US3653500A - Filled capsules - Google Patents

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Publication number
US3653500A
US3653500A US841044A US3653500DA US3653500A US 3653500 A US3653500 A US 3653500A US 841044 A US841044 A US 841044A US 3653500D A US3653500D A US 3653500DA US 3653500 A US3653500 A US 3653500A
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Prior art keywords
capsule
capsules
gelatin
filled
open end
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Expired - Lifetime
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US841044A
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Howard C Allisbaugh
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Eli Lilly and Co
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Eli Lilly and Co
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S206/00—Special receptacle or package
    • Y10S206/828—Medicinal content
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S220/00—Receptacles
    • Y10S220/34—Anti-tamper pharmaceutical capsules, e.g. tamper indicating or resistant

Definitions

  • ABSTRACT A method for making filled capsules containing dry material in which the dry material is placed into a capsule body to a level slightly below the open end of the body and a measured amount of molten gelatin is placed over the body's open end in contact with the dry material whereby upon solidification of the molten gelatin a fused joint is effected with the capsule bodys open end.
  • Unauthorized persons may, and frequently do, remove the cap from the capsule, dilute the powder component with a suitable filler, then refill the capsule with the diluted original contents.
  • the expensive; tablet in some capsules may also be removed.
  • the usual method of detection of this unauthorized modification of the formula is failure to obtain expected therapeutic response on admimistration of the medication.
  • Locking type capsules have also been developed with recessed and raised surfaces in the capsule caps and bodies which cooperate to minimizeaccidental separation.
  • the hard-gelatin capsule body is filled with the desireddry powder to a level slightly below the capsule bodys open end. In some instances it may be desireable to then tamp or vibrate the filled capsule body to obtain a certain degree of compacting.
  • a measured amount of molten gelatin is placed over the open end of the capsule and in contact with the exposed surface of the dry powder. The measured amount is such that a neat-appearing curved surface is fused with the bodys open end upon coupling and solidification of the molten gelatin.
  • the fused and softened capsule body wall shrinks tightly to the gelatin closure thereby forming a one-piece capsule which is impossible to open without destruction.
  • FIG. 1 is a perspective view of a filled capsule sealed in accordance with my invention.
  • FIG. 2 is a longitudinal section of the capsule of FIG. 1.
  • FIG. 3 is a longitudinal section of a capsule body filled with dry powder prior to sealing the body.
  • FIG. 4 is a schematic view of the method of this invention for sealing filled capsule bodies.
  • Capsule 11 is a conventional capsule body 15 which has been formed from gelatin. In the pharmaceutical industry these partially brittle capsules are known as hard-gelatin capsules.
  • a closure 17, also formed from gelatin is shown fused with the open end 18 of body 15. It is to be noted that the open end 18 is slightly curved inwardly due to a shrinkage process to be subsequently explained.
  • capsule body 15 is first filled with dry powder 13. It is desirable that the top level 20 of the dry powder is slightly below the body's open end 18. Thus, if a particular quantity of powder to be placed in the body is such that tamping or vibration is called for, the capsule may first be completely filled. However, prior to sealing the capsule it is desirable to lower thelevel of the dry powder to approximately one-sixteenth of an inch below a size 0 capsule in order to obtain a well-fused closure on the body.
  • capsule bodies 15 with their open ends upward are positioned in a conveyor means 21.
  • the conveyor means may travel across a vibratory table or under a reciprocating tamping pad 23 to obtain a slight lowering of the powder beneath the open ends of the capsule bodies.
  • Pad 23 has a resilient surface 26 which, when pressed onto open ends 18 of the capsules, slightly depresses the powder level 20.
  • the capsule bodies are then conveyed to a sealing station which in the schematic drawing of FIG. 4 introduces a measured amount of molten gelatin 22 onto each bodys open end.
  • the preferred amount of molten gelatin to be dropped onto the open end of a size 0 capsule body is approximately 0.22 ml.
  • the temperature of the molten gelatin is preferably between l30l60 F.
  • Valve means 24 is provided in communication through conduit 25 with a reservoir of molten gelatin 27.
  • Valve means 24 may comprise a structure similar to a hypodermic syringe which is activated in synchronization with the advance of the unsealed capsules to automatically drop a predetermined amount of molten gelatin.
  • closure 17 has completely solidified and dried sufficiently to avoid sticking with other filled and sealed capsules.
  • the now softened body end 18 fuses and shrinks tightly to the closure, thereby forming a unitary capsule that cannot be separated without destroying it.
  • the capsule body end 18 is drawn inwardly and the inner surface of closure 17 is drawn upwardly due to the shrinkage processes during the solidifying of the molten gelatin.
  • the filling operation for producing capsules in accordance with my invention is substantially speeded up over that currently in use for two-piece capsules; Since may method uses only a body it is no longer necessary to separate a cap section from a body section prior to filling the body section.
  • a bank of automatic syringes may be used to deliver the measured amounts of molten gelatin onto the open ends of the filled bodies.
  • relatively simple equipment may be used to seal at least capsule bodies per minute in a single row.
  • a number of rows of capsule bodies can be simultaneously filled thereby producing several hundred sealed capsules per minute.
  • the drying cycle of these sealed capsules may be accelerated by providing a flow of controlled dehumidified air at a predetermined temperature.
  • Closure 17 may be of a different colored gelatin to provide a two-color combination capsule. Where two-piece capsulcs have generally called for printing of a companys logo on each capsule section, it is apparent that this printing operation may be halved by merely printing on the capsule body

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Seasonings (AREA)

Abstract

A method for making filled capsules containing dry material in which the dry material is placed into a capsule body to a level slightly below the open end of the body and a measured amount of molten gelatin is placed over the body''s open end in contact with the dry material whereby upon solidification of the molten gelatin a fused joint is effected with the capsule body''s open end.

Description

United 9 States Patent Allisbaugh 1 Apr. 4, 1972 [54] FILLED CAPSULES [7 21 Inventor: Howard C. Allisbaugh, Indianapolis, Ind. [73] Assignee: Eli Lilly and Company, Indianapolis, lnd.
[22] Filed: July 11, 1969 [21] Appl. No.: 841,044
[52] U.S.Cl ..206/56 AA,53/24, 99/181,
206/84, 424/37 [51] Int. Cl B65d 79/00, A6lk 9/04, B6Sb l/OO [58] Field of Search ..53/24, 25, 124, 124 B, 37,
53/39, 140, 32-34, 2 PC, 111 RC; 424/37; 99/181; 206/84, 56 AA [56] References Cited UNITED STATES PATENTS 2,329,928 9/1943 Mulligan ..53/21 FC 464,121 12/1891 Heineman.. ..424/21 1,256,307 2/1918 Grant ..99/181 1,792,010 2/1931 Goss 424/37 X 1,846,052 2/1932 Grant ..99/181 1,911,020 5/1933 Grant ..99/181 2,046,609 7/1936 Clark ..99/181 2,028,241 1/1936 Paul ..53/24 2,031,660 2/1936 Loepslnger 53/25 2,046,366 7/1936 Collins ..53/24 2,046,367 7/1936 Collins... ..53/24 2,379,342 6/1945 Cozzoli ..53/25 3,078,629 2/1 963 Besemer ..53/37 3,162,000 12/1964 Kraven 3,324,902 6/1967 Lense 3,505,775 4/1970 Andersen..
3,518,340 6/1970 Raper ..53/37 X Primary Examiner-'Wayne A. Morse, Jr. Altorney-Everet F. Smith and Houston L. Swenson [57] ABSTRACT A method for making filled capsules containing dry material in which the dry material is placed into a capsule body to a level slightly below the open end of the body and a measured amount of molten gelatin is placed over the body's open end in contact with the dry material whereby upon solidification of the molten gelatin a fused joint is effected with the capsule bodys open end.
1 Claims, 4 Drawing Figures Patented April 4, 1972 m m T N LE 0 M M 2 INVENTOR. HOWARD C. ALLISBAUGH ATTO RNEY FILLED CAPSULES BACKGROUND OF THE INVENTION Filling pre-formed empty hard-gelatin capsule bodies with medicinal or other dry powders, then closing with a preformed capsule cap, is the current method of dispensing many dry medicines. This method of closing hard-gelatin capsules is universally acceptable in all pharmaceutical houses but has certain disadvantages. Many hard-gelatin capsules contain very expensive formulations, and some even contain small compressed tablets of a second medicament designed to supplement the action of powders in the capsules. Unauthorized persons may, and frequently do, remove the cap from the capsule, dilute the powder component with a suitable filler, then refill the capsule with the diluted original contents. The expensive; tablet in some capsules may also be removed. The usual method of detection of this unauthorized modification of the formula is failure to obtain expected therapeutic response on admimistration of the medication.
An even more common problem is the accidental separation of one or several capsule caps from their filled bodies while being handled and shipped. Powder from the separated bodies will sift among other capsules in the bottle causing them to take on an unappealing dusty appearance. If the powder is bitter, then it may be necessary to discardthe entire contents of the bottle.
Certain manufacturers eliminate the above problems by sealing the body to the cap by applying a band of hot gelatin solution over the junction of the edge of the cap and the side of the body of the filled capsules. Locking type capsules have also been developed with recessed and raised surfaces in the capsule caps and bodies which cooperate to minimizeaccidental separation.
SUMMARY OF THE INVENTION I have found that accidental spillage, tampering with and pilfering of medication from filled capsules can be prevented by closing the hard-gelatin capsule bodies by the following method. The hard-gelatin capsule body is filled with the desireddry powder to a level slightly below the capsule bodys open end. In some instances it may be desireable to then tamp or vibrate the filled capsule body to obtain a certain degree of compacting. After the body has received the powder a measured amount of molten gelatin is placed over the open end of the capsule and in contact with the exposed surface of the dry powder. The measured amount is such that a neat-appearing curved surface is fused with the bodys open end upon coupling and solidification of the molten gelatin. As drying of the fused capsule wall and the molten gelatin progresses, the fused and softened capsule body wall shrinks tightly to the gelatin closure thereby forming a one-piece capsule which is impossible to open without destruction.
BRIEF DESCRIPTION OF THE DRAWING FIG. 1 is a perspective view of a filled capsule sealed in accordance with my invention.
7 FIG. 2 is a longitudinal section of the capsule of FIG. 1.
FIG. 3 is a longitudinal section of a capsule body filled with dry powder prior to sealing the body.
FIG. 4 is a schematic view of the method of this invention for sealing filled capsule bodies.
DESCRIPTION OF THE PREFERRED EMBODIMENT Referring to FIGS. 1 and 2, a filled and sealed capsule 11 is shown containing a dry powder 13. Capsule 11 is a conventional capsule body 15 which has been formed from gelatin. In the pharmaceutical industry these partially brittle capsules are known as hard-gelatin capsules. A closure 17, also formed from gelatin is shown fused with the open end 18 of body 15. It is to be noted that the open end 18 is slightly curved inwardly due to a shrinkage process to be subsequently explained.
In making capsules of the above type, capsule body 15 is first filled with dry powder 13. It is desirable that the top level 20 of the dry powder is slightly below the body's open end 18. Thus, if a particular quantity of powder to be placed in the body is such that tamping or vibration is called for, the capsule may first be completely filled. However, prior to sealing the capsule it is desirable to lower thelevel of the dry powder to approximately one-sixteenth of an inch below a size 0 capsule in order to obtain a well-fused closure on the body.
As shown in FIG. 4, capsule bodies 15 with their open ends upward are positioned in a conveyor means 21. Upon filling the bodies with dry powder the conveyor means may travel across a vibratory table or under a reciprocating tamping pad 23 to obtain a slight lowering of the powder beneath the open ends of the capsule bodies. Pad 23 has a resilient surface 26 which, when pressed onto open ends 18 of the capsules, slightly depresses the powder level 20. The capsule bodies are then conveyed to a sealing station which in the schematic drawing of FIG. 4 introduces a measured amount of molten gelatin 22 onto each bodys open end. The preferred amount of molten gelatin to be dropped onto the open end of a size 0 capsule body is approximately 0.22 ml. The temperature of the molten gelatin is preferably between l30l60 F.
A valve means 24 is provided in communication through conduit 25 with a reservoir of molten gelatin 27. Valve means 24 may comprise a structure similar to a hypodermic syringe which is activated in synchronization with the advance of the unsealed capsules to automatically drop a predetermined amount of molten gelatin.
The filled, and now sealed, capsule bodies are left in their conveyor until closure 17 has completely solidified and dried sufficiently to avoid sticking with other filled and sealed capsules. As the drying of closure 17 occurs, the now softened body end 18 fuses and shrinks tightly to the closure, thereby forming a unitary capsule that cannot be separated without destroying it. The capsule body end 18 is drawn inwardly and the inner surface of closure 17 is drawn upwardly due to the shrinkage processes during the solidifying of the molten gelatin.
The advantages of producing capsules of this method are numerous and include substantial savings in cost and time with respect to material and production methods. Since only a capsule body is used with a small amount of additional gelatin for closure 17, it is apparent that nearly twice as many capsules can be made with the same amount of gelatin normally required for forming two-piece capsules. In the prior art the filling and assembling of two-piece capsules has required apparatus that must be maintained without any wear on the parts. In particular, the problems normally encountered in assuring that the joining process of telescoping a cap over a body does not split a cap or body section are eliminated. Current production of two-piece capsules has required discarding an entire capsule when a flaw is detected in either the cap or body. The capsule of this invention, if defective, calls for only the discarding of the body and the small closure 17. The wall thickness of a capsule body for my novel capsule is not a critical dimension since it is no longer necessary to telescope a cap section over it.
The filling operation for producing capsules in accordance with my invention is substantially speeded up over that currently in use for two-piece capsules; Since may method uses only a body it is no longer necessary to separate a cap section from a body section prior to filling the body section. A bank of automatic syringes may be used to deliver the measured amounts of molten gelatin onto the open ends of the filled bodies. Thus, relatively simple equipment may be used to seal at least capsule bodies per minute in a single row. In a large production operation a number of rows of capsule bodies can be simultaneously filled thereby producing several hundred sealed capsules per minute. The drying cycle of these sealed capsules may be accelerated by providing a flow of controlled dehumidified air at a predetermined temperature.
This method has been found applicable for all sizes of capsules. Upon determining the amount of shrinkage occurring for a particular size capsule body, a predetermined amount of molten gelatin may be dispensed by the syringes to produce a smooth contoured end that is esthetically appealing to the trade. Closure 17 may be of a different colored gelatin to provide a two-color combination capsule. Where two-piece capsulcs have generally called for printing of a companys logo on each capsule section, it is apparent that this printing operation may be halved by merely printing on the capsule body
US841044A 1969-07-11 1969-07-11 Filled capsules Expired - Lifetime US3653500A (en)

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CA (1) CA924239A (en)
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DE (1) DE2034198C3 (en)
ES (1) ES381678A1 (en)
FR (1) FR2055048A5 (en)
GB (1) GB1267304A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196564A (en) * 1977-05-20 1980-04-08 S.A. Capsugel A.G. Method of manufacturing a joined capsule filled with viscous material
DE3438235A1 (en) * 1983-10-20 1985-05-30 Warner-Lambert Co., Morris Plains, N.J. PRINTED ARTICLES
US4576284A (en) * 1983-12-02 1986-03-18 Warner-Lambert Company Closing of filled capsules
USD285837S (en) 1982-12-20 1986-09-23 Warner-Lambert Company Pharmaceutical capsule
US5074426A (en) * 1986-11-13 1991-12-24 Warner-Lambert Company Dividable capsule
US20110247302A1 (en) * 2003-03-21 2011-10-13 Warner-Lambert Company Llc Apparatus For And Method of Sealing Capsules
USD684253S1 (en) * 2011-02-24 2013-06-11 Moldex-Metric, Inc. Cylinder earplug
US20140009959A1 (en) * 2011-03-22 2014-01-09 Lg Innotek Co., Ltd. Display device and light conversion member
EP1399105B2 (en) † 2001-06-13 2018-09-05 Boehringer Ingelheim Pharma GmbH & Co.KG Method for cleaning hard gelatine capsules
CN110471318A (en) * 2019-06-26 2019-11-19 康美药业股份有限公司 A kind of intelligence control system of pharmacy heating cooking stove

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2722806C2 (en) * 1977-05-20 1984-12-13 Capsugel AG, Basel Capsule body for a push-fit capsule for drugs or other substances to be packaged in portions, as well as a process for its production
DE102010028125A1 (en) * 2010-04-22 2011-10-27 Robert Bosch Gmbh Device for filling and closing capsules filled with at least one filling substance

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US464121A (en) * 1891-12-01 Capsule
US1256307A (en) * 1917-06-26 1918-02-12 Margaret Grant Process and container for canning or preserving jellies and the like.
US1792010A (en) * 1929-04-24 1931-02-10 Lake Erie Chemical Company Gelatin-composition container
US1846052A (en) * 1929-06-12 1932-02-23 Grant Margaret Container and method for sealing jelly or preserves
US1911020A (en) * 1929-06-12 1933-05-23 Grant Margaret Method for sealing jelly, preserves, or the like in containers, and product for such use
US2028241A (en) * 1934-06-15 1936-01-21 United States Radium Corp Method of making self-luminous element
US2031660A (en) * 1932-11-26 1936-02-25 Gen Fire Extinguisher Co Method of sealing charged glass bulbs
US2046367A (en) * 1934-03-16 1936-07-07 Columbus Dental Mfg Co Method of packing homogeneous mixtures of pulverized heterogeneous materials
US2046366A (en) * 1936-01-06 1936-07-07 Columbus Dental Mfg Co Granular material package and method of producing the same
US2046609A (en) * 1935-10-23 1936-07-07 Clark Grover Container and method of sealing
US2329928A (en) * 1942-02-02 1943-09-21 Blue Line Chemical Co Sterilizing medicinal pellets or the like
US2379342A (en) * 1942-03-21 1945-06-26 Frank J Cozzoli Method of sealing filled tubes
US3078629A (en) * 1960-01-08 1963-02-26 Upjohn Co Method for sealing hard filled capsules
US3162000A (en) * 1962-06-04 1964-12-22 Cooper Tinsley Lab Inc Method of sealing two-piece gelatin capsules
US3324902A (en) * 1965-05-26 1967-06-13 Bartelt Engineering Co Inc Method of filling capsules
US3505775A (en) * 1966-06-08 1970-04-14 Andersen Prod H W Method of managing a volatile substance
US3518340A (en) * 1968-04-15 1970-06-30 Dow Corning Method of forming silicone rubber drug carriers

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US464121A (en) * 1891-12-01 Capsule
US1256307A (en) * 1917-06-26 1918-02-12 Margaret Grant Process and container for canning or preserving jellies and the like.
US1792010A (en) * 1929-04-24 1931-02-10 Lake Erie Chemical Company Gelatin-composition container
US1846052A (en) * 1929-06-12 1932-02-23 Grant Margaret Container and method for sealing jelly or preserves
US1911020A (en) * 1929-06-12 1933-05-23 Grant Margaret Method for sealing jelly, preserves, or the like in containers, and product for such use
US2031660A (en) * 1932-11-26 1936-02-25 Gen Fire Extinguisher Co Method of sealing charged glass bulbs
US2046367A (en) * 1934-03-16 1936-07-07 Columbus Dental Mfg Co Method of packing homogeneous mixtures of pulverized heterogeneous materials
US2028241A (en) * 1934-06-15 1936-01-21 United States Radium Corp Method of making self-luminous element
US2046609A (en) * 1935-10-23 1936-07-07 Clark Grover Container and method of sealing
US2046366A (en) * 1936-01-06 1936-07-07 Columbus Dental Mfg Co Granular material package and method of producing the same
US2329928A (en) * 1942-02-02 1943-09-21 Blue Line Chemical Co Sterilizing medicinal pellets or the like
US2379342A (en) * 1942-03-21 1945-06-26 Frank J Cozzoli Method of sealing filled tubes
US3078629A (en) * 1960-01-08 1963-02-26 Upjohn Co Method for sealing hard filled capsules
US3162000A (en) * 1962-06-04 1964-12-22 Cooper Tinsley Lab Inc Method of sealing two-piece gelatin capsules
US3324902A (en) * 1965-05-26 1967-06-13 Bartelt Engineering Co Inc Method of filling capsules
US3505775A (en) * 1966-06-08 1970-04-14 Andersen Prod H W Method of managing a volatile substance
US3518340A (en) * 1968-04-15 1970-06-30 Dow Corning Method of forming silicone rubber drug carriers

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196564A (en) * 1977-05-20 1980-04-08 S.A. Capsugel A.G. Method of manufacturing a joined capsule filled with viscous material
USD285837S (en) 1982-12-20 1986-09-23 Warner-Lambert Company Pharmaceutical capsule
DE3438235A1 (en) * 1983-10-20 1985-05-30 Warner-Lambert Co., Morris Plains, N.J. PRINTED ARTICLES
US4576284A (en) * 1983-12-02 1986-03-18 Warner-Lambert Company Closing of filled capsules
US5074426A (en) * 1986-11-13 1991-12-24 Warner-Lambert Company Dividable capsule
EP1399105B2 (en) † 2001-06-13 2018-09-05 Boehringer Ingelheim Pharma GmbH & Co.KG Method for cleaning hard gelatine capsules
US20110247302A1 (en) * 2003-03-21 2011-10-13 Warner-Lambert Company Llc Apparatus For And Method of Sealing Capsules
US8491298B2 (en) * 2003-03-21 2013-07-23 Capsugel Belgium Nv Apparatus for sealing a pharmaceutically acceptable hard shell capsule
USD684253S1 (en) * 2011-02-24 2013-06-11 Moldex-Metric, Inc. Cylinder earplug
US20140009959A1 (en) * 2011-03-22 2014-01-09 Lg Innotek Co., Ltd. Display device and light conversion member
US9976722B2 (en) * 2011-03-22 2018-05-22 Lg Innotek Co., Ltd. Display device and light conversion member
CN110471318A (en) * 2019-06-26 2019-11-19 康美药业股份有限公司 A kind of intelligence control system of pharmacy heating cooking stove

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Publication number Publication date
CH508398A (en) 1971-06-15
DE2034198C3 (en) 1973-12-06
DE2034198A1 (en) 1971-12-09
GB1267304A (en) 1972-03-15
CA924239A (en) 1973-04-10
ES381678A1 (en) 1972-12-01
FR2055048A5 (en) 1971-05-07
DE2034198B2 (en) 1973-05-24
BE753194A (en) 1971-01-11

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