US20120271225A1 - Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma - Google Patents

Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma Download PDF

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Publication number
US20120271225A1
US20120271225A1 US13/392,221 US201013392221A US2012271225A1 US 20120271225 A1 US20120271225 A1 US 20120271225A1 US 201013392221 A US201013392221 A US 201013392221A US 2012271225 A1 US2012271225 A1 US 2012271225A1
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US
United States
Prior art keywords
flexible
plasma
electrode
dielectric
atmospheric pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/392,221
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English (en)
Inventor
Manfred Stieber
Klaus-Dieter Weltmann
Stefan Horn
Ronny Brandenburg
Thomas Von Woedtke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INP GREIFSWALD LEIBNIZ-INSTITUT fur PLASMAFORSCHUNG und TECHNOLOGIE EV
INP Greifswald Leibniz Institut fur Plasmaforschung und Technologie eV
Original Assignee
Neoplas GmbH
INP Greifswald Leibniz Institut fur Plasmaforschung und Technologie eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neoplas GmbH, INP Greifswald Leibniz Institut fur Plasmaforschung und Technologie eV filed Critical Neoplas GmbH
Assigned to NEOPLAS GMBH, INP GREIFSWALD LEIBNIZ-INSTITUT FUER PLASMAFORSCHUNG UND TECHNOLOGIE E.V. reassignment NEOPLAS GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: STIEBER, MANFRED, WELTMANN, KLAUS-DIETER, VON WOEDTKE, THOMAS, HORN, STEFAN, BRANDENBURG, RONNY
Publication of US20120271225A1 publication Critical patent/US20120271225A1/en
Assigned to INP GREIFSWALD LEIBNIZ-INSTITUT FUER PLASMAFORSCHUNG UND TECHNOLOGIE E.V. reassignment INP GREIFSWALD LEIBNIZ-INSTITUT FUER PLASMAFORSCHUNG UND TECHNOLOGIE E.V. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NEOPLAS GMBH
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/042—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating using additional gas becoming plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • H05H1/2439—Surface discharges, e.g. air flow control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A61B2018/00583—Coblation, i.e. ablation using a cold plasma
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2240/00—Testing
    • H05H2240/20—Non-thermal plasma
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/32—Surgery, e.g. scalpels, blades or bistoury; Treatments inside the body
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/34—Skin treatments, e.g. disinfection or wound treatment

Definitions

  • the invention relates to a device for surface treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric-pressure plasma.
  • the centerpiece of the device is a special electrode arrangement for generating a dielectric barrier surface discharge, which can be applied flexibly onto arbitrarily curved surfaces.
  • this invention it is possible to generate, in the region of diseased skin or mucous membrane parts of the human body, in the immediate proximity of the skin or mucous membrane surface or of wounds, a superficial plasma for treatment of diseased areas, which plasma is safe as regards the stress on the skin or mucous membrane due to temperature and electrical voltages.
  • plasma technology for applications of this type is rated as sufficiently important that an independent discipline known as plasma medicine is now beginning to develop on the international front.
  • plasma-based therapeutic approaches of this type can be systematically developed and employed, suitable plasma sources are needed that on the one hand work painlessly and ensure that the tissue to be treated is not harmed by temperature, desiccation or electrical voltages, and on the other hand can be used flexibly for large-area applications for various body regions under variable plasma conditions.
  • Devices for plasma treatment of living tissue with non-thermal atmospheric plasmas have been proposed in several publications (DE 3618412 A1, WO 2004/105810 A1, WO 2006/116252 A2).
  • the devices described in these publications are equipped with rigid electrode systems or nozzles for generation of atmospheric-pressure plasmas in the region of the tissue surfaces to be treated, and so they permit only local treatment of relatively small areas.
  • the object of the invention was to find a technical solution for generation of a superficial plasma that makes it possible to treat relatively large areas of body parts, especially of arbitrarily curved areas of human or animal skin or mucous membrane.
  • an electrode system for generating a dielectric barrier surface discharge is provided that on the one hand is composed of flexible materials, so that it can be conformed to curved surfaces, and on the other hand has an outer, electrically conductive surface, which is used as a grounded electrode and is structured in such a way that dielectric barrier surface discharges can form in the interstices of the structure that remain open.
  • a substantial advantage of the invention that is important especially for wound healing is the fact among others that, because of the design as a cuff that conforms to the body, the treated area is covered and thus is protected from desiccation, whereby the moist environment necessary according to the prior art for wound healing is better assured than during the application of open, rigid electrode systems with a gas flow that may be necessary.
  • the design as a DBD (dielectric barrier discharge) without or with a small gas flow also counteracts the danger of desiccation.
  • the elastic electrode system can also be configured as a shapeable (inflatable) volume (for example, as a silicone ball), in such a way that treatments on the one hand of the mucous membrane surfaces of body cavities and on the other hand of arbitrarily shaped skin or mucous membrane areas can be performed with the plasma generated on the inner or outer surface of this electrode system.
  • a shapeable (inflatable) volume for example, as a silicone ball
  • This arrangement offers the possibility of a combination with catheters, endoscopes and surgical instruments. It works both at atmospheric pressure and at slight overpressure or underpressure, with use of different gases or gas mixtures, if appropriate in combination with the transport of active substances, and is usable for diverse applications toward decontamination, sterilization, antisepsis, wound healing, etc., both in medicine and in other areas of the life sciences. Slight overpressure or underpressure means that only minor deviations from atmospheric pressure are involved here.
  • Subject matter of the invention is also a method for treating areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric-pressure plasma.
  • the inventive method consists in the fact that an electrode system of flexible materials for generating a dielectric barrier surface discharge is provided, so that it can be conformed to curved surfaces, and that the electrode system has an outer, electrically conductive surface, which is used and structured as a grounded electrode, wherein a dielectric barrier surface discharge is generated in the interstices of the structure that remain open.
  • the elastic materials for electrodes and dielectric into a surface with a closed volume, preferably a silicone balloon, and to ignite a plasma both on the inside of the hollow body and on the outside.
  • FIGS. 1 and 2 show the basic structure of the inventive device. Of those, FIG. 2 is the assembled planar electrode arrangement while FIG. 1 represents an exploded view of this arrangement for demonstration purposes.
  • FIG. 3 shows an exemplary embodiment in curved form with a gas port for the optional supply of a process gas
  • FIG. 4 shows an exemplary embodiment of an arm cuff.
  • the basic structure of an electrode system configured as a shapeable silicone ball is schematically illustrated in FIG. 5
  • the application of such an inflatable plasma source for treating the inner surface of body cavities in combination with an endoscope is schematically illustrated in FIGS. 6 a and 6 b.
  • Flexible insulating material such as elastomer, silicone film
  • Flexible high-voltage electrode such as metal gauze, metal foil, electrically conductive elastomer

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Surgical Instruments (AREA)
  • Plasma Technology (AREA)
  • Electrotherapy Devices (AREA)
  • Materials For Medical Uses (AREA)
US13/392,221 2009-08-25 2010-07-27 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma Abandoned US20120271225A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE202009011521U DE202009011521U1 (de) 2009-08-25 2009-08-25 Plasma-Manschette
DE202009011521.6 2009-08-25
PCT/EP2010/060859 WO2011023478A1 (de) 2009-08-25 2010-07-27 Vorrichtung zur flächigen behandlung von bereichen menschlicher oder tierischer haut- bzw. schleimhautoberflächen mittels eines kalten atmosphärendruckplasmas

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/060859 A-371-Of-International WO2011023478A1 (de) 2009-08-25 2010-07-27 Vorrichtung zur flächigen behandlung von bereichen menschlicher oder tierischer haut- bzw. schleimhautoberflächen mittels eines kalten atmosphärendruckplasmas

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/732,387 Continuation US10265116B2 (en) 2009-08-25 2015-06-05 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma

Publications (1)

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US20120271225A1 true US20120271225A1 (en) 2012-10-25

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Family Applications (3)

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US13/392,221 Abandoned US20120271225A1 (en) 2009-08-25 2010-07-27 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma
US14/732,387 Active 2032-01-07 US10265116B2 (en) 2009-08-25 2015-06-05 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma
US16/285,254 Active 2030-09-30 US11006995B2 (en) 2009-08-25 2019-02-26 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma

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US14/732,387 Active 2032-01-07 US10265116B2 (en) 2009-08-25 2015-06-05 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma
US16/285,254 Active 2030-09-30 US11006995B2 (en) 2009-08-25 2019-02-26 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma

Country Status (5)

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US (3) US20120271225A1 (de)
EP (1) EP2471348B1 (de)
DE (1) DE202009011521U1 (de)
ES (1) ES2759001T3 (de)
WO (1) WO2011023478A1 (de)

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JP2016509741A (ja) * 2013-01-15 2016-03-31 シノギー・ゲーエムベーハーＣＩＮＯＧＹ ＧｍｂＨ ハンドルケーシングに回転自在に取り付けられたローラを有するプラズマ処理装置
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US10265116B2 (en) 2019-04-23
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