US20110136078A1 - Implant body, method of manufacture of same, and dental implant - Google Patents

Implant body, method of manufacture of same, and dental implant Download PDF

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Publication number
US20110136078A1
US20110136078A1 US12/995,233 US99523309A US2011136078A1 US 20110136078 A1 US20110136078 A1 US 20110136078A1 US 99523309 A US99523309 A US 99523309A US 2011136078 A1 US2011136078 A1 US 2011136078A1
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Prior art keywords
implant body
bone
base material
surface layer
zirconia
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US12/995,233
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English (en)
Inventor
Teruo Ishiwata
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NANTO SEIMITSU CO Ltd
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NANTO SEIMITSU CO Ltd
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Assigned to NANTO SEIMITSU CO., LTD. reassignment NANTO SEIMITSU CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ISHIWATA, TERUO
Publication of US20110136078A1 publication Critical patent/US20110136078A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
    • A61C8/0015—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating being a conversion layer, e.g. oxide layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C13/00—Dental prostheses; Making same
    • A61C13/0003—Making bridge-work, inlays, implants or the like
    • A61C13/0006—Production methods
    • A61C13/0018—Production methods using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
    • A61K6/818—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising zirconium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
    • A61C8/0022—Self-screwing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Definitions

  • the present invention relates to an implant body fixed in a tightly attached configuration to bone, for example, an implant body embedded in the bone of the jaw or the like when damage has occurred to the tooth root of a permanent tooth.
  • the invention also relates to a method of manufacture for the implant body, and to a dental implant.
  • an implant body may be embedded into the bone and fixed in a contact configuration for application as an artificial bone, a bone attachment material, a bone reinforcing material, or the like.
  • a dental implant in which an implant body is inserted into a drill hole in the alveolar bone, and is fixed thereto.
  • the dental implant is generally configured from an implant body that is fixed to the alveolar bone, and an abutment that is threadably attached to the implant body to thereby enable detachable mounting of an artificial dental crown.
  • Patent Literature 1 discusses several materials including a ceramic material as a material for an implant.
  • Japanese Patent Application Laid-Open No. 4046213 discloses the chemical, electrical, mechanical, laser processing or the like to create surface roughness on the surface of the implant in order to impart biocompatibility.
  • the present invention is proposed in light of the above problems, and has the object of providing an implant body, a method of manufacture for the same, and a dental implant that enables improved bio-affinity and that enables strong bone attachment.
  • the implant body according to the present invention is an implant body that is fixed in a contact configuration to the bone, and is characterized in a configuration of a base material formed from zirconia, and a surface layer formed on the surface of the base material and having a lower hardness than the base material.
  • the implant body includes the base material formed from zirconia, and the surface layer formed on the surface of the base material and having a lower hardness than the base material, in addition to having superior mechanical strength due to the zirconia base material, the soft and flexible surface layer functions as a buffer layer to mitigate the difference in the degree of hardness between the bone and the base material, and therefore the soft surface further improves the bone adhesion characteristics.
  • the implant body according to the present invention is characterized by the formation of a plurality of crack cavities on the surface layer.
  • the implant body since the implant body forms a plurality of crack cavities on the surface layer, rather than simple roughening, the bone cells can enter into the crack cavities in the surface layer.
  • the contact surface area is greatly increased, and a cross-linking effect is obtained. Furthermore high bone adhesion characteristics and bone attachment are obtained.
  • the implant body according to the present invention is characterized in that the hardness of the surface layer is less than or equal to the hardness of the bone.
  • the hardness of the surface layer in the implant body is less than or equal to the hardness of the bone, attachment of bone tissue is facilitated by the flexible surface which has the same hardness as the bone or is softer than the bone.
  • the surface layer of the implant body according to the present invention is characterized in being formed by zirconia hydroxide.
  • zirconia hydroxide since the surface layer of the implant body is formed by zirconia hydroxide, high bone adhesion characteristics and an improved bio-affinity with bone tissue are obtained by a zirconia hydroxide surface layer.
  • the zirconia hydroxide surface layer is thought to have an ion exchange action and strengthens the increase in calcium ions and migration of cells to thereby obtain a considerable improvement in bone adhesion.
  • the dental implant according to the present invention is characterized by provision of the implant body according to the present invention that is inserted in a drill hole in the alveolar bone that acts as the bone, and is fixed thereto. That is to say, since the dental implant is provided with the implant body according to the present invention that is inserted and fixed in a drill hole in the alveolar bone, superior mechanical strength is obtained, and high bone adhesion to the alveolar bone is obtained by the soft flexible surface layer.
  • the method of manufacturing the implant body according to the present invention is a manufacturing method for the implant body that is fixed in a contact configuration to the bone.
  • the method is characterized by including a step of forming a zirconia hydroxide surface layer having a lower hardness than the base material on the surface of the zirconia base material by irradiation of laser light in air including water vapor.
  • the zirconia hydroxide surface layer having a lower hardness than the base material is formed on the surface of the base material formed from zirconia by irradiation of laser light in air including water vapor, formation of soft surface layer of zirconia hydroxide having a high adhesion is facilitated on the base material surface.
  • the zirconia of the base material is irradiated with short-wavelength laser light such as solid-state laser light, and undergoes surface roughening by changing the surface configuration due to the high-energy laser light.
  • the water vapor reacts with the zirconia to thereby enable formation of a hydroxide substance, in other words, a hydroxide (zirconium hydroxide) surface layer.
  • a hydroxide (zirconium hydroxide) surface layer Furthermore the zirconia hydroxide surface layer resulting from the manufacturing method enables a reduction in the level of hardness due to the production of a plurality of crack cavities.
  • the method of manufacturing of the implant body according to the present invention is characterized in that the laser light is laser light that has a fundamental wave caused by an Nd:YAG laser or a YVO 4 laser.
  • the method of manufacturing of the implant body uses laser light having a fundamental wave caused by an Nd:YAG laser or a YVO 4 laser, a zirconium hydroxide surface layer is formed on the zirconium base material surface by short-wavelength high-energy laser light, and facilitates formation of a plurality of crack cavities.
  • the manufacturing method for an implant body according to the present invention is characterized in that the hardness of the surface layer is less than or equal to the hardness of the bone as a result of irradiation with the laser light.
  • the hardness of the surface layer is less than or equal to the hardness of the bone as a result of irradiation with the laser light, as shown above, a surface layer is obtained in which attachment of bone tissue is facilitated.
  • the present invention obtains the following effect.
  • the implant body according to the present invention forms a surface layer that has a lower hardness than the base material on the surface of the base material formed from zirconia, in addition to mechanical strength that is superior to the zirconia base material, the soft and flexible surface layer functions as a buffer layer to mitigate the difference in the degree of hardness between the bone and the base material, and therefore the soft surface further improves the bone adhesion characteristics. Therefore the implant body obtains improved bio-affinity and high bone attachment. In particular, high bone attachment characteristics are obtained with respect to alveolar bone by application of the implant body of the dental implant that inserts and fixes the implant body to the drill hole in the alveolar bone.
  • FIG. 1 is a front view showing a dental implant according to a first embodiment of an implant body, a method of manufacturing the same, and a dental implant according to the present invention.
  • FIG. 2 is a schematic enlarged sectional view showing an implant body according to the present invention.
  • FIG. 3 is a graph shows the results of infrared spectrophotometric analysis of the surface according to a working example and a comparative example of an implant body, a method of manufacturing the same, and a dental implant according to the present invention.
  • FIG. 4 is an SEM image of the surface of the implant body according to a working example of an implant body, a method of manufacturing the same, and a dental implant according to the present invention.
  • FIG. 5 is an SEM image of the surface of the implant body according to a working example of an implant body, a method of manufacturing the same, and a dental implant according to the present invention.
  • FIG. 6 is an SEM image of the surface of the implant body according to a working example of an implant body, a method of manufacturing the same, and a dental implant according to the present invention.
  • FIG. 7 is an enlarged photographic image of the principal sectional portions using an optical microscope 4 weeks after the insertion of an actual implant body into an experimental rat according to a comparative example of an implant body, a method of manufacturing the same, and a dental implant according to the present invention.
  • FIG. 8 is an enlarged photographic image of the principal sectional portions using an optical microscope 4 weeks after the insertion of an implant body into an experimental rat according to a comparative example of an implant body, a method of manufacturing the same, and a dental implant according to the present invention.
  • FIG. 9 is an enlarged photographic image of the principal sectional portions using an optical microscope 4 weeks after the insertion of an implant body into an experimental rat according to a working example of an implant body, a method of manufacturing the same, and a dental implant according to the present invention.
  • FIG. 10 is an enlarged photographic image of the principal sectional portions using an optical microscope 4 weeks after the insertion of an implant body into an experimental rat according to a working example of an implant body, a method of manufacturing the same, and a dental implant according to the present invention.
  • FIG. 11 is an enlarged photographic image of the principal sectional portions using an optical microscope 4 weeks after the insertion of an implant body into an experimental rat according to a comparative example of an implant body, a method of manufacturing the same, and a dental implant according to the present invention
  • FIG. 12 is an enlarged photographic image of the principal sectional portions using an optical microscope 4 weeks after the insertion of an implant body into an experimental rat according to a working example of an implant body, a method of manufacturing the same, and a dental implant according to the present invention.
  • the implant body 2 is an implant body fixed in a contact configuration to the bone, and as shown in FIG. 1 , is applied to an implant body for a dental implant 1 inserted and fixed to a drill hole in alveolar bone that acts as the bone described above.
  • the implant body 2 is formed substantially in a cylindrical shape with a tip that has a gradually reducing external diameter towards a lower portion (distal end).
  • the outer periphery of the implant body 2 forms as a male threaded portion 3 .
  • the male threaded portion 3 is formed by gradually varying the shape with respect to the axial direction of the implant body 2 .
  • the male threaded portion 3 is configured as a self-tapping threaded portion 3 a in which the distal end is provided with an engraved groove on the thread, and thereby enables direct threadable engagement in the drilled hole of the alveolar bone.
  • An abutment (not shown) can be fixed by a bonding means such as a threaded structure to an upper portion of the implant body 2 .
  • a bonding means such as a threaded structure
  • the male thread is formed on the lower portion of the abutment
  • a female threaded hole (not shown) enabling threadable engagement with the male thread of the lower portion of the abutment is formed on the upper portion of the implant body 2 .
  • the implant body 2 as shown in FIG. 2 is configured from a base material 2 a formed from zirconia and a surface layer 2 b formed on the surface of the base material 2 a from zirconia hydroxide having a hardness that is lower than the base material 2 a.
  • a plurality of crack cavities W is formed on the surface layer 2 b, and therefore further reduces the surface hardness.
  • the hardness of the surface layer 2 b is less than or equal to the hardness of the alveolar bone.
  • the hardness of the surface layer 2 b in the present embodiment is of the level of 300 Hv in contrast to a Vickers hardness of the level of 500 Hv in normal alveolar bone.
  • a base material 2 a of the implant body 2 that has an outer configuration including a male threaded portion 3 is prepared using zirconia (zirconia ceramic).
  • a surface layer 2 b of zirconia hydroxide is formed on the surface of the base material 2 a by irradiating laser light in air containing moisture (in an atmosphere containing water vapor).
  • the laser light that is employed at this time must be high-energy laser light, and for example, laser light (fundamental wave) produced by a Nd:YAG laser or a YVO 4 laser which are solid-state lasers is used.
  • a setting is adapted so that the hardness of the surface layer 2 b is less than or equal to the hardness of the alveolar bone.
  • the output or the like of the Nd:YAG laser light or the YVO 4 laser light is set and irradiated so that a surface layer having a hardness of substantially 300 Hv is formed.
  • a blackened surface layer 2 b is formed by irradiation of laser light.
  • the implant body 2 and the dental implant 1 provided with the implant body 2 according to the present embodiment are provided with a base material 2 a that is formed from zirconia and a surface layer 2 b that has a lower hardness than the base material 2 a and is formed on the surface of the base material 2 a, in addition to mechanical strength that is superior to that of the zirconia base material 2 a, the soft and flexible surface layer 2 b functions as a buffer layer to mitigate the difference in the degree of hardness between the bone such as alveolar bone and the base material 2 a. Furthermore the bone adhesion characteristics are improved by the soft surface.
  • the bone cells can enter into the crack cavity W of the surface layer 2 b. Entry of the bone cells causes a considerable increase in the contact surface area, obtains a cross-linking effect, and enables high bone adhesion and bone attachment.
  • an implant having a surface formed from a dense high-hardness ceramic material as in the conventional example exhibits an upper limit to improvement in bone adhesion that is enabled by simply roughening the surface.
  • the hardness of the surface layer 2 b is reduced by the plurality of crack cavities W formed in the surface and the bone cells can enter into an inner portion through the crack cavities W.
  • the hardness of the surface layer 2 b is less than or equal to the hardness of the bone such as alveolar bone, a hardness that is equivalent to bone such as alveolar bone or a surface that is softer and more flexible than bone such as alveolar bone facilitates improved close adhesion of bone tissue.
  • the surface layer 2 b is formed from zirconia hydroxide, superior bio-affinity and high bone attachment to bone tissue are enabled by the zirconia hydroxide of the surface layer 2 b.
  • the zirconia hydroxide of the surface layer 2 b has an ion exchange effect which is thought to increase calcium ions and strengthen the growth of cells, and cause a considerable improvement in bone adhesion.
  • the method of manufacturing the implant body 2 forms a surface layer 2 b of zirconia hydroxide having a lower hardness than the base material 2 a on the surface of the zirconia base material 2 a by irradiating laser light in air containing moisture, formation of a soft zirconia hydroxide surface layer 2 b having high adhesion characteristics on the surface of the base material 2 a can be facilitated.
  • the surface configuration of the zirconia of the base material 2 a that is irradiated with short-wave laser light such as a solid-state laser or the like undergoes roughening due to high energy laser light.
  • the zirconia reacts with the moisture to form a surface layer 2 b of a hydroxide compound, in other words, a hydroxide (zirconia hydroxide).
  • the surface layer 2 b of zirconia hydroxide formed by the method of manufacture has a reduced hardness due to the production of a plurality of crack cavities W.
  • laser light having a fundamental wave resulting from a Nd:YAG laser or a YVO 4 laser produces short-wavelength high-energy laser light and therefore forms a zirconia hydroxide surface layer 2 b on the surface of the zirconia base material 2 a and facilitates formation of the plurality of crack cavities W.
  • a non-processed zirconia implant body without a hydroxide surface layer 2 b processed using laser light as described above and formed from an unmodified zirconia base material 2 a for the purposes of comparison, and a zirconia implant body processed by laser to form a hydroxide zirconia surface layer 2 b using the laser light as described above as a working example were prepared.
  • the irradiation laser light used an Nd:YAG laser as a fundamental wave.
  • a nano-hardness tester is a measurement apparatus that measures the load and the hardness, and is set to an engraved depth of 1 ⁇ m.
  • the results of two measurements of the Vickers hardness of the comparative example that is only formed from a zirconia base material 2 a are 998 Hv and 1129 Hv.
  • the working example that forms a zirconia hydroxide surface layer 2 b had a Vickers hardness of 336 Hv and 328 Hv.
  • the hardness of the surface of the working example that forms a zirconia hydroxide surface layer 2 b is clearly lower than the comparative example that is only formed from a zirconia base material 2 a, and the surface is also soft in comparison to alveolar bone which normally has a hardness of the level of 500 Hv.
  • the surface layer 2 b of the implant body 2 of the working examples is shown by SEM images captured using an electron microscope at different magnifications as shown in FIG. 4 to FIG. 6 . As shown by these SEM images, a plurality of crack cavities W is produced in the surface layer 2 b.
  • An implant body having a diameter of 1.6 mm and a length of 7.0 mm was used and embedded into the tibia of a four-week old SD rat.
  • the implant body used in the present working example formed a surface layer due to irradiation with YVO 4 laser light.
  • FIG. 7 , FIG. 8 and FIG. 11 are enlarged photographic images captured with an optical microscope of the principal sectional components when using the comparative example which only includes the zirconia base material 2 a.
  • the uniformly black section in the enlarged photographic images represents the implant body, and the partially black portion in the periphery thereof is a bone component that is dyed with toluidine blue (the original photographic images are color images, and the bone components are expressed as blue).
  • FIG. 9 , FIG. 10 and FIG. 12 are enlarged photographic images captured using an optical microscope of the principal sectional components when using the working example which forms a zirconia hydroxide surface layer 2 b.
  • the magnifications used in the images are as follows: FIG. 7 is 10 times, FIG. 8 is 40 times, FIG. 9 is 10 times, FIG. 10 is 40 times, FIG. 11 is 150 times, and FIG. 12 is 50 times.
  • the results of calculating the contact ratio between the surface of the implant body and the bone tissue results in a contact ratio for the comparative example of 27.9% in contrast to a contact ratio for the embodiment of 64.8% which therefore represents a considerable improvement in the contact ratio.
  • laser irradiation was performed using laser light produced by an Nd:YAG laser or a YVO 4 laser
  • another type of laser light may be employed to the degree that it is high-energy laser light that enables formation of a zirconia hydroxide surface layer 2 b by hydroxide formation on the surface of the zirconia base material 2 a.
  • laser light from another solid-state laser or laser light from a harmonic wave may be employed to the degree that it is high-energy laser light that enables formation of a zirconia hydroxide surface layer 2 b by hydroxide formation on the surface of the zirconia base material 2 a.
  • the implant body according to the present invention is applied as an implant body for a dental implant forming an artificial tooth root fixed by insertion into a drill hole in the alveolar bone.
  • the implant body may be applied as an implant body that is embedded or the like into bone in another region and fixed in a state of contact.
  • the implant body according to the present invention may be applied as artificial bone or a bone filling material in relation to damage to bone resulting from fracture or removal of benign tumors, or to supplement cartilage that is removed due to lumbar vertebrae surgery.
  • the implant body according to the present invention may be employed in relation to a member for an artificial joint, a bone attachment material used to fix positions of bone fracture, or a vertebral fixing apparatus.

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Dentistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Manufacturing & Machinery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dental Prosthetics (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
  • Prostheses (AREA)
US12/995,233 2008-05-30 2009-05-29 Implant body, method of manufacture of same, and dental implant Abandoned US20110136078A1 (en)

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JP2008-143883 2008-05-30
JP2008143883 2008-05-30
JP2009-124780 2009-05-23
JP2009124780A JP5207480B2 (ja) 2008-05-30 2009-05-23 インプラント体及びその製造方法並びに歯科用インプラント
PCT/JP2009/060303 WO2009145361A1 (ja) 2008-05-30 2009-05-29 インプラント体及びその製造方法並びに歯科用インプラント

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US14/254,981 Expired - Fee Related US9549791B2 (en) 2008-05-30 2014-04-17 Implant body, method of manufacture of same, and dental implant

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KR (2) KR101301205B1 (zh)
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AU (1) AU2009252215B2 (zh)
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CH (1) CH701567B1 (zh)
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US11051915B2 (en) 2016-11-10 2021-07-06 Nantoh. Co., Ltd. Biological tissue rootage face, implant, method for forming biological tissue rootage face, and method for producing implant

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JP5514972B2 (ja) * 2009-12-10 2014-06-04 株式会社ナントー精密 インプラント
JP5514991B2 (ja) * 2009-12-10 2014-06-04 株式会社ナントー精密 インプラント
US9283303B2 (en) 2011-06-03 2016-03-15 DePuy Synthes Products, Inc. Surgical implant
JP2014124500A (ja) * 2012-12-27 2014-07-07 Nanto Precision Co Ltd インプラント体、アバットメント体、インプラント、インプラントの製造方法
JP6573102B2 (ja) * 2015-04-27 2019-09-11 国立研究開発法人産業技術総合研究所 医療機器材料及びその製造方法
RU2630883C1 (ru) * 2016-03-17 2017-09-13 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Томский государственный университет систем управления и радиоэлектроники Способ изготовления деталей зубного имплантата из циркония
WO2020136988A1 (ja) 2018-12-26 2020-07-02 Ｊｆｅスチール株式会社 高強度溶融亜鉛めっき鋼板およびその製造方法

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140166509A1 (en) * 2011-09-09 2014-06-19 Osstemimplant Co., Ltd. Ampoule for storing implant capable of maintaining humidity
US9517115B2 (en) * 2011-09-09 2016-12-13 Osstemimplant Co., Ltd. Ampoule for storing implant capable of maintaining humidity
US11051915B2 (en) 2016-11-10 2021-07-06 Nantoh. Co., Ltd. Biological tissue rootage face, implant, method for forming biological tissue rootage face, and method for producing implant
US11596505B2 (en) 2016-11-10 2023-03-07 Nantoh. Co., Ltd Biological tissue rootage face, implant, method for forming biological tissue rootage face, and method for producing implant

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BRPI0912083A2 (pt) 2019-09-24
RU2010147886A (ru) 2012-07-10
CA2725890A1 (en) 2009-12-03
AU2009252215A1 (en) 2009-12-03
KR20130047760A (ko) 2013-05-08
CH701567B1 (de) 2013-09-13
WO2009145361A1 (ja) 2009-12-03
US9549791B2 (en) 2017-01-24
SE536598C2 (sv) 2014-03-18
EP2305179A4 (en) 2015-07-01
CA2725890C (en) 2013-09-03
JP5207480B2 (ja) 2013-06-12
JP2010005379A (ja) 2010-01-14
CN102046109B (zh) 2014-12-31
CN102046109A (zh) 2011-05-04
DE112009001256T5 (de) 2011-09-29
KR101273548B1 (ko) 2013-06-14
US20140227663A1 (en) 2014-08-14
SE1051232A1 (sv) 2010-11-24
RU2471451C2 (ru) 2013-01-10
KR101301205B1 (ko) 2013-08-29
EP2305179A1 (en) 2011-04-06
KR20110008294A (ko) 2011-01-26

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