molded plastic tamper-proof cap with pull ring and tearable membranes
US4501372A (en) * 1983-03-22 1985-02-26 Gerhard Hansen Tear-open closure for a container
US4512486A (en) * 1981-11-16 1985-04-23 Toyo Seikan Kaisha Limited Stopper assembly for medical liquid container and method and apparatus for manufacturing the same
US4632673A (en) * 1983-06-15 1986-12-30 Hantaaki Oy Pierceable port for containers
US5314084A (en) * 1992-08-21 1994-05-24 The West Company, Incorporated Two piece all plastic seal
US5316163A (en) * 1992-08-24 1994-05-31 Pohl Gmbh & Co. Kg Bottle top having inner and outer caps for securing and sealing a resilient stopper
US5326534A (en) * 1988-12-16 1994-07-05 Terumo Kabushiki Kaisha Liquid collection tube
US5344036A (en) * 1992-06-04 1994-09-06 Akzo N.V. Container system
US5368177A (en) * 1992-09-23 1994-11-29 Pohl Gmbh & Co. Kg Infusion bottle
US5598938A (en) * 1993-05-12 1997-02-04 Capsulit S.P.A. Capsules for infusion and injection bottles
US5823373A (en) * 1995-10-18 1998-10-20 Daikyo Seiko, Ltd. Plastic cap and a process for the production of the same
US5957314A (en) * 1996-04-09 1999-09-28 Taisei Kako Co., Ltd. Crown caps for drug containers
US6223918B1 (en) * 1998-07-14 2001-05-01 Nycomed Imaging As Package
WO2002098748A1 (de) * 2001-06-07 2002-12-12 West Pharmaceutical Services Deutschland Gmbh & Co. Kg Verschluss für eine medikamentenflasche sowie verfahren zu dessen herstellung
US6659296B2 (en) * 2000-01-26 2003-12-09 Amersham Health As Cap for container
US20080039773A1 (en) * 2006-04-24 2008-02-14 Daniel Py Needle penetrable and laser resealable lyophilization device and related method
US20090084804A1 (en) * 2007-10-01 2009-04-02 Hospira, Inc. Snap-over port cap
US20090120934A1 (en) * 2007-11-08 2009-05-14 Hospira, Inc. Snap-over clamshell protective port cap
US20100326990A1 (en) * 2008-02-15 2010-12-30 Mader Juergen Closure Cap
US20210001108A1 (en) * 2015-07-30 2021-01-07 Carefusion 303, Inc. Tamper-resistant cap
US11357701B2 (en) * 2017-02-23 2022-06-14 Brevetti Angela S.R.L. Process for realizing a closing device for an aseptic container
WO2023144800A1 (en) * 2022-01-31 2023-08-03 Metalco S.R.L. Closing element for pharmaceutical containers and process for producing such closing element
USD1006621S1 (en) 2021-06-11 2023-12-05 KAISHA PACKAGING Private Ltd. Tamper evident plastic closure
US11850210B2 (en) 2021-05-06 2023-12-26 Kaisha Packaging Private Limited Tamper evident plastic closure for vials for storing substances for medical or pharmaceutical applications and use thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4890222U (enrdf_load_stackoverflow) * 1972-02-02 1973-10-30
JPS5664961A (en) * 1979-11-01 1981-06-02 Fujisawa Pharmaceutical Co Plug body for vial
AR231626A1 (es) * 1982-01-30 1985-01-31 Gesepa Patentverwertung Elemento de cierre para recipientes y procedimiento para su fabricacion
JPS63135641U (enrdf_load_stackoverflow) * 1988-01-21 1988-09-06
DE4309654C2 (de) * 1993-03-25 1995-04-13 Pohl Gmbh & Co Kg Ringförmige Dichtung

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2387955A (en) * 1942-01-08 1945-10-30 Aluminum Co Of America Tamperproof closure
US3047178A (en) * 1958-06-24 1962-07-31 Baxter Laboratories Inc Closure system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1049887A (fr) * 1952-01-25 1954-01-04 Dispositif de bouchage, notamment pour flacons de liquides destinés à des transfusions ou injections
US3364890A (en) * 1965-02-12 1968-01-23 West Co Container closure and method of making the same
DE6930705U (de) * 1969-08-02 1970-06-18 Behringwerke Ag Schraubkappe fuer infusionsflasche.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2387955A (en) * 1942-01-08 1945-10-30 Aluminum Co Of America Tamperproof closure
US3047178A (en) * 1958-06-24 1962-07-31 Baxter Laboratories Inc Closure system

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211333A (en) * 1978-06-05 1980-07-08 Merck & Co., Inc. Tamperproof container
US4227617A (en) * 1979-08-30 1980-10-14 Aluminum Company Of America Container closure
DE3028281A1 (de) * 1979-08-30 1982-02-18 Aluminum Company Of America, Pittsburgh, Pa. Verschlussanordnung
US4286640A (en) * 1980-01-21 1981-09-01 Abbott Laboratories Tamperproof port cover
US4320861A (en) * 1980-05-12 1982-03-23 Rieke Corporation Molded plastic tamper-proof cap with pull ring and tearable membranes
US4512486A (en) * 1981-11-16 1985-04-23 Toyo Seikan Kaisha Limited Stopper assembly for medical liquid container and method and apparatus for manufacturing the same
US4501372A (en) * 1983-03-22 1985-02-26 Gerhard Hansen Tear-open closure for a container
US4632673A (en) * 1983-06-15 1986-12-30 Hantaaki Oy Pierceable port for containers
US5326534A (en) * 1988-12-16 1994-07-05 Terumo Kabushiki Kaisha Liquid collection tube
US5344036A (en) * 1992-06-04 1994-09-06 Akzo N.V. Container system
US5314084A (en) * 1992-08-21 1994-05-24 The West Company, Incorporated Two piece all plastic seal
US5316163A (en) * 1992-08-24 1994-05-31 Pohl Gmbh & Co. Kg Bottle top having inner and outer caps for securing and sealing a resilient stopper
US5368177A (en) * 1992-09-23 1994-11-29 Pohl Gmbh & Co. Kg Infusion bottle
US5598938A (en) * 1993-05-12 1997-02-04 Capsulit S.P.A. Capsules for infusion and injection bottles
US5823373A (en) * 1995-10-18 1998-10-20 Daikyo Seiko, Ltd. Plastic cap and a process for the production of the same
US6042770A (en) * 1995-10-18 2000-03-28 Daikyo Seiko Ltd. Process for the production of plastic cap
US5957314A (en) * 1996-04-09 1999-09-28 Taisei Kako Co., Ltd. Crown caps for drug containers
US6223918B1 (en) * 1998-07-14 2001-05-01 Nycomed Imaging As Package
US6659296B2 (en) * 2000-01-26 2003-12-09 Amersham Health As Cap for container
WO2002098748A1 (de) * 2001-06-07 2002-12-12 West Pharmaceutical Services Deutschland Gmbh & Co. Kg Verschluss für eine medikamentenflasche sowie verfahren zu dessen herstellung
US20040112855A1 (en) * 2001-06-07 2004-06-17 West Pharmaceutical Services Deutschland Gmbh & Co. Kg Closure for a medicament bottle and method for the production thereof
US7137519B2 (en) 2001-06-07 2006-11-21 West Pharmaceutical Services Deutschland GmbH Co. KG Closure for a medicament bottle
US20070080129A1 (en) * 2001-06-07 2007-04-12 West Pharmaceutical Services Deutschland Gmbh & Co. Kg Method for production of closure for a medicine bottle
US7334310B2 (en) 2001-06-07 2008-02-26 West Pharmaceutical Services Deutschland Gmbh & Co., Kg Method for production of closure for a medicine bottle
US20080039773A1 (en) * 2006-04-24 2008-02-14 Daniel Py Needle penetrable and laser resealable lyophilization device and related method
US9222728B2 (en) * 2006-04-24 2015-12-29 Medinstill Development Llc Penetrable and resealable lyophilization device
US20090084804A1 (en) * 2007-10-01 2009-04-02 Hospira, Inc. Snap-over port cap
US8091727B2 (en) 2007-11-08 2012-01-10 Hospira, Inc. Snap-over clamshell protective port cap
US20090120934A1 (en) * 2007-11-08 2009-05-14 Hospira, Inc. Snap-over clamshell protective port cap
US20100326990A1 (en) * 2008-02-15 2010-12-30 Mader Juergen Closure Cap
US8720715B2 (en) * 2008-02-15 2014-05-13 Spang & Brands Gmbh Closure cap for a medicine container
US20210001108A1 (en) * 2015-07-30 2021-01-07 Carefusion 303, Inc. Tamper-resistant cap
US11819652B2 (en) * 2015-07-30 2023-11-21 Carefusion 303, Inc. Tamper-resistant cap
US11357701B2 (en) * 2017-02-23 2022-06-14 Brevetti Angela S.R.L. Process for realizing a closing device for an aseptic container
US11850210B2 (en) 2021-05-06 2023-12-26 Kaisha Packaging Private Limited Tamper evident plastic closure for vials for storing substances for medical or pharmaceutical applications and use thereof
USD1006621S1 (en) 2021-06-11 2023-12-05 KAISHA PACKAGING Private Ltd. Tamper evident plastic closure
WO2023144800A1 (en) * 2022-01-31 2023-08-03 Metalco S.R.L. Closing element for pharmaceutical containers and process for producing such closing element

Also Published As

Publication number Publication date
FR2231361B1 (enrdf_load_stackoverflow) 1978-01-27
ES226235Y (es) 1977-08-01
IT1013302B (it) 1977-03-30
GB1465326A (en) 1977-02-23
DE2327553B2 (de) 1975-09-11
SE397267B (sv) 1977-10-31
JPS5733225B2 (enrdf_load_stackoverflow) 1982-07-15
ES226235U (es) 1977-04-01
FR2231361A1 (enrdf_load_stackoverflow) 1974-12-27
JPS5036290A (enrdf_load_stackoverflow) 1975-04-05
DE2327553A1 (de) 1974-12-19
SE7406987L (enrdf_load_stackoverflow) 1974-12-02

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