US3468808A - Production of high purity radioactive technetium-99m - Google Patents
Production of high purity radioactive technetium-99m Download PDFInfo
- Publication number
- US3468808A US3468808A US646453A US3468808DA US3468808A US 3468808 A US3468808 A US 3468808A US 646453 A US646453 A US 646453A US 3468808D A US3468808D A US 3468808DA US 3468808 A US3468808 A US 3468808A
- Authority
- US
- United States
- Prior art keywords
- technetium
- molybdenum
- radioactive
- slurry
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title description 32
- 229940056501 technetium 99m Drugs 0.000 title description 32
- 230000002285 radioactive effect Effects 0.000 title description 22
- 238000004519 manufacturing process Methods 0.000 title description 7
- 238000000034 method Methods 0.000 description 32
- 239000002002 slurry Substances 0.000 description 16
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 15
- 229910052750 molybdenum Inorganic materials 0.000 description 15
- 239000011733 molybdenum Substances 0.000 description 15
- 229950009740 molybdenum mo-99 Drugs 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- ZOKXTWBITQBERF-AKLPVKDBSA-N Molybdenum Mo-99 Chemical compound [99Mo] ZOKXTWBITQBERF-AKLPVKDBSA-N 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 11
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 11
- 229910001928 zirconium oxide Inorganic materials 0.000 description 11
- 239000000758 substrate Substances 0.000 description 10
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000007800 oxidant agent Substances 0.000 description 6
- 229910052713 technetium Inorganic materials 0.000 description 6
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 6
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 5
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 5
- 239000000460 chlorine Substances 0.000 description 5
- 238000010828 elution Methods 0.000 description 5
- JGJLWPGRMCADHB-UHFFFAOYSA-N hypobromite Inorganic materials Br[O-] JGJLWPGRMCADHB-UHFFFAOYSA-N 0.000 description 5
- 239000012535 impurity Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 150000003754 zirconium Chemical class 0.000 description 5
- 229910052726 zirconium Inorganic materials 0.000 description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- JKQOBWVOAYFWKG-UHFFFAOYSA-N molybdenum trioxide Chemical group O=[Mo](=O)=O JKQOBWVOAYFWKG-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical class [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical compound [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 239000000908 ammonium hydroxide Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000004993 emission spectroscopy Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- -1 molybdate ions Chemical class 0.000 description 2
- 239000012286 potassium permanganate Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- OYEHPCDNVJXUIW-FTXFMUIASA-N 239Pu Chemical compound [239Pu] OYEHPCDNVJXUIW-FTXFMUIASA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- APUPEJJSWDHEBO-UHFFFAOYSA-P ammonium molybdate Chemical compound [NH4+].[NH4+].[O-][Mo]([O-])(=O)=O APUPEJJSWDHEBO-UHFFFAOYSA-P 0.000 description 1
- 235000018660 ammonium molybdate Nutrition 0.000 description 1
- 239000011609 ammonium molybdate Substances 0.000 description 1
- 229940010552 ammonium molybdate Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003637 basic solution Substances 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- XTEGARKTQYYJKE-UHFFFAOYSA-N chloric acid Chemical class OCl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-N 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 1
- 239000005078 molybdenum compound Substances 0.000 description 1
- 150000002752 molybdenum compounds Chemical class 0.000 description 1
- WFLYOQCSIHENTM-UHFFFAOYSA-N molybdenum(4+) tetranitrate Chemical compound [N+](=O)([O-])[O-].[Mo+4].[N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[N+](=O)([O-])[O-] WFLYOQCSIHENTM-UHFFFAOYSA-N 0.000 description 1
- ICYJJTNLBFMCOZ-UHFFFAOYSA-J molybdenum(4+);disulfate Chemical compound [Mo+4].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ICYJJTNLBFMCOZ-UHFFFAOYSA-J 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- VKJKEPKFPUWCAS-UHFFFAOYSA-M potassium chlorate Chemical compound [K+].[O-]Cl(=O)=O VKJKEPKFPUWCAS-UHFFFAOYSA-M 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 1
- JFALSRSLKYAFGM-OIOBTWANSA-N uranium-235 Chemical compound [235U] JFALSRSLKYAFGM-OIOBTWANSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B61/00—Obtaining metals not elsewhere provided for in this subclass
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
Definitions
- This invention relates to a novel process for the production of radioactive technetium-99m.
- this invention relates to a novel process for the production of radioactive technetium-99m in high yields.
- a further aspect of this invention is directed to a novel process for the production of radioactive technetium-99m which can be obtained in a high degree of purity.
- technetium- 99m is an extremely useful tool for diagnosis.
- High purity technetium-99m is used primarily as a radioisotope in a variety of medical research and diagnosis. It is well suited for liver, lung, blood pool and tumor scanning, and is preferred over other radioactive isotopes because of its short half-life which results in reduced exposure of the organs to radiation.
- technetium-99m can also be employed in industrial applications, such as in the measurement of flow rates, process control, radiometric chemistry, and the like.
- radioactive molybdenum- 99..Ihe user then extracts the technetium from the molybdenum-99 as his needs require.
- radioactive technetium-99m has been produced by a variety of methods.
- M. S. Faddeeva et al., Zhur. Neorg. Khim., 3, 165-166 (1958) has disclosed a process for extracting technetium-99m from 6 N aqueous K CO solutions containing dissolved molybdenum-99* containing material, using methyl ethyl ketone as the extracting medium, followed by washing the ketone solutions with K C aqueous solution.
- the technetium-99m recovered by this process was not pure, since the product contained detectable K CO and would therefore not be useable for many purposes, such as for medical purposes.
- molybdenum trioxide is molybdenum trioxide.
- other compounds it is often necessary to isolate the molybdenum component after irradiation.
- Illustrative compounds which can be employed as the source of molybdenum-99 include, among others, molybdenum metal, molybdenum nitrate, molybdenum sulfate, organic molybdenum compounds such 'as molybdenum acetylacetonates, and fissionable materials such as uranium-235, uranium- 238, plutonium-239, and the like.
- Irradiation of compounds to produce molybdenum-99 is a well known technique and can be effected by placing the proper compound in the irradiation zone of a nuclear reactor, particle generator, or neutron isotopic source.
- the irradiated compound is dissolved in a suitable solvent.
- a suitable solvent such as sodium hydroxide, ammonium hydroxide, and the like, the techniques to dissolve and isolate a pure molybdenum- 99 solution are well known in the art.
- molybdenum solution such as aqueous ammonium molybdate is contacted with oxidized zirconium salts.
- the oxidized zirconium salts are prepared by contacting a compound, such as hydrous zirconium oxide, with an oxidizing agent, in the presence of an acid.
- Suitable oxidizing agents which can be employed include, among others, bromine water, chlorine water, iodide water, permanganate salts, such as potassium permanganate, chlorate salts, such as potassium chlorate, hydrogen peroxide, organic peroxides, such as benzoyl peroxide and the like.
- the pH of the contacted solution is adjusted to a range between 2 to 7 and more preferably between 3.5 and 6.0. Normally, it is preferable to heat the solution during pH adjustment and control and to maintain this heat for a duration of approximately twenty minutes to insure adsorption of the molybdenum on the zirconium substrate. Temperature is not necessarily critical and need only be sufiicient to insure complete reaction of the molybdenum and the oxidized zirconium salt. In practice, temperatures greater than 70 C., have been found satisfactory, with the preferred temperature being the boiling point of the slurry.
- the zirconium substrate containing the molybdenum is then transferred to an appropriate elution system such as a column, or vessel, preferably glass, or other inert material.
- an appropriate elution system such as a column, or vessel, preferably glass, or other inert material.
- the supernatant liquid is allowed to drain or removed by filtration or decantation and the substrate washed with isotonic saline.
- the technetium-99m in the column or vessel which contains 99Mo-99mTc activity can subsequently be isolated, e.g., milked, filtered, centrifuged or the like for technetium-99m as it is formed with an acidic, neutral or basic solution.
- an acidic, neutral or basic solution e.g., milked, filtered, centrifuged or the like for technetium-99m as it is formed with an acidic, neutral or basic solution.
- the process of the present invention provides a simple method for the preparation of technetium-99m in a high degree of efficiency.
- recovery of technetium-99m can be effected with isotonic saline in elficiencies as high as 95% and higher, over a pH range of about 4.0 to about 7.0 without appreciable dissolution of the zirconium substrate or removal of any molybdenum from the zirconium substrate.
- a further advantage characteristic of the process of this invention is that the substrate and/or the entire elution system can be sterilized, i.e., by autoclaving at the normally prescribed temperatures and pressures.
- EXAMPLE 1 To 100 grams of Bio-Rad hydrous zirconium oxide (100-200 mesh) was added 100 milliliters of 0.1 MHCl and 10 milliliters of saturated bromine water. The mixture was stirred and allowed to stand for 10 minutes. Thereafter l5 milliliters of 1 M NaOH was added to the slurry. A sufficient volume of this slurry was transferred into a 150' milliliter beaker to provide 1 milliliter of slurry per 57 milligrams of molybdenum. Thereafter the slurry was washed three times with water and four drops of saturated bromine water added.
- the column was tested for molybdenum break-through 4 by radiometric analysis and no molybdenum-99 was observed. Chemical purity was tested by emission spectroscopy for the major elements of the column substrate, i.e., zirconium, and none was detectable.
- EXAMPLE 2 A comparison of adsorption-elution characteristics of the column of Example 1 and one prepared in accordance with a recent method, wherein an alumina column is employed the data obtained is set forth in Table I below:
- radiometric analysis of the eluted technetium-99m indicates that it contains up to percent of the available technetium-99m and the radionuclidic purity is greater than 99.99 percent.
- the total metal element impurity is less than 1 part per million as determined by emission spectroscopy techniques.
- the substrate and/or the entire elution system can be sterilized by acceptable autoclave techniques with no reduction in radionuclidic impurity, no increase in the metal element impurities and no reduction in the amount of technetium-99m recoverable.
- said oxidizing agent is selected from the group consisting of bromine water, chlorine water, iodine Water, potassium permanganate, potgssium chlorate, hydrogen peroxide, and benzoylper- 0x1 e.
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64645367A | 1967-06-16 | 1967-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3468808A true US3468808A (en) | 1969-09-23 |
Family
ID=24593130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US646453A Expired - Lifetime US3468808A (en) | 1967-06-16 | 1967-06-16 | Production of high purity radioactive technetium-99m |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3468808A (en:Method) |
| BE (1) | BE716569A (en:Method) |
| DE (1) | DE1758118C3 (en:Method) |
| FR (1) | FR1561828A (en:Method) |
| GB (1) | GB1207246A (en:Method) |
| IL (1) | IL29607A (en:Method) |
| NL (1) | NL6804929A (en:Method) |
| SE (1) | SE350954B (en:Method) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2207309A1 (de) * | 1971-03-02 | 1972-09-07 | Philips Nv | Verfahren zur Herstellung eines Radioisotopen erzeugenden Generators mit einem verbesserten Eluierungsgrad und durch dieses Verfahren hergestellter Generator |
| US4010109A (en) * | 1973-07-02 | 1977-03-01 | Kurt Sauerwein | Device for marking fluent materials |
| US4158700A (en) * | 1976-03-08 | 1979-06-19 | Karageozian Hampar L | Method of producing radioactive technetium-99M |
| US4206358A (en) * | 1977-10-19 | 1980-06-03 | Australian Atomic Energy Commission | Technetium-99 generators |
| US20110206579A1 (en) * | 2010-02-19 | 2011-08-25 | Glenn Daniel E | Method and apparatus for the extraction and processing of molybdenum-99 |
| CN103650061A (zh) * | 2011-07-13 | 2014-03-19 | 马林克罗特有限公司 | 制备Tc-99m的方法 |
| US20160042826A1 (en) * | 2014-08-06 | 2016-02-11 | Research Triangle Institute | High efficiency neutron capture product production |
| US9576690B2 (en) | 2012-06-15 | 2017-02-21 | Dent International Research, Inc. | Apparatus and methods for transmutation of elements |
| US9793023B2 (en) | 2013-09-26 | 2017-10-17 | Los Alamos National Security, Llc | Recovery of uranium from an irradiated solid target after removal of molybdenum-99 produced from the irradiated target |
| US9842664B2 (en) | 2013-09-26 | 2017-12-12 | Los Alamos National Security, Llc | Recovering and recycling uranium used for production of molybdenum-99 |
| CN110325271A (zh) * | 2017-02-24 | 2019-10-11 | Bwxt同位素技术集团有限公司 | 金属-钼酸盐及其制造方法 |
| WO2020005674A3 (en) * | 2018-06-20 | 2020-02-06 | BWXT Isotope Technology Group, Inc. | SYSTEM AND METHOD FOR EVALUATING ELUTION EFFICIENCY AND RADIOPURITY OF Tc-99m GENERATORS |
| CN113168929A (zh) * | 2019-03-11 | 2021-07-23 | 新华锦集团有限公司 | 99mTc分离提纯系统及99mTc分离提纯方法 |
| CN114121330A (zh) * | 2021-11-11 | 2022-03-01 | 中国核动力研究设计院 | 一种钼锝发生器、制备方法及装置 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4280053A (en) * | 1977-06-10 | 1981-07-21 | Australian Atomic Energy Commission | Technetium-99m generators |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB896758A (en) * | 1959-11-13 | 1962-05-16 | Atomic Energy Authority Uk | Improvements in or relating to the separation of technetium from fission product solutions |
-
1967
- 1967-06-16 US US646453A patent/US3468808A/en not_active Expired - Lifetime
-
1968
- 1968-03-08 IL IL29607A patent/IL29607A/en unknown
- 1968-04-05 DE DE1758118A patent/DE1758118C3/de not_active Expired
- 1968-04-08 NL NL6804929A patent/NL6804929A/xx unknown
- 1968-04-16 GB GB07816/68A patent/GB1207246A/en not_active Expired
- 1968-05-08 FR FR1561828D patent/FR1561828A/fr not_active Expired
- 1968-06-05 SE SE07522/68A patent/SE350954B/xx unknown
- 1968-06-14 BE BE716569D patent/BE716569A/xx unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB896758A (en) * | 1959-11-13 | 1962-05-16 | Atomic Energy Authority Uk | Improvements in or relating to the separation of technetium from fission product solutions |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2207309A1 (de) * | 1971-03-02 | 1972-09-07 | Philips Nv | Verfahren zur Herstellung eines Radioisotopen erzeugenden Generators mit einem verbesserten Eluierungsgrad und durch dieses Verfahren hergestellter Generator |
| US4010109A (en) * | 1973-07-02 | 1977-03-01 | Kurt Sauerwein | Device for marking fluent materials |
| US4158700A (en) * | 1976-03-08 | 1979-06-19 | Karageozian Hampar L | Method of producing radioactive technetium-99M |
| US4206358A (en) * | 1977-10-19 | 1980-06-03 | Australian Atomic Energy Commission | Technetium-99 generators |
| US20110206579A1 (en) * | 2010-02-19 | 2011-08-25 | Glenn Daniel E | Method and apparatus for the extraction and processing of molybdenum-99 |
| US8449850B2 (en) * | 2010-02-19 | 2013-05-28 | Babcock & Wilcox Technical Services Group, Inc. | Method and apparatus for the extraction and processing of molybdenum-99 |
| CN103650061A (zh) * | 2011-07-13 | 2014-03-19 | 马林克罗特有限公司 | 制备Tc-99m的方法 |
| US9576690B2 (en) | 2012-06-15 | 2017-02-21 | Dent International Research, Inc. | Apparatus and methods for transmutation of elements |
| US9842664B2 (en) | 2013-09-26 | 2017-12-12 | Los Alamos National Security, Llc | Recovering and recycling uranium used for production of molybdenum-99 |
| US9793023B2 (en) | 2013-09-26 | 2017-10-17 | Los Alamos National Security, Llc | Recovery of uranium from an irradiated solid target after removal of molybdenum-99 produced from the irradiated target |
| US20160042826A1 (en) * | 2014-08-06 | 2016-02-11 | Research Triangle Institute | High efficiency neutron capture product production |
| CN110325271A (zh) * | 2017-02-24 | 2019-10-11 | Bwxt同位素技术集团有限公司 | 金属-钼酸盐及其制造方法 |
| CN110325271B (zh) * | 2017-02-24 | 2022-11-01 | Bwxt同位素技术集团有限公司 | 金属-钼酸盐及其制造方法 |
| WO2020005674A3 (en) * | 2018-06-20 | 2020-02-06 | BWXT Isotope Technology Group, Inc. | SYSTEM AND METHOD FOR EVALUATING ELUTION EFFICIENCY AND RADIOPURITY OF Tc-99m GENERATORS |
| CN112384991A (zh) * | 2018-06-20 | 2021-02-19 | Bwxt同位素技术集团有限公司 | 用于评估锝-99m发生器的洗脱效率和放射性纯度的系统和方法 |
| US11391853B2 (en) | 2018-06-20 | 2022-07-19 | BWXT Isotope Technology Group, Inc. | System and method for evaluating elution efficiency and radiopurity of tc-99m generators |
| CN113168929A (zh) * | 2019-03-11 | 2021-07-23 | 新华锦集团有限公司 | 99mTc分离提纯系统及99mTc分离提纯方法 |
| CN113168929B (zh) * | 2019-03-11 | 2024-04-19 | 新华锦集团有限公司 | 99mTc分离提纯系统及99mTc分离提纯方法 |
| CN114121330A (zh) * | 2021-11-11 | 2022-03-01 | 中国核动力研究设计院 | 一种钼锝发生器、制备方法及装置 |
| CN114121330B (zh) * | 2021-11-11 | 2024-05-14 | 中国核动力研究设计院 | 一种钼锝发生器、制备方法及装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL29607A (en) | 1971-10-20 |
| DE1758118A1 (de) | 1970-12-23 |
| GB1207246A (en) | 1970-09-30 |
| BE716569A (en:Method) | 1968-12-16 |
| DE1758118C3 (de) | 1974-05-30 |
| FR1561828A (en:Method) | 1969-03-28 |
| DE1758118B2 (de) | 1973-10-18 |
| SE350954B (en:Method) | 1972-11-13 |
| NL6804929A (en:Method) | 1968-12-17 |
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| AS | Assignment |
Owner name: CINTICHEM, INC., NEW YORK Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:UNION CARBIDE CORPORATION, A CORP. OF NY;REEL/FRAME:003951/0224 Effective date: 19810428 Owner name: CINTICHEM, INC., A CORP. OF DE, NEW YORK Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:UNION CARBIDE CORPORATION, A CORP. OF NY;REEL/FRAME:003951/0224 Effective date: 19810428 Owner name: CINTICHEM, INC., LONG MEADOW ROAD, P.O. BOX 204, T Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:UNION CARBIDE CORPORATION, A CORP. OF NY;REEL/FRAME:003951/0224 Effective date: 19810428 |