US3823843A - Locking capsule - Google Patents

Locking capsule Download PDF

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Publication number
US3823843A
US3823843A US00301045A US30104572A US3823843A US 3823843 A US3823843 A US 3823843A US 00301045 A US00301045 A US 00301045A US 30104572 A US30104572 A US 30104572A US 3823843 A US3823843 A US 3823843A
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United States
Prior art keywords
section
cap
closed end
cylinder wall
total length
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US00301045A
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English (en)
Inventor
M Stephens
R Wuest
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Eli Lilly and Co
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Eli Lilly and Co
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Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to US00301045A priority Critical patent/US3823843A/en
Priority to IL43276A priority patent/IL43276A/en
Priority to ZA00737430A priority patent/ZA737430B/xx
Priority to IE1686/73A priority patent/IE39685B1/xx
Priority to AU60790/73A priority patent/AU468525B2/en
Priority to CA182,186A priority patent/CA1017705A/en
Priority to NLAANVRAGE7313620,A priority patent/NL175713C/xx
Priority to IT30386/73A priority patent/IT998821B/it
Priority to DE19732353103 priority patent/DE2353103A1/de
Priority to GB1917273*[A priority patent/GB1442121A/en
Priority to YU02768/73A priority patent/YU276873A/xx
Priority to CH1505373A priority patent/CH568192A5/xx
Priority to DK577873AA priority patent/DK133852B/da
Priority to RO7376425A priority patent/RO70489A/ro
Priority to SU1974015A priority patent/SU567391A3/ru
Priority to AT905473A priority patent/AT338433B/de
Priority to HUEI501A priority patent/HU169055B/hu
Priority to BR8349/73A priority patent/BR7308349D0/pt
Priority to BE1005459A priority patent/BE806487A/xx
Priority to SE7314524A priority patent/SE404906B/xx
Priority to ES420003A priority patent/ES420003A1/es
Priority to BG024848A priority patent/BG28241A3/xx
Priority to JP12060473A priority patent/JPS571265B2/ja
Priority to CS737390A priority patent/CS177152B2/cs
Priority to FR7338231A priority patent/FR2204541B1/fr
Priority to DD174321A priority patent/DD111188A5/xx
Application granted granted Critical
Publication of US3823843A publication Critical patent/US3823843A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S220/00—Receptacles
    • Y10S220/34—Anti-tamper pharmaceutical capsules, e.g. tamper indicating or resistant

Definitions

  • a locking capsule for packaging unit doses of physiologically active agents, said capsule having a body portion and a cap portion which are adapted to be telescopically joined together in a frictionally engaged pre-locking position prior to the filling thereof and to be fully telescopically joined together in a mechanically locked position when filled.
  • FIG. 1 A first figure.
  • This invention relates to two-piece hard shell capsules one piece thereof comprising the body portion and the other piece the cap portion, said two pieces being telescopically joined together. More particularly this invention relates to a two-piece hard-shell locking capsule in which the body portion can be partially telescoped into the cap portion at which point a friction pre-lock is established, or alternatively fully telescoped into a completely closed position wherein a mechanical lock is effected.
  • the inside diameter of the cap diminished progressively from the open end to theclosed end, and eventually reached a dimension that was less than the outside diameter of the body at the latters open end.
  • the capsules were designed so that the point where the inside diameter of the cap and the outside diameter of the body, at the latters open end, coincided would be at some distance from the beginning of the radius of the closed end of the cap. Friction was depending upon to maintain a tight fit between the body and cap when the capsule was closed by fully telescoping the body into the cap.
  • U.S. Pat. No. 3,399,803 claimed a locking capsule which shifted the emphasis from a frictional engage ment to the mating of an inwardly extending annular ring appropriately positioned in each of the cap and body portions. This in effect accomplished a mechanical locking of the cap and body when the body was fully telescoped into the cap in a fully closed position.
  • a pair of diametrically opposed indents were extended radially inwardly from the sides of the wall of the cap. These indentswere of sufficient depth to effect a significant reduction in the inside diameter of the cap at the lateral planein which, said indents were positioned, and of a sufficient area to'provide a substantial frictional area.
  • Telescoping a conventional tapered body into such a cap results in an immediate contact between the outside diameter of the body and the inside surface of the indents establishing a frictional engagement.
  • a frictional pre-locking feature is thus provided, and when the body is fully telescoped into the cap in a completely closed position the frictional engagement is maintained and stabilized.
  • the manufacture of two-piece hard capsules is conventionally carried out by independently molding the cap and body portions on corrosion resistant pins.
  • the pins are dipped into a highly viscous gelatin disprsion and slowly withdrawn.
  • the amount of gelatin adhering to the pin can be controlled.
  • the gelatin forms a film which takes on the contour of the pin as the surface tension ofthe gelatin keeps the file thickness essentially uniform.
  • the outside surface of the gelatin film has the same general contour as the pin employed as a mold.
  • the mold pins are lubricated with a special soap-type grease before being dipped into the gelatin. Consequently the molded cap or body portion can be easily removed from the mold pin after the gelatin film has been dried to an appropriate moisture content, generally l4 to 16 percent water.
  • the cap and body portions of the capsule are mechanically stripped from the mold pins and trimmed to an established length with a rotary knife or by rotating the molded piece against a stationary knife.
  • the trimmed body portion is then mechanically telescoped into the trimmed cap portion to form the two-piece hard capsule.
  • the empty two-piece hard capsules are collected in a random pack and introduced into the feeding hopper on a capsule filling machine in that form.
  • the feeding hopper rectifies the empty capsules into a position where the body portion is alwaysoriented in the same direction.
  • the rectified capsules are fed into a capsule holding device and the body is separated from the cap,
  • Gelatin the preferred material of which capsules are made, is a hydrophilic colloid which has the capacity to take up and lose water as the humidity varies in the environment to which the gelatin is exposed.
  • the Water content of the gelatin varies there are changes in the dimensions of the capsules formed from the colloid. Consequently it is extremely difficult to design the dimensions of a capsule cap and the capsule body which is telescoped thereinto with sufficient precision as to always maintain a close and sufficient fit to assure that the capsules will not come apart under the conditions of humidity and handling to which they are subjected.
  • the fit between the outside surface of the cylinder wall of the body portion and the inside surface of the cylinder wall of the cap of the empty capsule should be snug to hold the capsule together, but not locked to the extent that the separation of the body from the cap is difficult in the-filling operation. It is also important that the two-pieces of the capsule should be held together after being rejoined as filled capsules, with as strong a lock as is possible. Yet the lock effected in a completely telescoped filled capsule should not be one that is accomplished with great difficulty. The rejoining operation taking place on modern high speed filling equipment is accomplished in a fraction of a second. And this doesnt provide much time for the air, which is trapped in the closed end of the cap portion when the body portion is telescoped thereinto, to escape and the internal pressure to equalize with the atmospheric pressure on the outside.
  • a further object of this invention is to provide a locking capsule which will require only a momentary deformation of the capsue structure in effecting a locked capsule after the capsule has been filled and telescopically rejoined into a fully closed condition.
  • Another object of this invention is to provide a mechanical lock between the capsule cap and body portions when the two are completely telescoped together the cap portion is held stationary.
  • the body portion is that can be effected on high speed filling equipment.
  • a mechanical lock is effected in the fully telescoped capsule by providing a plurality of lateral ridges extending radially inwardly in the same circumferential plane in the cylinder wall of the cap separated by lateral areas which do not extend radially inwardly, and a circumferential constriction in the body between the open and closed end thereof which slips over the lateral ridges in the cap when the two pieces are telescoped together.
  • the lateral areas, between the lateral ridges, which do not extend radially inward provide a conduit through which the air can escape as the body is telescoped into the cap permitting high speed rejoining without an attendant pressure build-up in the closed end of the cap portion of the capsule.
  • FIG. I is aside view of a capsule cap pin.
  • FIG. 2 is a side view of a capsule body pin.
  • FIG. 3 is a partial section of the side of a capsule cap pin showing the contour of the location where indents are present on the pin.
  • FIG. 4 is a partial section of the side of a capsule body pin showing the contour of the location on the pin where a constriction approximating an ogee curve is present on the pin.
  • FIG. 5 is a cross-sectional view of closed end and part of the cylinder of a capsule cap.
  • FIG. 6 is a cross-sectional view of the open end and part of the cylinder of a capsule body.
  • FIG. 7 is a bottom view of the open end of a capsule
  • FIG. 8 is a top view of the open end of a capsule body.
  • FIG. 9 is a side view of a completely telescoped locking two-piece hard capsule in the locked position.
  • FIG. 10 is a cross-sectional view of a completely telescoped locking capsule in the locked position.
  • FIG. II is a cross-sectional view of a locking capsule partially telescoped into the pre-lock position.
  • FIG. 1 the salient features of the cap molding pin 1, on which the cap portion of the locking capsule of this invention is molded, are shown.
  • the surface of the cylinder wall 2 tapers outwardly, in relation to the axial center-line of the pin, away from the end cap at the open end. This makes the rejoining operation easier as it is not required that the centering of the body with the cap should be extremely precise.
  • a plurality of independent lateral indentations 3 are formed in the cap pin which result in radial inwardly extending lateral ridges in the inside surface of the cap.
  • each of the indentations there is an area between each of the indentations that. is not indented so that the ridges are laterally separated.
  • Disposed between the ends of the lateral indentations 3 are a plurality of longitudinal indentations 4 which originate in said lateral indentations 3 distant from the end 5 of the pin and progress away from the end 5.
  • the longitudinal indentations 4 blend into the lateral indentations 3, and there is generally one longitudinal indentation 4 associated with each lateral indentation 3. This, however, is not a requirement, and as long as longitudinal indentations are disposed at approximately equal distances around the circumference of the pin, raised 5 of the pin 1 whereon the closed end of the cap is formed.
  • the cap portion tapering outwardly from the closed end to the open end thereof as this allows for a greater clearance between the outside diameter of the body portion and the inside diameter of the areas-extending radially inwardly are formed in the cap which effect a frictional contact between the inside surface of the cap and the outside surface of the body.
  • three lateral indentations are sufficient to provide an effective number of lateral ridges extending radially inwardly in the cap and three raised areas disposed between the ends thereof suffice.
  • the total length of the lateral indentations should not, as a rule. exceed about 300 of the circumference of the pin.
  • FIG. 3 A profile of the lateral indentation 3 and the longitudinal indentation 4 is shown in FIG. 3.
  • the longitudinal indentation 4 originates in the slope of the side of lateral indentation 3 and progresses away from the latter.
  • the longitudinal indentation 4 is generally about twothirds the depth of the lateral indentations 3, but can be of equal depth. It is imperative that the longitudinal indentation 4 originate in the lateral indentation 3 as it is essential that the two indentations blend together so that there will be no area in the inside surface of the cylinder wall of the cap between the lateral ridges and the longitudinal raised areas that extends radially inwardly by a lesser amount than said raised areas.
  • a body mold pin 6 is shown from a side view.
  • the pin has a general taper inwardly toward the end 12 of the pin on which the closed end of the body is formed;
  • a constriction 7 in thepin which is in the geometric form of a longitudinally extending ogee curve.
  • the ogee curve provides the benefit over a chamfer of a smoother leading and trailing edge which reduces the opportunity for the formation of bubbles in the gelatin film at the point of change in the line of the cylinder wall of the mold pin.
  • the longitudinally extending ogee curve is disposed laterally around the circumference of the pin, and effects a uniform reduction in the diameter of the pin.
  • the cylinder wall 8 8.
  • the cylinder wall 10 immediately adjacent to the ogee curve 9 is essentially parallel to the axial center-line of the pin for a distance toward the end 12 of the pin to the point where the essentially parallel wall intersects a line projected from the intersection of the tapered wall 8 with the ogee curve 9 toward the end 12 of the pin at the same degree of taper as is present in the tapered wall 8. From this point until the cylinder wall 11 ogee curve 9 in said pin 6 is blown up in FIG. 4.
  • cylinder wall 8 tapers inwardly to the point of intersection with the leading edge of ogee curve 9.
  • Ogee curve 9 progresses away from cylinder wall 8 toward cylinder wall 10.
  • Cylinder wall 10 progresses away from ogee curve 9 essentially parallel to the axial center line of pin 6.
  • the distance covered by ogee curve 9 occupies from about one-twentieth to about one-tenth of the total distance from the end of the pin to the far edge of the ogee curve 9, and provides for a constriction of from about 0.004 to about 0.008 inches in the diameter of the pin from the beginning to the end of said ogee curve 9.
  • the capsule body is trimmed to provide a section between the open end of said body and the beginning of the ogee curve 9 which occupies from about one-thirtieth to about one-tenth of the total length of said body after trimming.
  • the cap portion 13 of the novel locking capsule of this invention is shown in cross-section iri FIG. 5.
  • the cap 13 has a cylinder wall 14 which is of essentially the same thickness throughout.
  • the inside surface 15 of said cylinder wall 14 conforms to the outside surface of the molding pin, such as that shown in FIG. 1, on which the cap 13 is formed.
  • the outside surface 16 generally follows the inside contour. For that reason the outside surface is depressed where the indentations 3 and 4 were present in the mold pins on which said cap was formed.
  • the raised area 17 is shown in FIG. 5 extending radially inwardly and the lateral ridges 19 also extend radially'inw'ardly.
  • the indentations l8 and 20, which are observed in the outside surface 16 are opposite said raised areas 17 and said lateral ridges 19, respectively.
  • the raised areas 17 originate at the lateral ridges 19 and are disposed between the ends thereof.
  • the raised areas 17 progress away from the lateral ridges 19 toward the open end of said cap portion 13.
  • a plurality oflateral ridges 19 disposed in the same circumferential plane with the apex thereof at a distance of from about one-tenth to about one-thirtieth of the total length of the cylinder wall 14 from thepoint of the intersection of the latter with the closed end 21 of said cap 13.
  • the apex of the lateral ridges is about one-twentieth of the cap length as described above.
  • independent lateral ridges 19 While there may be any number of independent lateral ridges 19 from two to infinity, the maximum feasible number would be about 12. Preferably there are three independent lateral ridges 19. Each of the independent lateral ridges 19 is separated from the next lateral ridge around the circumference by a section of the .inside surface 15 of said cap which is a lateral and longitudinal continuation of said inside surface 15 of said' cylindrical wall 14. The lateral ridges 19 are extended radially inwardly from about 0.002 to about 0.005
  • the in-' -ward radial extension is about 0.003 inch'at the apex of said lateral ridges l9.
  • the raised areas 17 disposed between the ends of said lateral ridges I9' are extended radially inwardly from about 0.0015 to about 0.0035 inch, preferably about 0.002 inch.
  • the plurality of lateralridges 19 have a total length of from about 180 to about 300, preferably about 300. And the separations between said lateral ridges 19 have a total length of about to about 180, preferably about 60.
  • the separation areas between said lateral ridges 19 serve the purpose of providing a conduit for the rapid escape of the air from the closed end 21 of said cap 13 when the body portion 22 of said capsule shown in FIG. 6 is fully telescoped into said cap 13.
  • the raised areas 17 blending into the lateral ridges l9 have a total lateral distance of from about to about preferably about 90 and occupy a longitudinal distance of from about one-tenth to about one-fourth of the total length of said cap 13, preferably about one-
  • the closed end 21 of said cap 13 is shown in FIG. 5 as a hemisphere. While this is the preferred geometric form of said closed end 21, such is not a requirement, and said closed end 21 can be in any reasonable combination of radii that avoids sharp angles.
  • a bottom plan view of said cap portion 13 is sho from the open end in FIG. 7.
  • the raised areas 17 are shown as located in essentiallythe center of each of the lateral ridges 19, such a positioning is not required as said raised areas can be located at any point between the ends of the lateral ridges l9.
  • Geometric symmetry suggests the centerline position and such is preferred.
  • the separations between the lateral ridges are shown as being essentially uniform, such geometric exactness is not required, but some reasonable symmetry is indicated to aid in the uniform escape of the air being compressed in the closed end 21 of the cap as the body portion is being fully telescoped thereinto.
  • the pin on which the cap 13 is molded is designed to provide an inside diameter in the'section of the cap 13 between the near edge of said lateral ridges l9 and the point ofintersection of the cylinder wall 14 and the beginning of the closed end 21 that is about the same as the outside diameter of the body 22 at the open end 33 of the latter.
  • the body portion 22 of the useful locking capsule of the present invention is shown in FIG. 6.
  • the body 22 has a cylindrical wall 23 that is of about the same thickness as the cylinder wall .14 of the cap 13.
  • the inside surface 24 of said body 22 follows the contour of the pin 6 on'whieh said body 22 is molded.
  • the outside surface 25 follows generally the contour of said inside surface 24, as was discussed hereinbefore in connection with said cap 13. It is the outside surface 25 of said body 22 which provides, incombination with the inside surface 15 of said cap 13 the elements which constitute this invention.
  • the elementsof the two portions cooperate to-effect the novel locking capsule disclosed herein.
  • the heart of the body 22 elements cooperating with the cap 13 elements is the construction 27 in the body 22 in the geometric form of a longitudinally extending ogee curve beginning at the intersection of said ogee curve and a tapered section 26 and ending at the intersection of the opposite end of said ogee curve and a section of said body 22 wherein said cylinder wall is essentially parallel with the axial centerline of said body 22.
  • the capsule body portion 22 is comprised of five longitudinally integrally molded sections, each intersecting with the next to effect a continuous cylinder wall from an open end to a closed end.
  • the first section 26, shown in FIG. 6, extends from the open end 33 toward said closed end of said body 22, said first section 26 occupying from about onethirtieth to about one-tenth of the total length of said body 22, preferably about one-twentieth, and tapers progressively inwardly. in relation to the axial center line of said body 22. Said taper progresses at from about 0.005 to about 0.020, preferably about 0.012 inch per linear inch. Said first section 26 has an outside surface diameter at the open end 33 of about the same diameter as the inside of the cap surface at the point in the cap portion 13 where the cylinder wall andclosed end intersect.
  • the second section 27 of said body 22 is a constriction which reduces the diameter of the outside surface 25 of said body 22 by from about 0.004 to about 0.008
  • the constriction progresses in the geometric form of a longitudinally extended ogee curve having two inverted radii of about 0.050 and 0.120 inches, respectively.
  • the ogee curve is laterally continuous around the circumference of said body 22.
  • the second section 27 is integrally molded with said first section 26.
  • the third section 2801 said body 22 occupies from about one-fifth to three-fifths of the total length of said body 22, preferably about two-fifths, and has a cylinder wall that is essentially parallel to the axial center line of said body from the point of intersection with'the trailing edge of the ogee curve of said second section 27 to the point of intersection with a projected line, having the same taper as said first section 26, from said first section 26 with the parallel walls of said third section 28.
  • Said third section 28 is integrally molded with said second section.
  • the fourth section 29 continues with the same taper as said first section 26 from the intersection of said third section 28 with said fourth section 29 to the intersection of the latter with the fifth section 30 which constitutes the closed end 30 of said body portion 22.
  • the fifth section 30 of said body 22 constitutes the closed end of said body 22 and is integrally molded with said fourth section 29.
  • Said fifth section occupies from about one-eighth to about two-fifths of the total length of said body 22, preferably about one-fourth, and can have any geometric form that avoids sharp angles, preferably either a hemisphere or a parabola.
  • FIG. 8 A top plan view from the open end of said body 22 is shown in FIG. 8.
  • the inside and outside walls are laterally symmetrical as illustrated.
  • FIG. 9 A completely closed capsule is shown in FIG. 9 with the indentations in the outside surface 16 of the cap where the lateral ridges l9 and raised areas 17 appear on the inside of the cap positioned to serve as a reference for the cross-sectional views of a completely tele- 10 scoped capsule shown in FIG. 10 and the partially telescoped capsule detailed in FIG. 11.
  • the first section 26 of the body 22 is shown telescoped into a position between the lateralridges 19 and the closed end 21 of the cap.
  • the second section 27 of said body 22 is located adjacent to the lateral ridges in the same circumferential plane.
  • a frictional grip is effected and the air in the closed end 21 of said cap 13 comes under compression.
  • the air escapes between the ends of the lateral ridges l9 and the first section 26 of the body 22 is compressed and deforms as it slides up on the lateral ridges 19, and returns to its original configuration as it slides down the back side of said lateral ridges 19.
  • said first section 26 slides completely behind said lateral ridges 19, said first section has an outside surface diameter greater than the inside diameter of the lateral ridges 19 and consequently a mechanical grip is established between the cap portion 13 and thebody portion 22 of the novel locking capsule of this invention.
  • the cylinder wall of the third section 28
  • FIG. 1 l A partially telescoped capsule is illustrated in FIG. 1 l.
  • the first section 26 of the body 22 is shown in frictional contact with the raised areas 17 which extend radially inwardly from the inside surface of the cap 13. In this position there is sufficient frictional contact to hold the partially telescoped capsule together under most conditions encountered in handling and shipping empty capsules and in the feeding mechanisms on high speed filling machines. And yet the frictional pressure is not so great that an easy separation of the cap can not be achieved in the conventional filling operation.
  • the positioning of the said areas 17 between the ends of lateral ridges 19, and the blending of longitudinal ends of the former into the sloping side of the latter provides a clear and continuous open channel for the escape of air from the closed end'of the cap 13 as the body 22 is telescoped thereinto, and assures that first section 26 of the body 22 will not become mechanically locked when the body 22 is partially telescoped into the cap 13 in a prelocked position.
  • a locking two-piece hard capsule comprising a cap portion and a body portion, said body portion telescop- 1 l 1. an essentially cylindrical cap portion having a closed end and an open end with the cylinder wall tapering generally outwardly from said closed end to said open end, said cylinder having an inside diameter at the intersection of said cylinder wall and said closed end about the same as the maximum outside diameter of the cylinder wall of the body portion which telescopes intosaid cap, said cap having a plurality of individual lateral ridges disposed in the same circumferential plane and extending radially inwardly from the inner surface of said cylinder wall of said cap, each lateral ridge separated from the next lateral ridge around said circumference of said cap by an area that is a lateral and longitudinal continuation of said inner sur face of said wall, and a plurality of raised areas extending radially inwardly from the inner surface of the cylindrical wall of said cap, each of said raised areas disposed between the ends of a lateral ridge and extending from said lateral ridge toward said open end
  • a third section integrally molded with said second section, extending from a point tangent to the trailing radius of said ogee curve toward said closed end, the cylinder wall of said third section being essentially parallel to the axial center line of said body,
  • a fourth section integrally molded with said third section, extending toward said closed end from the point where a projection of the inwardly tapering cylinder wall of said first section intersects the surface of said essentially parallel cylinder wall, said fourth section tapering inwardly at essentially the same rate as said first section, and
  • a locking capsule as defined in claim 3 wherein 5.
  • A'locking capsule as defined in claim 1 wherein the plurality of said raised areas disposed between the ends of said lateral ridges occupy a total lateral surface of from about to about of the circumference of said cap, and the longitudinal dimension of eachof said raised areas is from about one-tenth to about onefourth of the total length of said cap.
  • a locking capsule as defined in claim 1 wherein there are three raised areas each of which is disposed between the ends of each of three lateral ridges, each raised area having a lateral dimension of from about 30 to about 90 and a longitudinal dimension of about one-tenth to about one-fourth of the total length of said cap. 7. A locking capsule as defined in claim 6 wherein each raised area has alateral dimension of about 30 and a longitudinal dimension of about one-sixth the total length of said cap.
  • a locking capsule of claim 1 wherein said lateral ridges extend radially inwardly at the apex from about 0.002 to about 0.005 inches from the inner surface of the wall of said cap.
  • a locking capsule of claim 1 wherein said cap has three lateral ridges in the same circumferential plane extending radially inwardly at the apex about 0.003 inches and occupying about 300 of the circumference of said cap, said lateral ridges disposed about one-tenth of the distance from the intersection of the cylindrical wall of said cap with said closed end and said open end and three raised areas, each extending radially inwardly about 0.002 inches, each disposed between the ends of one of said lateral ridges and extending laterally through about 30 and longitudinally about one-sixth the total length of said cap.
  • a locking capsule according to claim 1 wherein said second section of said body is a constriction progressing from the point of departure from the tapered cylinder wall of said first section toward said closed end and occupying from about one-thirtieth to about onetwelfth of the total length of said body, said constriction being characterized by an ogee curve having inverted radii of about 0.050 and 0.120 inches,-respectively.
  • a locking capsule according to claim 13 wherein the inside diameter of said body is reduced by from about 0.004 to about 0.008 inches'from the intersection of said ogee curve and the trailing edge of said first section to the intersection of the trailing edge of said ogee curve and said third section.
  • a locking capsule according to claim 1 wherein said fourth section of said body comprises from about one-eighth to about two-fifths the total length of said body, and the cylinder wall tapers inwardly from the intersection of said fourth section with said third section at a rate of from about 0.005 to about 0.020 inch per linear inch.
  • a locking capsule according to claim 1 wherein said fifth section of said body comprises said closed end of said body and occupies from about one-eighth to about two-fifths of the total length of said body.
  • a locking capsule according to claim 1 wherein said body comprises:
  • a third section integrally molded with said second section, said third section occupying about twofifths of the total length of said body and having a cylinder wall essentially parallel to the axial centerline of said body;
  • a fourth section integrally molded with said third section, said fourth section occupying about onefourth of the total length of said body and having a cylinder wall tapering at the rate of about 0.012 inch per linear inch from the intersection of said fourth section with said third section to the intersection of said fourth section with said fifth section;
  • a locking two-piece hard capsule comprising a cap portion and a body portion, said body portion telescoping into said cap portion effecting a frictional prelock when said body is partially telescoped into, said cap and a mechanical lock when said body is completely telescoped into said cap, said capsule comprismg: I
  • an essentially cylindrical cap portion having a closed end and an open end with the cylinder wall tapering generally outwardly at the rate of about 14 0.012 inch per linear inch from said closed end to said open end, said cylinder having an inside diameter of about the same at the intersection of said cylinder wall and said closed end as the maximum outside diameter of the cylinder wall of the body portion which telescopes into said cap, further said cap having three lateral ridges disposed about onetenth of the distance from the intersection of the cylinder wall with the closed end of said cap and said open end of said cap, said lateral ridges being in the same circumferential plane and extending radially inwardly at the apex about 0.003inches and occupying about 300 of the circumference of said cap, said cap also having three raised areas each extending radially inwardly about 0.002 inches and each disposed between the ends of one of said three lateral ridges, each of said raised areas extending longitudinally from said lateral ridges toward said open end about one-sixth of the total length of said
  • an essentially cylindrical body having a closed end and an open end, said cylinder having an outside diameter at the open end thereof about the same as the inside diameter of the cap, into which said body telescopes, at the intersection of the cylinder wall of said cap with the closed end thereof, and comprising:
  • a second'section integrally molded with said first section, constricting the outside diameter of said body by about 0.004 inch from the trailing edge of said first section to the leading edge of said third section, said second section having the geometric form of an ogee curve and occupying about one-twentieth of the total length of said body;
  • a third section integrally molded with said second section, said third section occupying about two-fifths of the total length of said body and having a cylindrical wall essentially parallel to the axial center-line of said body;
  • a fourth section integrally molded with said third section, said fourth section occupying about one-fourth of the total length of said body and having a cylindrical walltapering inwardly toward the axial center-line of said body at the .rate of about 0.01 2 inch per linear inch from the intersection of said fourth section with said third section to the intersection of said fourth section with said fifth section;

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
  • Coating Apparatus (AREA)
US00301045A 1972-10-26 1972-10-26 Locking capsule Expired - Lifetime US3823843A (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
US00301045A US3823843A (en) 1972-10-26 1972-10-26 Locking capsule
IL43276A IL43276A (en) 1972-10-26 1973-09-19 Locking capsule
ZA00737430A ZA737430B (en) 1972-10-26 1973-09-19 Locking capsules
IE1686/73A IE39685B1 (en) 1972-10-26 1973-09-20 Improvements in locking telescopic capsules
AU60790/73A AU468525B2 (en) 1972-10-26 1973-09-27 Locking capsules
CA182,186A CA1017705A (en) 1972-10-26 1973-09-28 Locking capsules
NLAANVRAGE7313620,A NL175713C (nl) 1972-10-26 1973-10-03 Uit twee vergrendelbare delen bestaande capsule.
IT30386/73A IT998821B (it) 1972-10-26 1973-10-22 Capsula rigida in due pezzi a chiusura eloccata
DE19732353103 DE2353103A1 (de) 1972-10-26 1973-10-23 Zweiteilige verschliessbare hartkapsel
GB1917273*[A GB1442121A (en) 1972-10-26 1973-10-23 Locking telescopic capsules
YU02768/73A YU276873A (en) 1972-10-26 1973-10-24 Clampable capsule
RO7376425A RO70489A (ro) 1972-10-26 1973-10-25 Capsula pentru pulberi
CH1505373A CH568192A5 (de) 1972-10-26 1973-10-25
SU1974015A SU567391A3 (ru) 1972-10-26 1973-10-25 Капсула
AT905473A AT338433B (de) 1972-10-26 1973-10-25 Verschliessbare, zweiteilige hartkapsel
HUEI501A HU169055B (de) 1972-10-26 1973-10-25
BR8349/73A BR7308349D0 (pt) 1972-10-26 1973-10-25 Capsula travavel
BE1005459A BE806487A (fr) 1972-10-26 1973-10-25 Capsule a blocage
SE7314524A SE404906B (sv) 1972-10-26 1973-10-25 I tva delar utford och mekaniskt hoplasbar kapsel, serskilt for pulverformiga eller granulerade substanser
DK577873AA DK133852B (da) 1972-10-26 1973-10-25 Todelt medicinkapsel med hættelås.
ES420003A ES420003A1 (es) 1972-10-26 1973-10-26 Una capsula ensamblable de dos piezas de material duro.
BG024848A BG28241A3 (en) 1972-10-26 1973-10-26 Locking capsule
JP12060473A JPS571265B2 (de) 1972-10-26 1973-10-26
CS737390A CS177152B2 (en) 1972-10-26 1973-10-26 Fast closing hard capsul of gelatin
FR7338231A FR2204541B1 (de) 1972-10-26 1973-10-26
DD174321A DD111188A5 (de) 1972-10-26 1973-10-26

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00301045A US3823843A (en) 1972-10-26 1972-10-26 Locking capsule

Publications (1)

Publication Number Publication Date
US3823843A true US3823843A (en) 1974-07-16

Family

ID=23161696

Family Applications (1)

Application Number Title Priority Date Filing Date
US00301045A Expired - Lifetime US3823843A (en) 1972-10-26 1972-10-26 Locking capsule

Country Status (26)

Country Link
US (1) US3823843A (de)
JP (1) JPS571265B2 (de)
AT (1) AT338433B (de)
AU (1) AU468525B2 (de)
BE (1) BE806487A (de)
BG (1) BG28241A3 (de)
BR (1) BR7308349D0 (de)
CA (1) CA1017705A (de)
CH (1) CH568192A5 (de)
CS (1) CS177152B2 (de)
DD (1) DD111188A5 (de)
DE (1) DE2353103A1 (de)
DK (1) DK133852B (de)
ES (1) ES420003A1 (de)
FR (1) FR2204541B1 (de)
GB (1) GB1442121A (de)
HU (1) HU169055B (de)
IE (1) IE39685B1 (de)
IL (1) IL43276A (de)
IT (1) IT998821B (de)
NL (1) NL175713C (de)
RO (1) RO70489A (de)
SE (1) SE404906B (de)
SU (1) SU567391A3 (de)
YU (1) YU276873A (de)
ZA (1) ZA737430B (de)

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US4717040A (en) * 1987-04-15 1988-01-05 Equinox Industries Ltd. Rotationally moulded septic tank sleeves
US4792451A (en) * 1986-12-20 1988-12-20 Su-Heung Capsule Co., Ltd. Medicinal capsule
US4893721A (en) * 1982-10-29 1990-01-16 Warner-Lambert Company Tamper-proof capsules
US5750143A (en) * 1992-11-04 1998-05-12 R.P. Scherer Corporation Controlled release device
US5769267A (en) * 1995-11-09 1998-06-23 Warner-Lambert Company Container
US6360886B1 (en) 2000-03-13 2002-03-26 Kerr Corporation Capsule for use in preparing a dental amalgam
US20040182387A1 (en) * 1999-07-23 2004-09-23 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US20060157054A1 (en) * 2005-01-11 2006-07-20 Boehringer Lngelheim Pharma Gmbh & Co. Kg Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers
US20070036830A1 (en) * 2005-08-09 2007-02-15 Stef Vanquickenborne Container
US20070184077A1 (en) * 2005-08-09 2007-08-09 Stef Vanquickenborne Container
US7305986B1 (en) * 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
US20080160076A1 (en) * 1998-08-05 2008-07-03 Dieter Hochrainer Two-part capsule to accept pharmaceutical preparations for powder inhalers
US20090241949A1 (en) * 2008-03-27 2009-10-01 Smutney Chad C Dry powder inhalation system
WO2014049606A3 (en) * 2012-09-28 2014-06-19 Sci-Tech Centre Capsule for encapsulating a tablet
WO2014181200A1 (en) 2013-05-10 2014-11-13 Capsugel Belgium Nv Separable capsule
US9192675B2 (en) 2008-06-13 2015-11-24 Mankind Corporation Dry powder inhaler and system for drug delivery
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US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US9283193B2 (en) 2005-09-14 2016-03-15 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US9706944B2 (en) 2009-11-03 2017-07-18 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
WO2018008660A1 (ja) 2016-07-06 2018-01-11 クオリカプス株式会社 硬度が改善された硬質カプセル、及びその製造方法
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US9943571B2 (en) 2008-08-11 2018-04-17 Mannkind Corporation Use of ultrarapid acting insulin
US9983108B2 (en) 2009-03-11 2018-05-29 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
WO2018105339A1 (ja) 2016-12-07 2018-06-14 クオリカプス株式会社 ゲル化補助剤の析出が改善された硬質カプセル、及びその調製方法
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10342938B2 (en) 2008-06-13 2019-07-09 Mannkind Corporation Dry powder drug delivery system
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WO2020071395A1 (ja) 2018-10-02 2020-04-09 クオリカプス株式会社 強度が改善された硬質カプセル、及びその製造方法
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JPS58146681A (ja) * 1982-02-25 1983-09-01 株式会社大井製作所 自動車用扉開閉装置
JPS59130986A (ja) * 1983-01-17 1984-07-27 東進物産株式会社 自動車扉開閉装置
IE58468B1 (en) * 1984-10-25 1993-09-22 Warner Lambert Co Method for sealing capsules and capsule
CN1003578B (zh) * 1984-10-25 1989-03-15 沃纳·兰伯特公司 改进的胶囊形状
GB8611905D0 (en) * 1986-05-15 1986-06-25 Lilly Industries Ltd Capsules
JPS6323474U (de) * 1986-07-30 1988-02-16
GR1000200B (el) * 1988-12-08 1992-03-20 Su Heung Capsule Co Ltd Kaψουλα φαρμακων.
GB9223172D0 (en) * 1992-11-05 1992-12-16 Scherer Corp R P Capsule construction
GB9223148D0 (en) * 1992-11-05 1992-12-16 Scherer Corp R P Capsule cap
NL1033047C2 (nl) 2006-12-13 2008-06-16 Pharmachemie Bv Capsule, gevuld met een medicijn, in het bijzonder een inhaleerbaar medicijn.

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US3285408A (en) * 1964-10-16 1966-11-15 Lilly Co Eli Capsule with integral locking band
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US3508678A (en) * 1968-04-29 1970-04-28 Parke Davis & Co Locking capsule
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US4893721A (en) * 1982-10-29 1990-01-16 Warner-Lambert Company Tamper-proof capsules
US4792451A (en) * 1986-12-20 1988-12-20 Su-Heung Capsule Co., Ltd. Medicinal capsule
DE3834786A1 (de) * 1986-12-20 1990-04-19 Su Heung Capsule Co Drogenkapsel
US4717040A (en) * 1987-04-15 1988-01-05 Equinox Industries Ltd. Rotationally moulded septic tank sleeves
US5750143A (en) * 1992-11-04 1998-05-12 R.P. Scherer Corporation Controlled release device
US5769267A (en) * 1995-11-09 1998-06-23 Warner-Lambert Company Container
US20080160076A1 (en) * 1998-08-05 2008-07-03 Dieter Hochrainer Two-part capsule to accept pharmaceutical preparations for powder inhalers
US8298575B2 (en) 1998-08-05 2012-10-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-part capsule to accept pharmaceutical preparations for powder inhalers
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
US8215300B2 (en) 1999-07-23 2012-07-10 Mannkind Corporation Unit dose cartridge and dry powder inhaler
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US20060157054A1 (en) * 2005-01-11 2006-07-20 Boehringer Lngelheim Pharma Gmbh & Co. Kg Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers
US8662076B2 (en) * 2005-01-11 2014-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers
US8377471B2 (en) 2005-08-09 2013-02-19 Capsugel Belgium Nv Container
US20070184077A1 (en) * 2005-08-09 2007-08-09 Stef Vanquickenborne Container
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WO2014049606A3 (en) * 2012-09-28 2014-06-19 Sci-Tech Centre Capsule for encapsulating a tablet
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US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
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US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
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US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
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Also Published As

Publication number Publication date
ES420003A1 (es) 1976-03-01
IE39685B1 (en) 1978-12-06
NL7313620A (de) 1974-05-01
FR2204541A1 (de) 1974-05-24
IT998821B (it) 1976-02-20
BG28241A3 (en) 1980-03-25
SU567391A3 (ru) 1977-07-30
IL43276A0 (en) 1973-11-28
NL175713C (nl) 1984-12-17
DK133852C (de) 1977-01-10
FR2204541B1 (de) 1979-01-26
CH568192A5 (de) 1975-10-31
AT338433B (de) 1977-08-25
BR7308349D0 (pt) 1974-09-24
AU468525B2 (en) 1976-01-15
DD111188A5 (de) 1975-02-05
CA1017705A (en) 1977-09-20
IL43276A (en) 1976-02-29
AU6079073A (en) 1975-03-27
ZA737430B (en) 1975-04-30
ATA905473A (de) 1976-12-15
NL175713B (nl) 1984-07-16
JPS4980228A (de) 1974-08-02
YU276873A (en) 1982-02-28
DE2353103A1 (de) 1974-05-09
JPS571265B2 (de) 1982-01-09
HU169055B (de) 1976-09-28
GB1442121A (en) 1976-07-07
DK133852B (da) 1976-08-02
IE39685L (en) 1974-04-26
CS177152B2 (en) 1977-07-29
BE806487A (fr) 1974-04-25
SE404906B (sv) 1978-11-06
RO70489A (ro) 1981-08-17

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