US20120221121A1 - Bone fixated, articulated joint load control device - Google Patents
Bone fixated, articulated joint load control device Download PDFInfo
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- US20120221121A1 US20120221121A1 US13/467,931 US201213467931A US2012221121A1 US 20120221121 A1 US20120221121 A1 US 20120221121A1 US 201213467931 A US201213467931 A US 201213467931A US 2012221121 A1 US2012221121 A1 US 2012221121A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
- A61B17/64—Devices extending alongside the bones to be positioned
- A61B17/6425—Devices extending alongside the bones to be positioned specially adapted to be fitted across a bone joint
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
- A61B17/64—Devices extending alongside the bones to be positioned
- A61B17/6416—Devices extending alongside the bones to be positioned with non-continuous, e.g. hinged, pin-clamp connecting element
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
- A61B17/64—Devices extending alongside the bones to be positioned
- A61B17/6441—Bilateral fixators, i.e. with both ends of pins or wires clamped
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
- A61B2017/606—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors with resilient spring element
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Abstract
A load control device can be attached to bones on either side of an articulated joint in order to control the forces and loads experienced by the joint. The device comprises an apparatus for controlling the load on articular cartilage of a human or animal joint and includes: a first fixation assembly for attachment to a first bone; a second fixation assembly for attachment to a second bone; a link assembly coupled to the first fixation assembly by a first pivot and coupled to the second fixation assembly by a second pivot, the first and second fixation assembly thereby each being angularly displaceable relative to the link assembly. The apparatus enables a clinician to effectively control the environment of cartilage in a joint during a treatment episode.
Description
- This application is a continuation of U.S. Ser. No. 12/628,866, filed Dec. 1, 2009, which is a continuation of U.S. Ser. No. 12,425,969, filed on Apr. 17, 2009, which is a divisional of 10/675,855, filed on Sep. 25, 2003, now U.S. Pat. No. 7,763,020 and claims benefit to International Application No. PCT/GB02/00844, filed Feb. 27, 2002 the entire disclosure of which is expressly incorporated herein by reference.
- The present invention relates to devices for restricting or controlling the movement or loading levels on joints in the human or animal body.
- The human or animal body uses articular cartilage to surface many of its joints. This tissue tolerates relatively high levels of compression while having a low coefficient of friction—approximately that of wet ice on wet ice.
- Bone, on which the cartilage is supported, is stiffer and stronger. Away from the joints, bone normally forms in large, thick-walled tubes. However, under the cartilage at the joints, the bone forms a three dimensional mesh of so called “cancellous” bone. Cancellous bone is more compliant than the rest of the bone structure and helps spread the load that the cartilage experiences, thus reducing the peak stresses on the cartilage.
- Both cartilage and bone are living tissues that respond and adapt to the loads they experience. There is strong evidence that the loads that joint surfaces experience can be categorised into four regions or “loading zones”.
- 1. Under-Loading Zone.
- If a joint surface remains unloaded for appreciable periods of time the cartilage tends to soften and weaken.
- 2. Healthy Zone.
- Joint surfaces can and do last a lifetime and if they experience healthy levels of load they can be considered to effectively last indefinitely.
- 3. Tolerant Zone.
- As with engineering materials that experience structural loads, both bone and cartilage begin to show signs of failure at loads that are below their ultimate strength. Unlike engineering materials, however, cartilage and bone have some ability to repair themselves, bone more so. There are levels of loading that will cause micro-structural problems and trigger the repair processes. The body can tolerate these load levels as long as it has time to recuperate.
- 4. Overloaded Zone.
- There comes a level of load at which the skeleton will fail catastrophically. If the load level on a joint surface reaches this level even once then there will be severe consequences.
- One of the major consequences of excessive loading is osteoarthritis. This loading could be either from a single overload in the overloaded zone or from loading within the tolerant zone too frequently.
- The picture of safe joint loading is further complicated by the cascade of events that occur during the onset of osteoarthritis. These events include the break up of the cartilage, and bone ‘sclerosis’ in which the bone becomes denser and stiffer. This means that the maximum level of loading that can be considered healthy or tolerated falls, almost certainly to levels below that experienced in walking and standing.
- Newly implanted grafts or tissue-engineered constructs will also have lower tolerance limits while they are establishing themselves within the joint.
- In fact the treatment of osteoarthritis and other conditions is severely hampered when a surgeon is not able to control and prescribe the levels of joint load. Furthermore, bone healing research has shown that some mechanical stimulation can enhance the healing response and it is likely that the optimum regime for a cartilage/bone graft or construct will involve different levels of load over time, eg. during a particular treatment schedule.
- There is a need for a device that will facilitate the control of load on a joint undergoing treatment or therapy, to enable use of the joint within the healthy loading zone, or even within the healthy and tolerant loading zones, during the treatment episode.
- There is further need for a device to preferably provide such control while allowing full, or relatively full mobility of a patient undergoing the treatment.
- Such devices would be desirable particularly during the early treatment of, for example, an osteoarthritic joint. Under an appropriate treatment regime providing controlled loading, the condition of the joint may improve, possibly back to full health.
- In the prior art, existing load controlling regimes and devices for use in treatment or therapy of articulating joints include the following.
-
- a) Bed-rest or isolation of a joint is possible but, as indicated above, the long-term consequences of applying no load or generally maintaining the joint in the underloaded zone are not good.
- b) Passive movement of a joint has been tried with some success. During this treatment, movement is applied to the joint by an external device while the joint is rested. However, this does not give the opportunity to vary the load levels on the joint, eg. to work the joint within the healthy zone for that joint at any given stage of the treatment program.
- c) Traction across a joint has long been used to counteract the compressive loads normally experienced by the joint. This is done either in bed or using an external fixator. Fixators exist which not only apply traction, but also have simple hinges to allow some joint motion.
- d) External braces have been used to apply a bending moment across the joint and at 90.degree. to the motion to move the centre of pressure from one part of the joint to another. However, since these braces are not attached directly to the skeleton, control of the applied loads is poor.
- According to one aspect, the present invention provides an apparatus for controlling the load on articular cartilage of a human or animal joint comprising:
-
- a first fixation assembly for attachment to a first bone;
- a second fixation assembly for attachment to a second bone; and
- a link assembly coupled to the first fixation assembly by a first pivot and coupled to the second fixation assembly by a second pivot,
- the first and second fixation assembly thereby each being angularly displaceable relative to the link assembly.
- According to another aspect, the present invention provides a method of controlling loading on a joint comprising the steps of:
-
- attaching a first fixation assembly to a first bone;
- attaching a second fixation assembly to a second bone, the second bone being connected to the second bone by an articulating joint;
- coupling said first fixation assembly and said second fixation assembly by way of a link assembly so that said first fixation assembly and said second fixation assembly are each angularly displaceable relative to the link assembly.
-
FIG. 1 shows a perspective view of a fixator for controlling loads on articular cartilage according to a preferred embodiment of the present invention; -
FIG. 2 shows a perspective view of a pair of fixators ofFIG. 2 in a dual sided or bilateral configuration; -
FIG. 3 shows perspective views of a selection of central modules suitable for use with the fixators ofFIGS. 1 and 2 ; -
FIG. 4 shows a perspective view of an externally powered fixator; -
FIG. 5 shows perspective views of a selection of alternative fixation assemblies suitable for use in the fixators ofFIGS. 1 and 2 ; -
FIG. 6 shows a plan view of a bilateral configuration of fixators as inFIG. 2 , illustrating the effects of unilateral variation in the length of link assembly; and -
FIG. 7 shows a parallel-crosswise configuration of link assembly. - With reference to
FIG. 1 , there is shown an articulated joint load controlling device orfixator 10 according to one embodiment of the invention. Thefixator 10 comprises afirst fixation assembly 11, asecond fixation assembly 12 and alink assembly 13 connecting the first andsecond fixation assemblies - The first and
second fixation assemblies link assembly 13 by apivot second fixation assemblies link assembly 13. - Preferably, the axes of the
pivots second fixation assemblies - In an alternative embodiment, however, the
pivots pivots - Each
fixation assembly faceplate 20 having one ormore slots 21 defined in the faceplate surface. Coupled to thefaceplate 20 is aclamp plate 22 which may be tightened onto thefaceplate 20 by way of screws, or other means known in the art. Preferably, the clamp plate includes correspondingslots 23. As shown more clearly inFIG. 2 , theface plate 20 andclamp plate 22 together provide an anchorage for one or more bone pins 30 which can be screwed into or otherwise fixed to a bone using known techniques. Other examples of fixation assemblies are illustrated later in connection withFIG. 5 . - In the arrangement of
FIG. 1 , a singleload controlling fixator 10 may be attached to an articulating joint by way of first bone pins 30 screwed into one side of a first bone using thefirst fixation assembly 11, and second bone pins 30 screwed into a corresponding side of a second bone using thesecond fixation assembly 12. The first and second bones are on either side of an articulating joint to be controlled by the fixator. - In the arrangement of
FIG. 2 , two load controlling devices or fixators may be used in a bilateral configuration on either side of an articulating joint, the bone pins 30 passing right through the respective first and second bones on either side of the articulating joint. By applying compression in one fixator and tension in the other fixator, it is possible to apply a bending moment to the joint so as to move the centre of pressure within the joint in a controlled manner and so relieve the loads experienced by the areas of concern. - In further embodiments, first and
second fixation assemblies fixator 10 might be coupled to two or more link assemblies in series or in parallel with one another. For example, as shown inFIG. 7 , afixator 16 comprises afirst fixation assembly 11 and asecond fixation assembly 12 that are connected by a link assembly that comprises a pair oflink members second fixation assemblies face plates 17, the link members being laterally displaced from one another. In the embodiment shown, thelink member 18 andlink member 19 are not only laterally displaced from one another, but also angularly displaced from one another, in a crosswise formation. This arrangement provides a controlled, limited degree of freedom of relative movement of the first and second fixation assemblies. By adjusting the position of the two link members it is possible to mimic the movement of the knee. - Referring now to
FIG. 3 , various arrangements of link assemblies and their respective functions will now be described. - In a first arrangement, labelled
FIG. 3A , thelink assembly 40 comprises a rigid, fixed length member having abarrel centre section 41 and a pair oflugs 44 extending from each end. Each pair oflugs 44 includes a pair of coaxial apertures orhubs FIG. 1 ). Each pair oflugs 44 define therebetween aslot 45 adapted to receive a corresponding lug 25 (seeFIG. 1 ) of arespective fixation assembly link assembly 40 essentially maintains first andsecond pivots - In a further embodiment, the lug pairs 44 and
barrel centre section 41 may be screwed together for quick disassembly and re-assembly, enabling different lengthbarrel centre sections 41 to readily be used to provide alink assembly 40 of an appropriate length to the joint under treatment or therapy and to be changed during a treatment program. - In another arrangement, labelled
FIG. 3C , alink assembly 50 provides for a variable distance of separation ofpivots hubs Link assembly 50 comprises a pair oflugs 54 and a pair oflugs 55, each pair being mounted on acentral shaft 56 and being axially displaceable therealong. A pair of tension springs 57, 58 provide a means for biasing the distance of separation of thepivots - In another arrangement, labelled
FIG. 3D , alink assembly 60 provides for a variable distance of separation ofpivots hubs Link assembly 60 comprises a pair oflugs 64 and a pair oflugs 65, each pair being mounted on acentral shaft 66 and being axially displaceable therealong. Acompression spring 67 provides a means for biasing the distance of separation of thepivots - It will be understood that the functions of
link assembly 50 andlink assembly 60 may be combined to provide bias towards a central position so that there is resistance against movement of the pairs of lugs from a centre position. More generally, this provides means for biasing the first and second pivots towards an intermediate distance of separation between predetermined limits of separation of the lug pairs 54, 55 or 64, 65. - Although not shown in
FIGS. 3C or 3D, it is also possible to provide a locking member which is axially adjustable along the length of the link assembly to adjust the limit or limits of separation of the lug pairs. The locking member could be provided, for example, by way of a screw-threaded collar on thecentral shaft - In another arrangement, labelled as
FIG. 3F , the provision of a means for controlling the distance of separation ofpivots hydraulic cylinder 81, controlled externally by a controller (not shown) connected thereto by twofeed pipes - It will be understood that the functions of the pneumatic or
hydraulic cylinder 81 could be alternatively provided by an electrically driven system. - In another arrangement, labelled
FIG. 3E , the link assembly 70 (which may generally correspond with alinks pivots - In the preferred embodiment shown, a
cam surface hubs respective fixation assembly fixation assemblies - In another arrangement, the cam surfaces 76, 77 could be adapted to limit the angular displacement of that fixation assembly.
- In another arrangement, the cam surfaces may be used to provide a varying degree of resistance to angular displacement of the fixation assembly. More generally, the cam surface may be adapted to provide a means for progressively increasing resistance to angular displacement of the fixation assembly relative to the link assembly as a function of the angular displacement from a reference position.
- The means for limiting angular displacement could alternatively be provided by a stepped surface on the circumferential edge of the lug in a manner which will be understood by those skilled in the art.
- In conjunction with any of the link assemblies described above, a
link assembly 90 as shown inFIG. 3B may be provided with means for recording loads applied across the link assembly. The sensor may be adapted to monitor any one or more of the tensile load, the compression load, shear forces or bending forces applied across the link assembly. Preferably the sensor comprises a strain gauge. Such a device makes it possible to determine the load actually being carried by a joint. In the preferred embodiment shown, this is achieved by the installation ofstrain gauges 92 into the barrel 93 of thelink assembly 90. - Separate transducers could be added to monitor angular displacement of the fixation assemblies relative to the
link assembly 90. - In another arrangement, as shown in
FIG. 4 , the angular displacement of the fixation assemblies relative to one another may be controlled externally. This can be achieved by alinear actuator 100 linked to the first andsecond fixation assemblies brackets - The
linear actuator 100 may be powered electrically, pneumatically or hydraulically and enables movement of a joint to be automatically controlled for exercise within the healthy load zone without use of the associated musculature. - Referring back to
FIG. 2 , it will be noted that when the various link assemblies described in connection withFIG. 3 are used in the bilateral configuration, it is possible, by varying the length of thelink assembly 13 independently on either side of the joint, to alter the position of the centre of pressure in the joint. This can be particularly useful in the treatment of knees. An example of the effects of this is illustrated inFIG. 6 . In the figure, a bilateral configuration of fixation assemblies is shown similar to that ofFIG. 2 , viewed from above (ie. generally perpendicular to the pivot axes). In this example,fixation assemblies link assemblies link assembly 13 b results in a relative angular displacement of the bones 4, 5 that varies with articulation of the bones about the axis of the joint, thereby imposing an angulation on the joint. This will tend to have the effect of reducing the load experienced at the joint surface on the side nearest to the lengthened segment. - With reference to
FIG. 5 , alternative arrangements of fixation assemblies which themselves facilitate further angular degrees of freedom of the fixator are now described.FIG. 5A shows afixation assembly 110 have alug 25 for attachment to the variouspossible link assemblies apertures bone pin 30. In this arrangement, however, each aperture is defined in a correspondingrotatable collar fixation assembly 110. - The
fixation assembly 120 as shown inFIG. 5 b is similar to that ofFIG. 5 a, except that in this case theapertures rotatable collar fixation assembly 120. - The
fixation assembly 130 as shown inFIG. 5 c provides a further degree of freedom. In this arrangement, bone pins 30 are located inslots 131 formed between afirst clamp plate 132 and asecond clamp plate 133. Theclamp plates pivot 134, and about a second axis (preferably a longitudinal axis of the fixation assembly 130) onpivot 135. Taken together with the pivot throughaperture 136, this provides a full three rotational degrees of freedom of the bone relative to a link assembly. - The fixator device embodiments as generally described above therefore provide a means for applying and/or limiting tension, compression, torsion, bending and shear forces to an articulated joint in a controlled manner and provide for some or all of the following treatment regimes either in isolation or in any combination. Also it will be possible to change the regime or combination of regimes easily and without the need for a sterile environment or anaesthesia. It is noted that joints of the skeleton naturally experience compression and the fixators of the present invention can provide amelioration of this by applying tension.
- 1. Continuous Traction.
- The level of tension can be varied according to the length of the link assembly used and this can be further varied according to the bias strengths applied by the
springs - 2. Partial or Full Support.
- Some or all of the compression that would otherwise be carried by the joint may be taken by the device, and this can be a function of the angle of support by control of spring strength and angle of fixation to the bones.
- 3. Application of a Bending Moment, Torsion or Shear Force.
- Application of these loads to the joint allows the clinician to move the centre of pressure within the joint to regions that are healthy.
- 4. Application of an Externally Powered Loading Regime.
- This can occur normally while the subject is at rest at set angles, load levels, loading and unloading rates and frequencies using the powered embodiments described above. Providing a portable power supply will, however, allow the patient to continue to move freely.
- 5. Allowing the Joint Load to be Gradually Increased.
- This may be desirable at the end of a treatment episode. This can be done either by applying additional compression or a bending moment, shear force or torsion in the opposite direction from that described above.
- 6. Load Measurement.
- The device as described in connection with
FIG. 3B allows the clinician to detect and record the loads experienced across a joint, and also the load applied across the joint by the device. - The motive forces applied across the joints may be from normal physiological loads of the musculoskeletal system or from an externally applied source such as described with reference to
FIG. 4 . - It will be noted that the preferred design of the devices described above enable the link assemblies and fixation assemblies to be readily disconnected from the bone pins 30 in order to replace or adjust the devices during a treatment schedule. Still further, in the preferred designs, the link assemblies may be adjusted in situ. Preferably, the devices will be able to be removed in their entirety within an outpatient clinic.
- The articulated joint controlling devices of the present invention can be used in the treatment not only of rheumatoid arthritis, but for the treatment of many other conditions such as articular fractures, and following surgical procedures such as osteochondral transfers and joint surface replacement with cartilage graft.
- Other embodiments are within the scope of the appended claims.
Claims (30)
1. A device for controlling load on a knee joint, the device comprising:
first and second fixation assemblies configured for attachment to a side of a knee joint;
a link assembly connectable to the first and second fixation assemblies at first and second pivots respectively, wherein the link assembly is configured to provide a variable distance of separation of the first and second pivots;
wherein the link assembly comprises a spring; and
wherein the spring is arranged in the link assembly to bias the first and second pivots away from one another.
2. The device of claim 1 , wherein the first and second pivots comprise articulating surfaces.
3. The device of claim 1 , wherein the link assembly is configured to be positioned entirely outside of the articular surfaces of the knee joint.
4. The device of claim 1 , further comprising a first fastener configured to extend through the first fixation assembly and into the femur; and
a second fastener configured to extend through the second fixation assembly and into the tibia.
5. The device of claim 1 , wherein the spring comprises a coil spring.
6. The device of claim 1 , wherein the link assembly is configured to act in compression to counteract the natural compressive forces experienced by the knee joint.
7. The device of claim 1 , wherein the link assembly comprises means to apply a force in a direction of distraction of the knee joint.
8. The device of claim 1 , wherein the link assembly comprises a central shaft.
9. The device of claim 8 , wherein the link assembly comprises a hub mounted to the central shaft and configured to contact an end of the spring.
10. The device of claim 8 , wherein the central shaft extends through the spring.
11. A device for controlling load on a joint, the device comprising:
first and second fixation assemblies configured for attachment to a side of a joint;
a link assembly connectable to the first and second fixation assemblies at first and second pivots respectively, wherein the link assembly is configured to provide a variable distance of separation of the first and second pivots;
wherein the link assembly comprises a spring; and
wherein the spring is arranged in the link assembly to bias the first and second pivots away from one another.
12. The device of claim 11 , wherein the first and second pivots comprise articulating surfaces.
13. The device of claim 11 , wherein the link assembly is configured to be positioned entirely outside of the articular surfaces of the joint.
14. The device of claim 11 , further comprising a first fastener configured to extend through the first fixation assembly and into a first bone of the joint; and
a second fastener configured to extend through the second fixation assembly and into a second bone of the joint.
15. The device of claim 11 , wherein the spring comprises a coil spring.
16. The device of claim 11 , wherein the link assembly is configured to act in compression to counteract the natural compressive forces normally experienced by the joint.
17. The device of claim 11 , wherein the link assembly comprises means to apply a force in a direction of distraction of the joint.
18. The device of claim 11 , wherein the link assembly comprises a central shaft.
19. The device of claim 18 , wherein the link assembly comprises a hub mounted to the central shaft and configured to contact an end of the spring.
20. The device of claim 18 , wherein the central shaft extends through the spring.
21. A device for controlling load on a joint, the device comprising:
first and second fixation assemblies configured for attachment to a side of a joint;
a link assembly connectable to the first and second fixation assemblies at first and second pivot means respectively, wherein the link assembly is configured to provide a variable distance of separation of the first and second pivot means;
wherein the link assembly comprises a means for biasing; and
wherein the means for biasing is arranged in the link assembly to bias the first and second pivot means away from one another.
22. The device of claim 21 , wherein the first and second pivot means comprise articulating surfaces.
23. The device of claim 21 , wherein the link assembly is configured to be positioned entirely outside of the articular surfaces of the joint.
24. The device of claim 21 , further comprising a first fastener means configured to extend through the first fixation assembly and into the femur; and
a second fastener means configured to extend through the second fixation assembly and into the tibia.
25. The device of claim 21 , wherein the means for biasing comprises a coil spring.
26. The device of claim 21 , wherein the link assembly is configured to act in compression to counteract the natural compressive forces experienced by the joint.
27. The device of claim 21 , wherein the link assembly comprises means to apply a force in a direction of distraction of the joint.
28. The device of claim 21 , wherein the link assembly comprises a central shaft.
29. The device of claim 28 , wherein the link assembly comprises a hub mounted to the central shaft and configured to contact an end of the means for biasing.
30. The device of claim 28 , wherein the central shaft extends through the means for biasing.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/467,931 US20120221121A1 (en) | 2001-03-28 | 2012-05-09 | Bone fixated, articulated joint load control device |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0107708.0A GB0107708D0 (en) | 2001-03-28 | 2001-03-28 | Bone fixated,articulated joint load control device |
GB0107708.8 | 2001-03-28 | ||
GBPCT/GB02/00844 | 2002-02-27 | ||
PCT/GB2002/000844 WO2002078554A1 (en) | 2001-03-28 | 2002-02-27 | Bone fixated, articulated joint load control device |
US10/675,855 US7763020B2 (en) | 2001-03-28 | 2003-09-25 | Bone fixated, articulated joint load control device |
US12/425,969 US9610103B2 (en) | 2001-03-28 | 2009-04-17 | Bone fixated, articulated joint load control device |
US12/628,866 US9943336B2 (en) | 2001-03-28 | 2009-12-01 | Bone fixated, articulated joint load control device |
US13/467,931 US20120221121A1 (en) | 2001-03-28 | 2012-05-09 | Bone fixated, articulated joint load control device |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/628,866 Continuation US9943336B2 (en) | 2001-03-28 | 2009-12-01 | Bone fixated, articulated joint load control device |
Publications (1)
Publication Number | Publication Date |
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US20120221121A1 true US20120221121A1 (en) | 2012-08-30 |
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ID=9911714
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
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US10/675,855 Active 2025-09-22 US7763020B2 (en) | 2001-03-28 | 2003-09-25 | Bone fixated, articulated joint load control device |
US12/425,969 Expired - Lifetime US9610103B2 (en) | 2001-03-28 | 2009-04-17 | Bone fixated, articulated joint load control device |
US12/628,866 Expired - Lifetime US9943336B2 (en) | 2001-03-28 | 2009-12-01 | Bone fixated, articulated joint load control device |
US13/467,931 Abandoned US20120221121A1 (en) | 2001-03-28 | 2012-05-09 | Bone fixated, articulated joint load control device |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
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US10/675,855 Active 2025-09-22 US7763020B2 (en) | 2001-03-28 | 2003-09-25 | Bone fixated, articulated joint load control device |
US12/425,969 Expired - Lifetime US9610103B2 (en) | 2001-03-28 | 2009-04-17 | Bone fixated, articulated joint load control device |
US12/628,866 Expired - Lifetime US9943336B2 (en) | 2001-03-28 | 2009-12-01 | Bone fixated, articulated joint load control device |
Country Status (10)
Country | Link |
---|---|
US (4) | US7763020B2 (en) |
EP (2) | EP2027823B1 (en) |
AT (1) | ATE415131T1 (en) |
AU (1) | AU2002234756B2 (en) |
DE (1) | DE60230023D1 (en) |
ES (2) | ES2705481T3 (en) |
GB (1) | GB0107708D0 (en) |
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Also Published As
Publication number | Publication date |
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EP2027823A3 (en) | 2014-08-20 |
GB0107708D0 (en) | 2001-05-16 |
NZ528504A (en) | 2005-03-24 |
DE60230023D1 (en) | 2009-01-08 |
EP2027823B1 (en) | 2018-12-19 |
US9610103B2 (en) | 2017-04-04 |
ATE415131T1 (en) | 2008-12-15 |
EP1372500A1 (en) | 2004-01-02 |
US7763020B2 (en) | 2010-07-27 |
AU2002234756B2 (en) | 2006-04-27 |
US20050261680A1 (en) | 2005-11-24 |
WO2002078554A1 (en) | 2002-10-10 |
US9943336B2 (en) | 2018-04-17 |
EP2027823A2 (en) | 2009-02-25 |
US20090248026A1 (en) | 2009-10-01 |
ES2317989T3 (en) | 2009-05-01 |
US20100145336A1 (en) | 2010-06-10 |
EP1372500B1 (en) | 2008-11-26 |
ZA200307528B (en) | 2005-03-30 |
ES2705481T3 (en) | 2019-03-25 |
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Owner name: IMPERIAL INNOVATIONS LIMITED, UNITED KINGDOM Free format text: CHANGE OF NAME;ASSIGNOR:IMPERIAL COLLEGE INNOVATIONS LTD.;REEL/FRAME:041522/0047 Effective date: 20051228 |
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