US20100286425A1 - Organic-inorganic hybrid chiral sorbent and process for the preparation thereof - Google Patents
Organic-inorganic hybrid chiral sorbent and process for the preparation thereof Download PDFInfo
- Publication number
- US20100286425A1 US20100286425A1 US12/443,065 US44306507A US2010286425A1 US 20100286425 A1 US20100286425 A1 US 20100286425A1 US 44306507 A US44306507 A US 44306507A US 2010286425 A1 US2010286425 A1 US 2010286425A1
- Authority
- US
- United States
- Prior art keywords
- silica
- chiral
- process according
- alcohol
- aminopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
- B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28078—Pore diameter
- B01J20/28083—Pore diameter being in the range 2-50 nm, i.e. mesopores
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/29—Chiral phases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/3092—Packing of a container, e.g. packing a cartridge or column
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3204—Inorganic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
- B01J20/3259—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulfur with at least one silicon atom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
- B01J20/3261—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such comprising a cyclic structure not containing any of the heteroatoms nitrogen, oxygen or sulfur, e.g. aromatic structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
- B01J20/3263—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. an heterocyclic or heteroaromatic structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/58—Use in a single column
Definitions
- the present invention relates to an organic-inorganic hybrid chiral sorbent. More particularly it relates to optically pure covalently bonded amino alcohol to mesoporous silica as chiral selector for chiral resolution of various racemic compounds, viz. racemic mandelic acid, 2-phenyl propionic acid, diethyl tartrate, 2,2′-dihydroxy-1,1′-binaphthalene (BINOL) and cyano chromene oxide under medium pressure column chromatography.
- the present invention further relates to a process for the preparation of organic-inorganic hybrid chiral sorbent. These optically pure enantiomers find applications as intermediates in pharmaceutical industries.
- Teicoplanin is a glycopeptide antibiotic which contains 20 chiral centers.
- Teicoplanin is a toxic and naturally occurring complex molecule therefore cannot be easily tuned for various applications (ii) due to the presence of many glycosidic linkages it is prone to hydrolysis and/or alteration in conformation thereby change in optical properties under the elution conditions (iii) this separation process requires pH adjustment about 4 and 7; (iv) separation has to be conducted in reverse phase.
- M. Grun et al. J. Chromatogr. A 740 (1996) 1 described the behavior of silica, alumina, titania, zirconia and the novel mesoporous aluminosilicate MCM-41 in normal-phase high-performance liquid chromatography under comparable conditions.
- MCM-41 shows some interesting features as compared to mesoporous crystalline and amorphous oxides. The drawbacks of this process are; (i) This work includes only comparison of an ordered mesoporous aluminosilicate, silica, alumina, titania and zirconia in normal-phase high-performance liquid chromatography; (ii) it requires very large column (250 ⁇ 4 mm).
- the drawbacks of this process are; (i) enzymes shows very low enantio-selectivity; (ii) it's a time consuming process (more than 7 days); (iii) solvent, such as acetonitrile, cyclohexane, toluene, methyl-t-butyl ether, 2-methyl-2-pentanol, ethyl caprate is required for this system.
- Mitsuhashi Kazuya et at in U.S. Pat. No. 278,268 Oct. 23, 2002 disclosed a method for the synthesis of optically active mandelic acid derivatives by enzymatic separation.
- the drawbacks of this process are; (i) microorganism is essential to generate the (R)-mandelic acid derivative or (S)-mandelic acid derivative; (ii) requires appropriate buffer solution.
- the drawbacks of this process are; (i) deactivation of microorganism within a short period of time at higher and lower temperature; (ii) high concentration and high yield is difficult to obtain for alpha-hydroxy acid or alpha-hydroxyamide; (iii) the reaction rate is lowered with an increase in the concentration of the alpha-hydroxy acid or alpha-hydroxyamide product as a result, the reaction does not proceed to completion.
- the main object of the present invention is to provide an organic-inorganic hybrid chiral sorbent
- Another object of the invention is to provide a process for the preparation of organic-Inorganic hybrid chiral sorbent.
- Yet another object of the present invention is to provide a process for chiral resolution of racemic compounds using optically pure amino alcohols covalently attached on mesoporous silica as chiral selector for chiral resolution of various racemic compounds viz. racemic mandelic acid, 2-phenyl propionic acid, diethyl tartrate, 2,2′-dihydroxy-1,1′-binaphthalene (BINOL) and cyano chromene.
- racemic mandelic acid 2-phenyl propionic acid
- diethyl tartrate diethyl tartrate
- BINOL 2,2′-dihydroxy-1,1′-binaphthalene
- cyano chromene cyano chromene
- Yet another object of the present invention is to provide chiral resolution of racemic compounds using optically pure amino alcohol covalently attached on mesoporous silica as chiral selector for achieving high Enantiomeric Excess (ee) (99%) at room temperature.
- Yet another object of the present invention is to provide chiral resolution of racemic compounds using optically pure amino alcohol covalently attached on mesoporous silica as chiral selector under medium pressure slurry system.
- Still another object of the present invention is to provide chiral resolution of racemic compounds using optically pure amino alcohol covalently attached on mesoporous silica as chiral selector under medium pressure (0.5 kp/cm 2 ) column chromatography.
- the present invention provides an organic-inorganic hybrid chiral sorbent comprising amino alcohol covalently bonded to the surface of mesoporous silica material.
- amino alcohol used is amino propyl alcohol.
- the porous silica material used is having porosity in the range of 37 to 100 ⁇ and is selected from the group consisting of MCM-41, SBA-15 and MCF-48.
- the product obtained in the present invention is represented by the group of following chiral sorbent selected from (S)-aminopropyl alcohol@silica-41, (R)-aminopropyl alcohol@silica-41, (S)-aminopropyl alcohol@silica-15, (R)-aminopropyl alcohol@silica-15, (S)-aminopropyl alcohol@silica-F, (R)-aminopropyl alcohol@silica-F, (S)—N-methyl aminopropyl alcohol@silica-41, (R)—N-methyl aminopropyl alcohol@silica-41, (S)—N,N′dimethyl aminopropyl alcohol@silica-41, (S)—N,N′dimethyl aminopropyl alcohol@silica-15 and (S)—N-methyl aminopropyl alcohol@silica-15
- the chiral sorbent is useful for the separation of racemic mixture of compounds selected from the group consisting of mandelic acid, 2-phenyl propionic acid, diethyl tartrate, 2,2′-dihydroxy-1,1′-binaphthalene (BINOL) and cyano chromene oxide.
- the present invention further provides a process for the preparation of an organic-inorganic hybrid chiral sorbent, the said process comprising the steps of:
- the chiral epoxide used in step(a) is selected from the group consisting of propene oxide, 1-chloro-2,3-epoxypropane, 1-fluoro-2,3-epoxypropane, 1-bromo-2,3-epoxypropane, 1-methyl-2,3-epoxypropane, 1-methoxy-2,3-epoxypropane and 1-nitro-2,3-epoxypropane.
- the silylating agent used in step(a) is selected from the group consisting of chloropropyl triethoxysilane, chloropropyltrimethoxy, nitropropyltriethoxysilane, aminopropyltriethoxysilane and aminopropyltrimethoxy silane.
- the inorganic base used in step (a) is selected from the group consisting of sodium carbonate, potassium carbonate, rubidium carbonate and cesium carbonate.
- the organic solvent used in step(a) is selected from the group consisting of ethanol, methanol, isopropanol, acetone, acetonitrile, toluene, tetrahydrofuran, dichloroethane and dichloromethane.
- mesoporous silica used in step (c) is selected from the group consisting of MCM-41, SBA-15 and MCF-48.
- the inert atmosphere used is provided by using inert gas selected from nitrogen, argon and helium.
- the molar amount of aniline or substituted aniline with respect to chiral epoxide is in the range of 1:1 to 1:2.
- the substituted aniline used is selected from the group consisting of nitroaniline, chloroaniline, methoxyaniline and methylaniline.
- the amount of mesoporous silica used is in the range of 0.8 to 12 g/mmol of chiral epoxide.
- the chiral sorbent obtained in step(d) is represented by the group of following sorbents: mandelic acid, 2-phenyl propionic acid, diethyl tartrate, 2,2′-dihydroxy-1,1′-binaphthalene (BINOL) and cyano chromene oxide.
- the chiral sorbent obtained is useful for the separation of racemic mixtures of compound selected from the group consisting of mandelic acid, 2-phenyl propionic acid, diethyl tartrate, 2,2′-dihydroxy-1,1′-binaphthalene (BINOL) and cyano chromene oxide.
- the enantiomeric excess of racemates obtained is in the range of 30 to 99%.
- the maximum enantiomeric excess obtained for mandelic acid with aminopropylalcohol@silica sorbent is about 99%.
- organic-inorganic hybrid chiral sorbent which comprises of
- the synthesis process of amino alcohol modified silica was conducted on laboratory scale in a 100 ml three-necked round bottom flask fitted with an efficient water condenser using S-(+)-epichlorohydrin, 3-aminopropyl triethoxysilane, aniline and silica.
- the medium pressure column chromatography was carried out by making slurry of (S)-amino alcohol@silica 1 in hexane and isopropanol (9:1) was packed in a 260 ⁇ 16 mm glass column using medium-pressure (0.5 kp/cm 2 ) of nitrogen at room temperature.
- the separation process according to the present invention was carried out by using amount of analyte in the range of 10 to 30 mg, preferably using 2 g amino alcohol immobilized on silica as column packing material at medium-pressure (0.5 kp/cm 2 ) of nitrogen at room temperature. Higher separation of mandelic acid was obtained when the amount of analyte was more than 10 mg.
- the chiral products were characterized by the comparison of HPLC profile with authentic samples. In the preferred embodiment, the pressure of the column is maintained (0.25-0.75 kp/cm 2 ) of nitrogen at room temperature.
- the chiral amino alcohol immobilized on silica plays a very vital role in achieving better separation of analytes.
- the amino alcohol used to separate analyte is 2 g. With low quantity of amino alcohol modified silica the separation is sluggish. The use of optimal quantity amino alcohol modified silica (2 g) is essential as it definitely separates the different analyte.
- the time required for the chromatographic separation of analytes is more than 7 h to achieve higher enantiomeric excess.
- the time of separation may be varied by increasing pressure, it was observed that decreasing the time of chromatographic separation below 5 h resulted in lower separation of analyte
- the present invention relates to the preparation of chiral compounds suitable for various applications. These chiral compounds were separated from racemic compounds by medium pressure chromatographic separation using amino alcohol as selector at medium-pressure (0.5 kp/cm 2 ) of nitrogen at room temperature.
- the chromatographic separation of racemic compounds was found to be higher than that reported in literature where the separation depends on i) derivatization of stationary phase as well as analyte, ii) pH of eluents iii) high temperature requirement that result into diffusional problems, reproducibility and difficulty in their reuse.
- the method of present invention does not require any special device.
- step 1 The product of step 1 (0.674) was dissolved in dry toluene in a 3-necked 50 ml round bottom flask in an inert atmosphere. The dissolved mass was treated with MCM-41 (2.0 g) for 48 h. at the refluxing temperature of toluene. The reaction mass was filtered and washed with dry toluene for several time then dried under vacuum. The dried material was subjected to Soxhlet extraction with dry toluene for 10 h followed by drying the sample under vacuum. Yield; (2 g, loading 22.5% by TGA)
- the epoxy product from the step 2 (22.5% loading, 2 g) was treated with aniline (455 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 12 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to Soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. Yield; (2 g, loading 25.6% by TGA).
- step 1 The product of step 1 (0.674) was dissolved in dry toluene in 3-necked 50 ml round bottom flash in an inert atmosphere. Then this dissolved mass was treated with MCM-41 (2.0 g) for 48 h at refluxing temperature. The reaction mixture was processed as per the method given in step 2 of the example 1. (2 g, loading 22.0% by TGA)
- the epoxy product from the step 2 (22.0% loading, 2 g) was treated with aniline (455 ⁇ l) in 10 ml dry toluene in inert atmosphere.
- the suspension was treated as per the method given in step 3 of the example 1. Yield (2 g, loading 25.0% by TGA).
- step 1 The product of step 1 (0.65 g) was dissolved in dry toluene in 3-necked 50 ml round bottom flask in an inert atmosphere. Then this dissolved mass was treated with SBA-15 (2.0 g) for 48 h. at refluxing temperature. The reaction mass was filtered and washed with dry toluene for several time then dried under vacuum. The dried material was subjected to Soxhlet extraction with dry toluene for 10 h followed by drying the sample under vacuum. (2.2 g, loading 24.0% by TGA)
- the epoxy product from the step 2 (24.0% loading, 2 g) was treated with aniline (500 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 12 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° c. (2 g, loading 26.5%).
- step 1 The product of step 1 (0.674) was dissolved in dry toluene in 3-necked 50 ml round bottom flash in inert atmosphere. Then this dissolved mass was treated with SBA-15 (2.0 g) for 48 h. at refluxing temperature. Reaction was further processed as per the step 2 of the example 3. (2 g, loading 26.0% by TGA).
- the epoxy product from the step 2 (26.0% loading, 2 g) was treated with aniline (500 ⁇ l) in 10 ml dry toluene in inert atmosphere. The suspension was refluxed for 12 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 26.2%).
- step 1 The product of step 1 (0.674 g) was dissolved in dry toluene in 3-necked 50 ml round bottom flask in an inert atmosphere. Then this dissolved mass was treated with MCF (2.0 g) for 48 h. at refluxing temperature. The reaction mass was filtered and washed with dry toluene for several time then dried under vacuum. The dried material was subjected to Soxhlet extraction with dry toluene for 10 h followed by drying the sample under vacuum.(2.2 g, loading 27.0% by TGA)
- the epoxy product from the step 2 (27.0% loading, 2 g) was treated with aniline (600 ⁇ l) in 10 ml dry toluene in inert atmosphere. The suspension was refluxed for 12 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 27.6%).
- step 1 The product of step 1 (0.674 g) was dissolved in dry toluene in 3-necked 50 ml round bottom flash in inert atmosphere. Then this dissolved mass was treated with MCF (2.0 g) and processed as per the method of step 2 of example 5. Yield; 2 g, loading 26.5% by TGA.
- the epoxy product from the step 2 (26.5% loading, 2 g) was treated with aniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere and the reaction was processed as per the step 3 of the example 5. (Yield; 2 g, loading 27.0%).
- step 1 The product of step 1 (0.700 g) was dissolved in dry toluene in 3-necked 50 ml round bottom flask in an inert atmosphere.
- the reaction mixture was treated with MCM-41 (2 g) for 48 h. at the refluxing temperature of toluene.
- the reaction mass was filtered and washed with dry toluene for several time then dried under vacuum.
- the dried material was subjected to Soxhlet extraction with dry toluene for 10 h followed by drying the sample under vacuum (2.2 g, loading 20.5% by TGA)
- the epoxy product from the step 2 (20.5% loading, 2 g) was treated with aniline (455 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 12 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 25.6%).
- step 1 The product of step 1 (0.700 g) was dissolved in dry toluene in 3-necked 50 ml round bottom flask in inert atmosphere. Then this dissolved mass was treated with MCM-41 (2.0 g) in the manner described in step 2 of the example 7. (2.0 g, loading 21.0% by TGA)
- the epoxy product from the step 2 (21.1% loading, 2 g) was treated with aniline (455 ⁇ l) in 10 ml dry toluene in an inert atmosphere.
- the reaction was processed as per the method described in step 3 of the example 7. Yield (2 g, loading 25.0%).
- step 1 The product of step 1 (0.674 g) was dissolved in dry toluene in 3-necked 50 ml round bottom flask in an inert atmosphere. Then this dissolved mass was treated with SBA-15 (2.0 g) for 48 h. at refluxing temperature. The reaction mass was filtered and washed with dry toluene for several time then dried under vacuum. The dried material was subjected to Soxhlet extraction with dry toluene for 10 h followed by drying the sample under vacuum. Yield (2.4 g, loading 23.5% by TGA).
- the epoxy product from the step 2 (23.5% loading, 2 g) was treated with aniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 12 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 26.8%).
- This material was prepared by the method described in the step 1 of the example 7.
- this material was prepared by following the procedure given in step 2 of the example 7.
- the epoxy product from the step 2 (20.5% loading, 2 g) was treated with N-methylaniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 18 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 23.5%).
- This material was prepared by the method described in the step 1 of the example 7.
- This material was prepared by following the procedure given in step 2 of the example 7.
- the epoxy product from the step 2 (20.5% loading, 2 g) was treated with 4-methyl aniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 18 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhiet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 23.5%).
- This material was prepared by the method described in the step 1 of the example 7.
- This material was prepared by following the procedure given in step 2 of the example 7.
- the epoxy product from the step 2 (20.5% loading, 2 g) was treated with 4-chloro aniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 18 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 23.5%).
- This material was prepared by the method described in the step 1 of the example 7.
- This material was prepared by following the procedure given in step 2 of the example 7.
- the epoxy product from the step 2 (20.5% loading, 2 g) was treated with 4-methoxy aniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 18 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 23.5%).
- This material was prepared by the method described in the step 1 of the example 5.
- this material was prepared by following the procedure given in step 2 of the example 5.
- the epoxy product from the step 2 (20.5% loading, 2 g) was treated with 4-methoxy aniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 18 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 23.5%).
- This material was prepared by the method described in the step 1 of the example 5.
- this material was prepared by following the procedure given in step 2 of the example 5.
- the epoxy product from the step 2 (20.5% loading, 2 g) was treated with 4-chloro aniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 18 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 23.5%).
- This material was prepared by the method described in the step 1 of the example 5.
- this material was prepared by following the procedure given in step 2 of the example 5.
- the epoxy product from the step 2 (20.5% loading, 2 g) was treated with 4-methyl aniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 18 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 23.5%).
- This material was prepared by the method described in the step 1 of the example 9.
- This material was prepared by following the procedure given in step 2 of the example 9.
- the epoxy product from the step 2 (20.5% loading, 2 g) was treated with 4-methyl aniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 18 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 23.5%).
- This material was prepared by the method described in the step 1 of the example 9.
- This material was prepared by following the procedure given in step 2 of the example 9.
- the epoxy product from the step 2 (20.5% loading, 2 g) was treated with 4-methoxy aniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 18 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 23.5%).
- This material was prepared by the method described in the step 1 of the example 9.
- This material was prepared by following the procedure given in step 2 of the example 9.
- the epoxy product from the step 2 (20.5% loading, 2 g) was treated with 4-chloro aniline (600 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 18 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to the soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. (2 g, loading 23.5%).
- step 1 The product of step 1 (0.674) was dissolved in dry toluene in a 3-necked 50 ml round bottom flask in an inert atmosphere. The dissolved mass was treated with MCM-41 (2.0 g) for 48 h. at the refluxing temperature of toluene. The reaction mass was filtered and washed with dry toluene for several time then dried under vacuum. The dried material was subjected to Soxhlet extraction with dry toluene for 10 h followed by drying the sample under vacuum. Yield; (2 g, loading 22.5% by TGA)
- the epoxy product from the step 2 (22.5% loading, 2 g) was treated with aniline (455 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 12 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with dry toluene and subjected to Soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° c. Yield; (2 g, loading 25.6% by TGA).
- step 1 The product of step 1 (0.674) was dissolved in dry toluene in a 3-necked 50 ml round bottom flask in an inert atmosphere. The dissolved mass was treated with MCM-41 (2.0 g) for 48 h. at the refluxing temperature of toluene. The reaction mass was filtered and washed with dry toluene for several time then dried under vacuum. The dried material was subjected to Soxhlet extraction with dry toluene for 10 h followed by drying the sample under vacuum. Yield; (2 g, loading 22.5% by TGA)
- the epoxy product from the step 2 (22.5% loading, 2 g) was treated with aniline (455 ⁇ l) in 10 ml dry toluene in an inert atmosphere. The suspension was refluxed for 12 h. The reaction mixture was cooled to room temperature and the solid was filtered, washed repeatedly with -dry toluene and subjected to Soxhlet extraction with toluene and isopropanol (7:3) for 10 h. Finally the sample was dried under vacuum at 40° C. Yield; (2 g, loading 25.6% by TGA).
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2160/DEL/2006 | 2006-09-29 | ||
IN2160DE2006 | 2006-09-29 | ||
PCT/IN2007/000376 WO2008038300A1 (fr) | 2006-09-29 | 2007-08-30 | sorbant chiral hybride ORGANIQUE - INORGANIQUE ET SON PROCESSUS DE PRÉPARATION |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2007/000376 A-371-Of-International WO2008038300A1 (fr) | 2006-09-29 | 2007-08-30 | sorbant chiral hybride ORGANIQUE - INORGANIQUE ET SON PROCESSUS DE PRÉPARATION |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/954,402 Division US9272261B2 (en) | 2006-09-29 | 2013-07-30 | Organic-inorganic hybrid chiral sorbent and process for the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
US20100286425A1 true US20100286425A1 (en) | 2010-11-11 |
Family
ID=40590081
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/443,065 Abandoned US20100286425A1 (en) | 2006-09-29 | 2007-08-30 | Organic-inorganic hybrid chiral sorbent and process for the preparation thereof |
US13/954,402 Expired - Fee Related US9272261B2 (en) | 2006-09-29 | 2013-07-30 | Organic-inorganic hybrid chiral sorbent and process for the preparation thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/954,402 Expired - Fee Related US9272261B2 (en) | 2006-09-29 | 2013-07-30 | Organic-inorganic hybrid chiral sorbent and process for the preparation thereof |
Country Status (8)
Country | Link |
---|---|
US (2) | US20100286425A1 (fr) |
EP (1) | EP2066440B1 (fr) |
JP (1) | JP5312332B2 (fr) |
KR (1) | KR101408128B1 (fr) |
CN (1) | CN101568380B (fr) |
AU (1) | AU2007301436B2 (fr) |
CA (1) | CA2664855C (fr) |
WO (1) | WO2008038300A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114534311A (zh) * | 2021-08-26 | 2022-05-27 | 昆明医科大学 | 一种硫间隔臂(r)-bionl csp填料及其制备方法 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2935381B1 (fr) * | 2008-08-29 | 2010-12-17 | Servier Lab | Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine |
CN102734812B (zh) * | 2011-04-14 | 2014-10-29 | 北京化工大学 | 一种用于脱除含氰废气的方法 |
CN102746423B (zh) * | 2011-04-19 | 2014-03-19 | 中国科学院大连化学物理研究所 | 有机-无机杂化环糊精类手性分离多孔整体材料的制备 |
CN103018354A (zh) * | 2012-11-26 | 2013-04-03 | 沈阳化工大学 | 一种抗溃疡药物的手性分离分析方法 |
CN109689667B (zh) * | 2016-08-22 | 2022-07-12 | 南开大学 | 多孔手性材料及其用途 |
CN109529794B (zh) * | 2018-12-27 | 2021-12-17 | 中国人民解放军第四军医大学 | 光学纯扁桃酸衍生物-纤维素手性固定相、制备方法及应用 |
CN109821507A (zh) * | 2019-03-18 | 2019-05-31 | 云南师范大学 | 一种用于对映异构体拆分的CTpBD@SiO2手性柱 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5098841A (en) * | 1988-06-06 | 1992-03-24 | Ciba-Geigy Corporation | Process for the preparation of hydroxy acids |
US5223416A (en) * | 1990-03-30 | 1993-06-29 | Nitto Chemical Industry Co., Ltd. | Process for producing r(-)-mandelic acid and derivatives thereof |
US5296373A (en) * | 1991-06-26 | 1994-03-22 | Nitto Chemical Industry Co., Ltd. | Process for producing R(-)-mandelic acid or a derivative thereof from a mandelonitrile using rhodococcus |
US5441888A (en) * | 1992-11-05 | 1995-08-15 | Tanabe Seiyaku Co., Ltd. | Process for producing D-mandelic acid from benzoylformic acid |
US5714357A (en) * | 1993-02-03 | 1998-02-03 | Nitto Chemical Industry Co., Ltd. | Process for producing optically active α-hydroxycarboxylic acid having phenyl group |
US6326326B1 (en) * | 1998-02-06 | 2001-12-04 | Battelle Memorial Institute | Surface functionalized mesoporous material and method of making same |
US6777224B2 (en) * | 2001-10-24 | 2004-08-17 | Daicel Chemical Industries, Ltd. | Method for producing optically active mandelic acid derivatives |
US20100136319A1 (en) * | 2008-12-03 | 2010-06-03 | Keio University | Method for forming mesoporous silica layer, its porous coating, anti-reflection coating, and optical member |
US8063114B2 (en) * | 2004-04-30 | 2011-11-22 | Japan Science And Technology Agency | Inorganic mesoporous material having chiral twisted structure and process for producing the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004054708A2 (fr) * | 2002-12-18 | 2004-07-01 | University Of Ottawa | Adsorbant modifie conçu pour le lavage a sec et son utilisation |
US7767620B2 (en) * | 2004-03-16 | 2010-08-03 | Novx Systems Inc. | Hybrid porous organic-metal oxide materials |
JP4515812B2 (ja) * | 2004-04-28 | 2010-08-04 | ダイセル化学工業株式会社 | 光学異性体用分離剤 |
-
2007
- 2007-08-30 US US12/443,065 patent/US20100286425A1/en not_active Abandoned
- 2007-08-30 CN CN200780044113XA patent/CN101568380B/zh not_active Expired - Fee Related
- 2007-08-30 KR KR1020097008745A patent/KR101408128B1/ko not_active IP Right Cessation
- 2007-08-30 JP JP2009529857A patent/JP5312332B2/ja not_active Expired - Fee Related
- 2007-08-30 CA CA2664855A patent/CA2664855C/fr not_active Expired - Fee Related
- 2007-08-30 EP EP07827551.8A patent/EP2066440B1/fr not_active Expired - Fee Related
- 2007-08-30 AU AU2007301436A patent/AU2007301436B2/en not_active Ceased
- 2007-08-30 WO PCT/IN2007/000376 patent/WO2008038300A1/fr active Application Filing
-
2013
- 2013-07-30 US US13/954,402 patent/US9272261B2/en not_active Expired - Fee Related
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5098841A (en) * | 1988-06-06 | 1992-03-24 | Ciba-Geigy Corporation | Process for the preparation of hydroxy acids |
US5223416A (en) * | 1990-03-30 | 1993-06-29 | Nitto Chemical Industry Co., Ltd. | Process for producing r(-)-mandelic acid and derivatives thereof |
US5296373A (en) * | 1991-06-26 | 1994-03-22 | Nitto Chemical Industry Co., Ltd. | Process for producing R(-)-mandelic acid or a derivative thereof from a mandelonitrile using rhodococcus |
US5441888A (en) * | 1992-11-05 | 1995-08-15 | Tanabe Seiyaku Co., Ltd. | Process for producing D-mandelic acid from benzoylformic acid |
US5714357A (en) * | 1993-02-03 | 1998-02-03 | Nitto Chemical Industry Co., Ltd. | Process for producing optically active α-hydroxycarboxylic acid having phenyl group |
US6326326B1 (en) * | 1998-02-06 | 2001-12-04 | Battelle Memorial Institute | Surface functionalized mesoporous material and method of making same |
US6777224B2 (en) * | 2001-10-24 | 2004-08-17 | Daicel Chemical Industries, Ltd. | Method for producing optically active mandelic acid derivatives |
US8063114B2 (en) * | 2004-04-30 | 2011-11-22 | Japan Science And Technology Agency | Inorganic mesoporous material having chiral twisted structure and process for producing the same |
US20100136319A1 (en) * | 2008-12-03 | 2010-06-03 | Keio University | Method for forming mesoporous silica layer, its porous coating, anti-reflection coating, and optical member |
Non-Patent Citations (2)
Title |
---|
Mayani et al. Journal of Chromatography A, 1135 (2006), pp.186-93. * |
Rocchia et al., Phys. Stat. Sol. (a) 197, Nol. 2, pp. 365-369 (2003) * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114534311A (zh) * | 2021-08-26 | 2022-05-27 | 昆明医科大学 | 一种硫间隔臂(r)-bionl csp填料及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
KR101408128B1 (ko) | 2014-06-16 |
CA2664855C (fr) | 2014-04-29 |
WO2008038300A1 (fr) | 2008-04-03 |
CN101568380A (zh) | 2009-10-28 |
US20130317244A1 (en) | 2013-11-28 |
EP2066440A1 (fr) | 2009-06-10 |
CA2664855A1 (fr) | 2008-04-03 |
US9272261B2 (en) | 2016-03-01 |
AU2007301436A1 (en) | 2008-04-03 |
CN101568380B (zh) | 2013-08-28 |
EP2066440B1 (fr) | 2015-09-09 |
AU2007301436B2 (en) | 2013-03-14 |
JP5312332B2 (ja) | 2013-10-09 |
JP2010505110A (ja) | 2010-02-18 |
WO2008038300A8 (fr) | 2009-05-07 |
KR20090083895A (ko) | 2009-08-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9272261B2 (en) | Organic-inorganic hybrid chiral sorbent and process for the preparation thereof | |
JP3808500B2 (ja) | 分離剤としての大環状抗生物質 | |
US4322310A (en) | Chiral supports for resolution of racemates | |
US7749389B2 (en) | Filler used for separating optical isomers and process for separating optical isomers with the filler | |
US5104547A (en) | Separating materials for chromatography comprising cyclodextrin chemically bonded to a support via a carbamic acid group | |
EP0459530B1 (fr) | Phénylcarbamate substitué par des groupes alcoyles, dérivé de polysaccharide | |
Muderawan et al. | Urea bonded cyclodextrin derivatives onto silica for chiral HPLC | |
US5290440A (en) | High performance chiral selector | |
US20090008329A1 (en) | Separating agent for enantiomeric isomers | |
KR0167138B1 (ko) | 광학이성체용 분리제 | |
KR101011784B1 (ko) | 광학이성체용 분리제 | |
EP0182170B1 (fr) | Procédé de résolution de racémates | |
US7615150B2 (en) | Separation agent for separating optical isomer and method for preparation thereof | |
JPH0829404A (ja) | 光学異性体の擬似移動層式クロマト分離法 | |
US5514818A (en) | Resolution of stereoisomers of aliphatic epoxides | |
CN1472003A (zh) | 杯芳烃键合硅胶固定相及其制备方法和用途 | |
SU1217461A1 (ru) | Способ получени сорбента дл аффинной хроматографии | |
US20060081522A1 (en) | Separating agent for optical isomers | |
CA2571034A1 (fr) | Nouvelles colonnes chirales a large selectivite chirale | |
EP1623978B1 (fr) | Procede de production d'un (3r, 5s, 6e)-7- [2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptanoate d'ethyle | |
JPH05240848A (ja) | 分離剤 | |
WO2005105257A1 (fr) | Phase stationnaire chromatographique pour une separation de cyclodextrine et de derives de celle-ci |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |