US3853008A - Liquid sample supply apparatus - Google Patents

Liquid sample supply apparatus Download PDF

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Publication number
US3853008A
US3853008A US00228905A US22890572A US3853008A US 3853008 A US3853008 A US 3853008A US 00228905 A US00228905 A US 00228905A US 22890572 A US22890572 A US 22890572A US 3853008 A US3853008 A US 3853008A
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US
United States
Prior art keywords
probe support
probes
arm
arms
horizontally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00228905A
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English (en)
Inventor
J Hoffa
J Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Instruments Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Instruments Inc filed Critical Beckman Instruments Inc
Priority to US00228905A priority Critical patent/US3853008A/en
Priority to CA150,192A priority patent/CA978769A/en
Priority to GB4178872A priority patent/GB1361725A/en
Priority to IT29456/72A priority patent/IT967677B/it
Priority to CH1491872A priority patent/CH574595A5/xx
Priority to FR7300927A priority patent/FR2173521A5/fr
Priority to SE7302379A priority patent/SE378306B/xx
Priority to JP2029873A priority patent/JPS5319236B2/ja
Priority to DE19732309142 priority patent/DE2309142B2/de
Application granted granted Critical
Publication of US3853008A publication Critical patent/US3853008A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers

Definitions

  • a liquid sample supply apparatus including two reaction cells and means for withdrawing two samples from a single container and for delivering the samples simultaneously to the reaction cells.
  • the invention is particularly useful for rate photometric analyses in which it is essential that equal samples be added to a blank reagent and total reagent simultaneously so that blank rates are the same in each reagent.
  • the present invention relates to a liquid sample supply apparatus for supplying liquid sample automatically to a liquid'analysis apparatus.
  • the present invention is particularly applicable to in- AELC where E is the unknown enzyme that is to be determined.
  • E is the unknown enzyme that is to be determined.
  • a second or auxiliary enzyme is added to convert B to C which can be continuously measured.
  • C is often the substance NADH which absorbs light at 340 nm and can thus be measured in a UV spectrophotometer.
  • E What is needed therefore and constitutes the object of the present invention is a liquid sample supply apparatus for transferring equal samples from a single sample container to two separate reaction cells simultaneously.
  • a liquid sample supply apparatus including two reaction cells and means for with drawing two samples from a single container and for delivering the samples simultaneously to the reaction cells.
  • such apparatus comprises a pair of sample pick-up probes and means for sequentially moving the probes into and out of the sample container, shifting the probes laterally of the container, laterally displacing the probes relative to each other and thereafter moving each of the probes simultaneously into the reaction cells for delivering equal samples simultaneously to the cells.
  • the apparatus of the present invention which may comprise a spectrophotometer or other analytical instrument, includes a housing 12 formed with an opening 14 in one side thereof.
  • a pair of reaction cells l6and 18 are positioned in horizontal spacedapart relationship within the housing remote from the opening 14, as seen in FIG. 2.
  • A' sample container 20 is adapted to be-mounted by any suitable means, not shown, outside the housing 12 adjacent to the opening 14.
  • a pair of flexible tubes 22 and 24 are mounted in relatively rigid vertical supports 26 and 28, respectively, which are carried by a mechanism to be described in detail later.
  • the lower ends of the tubes 22 and 24 extend below the ends of the supports 26 and 28 to form sample pick-up probes 30 and 32, respectively.
  • the sample container 20 is positioned below the probes 30 and 32 in vertical alignment therewith, and the probes are positioned sufficiently close to each other so that when they are lowered by a mechanism to be disclosed in detail later, they will enter together into the container to become immersed in the sample 34 held therein.
  • the mechanism for imparting motion to the probes in accordance with the present invention includes a base 36 mounted within the housing I0.
  • a pivot shaft 38 is mounted vertically in the base 36 and is journaled for rotation about its longitudinal vertically extending axis by means of bearings and 42.
  • a generally horizontally extending plate 44 is fixedly mounted on the top of the base 36.
  • An elongated drive arm 46 is fixed to the shaft 38 by a set screw 47 and, hence, is rotatable about such axis in a horizontal plane.
  • a gear 48 concentric with the shaft 38 is located below the arm 46. The gear is fixedly connected to the arm by means of countersunk screws 50, only one being shown.
  • a washer 52 is interposed between the lower surface of the gear 48 and the upper surface of the plate 44.
  • the teeth on the gear 48 engage the teeth of a gear 54 fixed to a vertically disposed drive shaft 56 of a motor 58 attached to the plate 44.
  • a bushing 60 isrotatably mounted on the shaft 38 above the arm 46.
  • a second elongated arm 62 is pivotally mounted on the bushing 60 so as to be rotatable in a horizontal plane relative to the longitudinal axis of the vertical shaft 38.
  • the bushing 60 is formed with an outwardly extending flange 64 at its lower end which forms a bearing support between the arms 46 and 62.
  • A-pair of vertically extending cylindrical guide shafts 66 and 68 are fixedly mounted adjacent the end 69 of the arm 62 remote from the pivot shaft 38.
  • the upper ends of the shafts 66 and 68 extend through openings in a support plate 70 which is fixedly attached to the shafts by means of set screws 72 and 74.
  • a pair of generally L-shaped horizontally disposed probe support elements 76 and 78 are mounted for common vertical sliding movement on the guide shaft 166 by means of a bushing assembly 80.
  • the bushing assembly 80 includes an inner bushing 82 and an outer bushing 84.
  • the inner bushing is rotatable with respect to the shaft 66 and outer bushing 84.
  • the inner bushing is formed 1 with an outwardly extending annular flange 86 at its lower end which supports the lower element 78.
  • Outer bushing 84 is formed at its lower end with an outwardly extending annular flange 88 which provides a bearing surface between the lower surface of the upper element 76 and the upper surface of the lower element 78.
  • the upper element 76 is fixedly connected to the outer bushing 74 by means of a set screw 90.
  • a retaining ring or snap ring 92 is mounted in an annular groove 94 formed in the inner bushing 82 adjacent its upper end 96 so that the bushings 82 and 84, and hence the elements 76 and 78, will move together vertically on the shaft 66 when one of such elements is shifted vertically.
  • the second guide shaft 68 extends through an opening 96 in the upper element 76 so that such element is nonpivotally mounted with respect to the shaft 66.
  • the inner bushing 82 of bushingassembly is rotatable with respect to both the guide shaft 6 and the outer bushing 84, the lower element 78 may be pivotally rotated about the shaft 66 independent of the upper element 76.
  • the outer leg 100 of the upper L-shaped element 76 and the outer leg. 102 of the lower L-shaped element 78 are generally perpendicular to the elongated arms 62 and 46.
  • the probe support 26 is fixedly mounted in the outer end of leg 102 while probe support 28 is fixedly mounted in the outer end of leg 100.
  • thie legs 100 and 102 of the upper and lower. elements 76 and 78 respectively will. extend outwardly through the opening 14 in the housing 12 so that the sample pickup probes carried by the probe supports 26 and 28 will bedisposed ovver the sample container 20.
  • the elements 76 and 78 are movable vertically on the guide shaft 66 by means of a motor 104 fixedly mounted on top of the arm 62.
  • the motor has a horizontally disposed drive shaft 106 carrying a gear 108 which engages a second gear 1 10 rotatably mounted on a horizontally extending shaft. 112 carried by a frane 114.
  • An elongated arm 116 is fixedly connected to the gear by means of screws 117 and 118.
  • the outer end of the arm 1 16 is formed with an elongated slot 119 which receives a horizontally disposed pin 120 fixedly connected to the upper element 76.
  • the outer end 122 of the drive arm 46 extends beyond the end 69 of the arm 62.
  • a vertically extending drive post or rod 124 is fixedly connected to the arm 46 adjacent to the end 122.
  • the upper end of the drive post 124 extends through an elongated slot 126 in the lower element 78.
  • Such slot extends generally radially from the axis of rotation of the pivot shaft 38.
  • the post 124 therefore provides a driving connection between the drive arm 46 and the upper element 78 which is pivotally'mounted with respect to the guide shaft 66.
  • the drive post 124 carried by such arm will initially causev the lower element 78 to pivot in a horizontal plane about the guide shaft 66 and, upon further rotation of the arm, the post will pull both elements 76 and 78 as well as the arm 62in acounterclockwise direction until-the arms engage stopmeans carried by a bracket 130 fixed to the plate 44.'Since the element 78 is pivoted relative to the element 76, the outer ends of the legs 102 and 100 of such elements will spread apart, as seen in FIG. 2, thus separating laterally the sample pick-up probes 30 and 32.
  • the bracket 130 carries a pair of horizontally'disposed set screws 132 and 134.
  • the screw 132 is disposed in the same plane as the arm 62 while the screw 134 is disposed in the same plane as the drive arm 46.
  • The'outer end 136 of screw 132 extends beyond the outer end 138 of screw 134 so that rotation of arm 62 will be ceased prior to rotation of arm 46.
  • Theexact position of the ends 136 and 138 of the set screws 132 and 134, respectively, are set such that the sample pick-up probes 30 and 32 will be disposed in exact vertical alignment over the reaction cells 16 and 18 when the arms 62 and 46 are disposed in the'phantom-line position illustrated in FIG. 2 wherein such armsengage the ends of the set screws.
  • the bracket 130 also carries a microswitch 140 having an actuating am 141 disposed in the same plane as the drive arm 46.
  • a second bracket 142 is mounted on the plate 44 opposite the bracket 130.
  • This bracket also carries a pair of horizontally disposed set screws 144 and 146.
  • the set screw 144 is disposed in the same plane as the arm 62 while the set screw 146 is disposed in the same plane as arm 46. These screws are set so that the sample pickup probes 30 and 32 will be appropriately positioned to extend into the sample container when the arms 46 and 62 are located in the position shown in full lines in FIG. 2.
  • the bracket 142 also carries a microswitch 148 having an actuating arm 150 disposed in the plane of the drive arm 46 for engagement therewith.
  • An additional microswitch 152 is mounted on the arm 62 with its actuating arm 154 disposed in the path of vertical movement of the lower element 78.
  • Still a further microswitch 156 is mounted on the plate 711 with its actuating arm 168 disposed in the path of vertical movement of the upper element 76. The purposes of these switches will become more apparent from the following description
  • the cycle commences with the arms 46 and 62 and the pick-up probe carrying elements 76 and 78 positioned as shown in phantom in FIG. 2, with the sample pick-up probes and 32 in their up position above the reaction cells 18 and 16.
  • a control circuit not shown, including the microswitches 140, 148, 152 and 156, is energized manually, thereby energizing the motor 58 to rotate the drive arm 46 in the counterclockwise direction as viewed in FIG. 2. Normally there will be sufficient frictional engagement between the arms 46 and 62 by virtue of the bushing 60 interposed therebetween to cause the two arms to rotate together.
  • the drive arm 46 will rotate independently of the arm 62 for a short distance until the upper end of probe support 26 engages the rear surface 160 of element 76, whereupon such arms and elements will pivot together about the longitudinal axis of pivot shaft 38 until the arms 46 and 62 engage the set screws 146 and 144.
  • the various parts take the position illustrated in full lines in FIG. 2, wherein the sample pick-up probes 30 and 32 are positioned outside of the housing 12 in vertical alignment over the sample container 20.
  • the actuating arm 150 of microswitch 148 is engaged by the drive arm 46 thereby deenergizing the motor 58 and energizing the motor 104.
  • the control circuit energizes motor 104 to rotate its drive shaft 106 in counterclockwise direction thus effecting the raising of the elements 76 and 78, and thus vertical withdrawal of the pick-up probes from the sample container 20.
  • the upper element 76 reaches its uppermost position, it engages the actuating arm 158 of microswitch 156 thereby de-energizing the motor 104 and energizing motor 58 to translate the arms 46 and 62 in a horizontal plane in a clockwise direction as viewed in FIG. 2 about the longitudinal axis of pivot shaft 38.
  • the upper arm 62 will engage the set screw 132 and thereafter the lower arm 46 will engage the set screw 134 and switch arm 141.
  • the element 78 is pivoted laterally with respect to the element 76 thereby spreading the probe supports 26 and 28 apart so that when the arms engage set screws 132 and 134 such supports, and therefore the sample pick-up probes 30 and 32, will be disposed in exact vertical alignment over the reaction cells 18 and 16.
  • Engagement of the switch arm 141 deenergizes the motor 58 and energizes the motor 104 to lower the sample pick-up probes simultaneously into the reaction cells.
  • the control circuit energizes the pump assembly, not shown, which expels sample simultaneously into the reaction cells.
  • the motor 104 is again energized by the control circuit to raise the probes out of the reaction cell, thus completing one full cycle of operation of the apparatus.
  • the present invention there is provided an apparatus which allows the withdrawal of two like samples from a single container and the delivery of the samples simultaneously to two separate reaction cells. Because of the particular mounting of the elements 76 and 78 on the guide shafts 66 and 68, and the mechanism for raising and lowering such elements, the sample probes travel vertically in a straight, rather than in an arcuate path. Thus, the probes may be disposed in sample containers having an internal diameter as small as 10 mm. This feature is important when only very small samples are available, which is frequently encountered in the analysis of biological fiuids.
  • the horizontal and vertical travels of the sample probes are independent so that such travels can be programmed in and out of the reaction cells for both sample delivery and probe washing cycles. If the invention is employed for spectrophotometric analysis, it is normally desirable to isolate the reaction cells from the exterior of the housing so that no light from outside the housing will interfere in the analyses. Therefore, a suitable closure (not shown) could be provided for closing the opening 14 when the sample pick-up probes are disposed inside the housing.
  • a liquid sample supply apparatus for transferring two samples from a single container to two separate reaction cells simultaneously having a pair of vertically extending probes for insertion into the single container, means for lifting them vertically simultaneously, transporting them horizontally thereafter while horizontally separating them and thereafter positioning them over the horizontally separated reaction cells to discharge liquid drawn from the sample supply into said horizontally separated reaction cells
  • the invention comprises:
  • An apparatus as set forth in claim 2 including adjustable stop means engageable by said motion imparting means for controlling the extent of horizontal travel of said probes.
  • arms are each mounted for pivotal movement in a generally horizontal plane about a substantially vertically extending axis
  • the apparatus includes:
  • said connecting means comprising a vertically extending rod carried by said second arm, an elongated slot is provided in one probe support element extending generally radially from said axis, and the upper end of said rod being slidably received in said slot.
  • probe support elements have a generally L-shaped configuration, with one leg of each L-shaped element extending generally perpendicular to said arms, and said probes each being mounted adjacent the end of the extending leg of an L-shaped element.
  • the horizontally pivoted arms are mounted one above the other as upper and lower arms each mounted for pivotal movement in a generally horizontal plane about a substantially vertically extending axis;
  • a vertically extending guide shaft is provided which is fixedly mounted on said upper arm;
  • the probe support elements being mounted one above the other as upper and lower elements carrying one of said probes, said upper and lower probe support elements being mounted for common vertical movement on said guide shaft, said upper element being non-pivotally mounted to said guide shaft and said lower element being pivotably mounted on said guide shaft for movement in a rod being slidably received in said slot.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
US00228905A 1972-02-24 1972-02-24 Liquid sample supply apparatus Expired - Lifetime US3853008A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US00228905A US3853008A (en) 1972-02-24 1972-02-24 Liquid sample supply apparatus
CA150,192A CA978769A (en) 1972-02-24 1972-08-25 Liquid sample supply apparatus
GB4178872A GB1361725A (en) 1972-02-24 1972-09-08 Liquid sample supply apparatus
IT29456/72A IT967677B (it) 1972-02-24 1972-09-20 Apparecchio per fornire campioni di liquidi
CH1491872A CH574595A5 (en, 2012) 1972-02-24 1972-10-12
FR7300927A FR2173521A5 (en, 2012) 1972-02-24 1973-01-11
SE7302379A SE378306B (en, 2012) 1972-02-24 1973-02-20
JP2029873A JPS5319236B2 (en, 2012) 1972-02-24 1973-02-21
DE19732309142 DE2309142B2 (de) 1972-02-24 1973-02-23 Fluessigkeitsprobenentnahme- und zufuhrvorrichtung

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00228905A US3853008A (en) 1972-02-24 1972-02-24 Liquid sample supply apparatus

Publications (1)

Publication Number Publication Date
US3853008A true US3853008A (en) 1974-12-10

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Application Number Title Priority Date Filing Date
US00228905A Expired - Lifetime US3853008A (en) 1972-02-24 1972-02-24 Liquid sample supply apparatus

Country Status (9)

Country Link
US (1) US3853008A (en, 2012)
JP (1) JPS5319236B2 (en, 2012)
CA (1) CA978769A (en, 2012)
CH (1) CH574595A5 (en, 2012)
DE (1) DE2309142B2 (en, 2012)
FR (1) FR2173521A5 (en, 2012)
GB (1) GB1361725A (en, 2012)
IT (1) IT967677B (en, 2012)
SE (1) SE378306B (en, 2012)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000974A (en) * 1974-09-09 1977-01-04 Beckman Instruments, Inc. Sample residue cleaning system for biological analyzers
US4000973A (en) * 1974-09-09 1977-01-04 Beckman Instruments, Inc. Sample residue cleaning system for biological analyzers
US4202747A (en) * 1978-07-06 1980-05-13 Beckman Instruments, Inc. Flow cell fluid and sample supply mechanism
US4570495A (en) * 1983-06-04 1986-02-18 Horiba, Ltd. Apparatus for drawing liquid samples into a liquid testing machine
US4734261A (en) * 1985-01-29 1988-03-29 Fuji Photo Film Co., Ltd. Duplex pipette
US4800762A (en) * 1986-06-20 1989-01-31 Fuji Photo Film Co., Ltd. Liquid depositing device
US4801434A (en) * 1985-12-06 1989-01-31 Fuji Photo Film Co., Ltd. Dual pipette device
US4869114A (en) * 1987-12-04 1989-09-26 Fuji Photo Film Co., Ltd. Liquid depositing device and method
US5334353A (en) * 1993-02-03 1994-08-02 Blattner Frederick R Micropipette device
US5525515A (en) * 1993-02-03 1996-06-11 Blattner; Frederick R. Process of handling liquids in an automated liquid handling apparatus
US6234033B1 (en) * 1998-05-25 2001-05-22 Basf Aktiengesellschaft Automatic pipetting apparatus
US20060205082A1 (en) * 2005-03-10 2006-09-14 Middleton John S Reaction rate determination
US20060254370A1 (en) * 2003-05-28 2006-11-16 Andre Wicky Method and device for placement of a recipient in a device for sampling liquid
US20080060456A1 (en) * 2006-09-11 2008-03-13 Cummins Filtration Ip, Inc. Source dilution sampling system for emissions analysis
US20080060457A1 (en) * 2006-09-11 2008-03-13 Cummins Filtration Ip, Inc. Residence time chamber and sampling apparatus
US20090022626A1 (en) * 2007-07-20 2009-01-22 Tanoue Hidetsugu Automated analyzer
JP2015114148A (ja) * 2013-12-10 2015-06-22 日本電子株式会社 自動分析装置

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1130926B (it) 1980-03-07 1986-06-18 Erba Strumentazione Dispositivo per il prelievo di campioni da analizzare,specialmente in capionatori automatici
JP2501460B2 (ja) * 1988-03-23 1996-05-29 オリンパス光学工業株式会社 ヘマトクリット値の測定方法
CN113916602B (zh) * 2021-12-14 2022-03-01 四川清和科技有限公司 一种水质取样装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2932330A (en) * 1957-05-09 1960-04-12 Multi Fill Machine Co Machine for filling containers with measured charges
US3081158A (en) * 1959-12-28 1963-03-12 Technicon Instr Liquid treatment apparatus
US3252330A (en) * 1964-04-01 1966-05-24 Nelson G Kling Sample supply means for analysis apparatus
FR1539674A (fr) * 1967-05-12 1968-09-20 Centre Nat Rech Scient Appareillage destiné plus particulièrement à la détermination automatique des groupes sanguins
US3542515A (en) * 1968-08-06 1970-11-24 Perkin Elmer Corp Determining reaction rates by simultaneous two-point measurements
US3617222A (en) * 1967-05-12 1971-11-02 Centre Nat Rech Scient Method and apparatus for analyzing liquid substances likely to form agglutinates

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2932330A (en) * 1957-05-09 1960-04-12 Multi Fill Machine Co Machine for filling containers with measured charges
US3081158A (en) * 1959-12-28 1963-03-12 Technicon Instr Liquid treatment apparatus
US3252330A (en) * 1964-04-01 1966-05-24 Nelson G Kling Sample supply means for analysis apparatus
FR1539674A (fr) * 1967-05-12 1968-09-20 Centre Nat Rech Scient Appareillage destiné plus particulièrement à la détermination automatique des groupes sanguins
US3617222A (en) * 1967-05-12 1971-11-02 Centre Nat Rech Scient Method and apparatus for analyzing liquid substances likely to form agglutinates
US3542515A (en) * 1968-08-06 1970-11-24 Perkin Elmer Corp Determining reaction rates by simultaneous two-point measurements

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000974A (en) * 1974-09-09 1977-01-04 Beckman Instruments, Inc. Sample residue cleaning system for biological analyzers
US4000973A (en) * 1974-09-09 1977-01-04 Beckman Instruments, Inc. Sample residue cleaning system for biological analyzers
US4202747A (en) * 1978-07-06 1980-05-13 Beckman Instruments, Inc. Flow cell fluid and sample supply mechanism
US4570495A (en) * 1983-06-04 1986-02-18 Horiba, Ltd. Apparatus for drawing liquid samples into a liquid testing machine
US4734261A (en) * 1985-01-29 1988-03-29 Fuji Photo Film Co., Ltd. Duplex pipette
US4801434A (en) * 1985-12-06 1989-01-31 Fuji Photo Film Co., Ltd. Dual pipette device
US4800762A (en) * 1986-06-20 1989-01-31 Fuji Photo Film Co., Ltd. Liquid depositing device
US4869114A (en) * 1987-12-04 1989-09-26 Fuji Photo Film Co., Ltd. Liquid depositing device and method
US5334353A (en) * 1993-02-03 1994-08-02 Blattner Frederick R Micropipette device
US5525515A (en) * 1993-02-03 1996-06-11 Blattner; Frederick R. Process of handling liquids in an automated liquid handling apparatus
US6234033B1 (en) * 1998-05-25 2001-05-22 Basf Aktiengesellschaft Automatic pipetting apparatus
US20060254370A1 (en) * 2003-05-28 2006-11-16 Andre Wicky Method and device for placement of a recipient in a device for sampling liquid
US7497135B2 (en) * 2003-05-28 2009-03-03 Biomerieux Method for placing a receptacle containing a liquid in a device for sampling the liquid and sampling device for applying the method
US20060205082A1 (en) * 2005-03-10 2006-09-14 Middleton John S Reaction rate determination
US20080060456A1 (en) * 2006-09-11 2008-03-13 Cummins Filtration Ip, Inc. Source dilution sampling system for emissions analysis
US20080060457A1 (en) * 2006-09-11 2008-03-13 Cummins Filtration Ip, Inc. Residence time chamber and sampling apparatus
US20090178494A1 (en) * 2006-09-11 2009-07-16 Cummins Filtration Ip Inc. Source dilution sampling system for emissions analysis
US7587950B2 (en) 2006-09-11 2009-09-15 Cummins Filtration Ip Inc. Source dilution sampling system for emissions analysis
US7610793B2 (en) * 2006-09-11 2009-11-03 Cummins Filtration Ip Inc. Residence time chamber and sampling apparatus
US7966899B2 (en) 2006-09-11 2011-06-28 Cummins Filtration Ip, Inc. Source dilution sampling system for emissions analysis
US20090022626A1 (en) * 2007-07-20 2009-01-22 Tanoue Hidetsugu Automated analyzer
JP2015114148A (ja) * 2013-12-10 2015-06-22 日本電子株式会社 自動分析装置

Also Published As

Publication number Publication date
JPS5319236B2 (en, 2012) 1978-06-20
GB1361725A (en) 1974-07-30
DE2309142B2 (de) 1976-04-22
SE378306B (en, 2012) 1975-08-25
CA978769A (en) 1975-12-02
JPS4898889A (en, 2012) 1973-12-14
IT967677B (it) 1974-03-11
FR2173521A5 (en, 2012) 1973-10-05
CH574595A5 (en, 2012) 1976-04-15
DE2309142A1 (de) 1973-08-30

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