US20220339458A2 - Method for adjusting an apparatus for the treatment using nuclear spin resonances - Google Patents

Method for adjusting an apparatus for the treatment using nuclear spin resonances Download PDF

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US20220339458A2
US20220339458A2 US16/628,646 US201816628646A US2022339458A2 US 20220339458 A2 US20220339458 A2 US 20220339458A2 US 201816628646 A US201816628646 A US 201816628646A US 2022339458 A2 US2022339458 A2 US 2022339458A2
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magnetic resonances
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resonances
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Axel Muntermann
Margit Egg
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531—Measuring skin impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4806—Sleep evaluation
    • A61B5/4812—Detecting sleep stages or cycles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2529/00—Culture process characterised by the use of electromagnetic stimulation

Definitions

  • the invention relates to a method for adjustment, selective control, value acquisition, readjustment and in particular calibration of an apparatus for treatment using nuclear magnetic resonances.
  • the invention also relates to an apparatus for treatment using nuclear magnetic resonance, to a treatment system, and to the use of nuclear magnetic resonances in particular for therapeutic and cosmetic purposes.
  • the therapy apparatuses operated under the trade name MBST® are apparatuses in which, in the treatment zone, a magnetic field having a homogeneous field strength is superimposed by a perpendicularly irradiated alternating field in order to achieve nuclear magnetic resonances in the treatment zone.
  • Nuclear magnetic resonances can be generated in the treatment zone by appropriately tuning the frequency of the alternating field to the field strength of the perpendicular homogeneous field.
  • the field strength of the homogeneous magnetic field is modulated with a modulation frequency f m and is thus composed of a basic magnitude and a varying modulation magnitude. Due to the modulation, Larmor condition is achieved once per cycle, so that nuclear magnetic resonances are generated cyclically in the treatment volume.
  • AFP Adiabatic Fast Passage
  • a receiver coil with electronic monitoring electronics introduced into the treatment unit can be used to optically and acoustically monitor the proper functioning of the nuclear magnetic resonance treatment field, the treatment parameters, compensation of influencing interfering factors such as metals in the treatment area, changes in the field strength and intensity of the energy dose introduced into the body, the required resonance conditions, and other predetermined important test parameters to use them for readjustment processes with regard to quality, effectiveness and safety.
  • the treatment using nuclear magnetic resonances permits to achieve cosmetic effects, for example in the treatment of connective tissue weakness of the skin and cellulite, as well as therapeutic effects in all areas of disturbed or degenerative cell functions within the range of the joints of the bones, the organs, ligaments, muscles, tendons, both in postoperative wound healing, in skin burns, metabolic or circulatory disorder related to the bone, fracture healing, etc., as well as in other regenerative areas.
  • the body's own signals and electrical processes are becoming increasingly important in science.
  • the most original signal is, for example, the ECG or the EEG.
  • the decisive factor for a targeted treatment success using nuclear magnetic resonance is the precise determination of the cell resonance window of the individual cell groups to be regenerated.
  • the MBST® therapy systems operate at lower field strengths than the imaging nuclear magnetic resonance tomography apparatuses used for diagnosis. However, surprisingly, it has been found that good treatment successes can be achieved precisely with this type of systems which work at low field strengths.
  • the efficacy of the treatment also depends, inter alia, on the modulation frequency of the homogeneous field, the number of treatments, the duration of treatment, and on the intervals, that is the time period between multiple treatments.
  • the invention is based on the object to provide a method for adjusting an apparatus for treatment using nuclear magnetic resonances, in particular in terms of targeted control, value acquisition, readjustment and calibration, which allows to set the parameters of the apparatus more precisely in a simpler and more effective way, depending on the indication.
  • the object of the invention is already achieved by a method for adjusting, in particular calibrating an apparatus for treatment using nuclear magnetic resonances, by a treatment system, and by the use of nuclear magnetic resonances according to any one of the independent claims.
  • the invention relates to a method for adjusting, in particular for selective control, value acquisition, readjustment, and in particular a method for calibrating an apparatus for treatment using nuclear magnetic resonances.
  • the invention in particular relates to apparatuses for generating nuclear magnetic resonances which generate magnetic fields with a field strength of less than 50 Gauss, most preferably less than 30 Gauss, and modulation frequencies f m of less than 100 Hz.
  • the frequency of the perpendicularly irradiated alternating field is preferably less than 100 kHz and most preferably less than 50 kHz.
  • the modulation frequency f m is preferably between 1 and 100 Hz.
  • the influence of the treatment using nuclear magnetic resonances on the cellular clock of a user and/or on the chronotype of a user is determined, and the apparatus for treatment using nuclear magnetic resonances is adjusted on the basis of this determination.
  • the invention it is also possible to expose a human cell culture or a cell culture of animal origin to a treatment with nuclear magnetic resonances, and the influence of the treatment with nuclear magnetic resonances on the cellular clock of the cells of the cell culture is determined.
  • cell cultures of human origin such as liver cells or cartilage cells can be used.
  • the influence of the treatment with nuclear magnetic resonances on the circadian clock of the respective cell type is determined.
  • the parameters used for executing the treatment are varied, and the parameters for the treatment are set as a function of their influence on the circadian clock.
  • the circadian clock is structured hierarchically and includes a region that is located in the hypothalamus, known as suprachiasmatic nucleus (SCN), as well as peripheral clocks that are organ-specific and/or tissue-specific, and cellular clocks that are present in all cells of an organism and which are coordinated by the SCN together with the peripheral clocks.
  • SCN suprachiasmatic nucleus
  • peripheral clocks that are organ-specific and/or tissue-specific, and cellular clocks that are present in all cells of an organism and which are coordinated by the SCN together with the peripheral clocks.
  • the synchronization of the internal clock with the external day/night rhythm occurs mainly via the information from light photons which are transmitted to the SCN through the retina of the eye and cause both neuronal and humoral changes there.
  • many physiological processes are regulated in a circadian manner.
  • Circadian rhythms synchronized with the external day/night rhythm are an advantage for the organism, and prolonged disturbances of this synchronization (caused by shift work, jet lag, or sleep disorders) contribute to the development of a whole range of diseases, such as cardiovascular diseases, hormone-induced tumors, diabetes, obesity, but also pain and inflammatory diseases such as arthrosis.
  • the simplified molecular mechanism of the cellular circadian clock consists of several feedback loops, of which the central feedback loop is described below:
  • Period Period
  • Cryptochrome Cryptochrome
  • clock genes clock1, bmal1, per1, per2, cry1, and cry2.
  • hypoxia signal path On the molecular level, the hypoxia signal path is closely intertwined with the internal clock, for example in zebrafish as well as in mammals. So, since the two signal paths are obviously very conserved processes, it is also permissible to draw conclusions about an existing interaction of both signal paths in humans.
  • the hypoxia signal path also plays a central role in numerous human diseases, like the circadian clock.
  • diseases associated with reduced oxygen saturation in the tissue can be mentioned here, such as e.g. heart attack or stroke, or else diseases where reduced oxygen saturation is required under normal physiological conditions, such as in joints.
  • osteoarthritis should be mentioned here and, in fact, the importance of the hypoxia signaling pathway for the development and progression of osteoarthritis has been investigated and described several times.
  • the biologically necessary proteins that regulate and coordinate cell metabolism under hypoxia are transcription factors from the group of hypoxia-inducible factors (Hif), the most important representative thereof being Hif-1 ⁇ .
  • ROS free oxygen radicals
  • FIGS. 3 , A and B On the hif-1 ⁇ protein level, a clear synchronization effect of the nuclear magnetic resonances to the circadian rhythm of the protein can be found in the cell culture ( FIGS. 3 , A and B), which occurs both with a single 4-hour treatment and also with four repetitions of a one-hour treatment. Furthermore, the amount of oxidized peroxiredoxin (PRX), free oxygen radicals, and HIF-1 protein ( FIGS. 4 , A, B, and C) are regulated in the same direction, in the present case reduced, as a function of day time and of dose.
  • PRX oxidized peroxiredoxin
  • free oxygen radicals free oxygen radicals
  • HIF-1 protein FIGS. 4 , A, B, and C
  • a microcomputer chip card can be used to enter stored treatment sequences into the control unit via a chip card reader, and to ensure precise and correct execution of the nuclear magnetic resonance treatment.
  • a plurality of optional successive treatment time intervals which can be stored on the chip card, for example, ensure optimum control specifications for the treatment apparatus.
  • the sequences on the microcomputer chip card, the treatment procedure, and the treatment time can be selectively changed to initiate the resonance effects during the treatment time. This is crucial for triggering the resynchronization of the circadian clock of the cells.
  • a receiver coil introduced into the treatment unit and including electronic monitoring electronics can be used to optically and acoustically monitor the proper operation of the nuclear magnetic resonance treatment field, treatment parameters, changes in field strength and intensity, the energy dose introduced into the body, the required resonance conditions, and other predetermined decisive verification parameters, and can be used for readjustment processes in terms of quality, effectiveness and safety.
  • This readjustment for optimizing the treatment parameters may be implemented through a feedback loop.
  • Further monitoring electronics measure and monitor temperature changes in the area of the skin in order to identify metabolic changes and to consider them in the control and monitoring process of the control electronics of the treatment procedure, as optimization parameters.
  • the apparatus may in particular be parameterized and used in a way so as to achieve synchronization of the cellular circadian clock. This improves the effectiveness of a treatment, in particular the effectiveness of a treatment for osteoarthritis patients.
  • the time of treatment, the duration of treatment, the treatment interval, i.e. the time period between treatments, a modulation frequency of a field for an adiabatic cycle and/or a field strength of a magnetic field generated by the apparatus for treatment with magnetic fields are adjusted as a function of the respective phase of the cellular clock.
  • treatment is performed in a 12-hour or 24-hour rhythm+/ ⁇ 2 hours according to one embodiment of the invention.
  • Other treatment intervals are also possible.
  • the apparatus used for this purpose preferably includes a memory which stores parameterization data such as treatment duration, modulation frequency f m , and/or treatment interval as well as patient data.
  • a treatment plan may be stored in the apparatus, so that the apparatus will only perform a treatment if this is performed in compliance with the stored treatment plan.
  • the individual circadian clock, i.e. the chronotype, of the user is taken into account for calibration of the apparatus.
  • Particularly suitable for this purpose are the measurement of body temperature, heart rate, skin resistance, and/or blood pressure over a period of preferably at least 24, more preferably at least 48 hours, to represent the individual circadian clock of the user.
  • the treatment intervals and/or the optimum day time of the treatment can be determined on this basis.
  • the invention furthermore relates to an apparatus for treatment using nuclear magnetic resonances, which is adjusted by the method described above.
  • the invention moreover relates to a treatment system comprising an apparatus for treatment using nuclear magnetic resonances.
  • the treatment system comprises means for determining the chronotype of a user, in particular a sensor.
  • the senor is configured for measuring the body temperature, blood pressure, skin resistance, and/or heart rate of a user.
  • a combined sensor which measures body temperature, skin resistance, and heart rate over a period of at least 24 hours, preferably at least 48 hours.
  • the skin resistance is measured over this period of time, preferably exclusively.
  • Vidacek et al Personality differences in the phase of the circadian rhythms: a comparison of morningness and extraversion, ERGONOMICS 1988, Vol. 31, No. 6, 873-888, from which it is known that the skin resistance alone can be used to determine the chronotype.
  • the chronotype may be calculated in an external unit in which the sensor is arranged, or in the control unit of the apparatus for generating nuclear magnetic resonances, or in another external computer unit.
  • control unit of the apparatus for generating nuclear magnetic resonances is provided with information about the chronotype of the user.
  • the senor transmits data to a control unit of the apparatus in a wireless manner.
  • the data measured in an external unit comprising the sensor are stored, and are transferred, in particular to a control unit of the apparatus, by connecting the external unit thereto.
  • the information about the chronotype of the users may be stored in an external memory, but also in a memory of the control unit of the apparatus for treatment using nuclear magnetic resonances.
  • the apparatus for generating nuclear magnetic resonances is preferably controlled through a removable memory, in particular through a complex microprocessor chip card that includes a memory. This is used to initiate the biological processes of retriggering the circadian clock, via a plurality of programmable program steps with modifiable timing.
  • the treatment procedure is preferably automated and runs through a plurality of program steps with predefined timing.
  • the treatment data and treatment times are preferably buffered in the control unit in order to allow to continue the treatment without treatment gaps or corruption in the event of a power failure.
  • the biological and electrical patient data are measured by means of sensors prior to the therapy on the patient, are stored and then used directly for the treatment process as a reference or treatment basis, or are entered into the control unit before starting the therapy.
  • the individual circadian clock of the user can be taken into account, via the data from the sensor.
  • treatment time, treatment duration, treatment intervals, and/or the modulation frequency f m may be predetermined as a function of the data transferred from the sensor.
  • the invention relates to the use of nuclear magnetic resonances for synchronizing and/or re-clocking the circadian clock of the cells of a user. It has been found that in particular the period1 and cryptochrome1 mRNA oscillations can be shifted in their phases by a selective nuclear magnetic resonance treatment to thereby synchronize the circadian clock. Furthermore, the circadian oscillation of HIF-1a protein at cell level is also synchronized by nuclear magnetic resonances. Moreover, time- and dose-dependent changes can be produced in HIF-1, PRX, and in the amount of free oxygen radicals; the significance of this for human pathophysiology has already been mentioned (cf. above).
  • nuclear magnetic resonances relates to an exclusively cosmetic treatment, in particular the treatment of cellulite, as well as to a therapeutic, in particular postoperative treatment.
  • the nuclear magnetic resonance method can be applied very efficiently and highly effectively in any context of disturbed or degenerative cell functions in the area of the joints of the bones, of organs, ligaments, muscles, tendons, in postoperative wound healing, skin burns, metabolism or circulatory disorder in the area of the bone, fracture healing, etc., as well as in other regenerative areas.
  • the parameters of the treatment using nuclear magnetic resonances are set or entered in such a way that a maximum phase shift or a minimum phase shift, or the best possible synchronization of the circadian clock is resulting.
  • FIGS. 1 to 5 The subject-matter of the invention will now be explained in more detail with reference to the drawings of FIGS. 1 to 5 .
  • FIG. 1 shows the number of mRNA copies of representative genes from the central feedback loop of the internal clock, plotted over time, representing the oscillation of the internal clock. Shown are the oscillations of cryptochrome1, period1, period2, and clock1. A comparison is shown of oscillations between sham-treated cells and those treated with nuclear magnetic resonances for one hour on four consecutive days at the same time in each case. The phase shift can be clearly seen, it is significant for the period1 and cryptochrome1 genes, (cosinor fit analysis, GraphPad Prism 6.0)
  • FIG. 2 shows the changes in mRNA concentrations of hif-1 ⁇ and hif-3 ⁇ from the hypoxia signaling pathway between sham-treated cells and those treated with nuclear magnetic resonances for one hour on four consecutive days at the same time (A and E), and the selective synchronization of mRNA oscillations of hif-1 ⁇ and hif-3 ⁇ in whole zebrafish larvae according to the same treatment scheme (B and F), while hif-2 ⁇ remains unaffected both in cells and in whole zebrafish larvae ( FIGS. 2 , C and D).
  • FIG. 3 shows the synchronization of the circadian hif-1 protein oscillations in zebrafish cells achieved by nuclear magnetic resonances, on the one hand after a one-hour treatment that was repeated four times (A), on the other after a single four-hour treatment (B).
  • FIG. 4 shows the reduced and dose-dependent amounts of oxidized peroxiredoxin (A), free oxygen radicals (B), and hif-1 ⁇ protein (C).
  • a 4-hour treatment leads to a reduction in the amount of protein and the amount of free oxygen radicals, respectively, compared to a treatment of only one hour.
  • FIG. 5 is a schematic flowchart of a method for adjusting an apparatus for treatment using nuclear magnetic resonances.
  • FIG. 6 is a schematic view of an apparatus for treatment using nuclear magnetic resonances.
  • the x-axis represents the day time and the y-axis represents the specific number of mRNA copies based on 16 ng of total RNA.
  • a sham-treated control group is compared to a cell culture that was treated with an MBST® therapy apparatus on four consecutive days for one hour in each case. The treatment was carried out at the same time of day.
  • a cell culture of zebrafish fibroblasts was used for this purpose.
  • FIG. 1 shows the mRNA oscillations of the genes cryptochrome1, period1, period2, and clock1.
  • FIG. 2 shows the mRNA quantities of the genes hif-1 ⁇ , hif-2 ⁇ , and hif-3 ⁇ over the course of the day.
  • isoforms hif-1 ⁇ and hif-3 ⁇ are selectively controlled by nuclear magnetic resonances, on cell level (A and E) as well as in the whole organism (B and F), while hif-2 ⁇ remains unaffected both in cells and in whole zebrafish larvae.
  • FIG. 3 shows the quantities of hif-1 ⁇ protein of cells over the course of the day. It can be seen that nuclear magnetic resonances cause a synchronization of the circadian rhythm of hif-1 ⁇ protein expression in both treatment variants (four times one hour [A]—compared to a single treatment over four hours [B]).
  • FIG. 4 shows a dependence of the effect of nuclear magnetic resonances on the dose: only a 4-hour single treatment shows a significant reduction in the quantities of oxidized Prx (A), free oxygen radicals (B), and hif-1 ⁇ (C), in contrast to a single treatment of only one hour.
  • FIG. 5 is a flowchart of a method for adjusting an apparatus for treatment using nuclear magnetic resonances according to an exemplary embodiment of the invention.
  • the phase of the internal clock of the patient is determined through skin resistance, blood pressure, body temperature, and/or heart rate, i.e. the individual chronotype is determined.
  • the treatment duration, time interval of a sequence of treatments, day time window for treatment, and/or modulation frequency f m of the apparatus for treatment using nuclear magnetic resonances are set as a function of the chronotype.
  • a plurality of treatments are executed. These may be therapeutic treatments or else cosmetic treatments.
  • FIG. 6 is a schematic view of a system 6 according to the invention for treating a user with nuclear magnetic resonances.
  • the system 6 comprises an apparatus 1 for generating nuclear magnetic resonances in a tissue to be treated.
  • the apparatus 1 shown schematically here, comprises coils 2 and 3 which face each other in a Helmholtz arrangement and which are used to generate a homogeneous magnetic field that extends along the direction of the indicated x-axis.
  • an alternating magnetic field is irradiated by coil 4 , perpendicular to the homogeneous magnetic field generated by coils 2 and 3 .
  • the homogeneous field generated by coils 2 and 3 is composed of a basic magnitude and a modulation magnitude which is modulated by modulation frequency f m , for example in a rectangular shape.
  • the resonance condition is generated at least once during each cycle within the treatment volume.
  • the apparatus 1 comprises a memory which stores user data, data on the duration of treatment, the treatment interval and the modulation frequency f m .
  • the time window of the treatment, treatment duration, treatment interval, and/or modulation frequency are performed as a function of the chronotype of the person to be treated.
  • the system 6 comprises means for determining the chronotype of the user.
  • this is a sensor 5 which forms part of an external unit that can be attached to the user and transfers data to a control unit of the apparatus 1 , preferably in a wireless manner. This may also be achieved via the Internet, for example.
  • the senor 5 is able to measure heart rate, body temperature, or skin resistance over a period of at least 24 hours. On the basis of the measured values, the chronotype of the respective user is determined.
  • a treatment profile with optimized treatment parameters can now be established, preferably automatically by the control unit of the apparatus.
  • the apparatus 1 preferably comprises an apparatus control unit which also includes the memory with the aforementioned data, and the control unit of the apparatus calculates optimized treatment parameters preferably automatically, for example on the basis of a calculation program or on the basis of a database, and stores them in the memory in association with the respective user data.
  • the setting of the parameters of the treatment apparatus on the basis thereof allows to improve, in a simple way, the effectiveness of the treatment with nuclear magnetic resonances.
  • a microcomputer chip card is used to enter the stored treatment sequences into the control unit, via a chip card reader, which ensures the targeted and proper execution of the MBST® nuclear magnetic resonance treatment.
  • the sequences on the microcomputer chip card, the treatment procedure, and the treatment time can be selectively modified, verified and readjusted in order to initiate the resonance effects during the treatment duration.

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Application Number Priority Date Filing Date Title
DE102017114856.6A DE102017114856B4 (de) 2017-07-04 2017-07-04 Verfahren zur Einstellung eines Gerätes zur Behandlung mit Kernspinresonanzen
DE102017114856.6 2017-07-04
PCT/EP2018/067839 WO2019007912A1 (de) 2017-07-04 2018-07-02 Verfahren zur einstellung eines gerätes zur behandlung mit kernspinresonanzen

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