US3050239A - Centrifuge apparatus - Google Patents

Centrifuge apparatus Download PDF

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Publication number
US3050239A
US3050239A US854281A US85428159A US3050239A US 3050239 A US3050239 A US 3050239A US 854281 A US854281 A US 854281A US 85428159 A US85428159 A US 85428159A US 3050239 A US3050239 A US 3050239A
Authority
US
United States
Prior art keywords
rotor
tubes
centrifuge
support
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US854281A
Other languages
English (en)
Inventor
Jr Fred G Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Instruments Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL109202D priority Critical patent/NL109202C/xx
Priority to NL252802D priority patent/NL252802A/xx
Priority to US705859A priority patent/US3009388A/en
Priority to US814305A priority patent/US3071316A/en
Priority to US854281A priority patent/US3050239A/en
Application filed by Beckman Instruments Inc filed Critical Beckman Instruments Inc
Priority to GB19315/60A priority patent/GB889082A/en
Priority to FR830347A priority patent/FR1259932A/fr
Application granted granted Critical
Publication of US3050239A publication Critical patent/US3050239A/en
Priority to DEC34478A priority patent/DE1256921B/de
Priority to US509361A priority patent/US3402883A/en
Priority to GB50115/65A priority patent/GB1119420A/en
Priority to US525771A priority patent/US3481712A/en
Priority to GB48757/66A priority patent/GB1115297A/en
Priority to DE19671598301 priority patent/DE1598301A1/de
Priority to US00048386A priority patent/US3713775A/en
Priority to DE2103841A priority patent/DE2103841C3/de
Priority to GB2833172A priority patent/GB1357232A/en
Priority to CA114,539A priority patent/CA940428A/en
Priority to FR7122476A priority patent/FR2096403B1/fr
Priority to GB1828471*[A priority patent/GB1357231A/en
Priority to AU47751/72A priority patent/AU468478B2/en
Priority to CA184,119A priority patent/CA956915A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/54—Labware with identification means
    • B01L3/545—Labware with identification means for laboratory containers
    • B01L3/5453—Labware with identification means for laboratory containers for test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
    • B04B5/0421—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes pivotably mounted
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/10—Control of the drive; Speed regulating
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B04B7/02—Casings; Lids
    • B04B2007/025—Lids for laboratory centrifuge rotors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0429—Sample carriers adapted for special purposes
    • G01N2035/0436—Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/90—Collapsible wall structure

Definitions

  • This invention relates generally to a centrifuge apparatus and more particularly to a centrifuge apparatus suitable for microchemical analysis.
  • the liquid to be centrifuged is contained in a tube which, in turn, is supported in a Well formed in a metal rotor or in metal buckets carried by a supporting structure.
  • a heavy rotor or heavy buckets and supporting structure are required.
  • the inertia of conventional centrifuge rotors is much greater than that contributed by the liquid column itself.
  • the acceleration and deceleration time of a conventional rotor is often as great or greater than the actual time necessary for sedimentation.
  • FIGURE 1 is an elevational view, partly in section, of a centrifuge apparatus in accordance with the invention
  • FIGURE 2 shows a modified rotor for the centrifuge apparatus of FIGURE 1;
  • FIGURE 3 is an enlarged view of the rotor of FIG- URE 1;
  • FIGURE 4 is a sectional view taken along the line 44 of FIGURE 3;
  • FIGURE 5 shows a centrifuge tube suitable for use in the apparatus of the present invention.
  • FIGURE 6 shows a plurality of tubes mounted on a support.
  • the centrifuge apparatus of the present invention includes a housing 11 which houses a drive motor 12 for driving the rotor assembly 13. Controls 14 are provided for controlling the speed of rotation.
  • the motor shaft 16 extends upwardly through a bowl 17 which forms a rotor chamber to receive and support the rotor 18.
  • a set screw 19 is provided for adjusting the position of the rotor on the shaft 16.
  • the bowl 17 is seated on the rim 2'1 carried at the upper end of the housing 11 and a cover 22 is provided to close the top of the bowl. The cover may be lifted until the end 23 is accommodated in the longitudinal slot 24. The cover is then held open to provide access to the rotor chamber.
  • the rotor includes a plurality of longitudinal grooves 26 which are provided with slots 27.
  • the longitudinal grooves are spaced so that the rotor is balanced, for example the "ice slots may be equally spaced about the circumference of the rotor.
  • the rotor is locked to the shaft 16 by set screws 28.
  • Each pair of spaced slots 27 accommodates a tube support 31.
  • Each support is provided with a plurality of tube receiving apertures which receive the tubes 32.
  • the open ends of the tubes 32 are provided with a rim 33 which rides against the support 31.
  • the closed end extends outwardly from the support.
  • the tube 32 may be provided with a stopper or closure 34, FIGURE 5, to prevent loss of sample when the rotor is stationary.
  • the holder with tubes is placed in the accommodating slots 27 and the various tubes are disposed, FIGURE 1 for centrifugation. It is observed that, in general, the maximum diameter of the rotor is only slightly greater than the diameter of the circle including the rims of the tubes. Thus, it is apparent that the inertia of the rotor is at a minimum while affording suflicient support for the tubes.
  • the tubes may be readily mounted in the support 31 and that a complete assembly of the tubes and support may be conveniently placed on the rotor for a centrifugation operation.
  • the tubes 32 may be made of plastics and can be rotated at speeds which cause stresses in the tubes which are near the limits of their strength. In the event of failure of the light, plastic tube due to the stresses, there is little hazard to personnel.
  • the bowl 17 is provided to prevent scattering of materials should there be a breakage. Greater fields can be developed using plastic tubes than are available in so-called high speed centrifuges. With metal tubes, the performance of ultra centrifuges can be approached with the apparatus of the present invention while providing short acceleration and deceleration times.
  • the tubes can be easily separated from the support; they are inexpensive and may be disposed after use.
  • the sample tubes 32 may have an internal diameter such that if they are maintained in a horizontal position, the liquid to be operated upon will not flow outwardly from the open end because of surface tension. However, as previously described, if the tubes are of greater diameter, the stoppers 34 are provided for sealing the ends until centrifugation takes place.
  • Such a rotor may be of the type shown in FIGURE 2. That is, the rotor is cup-shaped and adapted to be accommodated on and suitably secured to the driving shaft 16. For example, a set screw 41 may be employed to secure the rotor to the shaft.
  • the rotor is slotted at equally spaced points and is adapted to receive the tube 32. The slots extend from the horizontal portion of the rotor upwardly and have a portion which is vertical.
  • the tube hangs vertically as shown in dotted outline at 42, while after the centrifuge begins to rotate, the tube will achieve a horizontal position as shown at 43.
  • centrifuge rotor which has a diameter exclusive of the centrifuge tubes which is near the minimum radius at which centrifugation in the liquid column occurs.
  • the tubes are provided with rims which serve to support the tubes from a supporting member, for example, a support plate or from a rotor including holes or slots.
  • the rotor has an external diameter only slightly greater than the diameter of a circle including the open end of the tubes.
  • a centrifuge rotor assembly for supporting centrifuge tubes including, a rotor member adapted to rotate about its axis and having formed therein a plurality of symmetrically disposed elongated rectilinear undercut slots in its outer peripheral surface with their longitudinal axes substantially parallel to the axis of the rotor, each of said slots having an axially facing open end, and a plurality of elongated tube supports each having at least one aperture therethrough to receive a centrifuge tube and support the same by its normally open end, said tube supports being removably positioned substantially entirely within said undercut slots through the open ends thereof with said apertures extending generally radially to support said tubes to extend radially outwardly from the rotor member.
  • a centrifuge assembly comprising elongated separation tubes each having an open end and a closed end, said tubes including a laterally extending rim at the normally open end, a rotor member adapted to rotate about its axis and having formed therein a plurality of symmetrically disposed elongated rectilinear undercut slots in its outer peripheral surface with their longitudinal axes substantially parallel to the axis of the rotor, each of said slots having an axially facing open upper end, a plurality of tube supports each having at least one aperture therethrough to receive one of said tubes and support the same from its rim, said tube supports being inser-table into said undercut slots from the upper end thereof to support the same from the rotor member whereby to support tubes to extend radially outwardly from the rotor member.
  • a centrifuge assembly comprising a housing, a centrifuge bowl carried by said housing, a drive motor disposed said housing and having a drive shaft extending into said bowl, a rotor member adapted to rotate about its axis having at least one elongated rectilinear undercut slot in its outer peripheral surface and with its longitudinal axis substantially parallel to the rotor member disposed in said bowl and carried by said drive shaft, said slot having an axially facing open upper end, at least one elongated tube having an open end and a closed end, said tube including a laterally extending rim at its open end, a tube support having at least one aperture, therethrough to receive said tube and support the same solely from the rim, said tube support being insertable within said undercut slot through the upper ends to support the tube to extend radially outwardly from the motor.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Centrifugal Separators (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
US854281A 1957-12-30 1959-11-20 Centrifuge apparatus Expired - Lifetime US3050239A (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
NL109202D NL109202C (ru) 1959-11-20
NL252802D NL252802A (ru) 1959-11-20
US705859A US3009388A (en) 1957-12-30 1957-12-30 Apparatus for determining fluid fractions and sedimentataion rates
US814305A US3071316A (en) 1959-05-19 1959-05-19 Bottle support and cap assembly for centrifuge
US854281A US3050239A (en) 1959-11-20 1959-11-20 Centrifuge apparatus
GB19315/60A GB889082A (en) 1959-11-20 1960-06-01 Centrifuge apparatus
FR830347A FR1259932A (fr) 1959-11-20 1960-06-17 Perfectionnements apportés aux centrifugeuses
DEC34478A DE1256921B (de) 1959-11-20 1964-11-25 Verfahren zur Dichtegradienten-Zentrifugation in einer Ultrazentrifuge und Zentrifuge zur Durchfuehrung des Verfahrens
US509361A US3402883A (en) 1959-11-20 1965-11-23 Method for operating an ultracentrifuge and a suitable centrifuge for said method
GB50115/65A GB1119420A (en) 1959-11-20 1965-11-25 Improvements in and relating to ultracentrifuges
US525771A US3481712A (en) 1959-11-20 1966-02-07 Sediment container and cap and analysis technique
GB48757/66A GB1115297A (en) 1959-11-20 1966-10-31 Sediment container and cap
DE19671598301 DE1598301A1 (de) 1959-11-20 1967-02-01 Sediment-Behaelter fuer Zentrifugen und Kappe fuer derartige Behaelter
US00048386A US3713775A (en) 1959-11-20 1970-06-22 Centrifuge clinical chemistry analysis system
DE2103841A DE2103841C3 (de) 1959-11-20 1971-01-27 Blutuntersuchungsvorrichtung
GB2833172A GB1357232A (en) 1959-11-20 1971-06-01 Centrifuge clinical chemistry analysis
CA114,539A CA940428A (en) 1959-11-20 1971-06-01 Centrifuge clinical chemistry analysis system
FR7122476A FR2096403B1 (ru) 1959-11-20 1971-06-21
GB1828471*[A GB1357231A (en) 1959-11-20 1971-06-22 Test apparatus for use in testing a liquid
AU47751/72A AU468478B2 (en) 1959-11-20 1972-10-13 Centrifuge clinical chemistry analysis system
CA184,119A CA956915A (en) 1959-11-20 1973-10-24 Centrifuge clinical chemistry analysis system

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US854281A US3050239A (en) 1959-11-20 1959-11-20 Centrifuge apparatus
DEC34478A DE1256921B (de) 1959-11-20 1964-11-25 Verfahren zur Dichtegradienten-Zentrifugation in einer Ultrazentrifuge und Zentrifuge zur Durchfuehrung des Verfahrens
US52577166A 1966-02-07 1966-02-07
US4838670A 1970-06-22 1970-06-22
GB1828471*[A GB1357231A (en) 1959-11-20 1971-06-22 Test apparatus for use in testing a liquid
AU47751/72A AU468478B2 (en) 1959-11-20 1972-10-13 Centrifuge clinical chemistry analysis system

Publications (1)

Publication Number Publication Date
US3050239A true US3050239A (en) 1962-08-21

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
US854281A Expired - Lifetime US3050239A (en) 1957-12-30 1959-11-20 Centrifuge apparatus
US509361A Expired - Lifetime US3402883A (en) 1959-11-20 1965-11-23 Method for operating an ultracentrifuge and a suitable centrifuge for said method
US525771A Expired - Lifetime US3481712A (en) 1959-11-20 1966-02-07 Sediment container and cap and analysis technique
US00048386A Expired - Lifetime US3713775A (en) 1959-11-20 1970-06-22 Centrifuge clinical chemistry analysis system

Family Applications After (3)

Application Number Title Priority Date Filing Date
US509361A Expired - Lifetime US3402883A (en) 1959-11-20 1965-11-23 Method for operating an ultracentrifuge and a suitable centrifuge for said method
US525771A Expired - Lifetime US3481712A (en) 1959-11-20 1966-02-07 Sediment container and cap and analysis technique
US00048386A Expired - Lifetime US3713775A (en) 1959-11-20 1970-06-22 Centrifuge clinical chemistry analysis system

Country Status (7)

Country Link
US (4) US3050239A (ru)
AU (1) AU468478B2 (ru)
CA (1) CA940428A (ru)
DE (3) DE1256921B (ru)
FR (1) FR2096403B1 (ru)
GB (5) GB889082A (ru)
NL (2) NL252802A (ru)

Cited By (45)

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US3498532A (en) * 1967-06-19 1970-03-03 Mse Holdings Ltd Zonal centrifuge attachment
US3713775A (en) * 1959-11-20 1973-01-30 Bio Dynamics Inc Centrifuge clinical chemistry analysis system
US3891140A (en) * 1974-02-27 1975-06-24 Becton Dickinson Co Centrifuge
US4135883A (en) * 1977-08-29 1979-01-23 Bio-Dynamics Inc. Blood analyzer system
US4306676A (en) * 1980-04-17 1981-12-22 Beckman Instruments, Inc. Tube holder for centrifuge rotor
US4341342A (en) * 1980-12-04 1982-07-27 Kabushiki Kaisha Kubota Seisakusho Centrifuge
US4375272A (en) * 1981-07-01 1983-03-01 Beckman Instruments, Inc. Fixed angle tube carrier
US4484907A (en) * 1983-10-20 1984-11-27 E. I. Du Pont De Nemours And Company Microtube adapter having a holding and uncapping apparatus
EP0137293A2 (en) * 1983-09-09 1985-04-17 E.I. Du Pont De Nemours And Company Centrifuge rotor having a retaining arrangement thereon
WO1985005569A1 (en) * 1984-06-04 1985-12-19 Beckman Instruments, Inc. Centrifuge rotor and method of assembly
WO1986005718A1 (en) * 1985-04-03 1986-10-09 Beckman Instruments, Inc. Split tube centrifuge rotor adapter
US4696666A (en) * 1986-07-18 1987-09-29 Rice Jr Richard D Centrifuge machine and rotor
US5295943A (en) * 1989-11-07 1994-03-22 E. I. Du Pont De Nemours And Company Adapter for holding a pair of centrifuge tubes
US6001310A (en) * 1996-10-11 1999-12-14 Shaffer; John V. Pliable centrifuge tube array
US6045494A (en) * 1996-07-09 2000-04-04 Tomy Seiko Co., Ltd. Centrifugal separating method and centrifugal machine
US6190300B1 (en) * 2000-03-10 2001-02-20 Labnet International Inc. Centrifuge rotor adapted for use with centrifuge tube strips
USD735881S1 (en) 2012-10-22 2015-08-04 Qiagen Gaithersburg, Inc. Tube strip holder for automated processing systems
US9135515B2 (en) 2012-10-22 2015-09-15 Qiagen Gaithersburg, Inc. Automated pelletized sample vision inspection apparatus and methods
US9180461B2 (en) 2012-10-22 2015-11-10 Qiagen Gaithersburg, Inc. Condensation-reducing incubation cover
US9212976B2 (en) 2013-03-15 2015-12-15 Qiagen Gaithersburg, Inc. Vision-guided aspiration apparatus and methods
US9260763B2 (en) 2012-10-22 2016-02-16 Qiagen Gaithersburg, Inc. Sample processing method using tube strips and tube strip holder
US9310281B2 (en) 2012-10-22 2016-04-12 Qiagen Gaithersburg, Inc. Automated pelletized sample blotting apparatus and methods
US9435718B2 (en) 2012-10-22 2016-09-06 Qiagen Gaithersburg, Inc. Automated pelletized sample decanting apparatus and methods
US9873921B2 (en) 2012-10-22 2018-01-23 Qiagen Gaithersburg, Inc. Ultrasonic biological sample analysis apparatus and methods
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US10071376B2 (en) 2007-07-13 2018-09-11 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
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US10179910B2 (en) 2007-07-13 2019-01-15 Handylab, Inc. Rack for sample tubes and reagent holders
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US10571935B2 (en) 2001-03-28 2020-02-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US10619191B2 (en) 2001-03-28 2020-04-14 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US10695764B2 (en) 2006-03-24 2020-06-30 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10710069B2 (en) 2006-11-14 2020-07-14 Handylab, Inc. Microfluidic valve and method of making same
US10731201B2 (en) 2003-07-31 2020-08-04 Handylab, Inc. Processing particle-containing samples
US10781482B2 (en) 2011-04-15 2020-09-22 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
US10799862B2 (en) 2006-03-24 2020-10-13 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US10822644B2 (en) 2012-02-03 2020-11-03 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11142785B2 (en) 2006-03-24 2021-10-12 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11453906B2 (en) 2011-11-04 2022-09-27 Handylab, Inc. Multiplexed diagnostic detection apparatus and methods
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system

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US3881627A (en) * 1973-05-09 1975-05-06 Ethyl Dev Corp Vial container and closure
US3982895A (en) * 1973-05-24 1976-09-28 Corning Glass Works Blood smeared slide centrifuge
US3906890A (en) * 1973-05-24 1975-09-23 Corning Glass Works Blood smeared slide centrifuge
US3902477A (en) * 1973-09-26 1975-09-02 Becton Dickinson Co Blood specimen container
CH589319A5 (ru) * 1974-11-29 1977-06-30 Hoffmann La Roche
CH587486A5 (ru) * 1974-11-29 1977-05-13 Hoffmann La Roche
US4074824A (en) * 1975-12-03 1978-02-21 Kontes Glass Company Container for storage and shipment of chemical standards, radioactive isotopes and the like
US4119407A (en) * 1976-03-08 1978-10-10 Bio-Dynamics, Inc. Cuvette with reagent release means
US4105415A (en) * 1976-04-21 1978-08-08 Lovett Wayne D Multi-purpose test tube
US4124965A (en) * 1976-08-13 1978-11-14 Bio-Dynamics Inc. Method for production of centrifugal release bag
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Publication number Publication date
GB1119420A (en) 1968-07-10
US3402883A (en) 1968-09-24
GB1357231A (en) 1974-06-19
NL252802A (ru)
GB1115297A (en) 1968-05-29
DE1256921B (de) 1967-12-21
CA940428A (en) 1974-01-22
DE2103841B2 (de) 1973-06-20
DE1598301A1 (de) 1970-12-10
DE2103841C3 (de) 1974-01-17
AU468478B2 (en) 1976-01-15
DE2103841A1 (de) 1972-02-10
AU4775172A (en) 1974-04-26
US3713775A (en) 1973-01-30
US3481712A (en) 1969-12-02
FR2096403B1 (ru) 1977-01-21
NL109202C (ru)
FR2096403A1 (ru) 1972-02-18
GB1357232A (en) 1974-06-19
GB889082A (en) 1962-02-07

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