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Mitral valve replacement with atrial anchoring

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Publication number
US20100217382A1
US20100217382A1 US12393010 US39301009A US20100217382A1 US 20100217382 A1 US20100217382 A1 US 20100217382A1 US 12393010 US12393010 US 12393010 US 39301009 A US39301009 A US 39301009A US 20100217382 A1 US20100217382 A1 US 20100217382A1
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Patent type
Prior art keywords
valve
mitral
assembly
stent
atrium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12393010
Inventor
Mark Chau
Seung Yi
Phillip P. Corso, JR.
Michael Popp
Kevin Golemo
Jane M. Olin
Son V. Nguyen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Edwards Lifesciences AG
Edwards Lifesciences Corp
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Edwards Lifesciences AG
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A61F2/2457Chordae tendineae prostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418Scaffolds therefor, e.g. support stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2427Devices for manipulating or deploying heart valves during implantation
    • A61F2/2436Deployment by retracting a sheath
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008Fixation appliances for connecting prostheses to the body
    • A61F2220/0016Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028Shapes in the form of latin or greek characters
    • A61F2230/0054V-shaped
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0073Quadric-shaped
    • A61F2230/0078Quadric-shaped hyperboloidal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter

Abstract

A prosthetic mitral valve assembly and method of inserting the same is disclosed. In certain disclosed embodiments, the prosthetic mitral valve assembly includes a stent and valve combination. The stent is designed so that the anchoring portion is positioned above the annulus of the mitral valve and in the left atrium. The stent is radially expandable so that it can expand into position against the walls of the left atrium and accommodate a wide range of anatomies. Contact between the stent and the native tissue in the left atrium reduces paravalvular leakage and prevents migration of the stent once in place.

Description

    FIELD
  • [0001]
    The present disclosure concerns a prosthetic mitral heart valve and a method for implanting such a heart valve.
  • BACKGROUND
  • [0002]
    Prosthetic cardiac valves have been used for many years to treat cardiac valvular disorders. The native heart valves (such as the aortic, pulmonary, tricuspid and mitral valves) serve critical functions in assuring the forward flow of an adequate supply of blood through the cardiovascular system. These heart valves can be rendered less effective by congenital, inflammatory, infectious conditions or disease. Such damage to the valves can result in serious cardiovascular compromise or death. For many years the definitive treatment for such disorders was the surgical repair or replacement of the valve during open heart surgery, but such surgeries are prone to many complications. More recently a transvascular technique has been developed for introducing and implanting a prosthetic heart valve using a flexible catheter in a manner that is less invasive than open heart surgery.
  • [0003]
    In this technique, a prosthetic valve is mounted in a crimped state on the end portion of a flexible catheter and advanced through a blood vessel of the patient until the valve reaches the implantation site. The valve at the catheter tip is then expanded to its functional size at the site of the defective native valve such as by inflating a balloon on which the valve is mounted.
  • [0004]
    Another known technique for implanting a prosthetic aortic valve is a transapical approach where a small incision is made in the chest wall of a patient and the catheter is advanced through the apex (i.e., bottom tip) of the heart. Transapical techniques are disclosed in U.S. Patent Application Publication No. 20070112422, which is hereby incorporated by reference. Like the transvascular approach, the transapical approach includes a balloon catheter having a steering mechanism for delivering a balloon-expandable prosthetic heart valve through an introducer to the aortic annulus. The balloon catheter includes a deflecting segment just proximal to the distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus.
  • [0005]
    The above techniques and others have provided numerous options for high-risk patients with aortic valve stenosis to avoid the consequences of open heart surgery and cardiopulmonary bypass. While procedures for the aortic valve are well-developed, such procedures are not necessarily applicable to the mitral valve.
  • [0006]
    Mitral valve repair has increased in popularity due to its high success rates, and clinical improvements noted after repair. Unfortunately, a significant percentage of patients still receive mitral valve replacement due to stenosis or anatomical limitations. There are a number of technologies aimed at making mitral repair a less invasive procedure. These technologies range from iterations of the Alfieri stitch procedure to coronary sinus-based modifications of mitral anatomy to subvalvular placations or ventricular remodeling devices, which would incidently correct mitral regurgitation.
  • [0007]
    However, for mitral valve replacement, few less-invasive options are available. There are approximately 60,000 mitral valve replacements (MVR) each year and it is estimated that another 60,000 patients should receive a MVR due to increased risk of operation and age. The large majority of these replacements are accomplished through open-heart surgery. One potential option for a less invasive mitral valve replacement is disclosed in U.S. Patent Application 2007/0016286 to Herrmann. However, the stent disclosed in that application has a claw structure for attaching the prosthetic valve to the heart. Such a claw structure could have stability issues and limit consistent placement of a transcatheter mitral replacement valve.
  • [0008]
    Accordingly, further options are needed for less-invasive mitral valve replacement.
  • SUMMARY
  • [0009]
    A prosthetic mitral valve assembly and method of inserting the same is disclosed.
  • [0010]
    In certain disclosed embodiments, the prosthetic mitral valve assembly includes a stent and valve combination. The stent is designed so that the anchoring portion is positioned above the annulus of the mitral valve and in the left atrium. The stent is radially expandable and can press against the walls of the left atrium with a pressure or friction fit to accommodate a wide range of anatomies.
  • [0011]
    In one embodiment, the entire prosthetic mitral valve assembly is positioned above the native annulus so that the native mitral valve leaflets and chordae are preserved. As a result, the prosthetic mitral valve and the native mitral valve function in series.
  • [0012]
    In another embodiment, a majority of the prosthetic mitral valve assembly is implantable in the left atrium. However, a lower portion of the mitral valve assembly extends into the native mitral valve rendering the native mitral valve incompetent. Contact between the stent and the native tissue in the left atrium reduces paravalvular leakage and prevents migration of the stent once in place.
  • [0013]
    In another embodiment, a majority of the prosthetic mitral valve assembly is implantable in the left atrium. A lower tapered portion partially extends into the native mitral valve but does not extend into the left ventricle in order to ensure that the chordae tendineae are not contacted by portions of the stent. This embodiment can improve cardiac performance while preserving the function of the chordae tendineae.
  • [0014]
    In yet another embodiment, the mitral valve assembly includes additional anchoring with one or more anchoring arms that contact an upper portion of the atrium or the pulmonary veins. The anchoring arms utilize the natural anatomy of the patient's heart in order to resist against upward migration of the assembly. Other embodiments also use the upper portion of the atrium or the pulmonary veins without using anchoring arms.
  • [0015]
    The foregoing and other objects, features, and advantages of the invention will become more apparent from the following detailed description, which proceeds with reference to the accompanying figures.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0016]
    FIG. 1 is a perspective view of an embodiment of a mitral valve assembly that can be inserted into the native mitral valve, but that is anchored above a native annulus.
  • [0017]
    FIG. 2 is a perspective view of another embodiment of a mitral valve assembly that can work in series with the native mitral valve.
  • [0018]
    FIG. 3 is a perspective view of another embodiment of a mitral valve assembly having outwardly extending prongs for anchoring the assembly.
  • [0019]
    FIG. 4 is a perspective view of another embodiment of a mitral valve assembly that can extend partially into the native mitral valve.
  • [0020]
    FIG. 5 is a cross-sectional view of a heart with the mitral valve assembly of FIG. 2 mounted in the left atrium.
  • [0021]
    FIG. 6 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with the mitral valve assembly extending to a roof of the atrium.
  • [0022]
    FIG. 7 is a cross-sectional view of a heart with another embodiment of the mitral valve assembly mounted in the left atrium and having at least one anchoring arm extending to a roof of the atrium.
  • [0023]
    FIG. 8 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with at least one anchoring arm extending into at least one pulmonary vein.
  • [0024]
    FIG. 9 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with at least one anchoring arm extending to a roof of the atrium.
  • [0025]
    FIG. 10 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with at least one anchoring arm extending into at least one pulmonary vein.
  • [0026]
    FIG. 11 is a cross-sectional view of a heart having the mitral valve assembly of FIG. 1 mounted in the left atrium with a lower portion of the mitral valve assembly positioned in the native mitral valve.
  • [0027]
    FIG. 12 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with the mitral valve assembly extending to the roof of the atrium and with a lower portion of the mitral valve assembly positioned in the native mitral valve.
  • [0028]
    FIG. 13 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with at least one anchoring arm extending to a roof of the atrium and with a lower portion of the mitral valve assembly positioned in the native mitral valve.
  • [0029]
    FIG. 14 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with at least one anchoring arm extending into pulmonary veins and with a lower portion of the mitral valve assembly positioned in the native mitral valve.
  • [0030]
    FIG. 15 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with at least one anchoring arm extending to a roof of the atrium and with a lower portion of the mitral valve assembly positioned in the native mitral valve.
  • [0031]
    FIG. 16 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with at least one anchoring arm extending into pulmonary veins and with a lower portion of the mitral valve assembly positioned in the native mitral valve.
  • [0032]
    FIG. 17 is a cross-sectional view of a heart having the mitral valve assembly of FIG. 4 mounted in the left atrium.
  • [0033]
    FIG. 18 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with the mitral valve assembly extending to a roof of the atrium.
  • [0034]
    FIG. 19 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with at least one anchoring arm extending to a roof of the atrium and with a lower portion of the mitral valve assembly partially extending into the native mitral valve.
  • [0035]
    FIG. 20 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with at least one anchoring arm extending into pulmonary veins and with a lower portion of the mitral valve assembly partially extending into the native mitral valve.
  • [0036]
    FIG. 21 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with at least one anchoring arm extending to a roof of the atrium and with a lower portion of the mitral valve assembly partially extending into the native mitral valve.
  • [0037]
    FIG. 22 is a cross-sectional view of a heart having another embodiment of the mitral valve assembly mounted in the left atrium with at least one anchoring arm extending into pulmonary veins and with a lower portion of the mitral valve assembly partially extending into the native mitral valve.
  • [0038]
    FIG. 23A is a cross-sectional view of the distal end portion of a delivery apparatus that can be used to implant a prosthetic mitral valve in the heart, according to another embodiment.
  • [0039]
    FIG. 23B is an enlarged view of a portion of FIG. 23A showing the connection between the valve stent and the distal end of the delivery apparatus.
  • [0040]
    FIG. 23C is a perspective view of the delivery apparatus of FIG. 23A.
  • [0041]
    FIGS. 23D and 23E illustrate the valve being deployed from the delivery apparatus shown in FIG. 23A.
  • [0042]
    FIG. 24A is a perspective view of a delivery apparatus for a prosthetic valve shown with the sheath of the delivery apparatus in a retracted position for deploying the valve, according to another embodiment.
  • [0043]
    FIG. 24B is a perspective view of the delivery apparatus of FIG. 24A shown with the sheath in a distal position for covering the valve during valve delivery.
  • [0044]
    FIG. 24C is an enlarged, perspective view of an end piece of the delivery apparatus of FIG. 24A and three posts of a valve stent that are received within respective recesses in the end piece.
  • [0045]
    FIG. 24D is a cross-sectional view of the end piece shown in FIG. 24C.
  • [0046]
    FIG. 25 is a perspective view of an embodiment of a prosthetic valve assembly having tensioning members coupled to prosthetic leaflets of the valve to simulate chordae tendineae.
  • [0047]
    FIG. 26 is a perspective view of a prosthetic valve assembly having tensioning members, according to another embodiment.
  • [0048]
    FIG. 27 is a perspective view of a prosthetic valve assembly having tensioning members, according to another embodiment.
  • DETAILED DESCRIPTION
  • [0049]
    As used herein, the singular forms “a,” “an,” and “the” refer to one or more than one, unless the context clearly dictates otherwise.
  • [0050]
    As used herein, the term “includes” means “comprises.” For example, a device that includes or comprises A and B contains A and B but can optionally contain C or other components other than A and B. A device that includes or comprises A or B may contain A or B or A and B, and optionally one or more other components such as C.
  • [0051]
    FIG. 1 is a perspective view of a mitral valve assembly 8 that can be used as a mitral valve replacement. The mitral valve assembly 8 includes a radially compressible and expandable stent 10 having an upper portion 12 with an enlarged end, a tapered middle portion 14 and a lower portion 16 with a circumference that is less than that of the upper portion 12. The stent can be an inverted bell shape, but other shapes can be used. Additionally, although only the middle portion 14 is shown as tapered, the stent 10 can have a continuous taper from the upper portion 12 to the lower portion 16. An upper edge 18 of the stent 10 can be a sawtoothed or scalloped pattern to maximize a surface area with which the stent connects to the native tissue. Alternatively, the upper edge can be a straight edge, or some other pattern.
  • [0052]
    The stent 10 can have a self-expanding frame 20 formed from a shape memory material, such as, for example, Nitinol. The illustrated embodiment shows that the stent frame 20 can include metal strips or struts arranged in a lattice pattern, but other patterns can be used. In certain embodiments the stent frame 20 can be made of stainless steel or any other suitable materials. The tapered middle portion 14 can have certain of the metal strips intentionally disconnected from the upper portion 12 in order to create prongs 22 extending outwardly from the stent 10 that assist in holding the prosthetic mitral valve assembly to the native tissue. Alternatively, barbs (not shown) can be separately attached to the stent in order to create the prongs. One advantage of the illustrated embodiment is that the prongs 22 are formed from the frame itself or integral with the frame, rather than being separately added. In other embodiments (not shown), the disconnected metal strips can be connected, if the prongs 22 are not desired. In such a case, each cell of the tapered portion 14 can be connected to the upper portion 12. A biocompatible sheet or fabric material 24 can be connected to the inner surface of the frame 20 to form an inner layer or envelope covering the open portions of the stent to reduce paravalular leakage. The sheet or fabric 24 can be made from synthetic materials, such as a polyester material or a biocompatible polymer. One example of a polyester material is polyethylene terephthalate (PET). Alternative materials can be used. For example, the sheet or fabric can be made from biological matter, such as natural tissue, pericardial tissue (e.g., bovine, porcine or equine pericadium) or other biological tissue. The sheet or fabric 24 can be connected to the frame 20 by sutures, such as shown at 26.
  • [0053]
    As shown in dashed lines, the mitral valve assembly 8 includes a valve 28 positioned in the lower portion 16 of the stent 10. The valve 28 can have a leafed-valve configuration, such as a bicuspid valve or tricuspid valve configuration. The valve 28 can be connected to the frame 20 using, for example, sutures 26 or other suitable connection techniques well-known in the art. Alternatively, the valve 18 can be a mechanical type valve, rather than a leafed type valve. Still further, the valve 18 can be made from biological matter, such as natural tissue, pericardial tissue (e.g., bovine, porcine or equine pericadium), a harvested natural valve, or other biological tissue. Alternatively, the valve can be made from biocompatible synthetic materials (e.g., biocompatible polymers), which are well known in the art. Blood flow through the valve proceeds in a direction from the upper portion 12 to the lower portion 16. Those skilled in the art will recognize that the particular type of valve used is not of importance and a wide variety of valves can be used.
  • [0054]
    The features of FIG. 1 can be used in any of the embodiments herein described. Thus, for each of the embodiments below, the materials that can be used for the valve, the biocompatible sheet, and the frame will not be repeated and should be assumed to be at least those described in FIG. 1. Additionally, the prongs and barbs of FIG. 1 can be used in any of the embodiments described herein.
  • [0055]
    FIG. 2 is a perspective view of another embodiment of a mitral valve assembly 38 sized for atrial implantation and designed to work in series with the native mitral valve, as further described below. The mitral valve assembly 38 includes a stent 40 having a frame 42 supporting a biocompatible sheet or fabric 44, both of which are similar to those already described. The stent supports a valve (not visible in FIG. 2) attached to and sized to be compatible with the frame 42. Any of the valves already described can be used. However, because of the location of the stent 40 in the atrium, the valve can be larger than that of FIG. 1.
  • [0056]
    FIG. 3 is a perspective view of another embodiment of a mitral valve assembly, which is the same as FIG. 2, but with prongs 45 added. More particularly, cells of the frame's lattice structure are left intentionally disconnected from adjacent cells and are bent outwardly to create the prongs 45. FIG. 3 is illustrative that prongs can be added to any of the embodiments described herein. Alternatively, the prongs can be removed from any of the embodiments simply by leaving the lattice structure fully connected. Furthermore, in any of the embodiments herein described, barbs (not shown) can be separately attached to the stent in order to create the prongs.
  • [0057]
    FIG. 4 shows another embodiment 46 of a mitral valve assembly having an upper portion and a lower tapered portion 47. The mitral valve assembly includes a frame 48 having a lattice structure with certain cells of the lattice left intentionally disconnected to create outwardly extending prongs 49, similar to those described in relation to FIG. 1 (the prongs can be eliminated or separate barbs added, as already described above). The lower tapered portion 47 partially extends into the native mitral valve, but does not extend into the left ventricle, which can improve cardiac performance and ensure that the chordae tendineae are not damaged by the assembly.
  • [0058]
    FIG. 5 shows a cross-sectional view of a heart with the prosthetic mitral-valve assembly 38 inserted into a patient's heart. For purposes of background, the four-chambered heart is explained further. On the left side of the heart, the native mitral valve 50 is located between the left atrium 52 and left ventricle 54. The mitral valve 50 generally comprises two leaflets, an anterior leaflet 56 and a posterior leaflet 58 that are attached to the left ventricle by chordae tendineae 59, which prevent eversion of the leaflets into the left atrium. The mitral valve leaflets are attached to a mitral valve annulus 60, which is defined as the portion of tissue surrounding the mitral valve orifice. More specifically, the mitral annulus constitutes the anatomical junction between the ventricle and the left atrium, and serves an insertion site for the leaflet tissue. The left atrium 52 receives oxygenated blood from the pulmonary veins 61 (only two of four pulmonary veins are shown for simplicity). The oxygenated blood that is collected in the left atrium 52 enters the left ventricle 54 through the mitral valve 50. Contraction of the left ventricle 54 forces blood through the left ventricular outflow tract and into the aorta (not shown). As used herein, the left ventricular outflow tract (LVOT) is intended to generally include the portion of the heart through which blood is channeled from the left ventricle to the aorta. On the right side of the heart, the tricuspid valve 66 is located between the right atrium 68 and the right ventricle 70. The right atrium 68 receives blood from the superior vena cava 72 and the inferior vena cava (not shown). The superior vena cava 72 returns de-oxygenated blood from the upper part of the body and the inferior vena cava returns de-oxygenated blood from the lower part of the body. The right atrium 68 also receives blood from the heart muscle itself via the coronary sinus. The blood in the right atrium 68 enters into the right ventricle 70 through the tricuspid valve 66. Contraction of the right ventricle forces blood through the right ventricle outflow tract and into the pulmonary arteries. The left and right sides of the heart are separated by a wall generally referred to as the septum 78. The portion of the septum that separates the two upper chambers (the right and left atria) of the heart is termed the artial (or interatrial) septum while the portion of the septum that lies between the two lower chambers (the right and left ventricles) of the heart is called the ventricular (or interventricular) septum. A healthy heart has a generally conical shape that tapers from a base to an apex 80.
  • [0059]
    The mitral valve assembly 38 is shown as positioned above the annulus 60 of the native mitral valve 50 and entirely within the left atrium. As already described, the stent 40 is radially expandable and is anchored in the atrium through a pressure or friction fit with the surrounding tissue. Through radial expansion, the frame 42 adapts to the natural anatomy of the patient's atrium. For purposes of illustration, a valve 90 is shown as visible through the biocompatible sheet 44. As shown, the native mitral valve 50 is competent and works in series with the prosthetic mitral valve assembly 38. Any regurgitant volume that passes back through the native valve in the left atrium is immediately blocked by the secondary prosthetic mitral valve assembly 38. The native valve absorbs the majority of the systolic pressure, while the prosthetic mitral valve assembly 38 receives only a fraction of the systolic pressure imparted by the regurgitant volume. As a result, the prosthetic mitral valve assembly can have improved durability and reduced risk of valve migration. Such an ability to work in series with the native mitral valve is also true of the embodiments described in FIGS. 6-10.
  • [0060]
    FIG. 6 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 100 inserted into the atrium. In this embodiment, a stent 102 has a self-expanding frame similar to stent 40 described above. The mitral valve assembly 100 has a dome-shaped upper portion 104 that can expand to fit the natural anatomical geometry of a roof of the atrium. As a result, the mitral valve assembly 100 can expand in two dimensions, such as a horizontal direction and a vertical direction. By expanding horizontally, the mitral-valve assembly uses side walls of the atrium to anchor the assembly. By expanding vertically, the assembly expands between the annulus of the mitral valve and the roof of the atrium in order to anchor the assembly in the atrium. Thus, the roof of the atrium can exert a downward pressure on the assembly in order to prevent upward migration. A biocompatible sheet 106 extends from a bottom edge of the stent to some point below the pulmonary veins 61 so that blood flow through the pulmonary veins remains unobstructed. A valve (not shown) can be positioned at a lower end of the assembly and works in series with the native mitral valve, similar to the embodiments already described.
  • [0061]
    FIG. 7 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 120 inserted into the atrium and positioned above the annulus 60 of the native mitral valve 50. The assembly 120 includes a radially-expandable stent 122 that is anchored in the atrium through a pressure or friction fit. Through radial expansion, the frame of the stent adapts to the natural anatomy of the patient's atrium. A valve 124 is shown as visible through a biocompatible sheet 126. As shown, the native mitral valve 50 is competent and works in series with the prosthetic mitral valve assembly 120. Any regurgitant volume that passes by the native valve is blocked by the secondary prosthetic valve assembly. As already described, the result is an assembly with improved durability and reduced risk of valve migration. As in the other embodiments, the biocompatible sheet 126 is attached to the stent 122 in order to prevent paravalvular leakage. Four anchoring arms 128 are coupled to the stent frame 122 and are equally spaced around the frame's circumference. The opposite ends of the anchoring arms 128 are coupled together adjacent the roof of the atrium to create an open-ended dome. The anchoring arms 128 allow the mitral valve assembly 120 to expand in two dimensions, such as a horizontal direction and a vertical direction. By expanding horizontally, the mitral-valve assembly uses side walls of the atrium to anchor the assembly. By expanding vertically, the assembly expands between the annulus of the mitral valve and the roof of the atrium in order to anchor the assembly in the atrium. Thus, the roof of the atrium can exert a downward pressure on the assembly in order to prevent upward migration. Although four anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, 5, 6, etc.) Additionally, the anchoring arms 128 can be made of a flexible metal (similar or identical to the stent) or polymer.
  • [0062]
    FIG. 8 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 140 inserted into the atrium and positioned above the annulus 60 of the native mitral valve 50. This embodiment also includes anchoring arms 142, similar to FIG. 7, except the anchoring arms 142 are coupled to a stent frame 144 at one end and to one or more pulmonary veins 61 at an opposite end. To couple the anchoring arms 142 to the pulmonary veins 61, pulmonary vein stents 146 are mounted into the pulmonary veins and are coupled to one end of the anchoring arms 142. The pulmonary vein stents 146 can be made from the same material as other stents described above and can be radially expandable. Additionally, the anchoring arms 142 can be made of a flexible metal (similar or identical to the stent) or polymer. Furthermore, although two anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, or 4). As in the other embodiments, a biocompatible sheet 150 can be attached to the stent in order to prevent paravalvular leakage.
  • [0063]
    FIG. 9 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 160 inserted into the atrium and positioned above the annulus 60 of the native mitral valve 50. The embodiment of FIG. 9 is similar to the embodiment of FIG. 7, but with one or more anchoring arms 162, each coupled at one end to a stent 164 and left uncoupled at an opposing end. The anchoring arms 162 can be made of a flexible metal (similar or identical to the stent) or polymer. Furthermore, although three anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, or 4). The anchoring arms press against the roof of the atrium to provide a pressure on the stent 164 in a direction of the mitral valve to prevent upward migration of the stent. As in the other embodiments, a biocompatible sheet 170 can be attached to the stent in order to prevent paravalvular leakage.
  • [0064]
    FIG. 10 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 180 inserted into the atrium and positioned above the annulus 60 of the native mitral valve 50. This embodiment is similar to the embodiment of FIG. 8, except anchoring arms 182 are coupled to a stent frame 184 at one end and to one or more pulmonary veins 61 at an opposite end using threaded pulmonary vein screws 186. The threaded screws 186 are mounted into the pulmonary veins and secure the anchoring arms in place. The anchoring arms can therefore provide a downward pressure on the stent frame 184 in order to resist upward migration of the stent. The pulmonary vein screws 186 can be hollow to allow blood to flow therethrough. Additionally, the anchoring arms 182 can be made of a flexible metal (similar or identical to the stent) or polymer. Furthermore, although two anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, or 4). As in the other embodiments, a biocompatible sheet 190 can be attached to the stent in order to prevent paravalvular leakage.
  • [0065]
    FIG. 11 shows a cross-sectional view of a heart with the prosthetic mitral-valve assembly 8 from FIG. 1 inserted into a patient's heart. As shown, the lower portion 16 can displace the native mitral valve leaflets 56, 58. The upper portion 12 allows for anchoring the stent 10 in the atrium. More particularly, the stent is secured in place using contact between the radially expanding upper portion 12 and the atrium walls. The lower portion 16 may or may not contact the native mitral valve leaflets 56, 58 as indicated by gaps 200 between the lower portion 16 and the mitral valve 50. A valve 202 is positioned in the lower portion 16 of the stent 10 so that the portion of the stent 10 for supporting the valve 202 is independent from the portion of the stent 10 for anchoring the stent in the heart. As in the other embodiments, a biocompatible sheet (not shown) can be attached to the stent in order to prevent paravalvular leakage.
  • [0066]
    FIG. 12 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 220 inserted into the atrium. In this embodiment, a stent 222 has a self-expanding frame similar to stents described above. The mitral valve assembly 222 has a dome-shaped upper portion 224 that can expand to fit the natural anatomical geometry of a roof of the atrium. As a result, the mitral valve assembly 220 can expand in two dimensions, such as a horizontal direction and a vertical direction, as indicated by the arrows. By expanding horizontally, the mitral-valve assembly uses side walls of the atrium to anchor the assembly. By expanding vertically, the assembly expands between the annulus of the mitral valve and the roof of the atrium in order to anchor the assembly in the atrium. Thus, the roof of the atrium can exert a downward pressure on the assembly in order to prevent upward migration. A valve 226 is positioned in the lower portion 230 of the stent so that the portion of the stent for supporting the valve 226 is independent from the portion of the stent for anchoring the stent in the heart. As in the other embodiments, a biocompatible sheet (not shown) is attached to the stent in order to prevent paravalvular leakage. However, the biocompatible sheet is desirably not be positioned so as to obstruct blood flow through the pulmonary veins.
  • [0067]
    FIG. 13 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 250 inserted into the atrium. As in the other embodiments, a biocompatible sheet 252 is attached to a stent frame 254 in order to prevent paravalvular leakage. Four anchoring arms 256 are coupled to the stent frame 254 so that they are equally spaced around the frame's circumference. The opposite ends of the anchoring arms 256 are coupled together adjacent the roof of the atrium to create an open-ended dome. The anchoring arms 256 allow the mitral valve assembly 250 to expand in two dimensions, such as a horizontal direction and a vertical direction. By expanding horizontally, the mitral-valve assembly uses side walls of the atrium to anchor the assembly. By expanding vertically, the assembly expands between the annulus of the mitral valve and the roof of the atrium in order to anchor the assembly in the atrium. Thus, the roof of the atrium can exert a downward pressure on the assembly in order to prevent upward migration. Although four anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, 5, 6, etc.) Additionally, the anchoring arms 256 can be made of a flexible metal (similar or identical to the stent) or polymer.
  • [0068]
    FIG. 14 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 270 inserted into the atrium and positioned above the annulus 60 of the native mitral valve 50. This embodiment also includes anchoring arms 272, similar to FIG. 13, except the anchoring arms 272 are coupled to a stent frame 274 at one end and to one or more pulmonary veins 61 at an opposite end. To couple the anchoring arms 272 to the pulmonary veins 61, pulmonary vein stents 276 are mounted into the pulmonary veins and are coupled to one end of the anchoring arms 272. The pulmonary vein stents 276 can be made from the same material as other stents described herein. Additionally, the anchoring arms 272 can be made of a flexible metal (similar or identical to the stent) or polymer. Furthermore, although two anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, or 4). As in the other embodiments, a biocompatible sheet (not shown) can be attached to the stent in order to prevent paravalvular leakage.
  • [0069]
    FIG. 15 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 290 inserted into the atrium and positioned above the annulus 60 of the native mitral valve 50. The embodiment of FIG. 15 is similar to the embodiment of FIG. 13, but with one or more anchoring arms 292, each coupled at one end to a stent 294 and left uncoupled at an opposing end. The anchoring arms 292 can be made of a flexible metal (similar or identical to the stent) or polymer. Furthermore, although three anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, or 4). The anchoring arms use the roof of the atrium to provide a pressure on the stent 294 in a direction of the mitral valve to prevent upward migration of the stent. As in the other embodiments, a biocompatible sheet (not shown) can be attached to the stent in order to prevent paravalvular leakage.
  • [0070]
    FIG. 16 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 300 inserted into the atrium and positioned above the annulus 60 of the native mitral valve 50. This embodiment is similar to the embodiment of FIG. 14, except anchoring arms 302 are coupled to a stent frame 304 at one end and to one or more pulmonary veins 61 at an opposite end using threaded pulmonary vein screws 306. The threaded screws 306 are mounted into the pulmonary veins and secure the anchoring arms in place. The anchoring arms can therefore provide a downward pressure on the stent frame 304 in order to resist upward migration of the stent. The pulmonary vein screws 306 can be hollow to allow blood to flow therethrough. Additionally, the anchoring arms 302 can be made of a flexible metal (similar or identical to the stent) or polymer. Furthermore, although two anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, or 4). As in the other embodiments, a biocompatible sheet (not shown) can be attached to the stent in order to prevent paravalvular leakage.
  • [0071]
    FIG. 17 shows a cross-sectional view of a heart with the prosthetic mitral-valve assembly from FIG. 4 inserted into a patient's heart. As shown, the lower tapered portion 47 can partially displace the native mitral valve leaflets 56, 58. The upper portion allows for anchoring the stent in the atrium. More particularly, the stent is secured in place using contact between the radially expanding upper portion and the atrium walls. The lower portion 47 only partially engages the native mitral valve leaflets 56, 58, but is sized so as not to extend into the left ventricle. As in the other embodiments, a biocompatible sheet (not shown) can be attached to the stent in order to prevent paravalvular leakage.
  • [0072]
    FIG. 18 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 30 inserted into the atrium. In this embodiment, a stent has a self-expanding frame 312 similar to stents described above. The mitral valve assembly 310 has a dome-shaped upper portion 314 that can expand to fit the natural anatomical geometry of a roof of the atrium. As a result, the mitral valve assembly can expand in two dimensions, such as a horizontal direction and a vertical direction. By expanding horizontally, the mitral-valve assembly uses side walls of the atrium to anchor the assembly. By expanding vertically, the assembly expands between the annulus of the mitral valve and the roof of the atrium in order to anchor the assembly in the atrium. Thus, the roof of the atrium can exert a downward pressure on the assembly in order to prevent upward migration. A valve 316 is positioned in the lower portion of the stent so that the portion of the stent for supporting the valve can be independent from the portion of the stent for anchoring the assembly in the heart. As in the other embodiments, a biocompatible sheet (not shown) can be attached to the stent in order to prevent paravalvular leakage. However, the sheet should be sized so as not to obstruct blood flow in the pulmonary veins.
  • [0073]
    FIG. 19 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 350 inserted into the atrium. This embodiment has characteristics of the mitral valve assembly of FIG. 4, but with additional atrial anchoring. As in the other embodiments, a biocompatible sheet (not shown) can be attached to a stent frame 354 in order to prevent paravalvular leakage. Four anchoring arms 356 are coupled to the stent frame 354 so that they are equally spaced around the frame's circumference. The opposite ends of the anchoring arms 356 are coupled together adjacent the roof of the atrium to create an open-ended dome. The anchoring arms 356 allow the mitral valve assembly 350 to expand in two dimensions, such as a horizontal direction and a vertical direction. By expanding horizontally, the mitral-valve assembly uses side walls of the atrium to anchor the assembly. By expanding vertically, the assembly expands between the annulus of the mitral valve and the roof of the atrium in order to anchor the assembly in the atrium. Thus, the roof of the atrium can exert a downward pressure on the assembly in order to prevent upward migration. Although four anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, 5, 6, etc.) Additionally, the anchoring arms 356 can be made of a flexible metal (similar or identical to the stent) or polymer. A lower tapered portion 360 of the mitral valve assembly 350 partially extends into the native mitral valve, but can remain distant enough from the left ventricle so as not to damage the chordae tendineae.
  • [0074]
    FIG. 20 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 400 inserted into the atrium and a majority thereof positioned above the annulus 60 of the native mitral valve 50. This embodiment also includes anchoring arms 402, similar to FIG. 8 with the anchoring arms 402 coupled to a stent frame 404 at one end and to one or more pulmonary veins 61 at an opposite end. To couple the anchoring arms 402 to the pulmonary veins 61, pulmonary vein stents 406 are mounted into the pulmonary veins and are coupled to one end of the anchoring arms 402. The pulmonary vein stents 406 can be made from the same material as other stents described herein. Additionally, the anchoring arms 402 can be made of a flexible metal (similar or identical to the stent) or polymer. Furthermore, although two anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, or 4). As in the other embodiments, a biocompatible sheet (not shown) can be attached to the stent in order to prevent paravalvular leakage.
  • [0075]
    FIG. 21 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 420 inserted into the atrium and positioned above the annulus 60 of the native mitral valve 50. The embodiment of FIG. 21 is similar to the embodiment of FIG. 15, with one or more anchoring arms 422, each coupled at one end to a stent 424 and left uncoupled at an opposing end. The anchoring arms 422 can be made of a flexible metal (similar or identical to the stent) or polymer. Furthermore, although three anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, or 4). The anchoring arms use the roof of the atrium to provide a pressure on the stent 424 in a direction of the mitral valve to prevent upward migration of the stent. As in the other embodiments, a biocompatible sheet (not shown) can be attached to the stent in order to prevent paravalvular leakage.
  • [0076]
    FIG. 22 shows a cross-sectional view of a heart with another embodiment of a prosthetic mitral-valve assembly 450 inserted into the atrium and positioned above the annulus 60 of the native mitral valve 50. This embodiment is similar to the embodiment of FIG. 16 with anchoring arms 452 coupled to a stent frame 454 at one end and to one or more pulmonary veins 61 at an opposite end using threaded pulmonary vein screws 456. The threaded screws 456 are mounted into the pulmonary veins and secure the anchoring arms in place. The anchoring arms can therefore provide a downward pressure on the stent frame 454 in order to resist upward migration of the stent. The pulmonary vein screws 456 can be hollow to allow blood to flow therethrough. Additionally, the anchoring arms 452 can be made of a flexible metal (similar or identical to the stent) or polymer. Furthermore, although two anchoring arms are shown, any number of anchoring arms can be used (e.g., 1, 2, 3, or 4). As in the other embodiments, a biocompatible sheet (not shown) can be attached to the stent in order to prevent paravalvular leakage.
  • [0077]
    Many of the embodiments described herein show one or more optional extension arms 500 that are used to assist in the delivery of the disclosed embodiments to the heart of a patient, as further described below. The extension arms 500 are generally shown as T-shaped extensions, but can be circular or other geometric shapes. Likewise, the extension arms 500 can be made of metal or a suture material.
  • [0078]
    FIGS. 23A-23E illustrate a delivery apparatus 700. The delivery apparatus 700 comprises an outer catheter shaft 702 and an inner catheter shaft 704 extending through the outer shaft. The distal end portion of the outer shaft 702 comprises a sheath that extends over a prosthetic, self-expanding stented valve 706 (shown schematically) and retains it in a compressed state during delivery through the patient's vasculature. The distal end portion of the inner shaft 704 is shaped to cooperate with one or more mating extension arms, or posts, 708 that extend from the stent of the valve 706 to form a releasable connection between the valve and the delivery apparatus. For example, in the illustrated embodiment each post 708 comprises a straight portion terminating at a circular ring portion and the distal end portion of the shaft 704 has a correspondingly shaped recesses 710 that receive respective posts 708. Each recess 710 can include a radially extending projection 712 that is shaped to extend into an opening 714 in a respective post 708. As best shown in FIG. 23B, each recess 710 and projection 712 can be sized to provide a small gap between the surfaces of the post 708 and the adjacent surfaces within the recess to facilitate insertion and removal of the post from the recess in the radial direction (i.e., perpendicular to the axis of the shaft 704).
  • [0079]
    When the valve 706 is loaded into the delivery apparatus 700, as depicted in FIG. 23A, such that each post 708 of the valve is disposed in a recess 710, the valve is retained against axial movement relative to the shaft 704 (in the proximal and distal directions) by virtue of the shape of the posts and the corresponding recesses. Referring to FIG. 23D, as the outer shaft 702 is retracted to deploy the valve 706, the valve is allowed to expand but is retained against “jumping” from the distal end of the sheath by the connection formed by the posts and the corresponding recesses for controlled delivery of the valve. At this stage the partially deployed valve is still retained by the shaft 704 and can be retracted back into the outer sheath 702 by retracting the shaft 704 relative to the outer sheath 702. Referring to FIG. 23E, when the outer sheath is retracted in the proximal direction past the posts 708, the expansion force of the valve stent causes the posts to expand radially outwardly from the recesses 710, thereby fully releasing the valve from the shaft 704.
  • [0080]
    While three posts 708 and corresponding recesses 710 are shown in the illustrated embodiment, any number of posts and recesses can be used. Furthermore, the posts and recesses can have various other shapes, such as square, oval, rectangular, triangular, or various combinations thereof. The posts can be formed from the same material that is used to form the valve stent (e.g., stainless steel or Nitinol). Alternatively, the posts can be loops formed from less rigid material, such as suture material. The loops are secured to the valve stent and are sized to be received in the recesses 710.
  • [0081]
    FIGS. 24A-24D illustrate a delivery apparatus 800 that is similar to the delivery apparatus shown in FIGS. 23A-23E. The delivery apparatus 800 includes a handle portion 802 having a rotatable knob 804, an outer catheter shaft 806 extending from the handle portion 802, and an inner catheter shaft 808 extending from the handle portion and through the outer catheter shaft 806. The distal end of the inner catheter shaft 808 includes an end piece 810 that is formed with an annular recess 812 and a plurality of axially extending, angularly spaced recesses 814. The recesses 812, 814 are sized and shaped to receive T-shaped posts 816 extending from the stent of a valve (not shown in FIGS. 24A-24D). Each post 816 has an axially extending portion 816 a that is received in a corresponding recess 814 and a transverse end portion 816 b that is received in the annular recess 812. The outer shaft 806 includes a sheath 818 that is sized and shaped to extend over the end piece 812 and the valve during delivery of the valve.
  • [0082]
    The outer shaft 806 is operatively connected to the knob 804 to effect longitudinal movement of the outer shaft 806 and the sheath 818 relative to the inner shaft 808 upon rotation of the knob 804. In use, the valve is mounted for delivery by placing the posts 816 of the valve in the recesses 812, 814 and moving the sheath distally to extend over the valve to maintain the valve in a compressed state. At or near the target site for implanting the valve, the knob 804 is rotated to retract the sheath 818 relative to the valve. As the sheath is retracted to deploy the valve, the valve is allowed to expand but is retained against “jumping” from the distal end of the sheath by the connection formed by the posts and the corresponding recesses for controlled delivery of the valve. At this stage the partially deployed valve is still retained by the end piece 810 and can be retracted back into the sheath by moving the shaft 806 distally relative to the valve. When the sheath is retracted in the proximal direction past the posts 816, the expansion force of the valve stent causes the posts to expand radially outwardly from the recesses 812, 814, thereby fully releasing the valve from the end piece 810.
  • [0083]
    FIG. 25 shows an embodiment comprising a prosthetic mitral valve assembly 952 having leaflets 954. Each leaflet 954 can be connected to a respective tension member 960, the lower ends of which can be connected at a suitable location on the heart. For example, the lower end portions of tension members 960 can extend through the apex 962 and can be secured in placed at a common location outside the heart. Tension members may be attached to or through the papillary muscles. The lower ends of tension members can be connected to an enlarged head portion, or anchor, 964, which secures the tension members to the apex. Tension members 960 can extend through a tensioning block 966. The tensioning block 966 can be configured to slide upwardly and downwardly relative to tension members 960 to adjust the tension in the tensioning members. For example, sliding the tensioning block 966 upwardly is effective to draw the upper portions of the tension members closer together, thereby increasing the tension in the tension members. The tensioning block 966 desirably is configured to be retained in place along the length of the tension members, such as by crimping the tensioning block against the tension members, once the desired tension is achieved. The tension members can be made of any suitable biocompatible material, such as traditional suture material, GORE-TEX®, or an elastomeric material, such as polyurethane. The tension members 960 further assist in securing the valve assembly in place by resisting upward movement of the valve assembly and prevent the leaflets 954 from everting so as to minimize or prevent regurgitation through the valve assembly. As such, the tethering de-stresses the moveable leaflets.
  • [0084]
    FIG. 26 shows another embodiment of a mitral valve assembly 1052 having prosthetic chordae tendineae. The prosthetic chordae tendineae comprise first and second tension members 1053 connected to a respective leaflet 1054 of the valve assembly. As shown, the lower end portions 1056 of each tension member 1053 can be connected at spaced apart locations to the inner walls of the left ventricle, using, for example, anchor members 1060. A slidable tensioning block 1076 can be placed over each tension member 1053 for adjusting the tension in the corresponding tension member. In certain embodiments, each tension member 1053 can comprise a suture line that extends through a corresponding leaflet 1054 and has its opposite ends secured to the ventricle walls using anchor members 1060.
  • [0085]
    In particular embodiments, the anchor member 1060 can have a plurality of prongs that can grab, penetrate, and/or engage surrounding tissue to secure the device in place. The prongs of the anchor member 1060 can be formed from a shape memory material to allow the anchor member to be inserted into the heart in a radially compressed state (e.g., via an introducer) and expanded when deployed inside the heart. The anchor member can be formed to have an expanded configuration that conforms to the contours of the particular surface area of the heart where the anchor member is to be deployed, such as described in co-pending application Ser. No. 11/750,272, published as US 2007-0270943 A1, which is incorporated herein by reference. Further details of the structure and use of the anchor member are also disclosed in co-pending application Ser. No. 11/695,583 to Rowe, filed Apr. 2, 2007, which is incorporated herein by reference.
  • [0086]
    Alternative attachment locations in the heart are possible, such as attachment to the papillary muscle (not shown). In addition, various attachment mechanisms can be used to attach tension members to the heart, such as a barbed or screw-type anchor member. Moreover, any desired number of tension members can be attached to each leaflet (e.g., 1, 2, 3 . . . etc.). Further, it should be understood that tension members can be used on any of the embodiments disclosed herein.
  • [0087]
    FIGS. 25-26 show the use of tension members that can mimic the function of chordae. The tethers can have several functions including preventing the valve from migrating into the left atrium, distressing the leaflets by preventing eversion, and preserving ventricular function by maintaining the shape of the left ventricle. In particular, the left ventricle can lose its shape over time as the natural chordae become stretched or break. The artificial chordae can help to maintain the shape. Although FIGS. 25 and 26 show a tricuspid valve, a bicuspid valve can be used instead.
  • [0088]
    FIG. 27 shows another embodiment of a mitral valve assembly 1090 including a valve 1092 and a stent 1094 (shown partially cut-away to expose a portion of the valve). Tension members, shown generally at 1096, can be connected between leaflets of the valve 1092 and the stent itself. Only two leaflets are shown, but additional tension members can be used for a third leaflet in a tricuspid valve. In the illustrated embodiment, the tension members 1096 can include groups 2002, 2004 of three tension members each. The three tension members 1096 of group 2002 can be attached, at one end, to one of the leaflets at spaced intervals and converge to attach at an opposite end to a bottom of the stent 1094. Group 2004 can be similarly connected between another of the leaflets and the bottom of the stent 1094. The tension members 1096 can be made of any suitable biocompatible material, such as traditional suture material, GORE-TEX®, or an elastomeric material, such as polyurethane. The tension members can prevent the leaflets from everting so as to minimize or prevent regurgitation through the valve assembly. As such, the tension members de-stress the moveable portions of the leaflets when the leaflets close during systole without the need to connect the tension members to the inner or outer wall of the heart.
  • [0089]
    Although groups of three tension members are illustrated, other connection schemes can be used. For example, each group can include any desired number of tension members (e.g., 1, 2, 3, . . . etc.). Additionally, the tension members can connect to any portion of the stent and at spaced intervals, if desired. Likewise, the tension members can connect to the leaflets at a point of convergence, rather than at spaced intervals. Further, the tension members can be used on bicuspid or tricuspid valves. Still further, it should be understood that tension members extending between the stent and the leaflets can be used on any of the embodiments disclosed herein.
  • [0090]
    One skilled in the art will recognize that the tethering shown in FIGS. 25-27 can be used with any of the embodiments described herein.
  • [0091]
    In view of the many possible embodiments to which the principles of the disclosed invention may be applied, it should be recognized that the illustrated embodiments are only preferred examples of the invention and should not be taken as limiting the scope of the invention. Rather, the scope of the invention is defined by the following claims. We therefore claim as our invention all that comes within the scope of these claims.

Claims (28)

1. A prosthetic mitral valve assembly for implantation in a heart having a native mitral valve positioned between a left atrium and left ventricle, comprising:
a radially-expandable stent sized so that an anchoring portion of the stent is implantable in the left atrium above an annulus of the native mitral valve with a pressure or friction fit against the atrium walls; and
a valve portion coupled to the stent.
2. The prosthetic mitral valve assembly of claim 1, wherein the valve portion is designed to work in series with the native mitral valve.
3. The prosthetic mitral valve assembly of claim 1, wherein the anchoring portion is an upper portion of the stent and the stent further includes a lower portion for extending into the native mitral valve, the valve portion being mounted in the lower portion of the stent so that the portion of the stent for anchoring the valve is independent of the portion of the stent for anchoring the mitral valve assembly in the heart.
4. The prosthetic mitral valve assembly of claim 1, wherein the stent is made of shape memory material formed in a lattice pattern.
5. The prosthetic mitral valve assembly of claim 1, wherein the stent includes anchoring arms designed to extend from the stent for contacting an upper portion of the atrium.
6. The prosthetic mitral valve assembly of claim 5, wherein each anchoring arm has a first end coupled to the stent and a second end designed to contact an upper portion of the atrium, wherein the second ends of the anchoring arms are coupled together.
7. The prosthetic mitral valve assembly of claim 5, wherein the anchoring arms are made of a flexible metal or polymer.
8. The prosthetic mitral valve assembly of claim 1, wherein the stent includes at least one anchoring arm designed to extend from the stent, the anchoring arm having a distal end for mounting in a pulmonary vein of a patient.
9. The prosthetic mitral valve assembly of claim 1, wherein the stent has an upper domed-shaped portion designed to contact an upper portion of the atrium.
10. The prosthetic mitral valve assembly of claim 1, wherein the valve portion further includes prosthetic leaflets and further including tension members coupled to the prosthetic leaflets for preventing the prosthetic leaflets from everting and reducing stresses induced by ventricular contraction.
11. The prosthetic mitral valve assembly of claim 10, wherein the tension members are coupled to the prosthetic leaflets at a first end of the tension members and coupled at an opposite end to the stent or to a patient's heart.
12. The prosthetic mitral valve assembly of claim 1, further including a tether coupled to the stent on one end thereof, the tether being configured to couple the stent to a portion of the heart remote from the stent.
13. The prosthetic mitral valve assembly of claim 1, further including prongs extending outwardly from the stent that are integral with the stent or separate barbs coupled to the stent.
14. A prosthetic mitral valve assembly, comprising:
a radially-expandable stent having an upper portion sized so that an anchoring portion of the stent is implantable in a left atrium above an annulus of a native mitral valve with a pressure or friction fit and a lower portion for extending into the native mitral valve, the upper portion of the stent having a circumference that is greater than a circumference of the lower portion; and
a valve portion coupled within the lower portion to the stent.
15. The prosthetic mitral valve assembly of claim 14, wherein the stent is made of shape memory material formed in a lattice pattern.
16. The prosthetic mitral valve assembly of claim 14, wherein the stent includes anchoring arms designed to extend from the stent for contacting an upper portion of the atrium.
17. The prosthetic mitral valve assembly of claim 16, wherein each anchoring arm has a first end coupled to the stent and a second end designed to contact an upper portion of the atrium, wherein the second ends of the anchoring arms are coupled together.
18. The prosthetic mitral valve assembly of claim 16, wherein the anchoring arms are made of a flexible metal or polymer.
19. The prosthetic mitral valve assembly of claim 14, wherein the stent includes at least one anchoring arm designed to extend from the stent, the anchoring arm having a distal end for mounting in a pulmonary vein of a patient.
20. The prosthetic mitral valve assembly of claim 14, wherein the upper portion of the stent has a domed-shaped end designed to contact an upper portion of the atrium.
21. The prosthetic mitral valve assembly of claim 14, wherein the prosthetic mitral valve assembly is adapted to expand into contact with the native mitral valve tissue to create the pressure or friction fit and secure the mitral valve assembly in a fixed position in the heart.
22. The prosthetic mitral valve assembly of claim 14, wherein the lower portion is tapered and is designed to only partially extend into the native mitral valve.
23. The prosthetic mitral valve assembly of claim 14, wherein the lower portion is designed to fully extend into the native mitral valve.
24. The prosthetic mitral valve assembly of claim 14, further including prongs extending outwardly from the stent that are integral with the stent or separate barbs coupled to the stent.
25. A method of implanting a prosthetic mitral heart valve, comprising:
inserting a prosthetic mitral valve assembly in a collapsed state into a heart using a delivery catheter;
expanding the prosthetic mitral valve assembly; and
positioning the prosthetic mitral valve assembly so that an anchoring portion of the stent is implantable in the left atrium above an annulus of the native mitral valve with a pressure fit.
26. The method of claim 25, further including positioning the prosthetic mitral valve assembly so that a first portion of the mitral valve assembly is in contact with a roof of a left atrium or is in contact with pulmonary veins in order to provide a downward force on a second portion of the mitral valve assembly and prevent the mitral valve assembly from upward migration.
27. The method of claim 25, wherein the mitral valve assembly includes a stent and a valve coupled to the stent.
28. The method of claim 25, wherein positioning the prosthetic mitral valve assembly includes wedging the mitral valve assembly into place so that an upper end thereof is prevented from moving upward through contact with a roof of the left atrium or through contact with the pulmonary veins and a lower end thereof is prevented from moving downward by leaflets of the native mitral valve.
US12393010 2009-02-25 2009-02-25 Mitral valve replacement with atrial anchoring Abandoned US20100217382A1 (en)

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EP20160195508 EP3150172A1 (en) 2009-02-25 2010-02-19 Mitral valve replacement with atrial anchoring
EP20100746662 EP2400926B1 (en) 2009-02-25 2010-02-19 Mitral valve replacement with atrial anchoring
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Cited By (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090030506A1 (en) * 2007-07-24 2009-01-29 Biotronik Vi Patent Ag Endoprosthesis and method for manufacturing same
US20090281618A1 (en) * 2008-04-23 2009-11-12 Medtronic, Inc. Prosthetic Heart Valve Devices and Methods of Valve Replacement
US20090292350A1 (en) * 2008-01-24 2009-11-26 Medtronic, Inc. Stents for Prosthetic Heart Valves
US20100036479A1 (en) * 2008-04-23 2010-02-11 Medtronic, Inc. Stented Heart Valve Devices
US20110106246A1 (en) * 2009-08-28 2011-05-05 Malewicz Andrzej M Transapical delivery device and method of use
US20110208298A1 (en) * 2010-02-24 2011-08-25 Medtronic Ventor Technologies Ltd Mitral Prosthesis and Methods for Implantation
US20110251675A1 (en) * 2010-04-09 2011-10-13 Medtronic, Inc. Transcatheter Prosthetic Heart Valve Delivery Device With Partial Deployment and Release Features and Methods
USD648854S1 (en) 2010-09-20 2011-11-15 St. Jude Medical, Inc. Commissure points
USD652926S1 (en) 2010-09-20 2012-01-24 St. Jude Medical, Inc. Forked end
USD652927S1 (en) 2010-09-20 2012-01-24 St. Jude Medical, Inc. Surgical stent
USD653342S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Stent connections
USD653341S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Surgical stent
USD653343S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Surgical cuff
USD654170S1 (en) 2010-09-20 2012-02-14 St. Jude Medical, Inc. Stent connections
USD654169S1 (en) 2010-09-20 2012-02-14 St. Jude Medical Inc. Forked ends
WO2012054776A1 (en) 2010-10-21 2012-04-26 Medtronic Inc Mitral bioprosthesis with low ventricular profile
USD660433S1 (en) 2010-09-20 2012-05-22 St. Jude Medical, Inc. Surgical stent assembly
USD660432S1 (en) 2010-09-20 2012-05-22 St. Jude Medical, Inc. Commissure point
USD660967S1 (en) 2010-09-20 2012-05-29 St. Jude Medical, Inc. Surgical stent
EP2478868A1 (en) * 2011-01-25 2012-07-25 The Provost, Fellows, Foundation Scholars, and the other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Implant device
US20120283757A1 (en) * 2009-10-29 2012-11-08 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
EP2529701A1 (en) * 2011-06-01 2012-12-05 Nvt Ag Cardiac valve prosthesis deployment system
CN102961199A (en) * 2012-11-30 2013-03-13 宁波健世生物科技有限公司 Anti-displacement pulmonary valve stent
US8425593B2 (en) 2007-09-26 2013-04-23 St. Jude Medical, Inc. Collapsible prosthetic heart valves
WO2013011502A3 (en) * 2011-07-21 2013-05-10 4Tech Inc. Method and apparatus for tricuspid valve repair using tension
US20130144380A1 (en) * 2009-04-15 2013-06-06 Cardiaq Valve Technologies, Inc. Vascular implant and delivery system
USD684692S1 (en) 2010-09-20 2013-06-18 St. Jude Medical, Inc. Forked ends
US8475525B2 (en) 2010-01-22 2013-07-02 4Tech Inc. Tricuspid valve repair using tension
US20130172978A1 (en) * 2011-12-16 2013-07-04 Tendyne Holdings Inc. Tethers for Prosthetic Mitral Valve
US20130282114A1 (en) * 2012-04-19 2013-10-24 Caisson Interventional, LLC Heart valve assembly systems and methods
US8585755B2 (en) 2009-12-04 2013-11-19 Edwards Lifesciences Corporation Prosthetic apparatus for implantation at mitral valve
WO2014059064A1 (en) * 2012-10-12 2014-04-17 St. Jude Medical, Cardiology Division, Inc. Valve holder and loading integration
US8778019B2 (en) 2010-09-17 2014-07-15 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and method for transcatheter heart valve delivery
WO2014110082A2 (en) 2013-01-08 2014-07-17 Medtronic CV Luxembourg S.a.r.l. Method of treating paravalvular leakage after prosthetic valve implantation
US8784481B2 (en) 2007-09-28 2014-07-22 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US8790398B2 (en) 2002-01-04 2014-07-29 Colibri Heart Valve Llc Percutaneously implantable replacement heart valve device and method of making same
US20140214159A1 (en) * 2011-08-11 2014-07-31 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US8808356B2 (en) 2008-07-15 2014-08-19 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US8814931B2 (en) 2010-08-24 2014-08-26 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and methods for transcatheter heart valve delivery systems
WO2014141239A1 (en) * 2013-03-14 2014-09-18 4Tech Inc. Stent with tether interface
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2014168655A1 (en) * 2013-04-12 2014-10-16 St. George Medical, Inc. Mitral heart valve prosthesis and associated delivery catheter
WO2014201384A1 (en) * 2013-06-14 2014-12-18 The Regents Of The University Of California Transcatheter mitral valve
WO2014203171A1 (en) * 2013-06-17 2014-12-24 Heldman Alan Prosthetic heart valve with linking element and methods for implanting same
US8940044B2 (en) 2011-06-23 2015-01-27 Valtech Cardio, Ltd. Closure element for use with an annuloplasty structure
US8961596B2 (en) 2010-01-22 2015-02-24 4Tech Inc. Method and apparatus for tricuspid valve repair using tension
US8961594B2 (en) 2012-05-31 2015-02-24 4Tech Inc. Heart valve repair system
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9011530B2 (en) 2008-12-22 2015-04-21 Valtech Cardio, Ltd. Partially-adjustable annuloplasty structure
US9011527B2 (en) 2010-09-20 2015-04-21 St. Jude Medical, Cardiology Division, Inc. Valve leaflet attachment in collapsible prosthetic valves
US9017399B2 (en) 2010-07-21 2015-04-28 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9034033B2 (en) 2011-10-19 2015-05-19 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
USD730520S1 (en) 2013-09-04 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Stent with commissure attachments
US9039759B2 (en) 2010-08-24 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Repositioning of prosthetic heart valve and deployment
USD730521S1 (en) 2013-09-04 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Stent with commissure attachments
US9050188B2 (en) 2013-10-23 2015-06-09 Caisson Interventional, LLC Methods and systems for heart valve therapy
USD732666S1 (en) * 2005-05-13 2015-06-23 Medtronic Corevalve, Inc. Heart valve prosthesis
US9066800B2 (en) * 2012-03-28 2015-06-30 Medtronic, Inc. Dual valve prosthesis for transcatheter valve implantation
US9078749B2 (en) 2007-09-13 2015-07-14 Georg Lutter Truncated cone heart valve stent
US9101469B2 (en) 2012-12-19 2015-08-11 W. L. Gore & Associates, Inc. Prosthetic heart valve with leaflet shelving
US9119719B2 (en) 2009-05-07 2015-09-01 Valtech Cardio, Ltd. Annuloplasty ring with intra-ring anchoring
US9119738B2 (en) 2010-06-28 2015-09-01 Colibri Heart Valve Llc Method and apparatus for the endoluminal delivery of intravascular devices
US9125740B2 (en) 2011-06-21 2015-09-08 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9131982B2 (en) 2013-03-14 2015-09-15 St. Jude Medical, Cardiology Division, Inc. Mediguide-enabled renal denervation system for ensuring wall contact and mapping lesion locations
US9144492B2 (en) 2012-12-19 2015-09-29 W. L. Gore & Associates, Inc. Truncated leaflet for prosthetic heart valves, preformed valve
US9180007B2 (en) 2009-10-29 2015-11-10 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
US9186238B2 (en) 2013-01-29 2015-11-17 St. Jude Medical, Cardiology Division, Inc. Aortic great vessel protection
US9241791B2 (en) 2012-06-29 2016-01-26 St. Jude Medical, Cardiology Division, Inc. Valve assembly for crimp profile
US9241790B2 (en) 2010-05-05 2016-01-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9265608B2 (en) 2011-11-04 2016-02-23 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
US9277994B2 (en) 2008-12-22 2016-03-08 Valtech Cardio, Ltd. Implantation of repair chords in the heart
US9283072B2 (en) 2012-07-25 2016-03-15 W. L. Gore & Associates, Inc. Everting transcatheter valve and methods
US9289292B2 (en) 2012-06-28 2016-03-22 St. Jude Medical, Cardiology Division, Inc. Valve cuff support
US9301840B2 (en) 2008-10-10 2016-04-05 Edwards Lifesciences Corporation Expandable introducer sheath
US9307980B2 (en) 2010-01-22 2016-04-12 4Tech Inc. Tricuspid valve repair using tension
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9314163B2 (en) 2013-01-29 2016-04-19 St. Jude Medical, Cardiology Division, Inc. Tissue sensing device for sutureless valve selection
US9326856B2 (en) 2013-03-14 2016-05-03 St. Jude Medical, Cardiology Division, Inc. Cuff configurations for prosthetic heart valve
JP2016067931A (en) * 2014-09-26 2016-05-09 エヌヴィーティー アーゲー Implantable device for treating heart valve counter-flow
US9333100B2 (en) 2008-01-24 2016-05-10 Medtronic, Inc. Stents for prosthetic heart valves
US9339274B2 (en) 2013-03-12 2016-05-17 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak occlusion device for self-expanding heart valves
US9345573B2 (en) * 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9351830B2 (en) 2006-12-05 2016-05-31 Valtech Cardio, Ltd. Implant and anchor placement
US9364354B2 (en) 2000-03-27 2016-06-14 Neovasc Medical Ltd Methods for treating abnormal growths in the body using a flow reducing implant
US9375312B2 (en) 2010-07-09 2016-06-28 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US9398951B2 (en) 2013-03-12 2016-07-26 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for paravalvular leak protection
US9398952B2 (en) 2012-12-19 2016-07-26 W. L. Gore & Associates, Inc. Planar zone in prosthetic heart valve leaflet
US9414918B2 (en) 2012-09-06 2016-08-16 Edwards Lifesciences Corporation Heart valve sealing devices
US9421098B2 (en) 2010-12-23 2016-08-23 Twelve, Inc. System for mitral valve repair and replacement
US9427315B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9456896B2 (en) 2008-09-29 2016-10-04 Edwards Lifesciences Cardiaq Llc Body cavity prosthesis
US9474606B2 (en) 2009-05-04 2016-10-25 Valtech Cardio, Ltd. Over-wire implant contraction methods
US9480563B2 (en) 2013-03-08 2016-11-01 St. Jude Medical, Cardiology Division, Inc. Valve holder with leaflet protection
US9480560B2 (en) 2009-09-29 2016-11-01 Edwards Lifesciences Cardiaq Llc Method of securing an intralumenal frame assembly
US9486306B2 (en) 2013-04-02 2016-11-08 Tendyne Holdings, Inc. Inflatable annular sealing device for prosthetic mitral valve
US9526611B2 (en) 2013-10-29 2016-12-27 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US9532868B2 (en) 2007-09-28 2017-01-03 St. Jude Medical, Inc. Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9549818B2 (en) 2013-11-12 2017-01-24 St. Jude Medical, Cardiology Division, Inc. Pneumatically power-assisted tavi delivery system
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9554902B2 (en) 2012-06-28 2017-01-31 St. Jude Medical, Cardiology Division, Inc. Leaflet in configuration for function in various shapes and sizes
US9561104B2 (en) 2009-02-17 2017-02-07 Valtech Cardio, Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US9597181B2 (en) 2013-06-25 2017-03-21 Tendyne Holdings, Inc. Thrombus management and structural compliance features for prosthetic heart valves
US9597183B2 (en) 2008-10-01 2017-03-21 Edwards Lifesciences Cardiaq Llc Delivery system for vascular implant
US9597185B2 (en) 2013-12-19 2017-03-21 St. Jude Medical, Cardiology Division, Inc. Leaflet-cuff attachments for prosthetic heart valve
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
US9610157B2 (en) 2014-03-21 2017-04-04 St. Jude Medical, Cardiology Division, Inc. Leaflet abrasion mitigation
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
US9615920B2 (en) 2012-06-29 2017-04-11 St. Jude Medical, Cardiology Divisions, Inc. Commissure attachment feature for prosthetic heart valve
US20170100240A1 (en) * 2015-10-12 2017-04-13 Horizon Scientific Corp. Mitral Valve Assembly
US9622861B2 (en) 2009-12-02 2017-04-18 Valtech Cardio, Ltd. Tool for actuating an adjusting mechanism
US9636222B2 (en) 2013-03-12 2017-05-02 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak protection
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9655719B2 (en) 2013-01-29 2017-05-23 St. Jude Medical, Cardiology Division, Inc. Surgical heart valve flexible stent frame stiffener
US9668856B2 (en) 2013-06-26 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Puckering seal for reduced paravalvular leakage
US9668857B2 (en) 2013-11-06 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
US9668858B2 (en) 2014-05-16 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve with paravalvular leak sealing ring
US9675454B2 (en) 2012-07-30 2017-06-13 Tendyne Holdings, Inc. Delivery systems and methods for transcatheter prosthetic valves
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9681952B2 (en) 2013-01-24 2017-06-20 Mitraltech Ltd. Anchoring of prosthetic valve supports
US9693865B2 (en) 2013-01-09 2017-07-04 4 Tech Inc. Soft tissue depth-finding tool
US9693861B2 (en) 2012-06-29 2017-07-04 St. Jude Medical, Cardiology Division, Inc. Leaflet attachment for function in various shapes and sizes
US9700409B2 (en) 2013-11-06 2017-07-11 St. Jude Medical, Cardiology Division, Inc. Reduced profile prosthetic heart valve
US9713530B2 (en) 2008-12-22 2017-07-25 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US9724192B2 (en) 2011-11-08 2017-08-08 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US9730793B2 (en) 2012-12-06 2017-08-15 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9737398B2 (en) 2012-12-19 2017-08-22 W. L. Gore & Associates, Inc. Prosthetic valves, frames and leaflets and methods thereof
US9737264B2 (en) 2014-08-18 2017-08-22 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
US9737400B2 (en) 2010-12-14 2017-08-22 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
US9744059B2 (en) 2003-11-19 2017-08-29 Neovasc Medical Ltd. Vascular implant
US9750606B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9750607B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9763778B2 (en) 2014-03-18 2017-09-19 St. Jude Medical, Cardiology Division, Inc. Aortic insufficiency valve percutaneous valve anchoring
EP3231393A1 (en) 2016-04-13 2017-10-18 Christian Vallbracht Minimally invasive implantable mitral and tricuspid valve
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element
US9795476B2 (en) 2010-06-17 2017-10-24 St. Jude Medical, Llc Collapsible heart valve with angled frame
US9801720B2 (en) 2014-06-19 2017-10-31 4Tech Inc. Cardiac tissue cinching
US9801721B2 (en) 2012-10-12 2017-10-31 St. Jude Medical, Cardiology Division, Inc. Sizing device and method of positioning a prosthetic heart valve
WO2017189276A1 (en) * 2016-04-29 2017-11-02 Medtronic Vascular Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
US9808201B2 (en) 2014-08-18 2017-11-07 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
US9808342B2 (en) 2012-07-03 2017-11-07 St. Jude Medical, Cardiology Division, Inc. Balloon sizing device and method of positioning a prosthetic heart valve
USD802766S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
USD802765S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
USD802764S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
US9844435B2 (en) 2013-03-01 2017-12-19 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve replacement
US9855140B2 (en) 2014-06-10 2018-01-02 St. Jude Medical, Cardiology Division, Inc. Stent cell bridge for cuff attachment
US9867697B2 (en) 2013-03-12 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for a paravalvular leak protection
US9867701B2 (en) 2011-08-18 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Devices and methods for transcatheter heart valve delivery
US9867611B2 (en) 2013-09-05 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Anchoring studs for transcatheter valve implantation
US9867556B2 (en) 2014-02-07 2018-01-16 St. Jude Medical, Cardiology Division, Inc. System and method for assessing dimensions and eccentricity of valve annulus for trans-catheter valve implantation
US9883943B2 (en) 2016-08-29 2018-02-06 Valtech Cardio, Ltd. Implantation of repair devices in the heart

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US8052749B2 (en) 2003-12-23 2011-11-08 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US7381219B2 (en) 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
EP1988851A2 (en) 2006-02-14 2008-11-12 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US8652201B2 (en) * 2006-04-26 2014-02-18 The Cleveland Clinic Foundation Apparatus and method for treating cardiovascular diseases
US8454686B2 (en) 2007-09-28 2013-06-04 St. Jude Medical, Inc. Two-stage collapsible/expandable prosthetic heart valves and anchoring systems
ES2627860T3 (en) 2008-10-10 2017-07-31 Boston Scientific Scimed, Inc. to place medical devices medical devices and installation systems
EP2496182A4 (en) 2009-11-05 2016-05-04 Univ Pennsylvania Valve prosthesis
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
US9522062B2 (en) * 2010-02-24 2016-12-20 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US20110224785A1 (en) * 2010-03-10 2011-09-15 Hacohen Gil Prosthetic mitral valve with tissue anchors
KR20130096730A (en) 2010-09-07 2013-08-30 폴 에이. 스펜스 Cannula systems and methods
EP3001978A1 (en) 2010-09-23 2016-04-06 CardiAQ Valve Technologies, Inc. Replacement heart valves, delivery devices and methods
US9579193B2 (en) 2010-09-23 2017-02-28 Transmural Systems Llc Methods and systems for delivering prostheses using rail techniques
US9005279B2 (en) * 2010-11-12 2015-04-14 Shlomo Gabbay Beating heart buttress and implantation method to prevent prolapse of a heart valve
US8845717B2 (en) 2011-01-28 2014-09-30 Middle Park Medical, Inc. Coaptation enhancement implant, system, and method
US8888843B2 (en) 2011-01-28 2014-11-18 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
JP2014527425A (en) 2011-07-12 2014-10-16 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Coupling system for medical equipment
US8951243B2 (en) 2011-12-03 2015-02-10 Boston Scientific Scimed, Inc. Medical device handle
US9011531B2 (en) 2012-02-13 2015-04-21 Mitraspan, Inc. Method and apparatus for repairing a mitral valve
WO2014062827A1 (en) 2012-10-16 2014-04-24 Spence Paul A Devices, systems, and methods for facilitating flow from the heart to a blood pump
US9023099B2 (en) * 2012-10-31 2015-05-05 Medtronic Vascular Galway Limited Prosthetic mitral valve and delivery method
WO2015013666A8 (en) 2013-07-26 2015-03-19 Cardiaq Valve Technologies, Inc. Systems and methods for sealing openings in an anatomical wall
EP3052053A4 (en) * 2013-10-05 2017-06-28 Sino Medical Sciences Tech Inc Device and method for mitral valve regurgitation method
US9839511B2 (en) 2013-10-05 2017-12-12 Sino Medical Sciences Technology Inc. Device and method for mitral valve regurgitation treatment
EP3076884A4 (en) 2013-12-04 2017-12-06 Heartware Inc Apparatus and methods for cutting an atrial wall
US9393111B2 (en) 2014-01-15 2016-07-19 Sino Medical Sciences Technology Inc. Device and method for mitral valve regurgitation treatment
US9820852B2 (en) 2014-01-24 2017-11-21 St. Jude Medical, Cardiology Division, Inc. Stationary intra-annular halo designs for paravalvular leak (PVL) reduction—active channel filling cuff designs
WO2015175863A1 (en) 2014-05-16 2015-11-19 St. Jude Medical, Cardiology Division, Inc. Stent assembly for use in prosthetic heart valves
US9861477B2 (en) 2015-01-26 2018-01-09 Boston Scientific Scimed Inc. Prosthetic heart valve square leaflet-leaflet stitch
US9788942B2 (en) 2015-02-03 2017-10-17 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US20160242905A1 (en) * 2015-02-20 2016-08-25 4C Medical Technologies, Inc. Devices, systems and methods for cardiac treatment
US9592121B1 (en) 2015-11-06 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US20170189177A1 (en) * 2015-12-30 2017-07-06 Caisson Interventional, LLC Systems and methods for heart valve therapy
WO2017165810A1 (en) * 2016-03-25 2017-09-28 Phillip Laby Fluid-actuated sheath displacement and articulation behavior improving systems, devices, and methods for catheters, continuum manipulators, and other uses

Citations (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6168614A (en) *
US3587115A (en) * 1966-05-04 1971-06-28 Donald P Shiley Prosthetic sutureless heart valves and implant tools therefor
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3671979A (en) * 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3714671A (en) * 1970-11-30 1973-02-06 Cutter Lab Tissue-type heart valve with a graft support ring or stent
US3755823A (en) * 1971-04-23 1973-09-04 Hancock Laboratories Inc Flexible stent for heart valve
US4035849A (en) * 1975-11-17 1977-07-19 William W. Angell Heart valve stent and process for preparing a stented heart valve prosthesis
US4106129A (en) * 1976-01-09 1978-08-15 American Hospital Supply Corporation Supported bioprosthetic heart valve with compliant orifice ring
US4222126A (en) * 1978-12-14 1980-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare Unitized three leaflet heart valve
US4265694A (en) * 1978-12-14 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making unitized three leaflet heart valve
US4339831A (en) * 1981-03-27 1982-07-20 Medtronic, Inc. Dynamic annulus heart valve and reconstruction ring
US4343048A (en) * 1979-08-06 1982-08-10 Ross Donald N Stent for a cardiac valve
US4345340A (en) * 1981-05-07 1982-08-24 Vascor, Inc. Stent for mitral/tricuspid heart valve
US4373216A (en) * 1980-10-27 1983-02-15 Hemex, Inc. Heart valves having edge-guided occluders
US4406022A (en) * 1981-11-16 1983-09-27 Kathryn Roy Prosthetic valve means for cardiovascular surgery
US4470157A (en) * 1981-04-27 1984-09-11 Love Jack W Tricuspid prosthetic tissue heart valve
US4535483A (en) * 1983-01-17 1985-08-20 Hemex, Inc. Suture rings for heart valves
US4574803A (en) * 1979-01-19 1986-03-11 Karl Storz Tissue cutter
US4592340A (en) * 1984-05-02 1986-06-03 Boyles Paul W Artificial catheter means
US4605407A (en) * 1983-01-11 1986-08-12 The University Of Sheffield Heart valve replacements
US4612011A (en) * 1983-07-22 1986-09-16 Hans Kautzky Central occluder semi-biological heart valve
US4643732A (en) * 1984-11-17 1987-02-17 Beiersdorf Aktiengesellschaft Heart valve prosthesis
US4655771A (en) * 1982-04-30 1987-04-07 Shepherd Patents S.A. Prosthesis comprising an expansible or contractile tubular body
US4692164A (en) * 1986-03-06 1987-09-08 Moskovskoe Vysshee Tekhnicheskoe Uchilische, Imeni N.E. Baumana Bioprosthetic heart valve, methods and device for preparation thereof
US4733665A (en) * 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4759758A (en) * 1984-12-07 1988-07-26 Shlomo Gabbay Prosthetic heart valve
US4762128A (en) * 1986-12-09 1988-08-09 Advanced Surgical Intervention, Inc. Method and apparatus for treating hypertrophy of the prostate gland
US4797901A (en) * 1985-08-22 1989-01-10 Siemens Aktiengesellschaft Circuit arrangement for testing a passive bus network with the carrier sense multiple access with collisions detection method
US4796629A (en) * 1987-06-03 1989-01-10 Joseph Grayzel Stiffened dilation balloon catheter device
US4829990A (en) * 1987-06-25 1989-05-16 Thueroff Joachim Implantable hydraulic penile erector
US4851001A (en) * 1987-09-17 1989-07-25 Taheri Syde A Prosthetic valve for a blood vein and an associated method of implantation of the valve
US4856516A (en) * 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US4922905A (en) * 1985-11-30 1990-05-08 Strecker Ernst P Dilatation catheter
US4986830A (en) * 1989-09-22 1991-01-22 Schneider (U.S.A.) Inc. Valvuloplasty catheter with balloon which remains stable during inflation
US4994077A (en) * 1989-04-21 1991-02-19 Dobben Richard L Artificial heart valve for implantation in a blood vessel
US5007896A (en) * 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
US5026366A (en) * 1984-03-01 1991-06-25 Cardiovascular Laser Systems, Inc. Angioplasty catheter and method of use thereof
US5032128A (en) * 1988-07-07 1991-07-16 Medtronic, Inc. Heart valve prosthesis
US5037434A (en) * 1990-04-11 1991-08-06 Carbomedics, Inc. Bioprosthetic heart valve with elastic commissures
US5047041A (en) * 1989-08-22 1991-09-10 Samuels Peter B Surgical apparatus for the excision of vein valves in situ
US5080668A (en) * 1988-11-29 1992-01-14 Biotronik Mess- und Therapiegerate GmbH & Co. KG Ingenieurburo Berlin Cardiac valve prosthesis
US5085635A (en) * 1990-05-18 1992-02-04 Cragg Andrew H Valved-tip angiographic catheter
US5089015A (en) * 1989-11-28 1992-02-18 Promedica International Method for implanting unstented xenografts and allografts
US5192297A (en) * 1991-12-31 1993-03-09 Medtronic, Inc. Apparatus and method for placement and implantation of a stent
US5282847A (en) * 1991-02-28 1994-02-01 Medtronic, Inc. Prosthetic vascular grafts with a pleated structure
US5295958A (en) * 1991-04-04 1994-03-22 Shturman Cardiology Systems, Inc. Method and apparatus for in vivo heart valve decalcification
US5332402A (en) * 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
US5397351A (en) * 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5411552A (en) * 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
US5411055A (en) * 1992-11-24 1995-05-02 Mannesmann Aktiengesellschaft Flow limiting throttle element
US5480424A (en) * 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US5500014A (en) * 1989-05-31 1996-03-19 Baxter International Inc. Biological valvular prothesis
US5545209A (en) * 1993-09-30 1996-08-13 Texas Petrodet, Inc. Controlled deployment of a medical device
US5545214A (en) * 1991-07-16 1996-08-13 Heartport, Inc. Endovascular aortic valve replacement
US5549665A (en) * 1993-06-18 1996-08-27 London Health Association Bioprostethic valve
US5591185A (en) * 1989-12-14 1997-01-07 Corneal Contouring Development L.L.C. Method and apparatus for reprofiling or smoothing the anterior or stromal cornea by scraping
US5609626A (en) * 1989-05-31 1997-03-11 Baxter International Inc. Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts
US5639274A (en) * 1995-06-02 1997-06-17 Fischell; Robert E. Integrated catheter system for balloon angioplasty and stent delivery
US5716417A (en) * 1995-06-07 1998-02-10 St. Jude Medical, Inc. Integral supporting structure for bioprosthetic heart valve
US5728068A (en) * 1994-06-14 1998-03-17 Cordis Corporation Multi-purpose balloon catheter
US5749890A (en) * 1996-12-03 1998-05-12 Shaknovich; Alexander Method and system for stent placement in ostial lesions
US5756476A (en) * 1992-01-14 1998-05-26 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell proliferation using antisense oligonucleotides
US5769812A (en) * 1991-07-16 1998-06-23 Heartport, Inc. System for cardiac procedures
US5855597A (en) * 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US5855602A (en) * 1996-09-09 1999-01-05 Shelhigh, Inc. Heart valve prosthesis
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US5925063A (en) * 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6027525A (en) * 1996-05-23 2000-02-22 Samsung Electronics., Ltd. Flexible self-expandable stent and method for making the same
US6168614B1 (en) * 1990-05-18 2001-01-02 Heartport, Inc. Valve prosthesis for implantation in the body
US6171335B1 (en) * 1997-01-24 2001-01-09 Aortech Europe Limited Heart valve prosthesis
US6174327B1 (en) * 1998-02-27 2001-01-16 Scimed Life Systems, Inc. Stent deployment apparatus and method
US6210408B1 (en) * 1999-02-24 2001-04-03 Scimed Life Systems, Inc. Guide wire system for RF recanalization of vascular blockages
US6217585B1 (en) * 1996-08-16 2001-04-17 Converge Medical, Inc. Mechanical stent and graft delivery system
US6231602B1 (en) * 1999-04-16 2001-05-15 Edwards Lifesciences Corporation Aortic annuloplasty ring
US6245102B1 (en) * 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
US6350277B1 (en) * 1999-01-15 2002-02-26 Scimed Life Systems, Inc. Stents with temporary retaining bands
US6425916B1 (en) * 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US6440164B1 (en) * 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US20030050694A1 (en) * 2001-09-13 2003-03-13 Jibin Yang Methods and apparatuses for deploying minimally-invasive heart valves
US6569196B1 (en) * 1997-12-29 2003-05-27 The Cleveland Clinic Foundation System for minimally invasive insertion of a bioprosthetic heart valve
US20030100939A1 (en) * 2001-11-23 2003-05-29 Mindguard Ltd. Expandable delivery appliance particularly for delivering intravascular devices
US6605112B1 (en) * 1996-12-18 2003-08-12 Venpro Corporation Device for regulating the flow of blood through the blood system
US20040039436A1 (en) * 2001-10-11 2004-02-26 Benjamin Spenser Implantable prosthetic valve
US6733525B2 (en) * 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
US6908481B2 (en) * 1996-12-31 2005-06-21 Edwards Lifesciences Pvt, Inc. Value prosthesis for implantation in body channels
US20050177224A1 (en) * 2004-02-11 2005-08-11 Fogarty Thomas J. Vascular fixation device and method
US20060025857A1 (en) * 2004-04-23 2006-02-02 Bjarne Bergheim Implantable prosthetic valve
US7018406B2 (en) * 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US20060149350A1 (en) * 2003-06-05 2006-07-06 Flowmedica, Inc. Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens
US20060167543A1 (en) * 1999-12-31 2006-07-27 Bailey Steven R Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US7374571B2 (en) * 2001-03-23 2008-05-20 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of manufacture
US20080154355A1 (en) * 2006-12-22 2008-06-26 Netanel Benichou Implantable prosthetic valve assembly and method of making the same

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1127325A (en) 1965-08-23 1968-09-18 Henry Berry Improved instrument for inserting artificial heart valves
US3472230A (en) 1966-12-19 1969-10-14 Fogarty T J Umbrella catheter
US3548417A (en) 1967-09-05 1970-12-22 Ronnie G Kischer Heart valve having a flexible wall which rotates between open and closed positions
GB1402255A (en) 1971-09-24 1975-08-06 Smiths Industries Ltd Medical or surgical devices of the kind having an inflatable balloon
US4297749A (en) 1977-04-25 1981-11-03 Albany International Corp. Heart valve prosthesis
US4056854A (en) 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
EP0103546B1 (en) 1982-08-09 1988-05-04 Domenico Iorio Surgical instrument for implanting prosthetic heart valves or the like
US4585705A (en) 1983-11-09 1986-04-29 Dow Corning Corporation Hard organopolysiloxane release coating
US4787899A (en) 1983-12-09 1988-11-29 Lazarus Harrison M Intraluminal graft device, system and method
US4979939A (en) 1984-05-14 1990-12-25 Surgical Systems & Instruments, Inc. Atherectomy system with a guide wire
DE3426300C2 (en) 1984-07-17 1987-12-03 Doguhan Dr.Med. 2800 Bremen De Baykut
US4878906A (en) 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
US4883458A (en) 1987-02-24 1989-11-28 Surgical Systems & Instruments, Inc. Atherectomy system and method of using the same
US4777951A (en) 1986-09-19 1988-10-18 Mansfield Scientific, Inc. Procedure and catheter instrument for treating patients for aortic stenosis
US4878495A (en) 1987-05-15 1989-11-07 Joseph Grayzel Valvuloplasty device with satellite expansion means
US5266073A (en) 1987-12-08 1993-11-30 Wall W Henry Angioplasty stent
US4966604A (en) 1989-01-23 1990-10-30 Interventional Technologies Inc. Expandable atherectomy cutter with flexibly bowed blades
US5059177A (en) 1990-04-19 1991-10-22 Cordis Corporation Triple lumen balloon catheter
US5152771A (en) 1990-12-31 1992-10-06 The Board Of Supervisors Of Louisiana State University Valve cutter for arterial by-pass surgery
JPH05184611A (en) 1991-03-19 1993-07-27 Kenji Kusuhara Valvular annulation retaining member and its attaching method
US5167628A (en) 1991-05-02 1992-12-01 Boyles Paul W Aortic balloon catheter assembly for indirect infusion of the coronary arteries
US5163953A (en) 1992-02-10 1992-11-17 Vince Dennis J Toroidal artificial heart valve stent
US5683448A (en) 1992-02-21 1997-11-04 Boston Scientific Technology, Inc. Intraluminal stent and graft
US5609627A (en) 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
US5554185A (en) 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US5571175A (en) 1995-06-07 1996-11-05 St. Jude Medical, Inc. Suture guard for prosthetic heart valve
DE19532846A1 (en) 1995-09-06 1997-03-13 Georg Dr Berg Valve for use in heart
DE19546692C2 (en) 1995-12-14 2002-11-07 Hans-Reiner Figulla Self-expanding heart valve prosthesis for implantation in the human body via a catheter system
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6206917B1 (en) 1997-05-02 2001-03-27 St. Jude Medical, Inc. Differential treatment of prosthetic devices
DE19857887B4 (en) 1998-12-15 2005-05-04 Markus Dr.med. Dr.disc.pol. Ferrari Anchoring support for a heart valve prosthesis
FR2788217A1 (en) 1999-01-12 2000-07-13 Brice Letac Implantable prosthetic valve by catheterization, or surgically
DE19907646A1 (en) 1999-02-23 2000-08-24 Georg Berg Valve for blood vessels uses flap holders and counterpart holders on stent to latch together in place and all channeled for guide wire.
EP1057460A1 (en) 1999-06-01 2000-12-06 Numed, Inc. Replacement valve assembly and method of implanting same
US6299637B1 (en) 1999-08-20 2001-10-09 Samuel M. Shaolian Transluminally implantable venous valve
ES2243188T3 (en) 1999-09-30 2005-12-01 Sorin Biomedica Cardio S.R.L. A device for operations of repairing or replacing heart valves.
FR2800984B1 (en) 1999-11-17 2001-12-14 Jacques Seguin Device for replacing a heart valve percutaneously
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US7510572B2 (en) 2000-09-12 2009-03-31 Shlomo Gabbay Implantation system for delivery of a heart valve prosthesis
US6461382B1 (en) 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
DE10049814B4 (en) 2000-10-09 2006-10-19 Albert-Ludwigs-Universität Apparatus for assisting surgical procedures within a vessel, especially for minimally invasive explantation and implantation of heart valves
DE10049812B4 (en) 2000-10-09 2004-06-03 Universitätsklinikum Freiburg Apparatus for filtering of macroscopic particles from the blood stream to the local removal of an aortic valve on the human or animal heart
DE10049815B4 (en) 2000-10-09 2005-10-13 Universitätsklinikum Freiburg Device for the local removal of an aortic valve on the human or animal heart
DE10049813C1 (en) 2000-10-09 2002-04-18 Universitaetsklinikum Freiburg Instrument for the local removal of built-up matter at an aortic valve, in a human or animal heart, is a hollow catheter with a cutting unit at the far end within a closure cap for minimum invasion
US6482228B1 (en) 2000-11-14 2002-11-19 Troy R. Norred Percutaneous aortic valve replacement
US6468660B2 (en) 2000-12-29 2002-10-22 St. Jude Medical, Inc. Biocompatible adhesives
US6488704B1 (en) 2001-05-07 2002-12-03 Biomed Solutions, Llc Implantable particle measuring apparatus
US6936067B2 (en) 2001-05-17 2005-08-30 St. Jude Medical Inc. Prosthetic heart valve with slit stent
US7141064B2 (en) 2002-05-08 2006-11-28 Edwards Lifesciences Corporation Compressed tissue for heart valve leaflets
JP4940388B2 (en) 2003-04-24 2012-05-30 クック メディカル テクノロジーズ エルエルシーCook Medical Technologies Llc Prosthetic valve proteinase with improved hydrodynamic characteristics - Ze
US7201772B2 (en) * 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
EP1653888B1 (en) 2003-07-21 2009-09-09 The Trustees of The University of Pennsylvania Percutaneous heart valve
US20060259137A1 (en) 2003-10-06 2006-11-16 Jason Artof Minimally invasive valve replacement system
US6906481B1 (en) * 2003-12-03 2005-06-14 The Boeing Company Power sharing high frequency motor drive modular system
US7470285B2 (en) 2004-02-05 2008-12-30 Children's Medical Center Corp. Transcatheter delivery of a replacement heart valve
US8109996B2 (en) 2004-03-03 2012-02-07 Sorin Biomedica Cardio, S.R.L. Minimally-invasive cardiac-valve prosthesis
US7276078B2 (en) 2004-06-30 2007-10-02 Edwards Lifesciences Pvt Paravalvular leak detection, sealing, and prevention
US7462191B2 (en) 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
US8062359B2 (en) 2005-04-06 2011-11-22 Edwards Lifesciences Corporation Highly flexible heart valve connecting band
EP1893131A1 (en) * 2005-04-20 2008-03-05 The Cleveland Clinic Foundation Apparatus and method for replacing a cardiac valve
US20060241745A1 (en) * 2005-04-21 2006-10-26 Solem Jan O Blood flow controlling apparatus
US7708775B2 (en) * 2005-05-24 2010-05-04 Edwards Lifesciences Corporation Methods for rapid deployment of prosthetic heart valves
WO2007025028A1 (en) * 2005-08-25 2007-03-01 The Cleveland Clinic Foundation Percutaneous atrioventricular valve and method of use
DE102005052628B4 (en) * 2005-11-04 2014-06-05 Jenavalve Technology Inc. Self-expanding, flexible wire mesh with integrated valve prosthesis for the transvascular cardiac valve replacement and a system comprising such a device and a delivery catheter
US8764820B2 (en) 2005-11-16 2014-07-01 Edwards Lifesciences Corporation Transapical heart valve delivery system and method
US20070213813A1 (en) * 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US8932348B2 (en) 2006-05-18 2015-01-13 Edwards Lifesciences Corporation Device and method for improving heart valve function
US8876895B2 (en) * 2006-09-19 2014-11-04 Medtronic Ventor Technologies Ltd. Valve fixation member having engagement arms
US9510943B2 (en) * 2007-01-19 2016-12-06 Medtronic, Inc. Stented heart valve devices and methods for atrioventricular valve replacement
US7896915B2 (en) * 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
EP2698129A1 (en) * 2007-06-04 2014-02-19 St. Jude Medical, Inc. Prosthetic heart valve
EP2155073A2 (en) * 2007-06-08 2010-02-24 St.Jude Medical, Inc Devices for transcatheter prosthetic heart valve implantation and access closure
US7833265B2 (en) 2008-03-13 2010-11-16 Pacesetter, Inc. Vascular anchoring system and method
US20090276040A1 (en) * 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve

Patent Citations (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6168614A (en) *
US3587115A (en) * 1966-05-04 1971-06-28 Donald P Shiley Prosthetic sutureless heart valves and implant tools therefor
US3671979A (en) * 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3714671A (en) * 1970-11-30 1973-02-06 Cutter Lab Tissue-type heart valve with a graft support ring or stent
US3755823A (en) * 1971-04-23 1973-09-04 Hancock Laboratories Inc Flexible stent for heart valve
US4035849A (en) * 1975-11-17 1977-07-19 William W. Angell Heart valve stent and process for preparing a stented heart valve prosthesis
US4106129A (en) * 1976-01-09 1978-08-15 American Hospital Supply Corporation Supported bioprosthetic heart valve with compliant orifice ring
US4222126A (en) * 1978-12-14 1980-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare Unitized three leaflet heart valve
US4265694A (en) * 1978-12-14 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making unitized three leaflet heart valve
US4574803A (en) * 1979-01-19 1986-03-11 Karl Storz Tissue cutter
US4343048A (en) * 1979-08-06 1982-08-10 Ross Donald N Stent for a cardiac valve
US4373216A (en) * 1980-10-27 1983-02-15 Hemex, Inc. Heart valves having edge-guided occluders
US4339831A (en) * 1981-03-27 1982-07-20 Medtronic, Inc. Dynamic annulus heart valve and reconstruction ring
US4470157A (en) * 1981-04-27 1984-09-11 Love Jack W Tricuspid prosthetic tissue heart valve
US4345340A (en) * 1981-05-07 1982-08-24 Vascor, Inc. Stent for mitral/tricuspid heart valve
US4406022A (en) * 1981-11-16 1983-09-27 Kathryn Roy Prosthetic valve means for cardiovascular surgery
US4655771B1 (en) * 1982-04-30 1996-09-10 Medinvent Ams Sa Prosthesis comprising an expansible or contractile tubular body
US4655771A (en) * 1982-04-30 1987-04-07 Shepherd Patents S.A. Prosthesis comprising an expansible or contractile tubular body
US4605407A (en) * 1983-01-11 1986-08-12 The University Of Sheffield Heart valve replacements
US4535483A (en) * 1983-01-17 1985-08-20 Hemex, Inc. Suture rings for heart valves
US4612011A (en) * 1983-07-22 1986-09-16 Hans Kautzky Central occluder semi-biological heart valve
US5026366A (en) * 1984-03-01 1991-06-25 Cardiovascular Laser Systems, Inc. Angioplasty catheter and method of use thereof
US4592340A (en) * 1984-05-02 1986-06-03 Boyles Paul W Artificial catheter means
US4643732A (en) * 1984-11-17 1987-02-17 Beiersdorf Aktiengesellschaft Heart valve prosthesis
US4759758A (en) * 1984-12-07 1988-07-26 Shlomo Gabbay Prosthetic heart valve
US4797901A (en) * 1985-08-22 1989-01-10 Siemens Aktiengesellschaft Circuit arrangement for testing a passive bus network with the carrier sense multiple access with collisions detection method
US4733665A (en) * 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4733665B1 (en) * 1985-11-07 1994-01-11 Expandable Grafts Partnership Expandable intraluminal graft,and method and apparatus for implanting an expandable intraluminal graft
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4922905A (en) * 1985-11-30 1990-05-08 Strecker Ernst P Dilatation catheter
US4692164A (en) * 1986-03-06 1987-09-08 Moskovskoe Vysshee Tekhnicheskoe Uchilische, Imeni N.E. Baumana Bioprosthetic heart valve, methods and device for preparation thereof
US4762128A (en) * 1986-12-09 1988-08-09 Advanced Surgical Intervention, Inc. Method and apparatus for treating hypertrophy of the prostate gland
US4796629A (en) * 1987-06-03 1989-01-10 Joseph Grayzel Stiffened dilation balloon catheter device
US4829990A (en) * 1987-06-25 1989-05-16 Thueroff Joachim Implantable hydraulic penile erector
US4851001A (en) * 1987-09-17 1989-07-25 Taheri Syde A Prosthetic valve for a blood vein and an associated method of implantation of the valve
US5032128A (en) * 1988-07-07 1991-07-16 Medtronic, Inc. Heart valve prosthesis
US5080668A (en) * 1988-11-29 1992-01-14 Biotronik Mess- und Therapiegerate GmbH & Co. KG Ingenieurburo Berlin Cardiac valve prosthesis
US5007896A (en) * 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
US4856516A (en) * 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US4994077A (en) * 1989-04-21 1991-02-19 Dobben Richard L Artificial heart valve for implantation in a blood vessel
US5500014A (en) * 1989-05-31 1996-03-19 Baxter International Inc. Biological valvular prothesis
US5609626A (en) * 1989-05-31 1997-03-11 Baxter International Inc. Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts
US5047041A (en) * 1989-08-22 1991-09-10 Samuels Peter B Surgical apparatus for the excision of vein valves in situ
US4986830A (en) * 1989-09-22 1991-01-22 Schneider (U.S.A.) Inc. Valvuloplasty catheter with balloon which remains stable during inflation
US5089015A (en) * 1989-11-28 1992-02-18 Promedica International Method for implanting unstented xenografts and allografts
US5591185A (en) * 1989-12-14 1997-01-07 Corneal Contouring Development L.L.C. Method and apparatus for reprofiling or smoothing the anterior or stromal cornea by scraping
US5037434A (en) * 1990-04-11 1991-08-06 Carbomedics, Inc. Bioprosthetic heart valve with elastic commissures
US5085635A (en) * 1990-05-18 1992-02-04 Cragg Andrew H Valved-tip angiographic catheter
US5411552A (en) * 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
US6582462B1 (en) * 1990-05-18 2003-06-24 Heartport, Inc. Valve prosthesis for implantation in the body and a catheter for implanting such valve prosthesis
US6168614B1 (en) * 1990-05-18 2001-01-02 Heartport, Inc. Valve prosthesis for implantation in the body
US5607464A (en) * 1991-02-28 1997-03-04 Medtronic, Inc. Prosthetic vascular graft with a pleated structure
US5282847A (en) * 1991-02-28 1994-02-01 Medtronic, Inc. Prosthetic vascular grafts with a pleated structure
US5295958A (en) * 1991-04-04 1994-03-22 Shturman Cardiology Systems, Inc. Method and apparatus for in vivo heart valve decalcification
US5443446A (en) * 1991-04-04 1995-08-22 Shturman Cardiology Systems, Inc. Method and apparatus for in vivo heart valve decalcification
US5397351A (en) * 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5545214A (en) * 1991-07-16 1996-08-13 Heartport, Inc. Endovascular aortic valve replacement
US5769812A (en) * 1991-07-16 1998-06-23 Heartport, Inc. System for cardiac procedures
US5192297A (en) * 1991-12-31 1993-03-09 Medtronic, Inc. Apparatus and method for placement and implantation of a stent
US5756476A (en) * 1992-01-14 1998-05-26 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell proliferation using antisense oligonucleotides
US5332402A (en) * 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
US5411055A (en) * 1992-11-24 1995-05-02 Mannesmann Aktiengesellschaft Flow limiting throttle element
US5549665A (en) * 1993-06-18 1996-08-27 London Health Association Bioprostethic valve
US5545209A (en) * 1993-09-30 1996-08-13 Texas Petrodet, Inc. Controlled deployment of a medical device
US5480424A (en) * 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US5728068A (en) * 1994-06-14 1998-03-17 Cordis Corporation Multi-purpose balloon catheter
US5639274A (en) * 1995-06-02 1997-06-17 Fischell; Robert E. Integrated catheter system for balloon angioplasty and stent delivery
US5716417A (en) * 1995-06-07 1998-02-10 St. Jude Medical, Inc. Integral supporting structure for bioprosthetic heart valve
US6027525A (en) * 1996-05-23 2000-02-22 Samsung Electronics., Ltd. Flexible self-expandable stent and method for making the same
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US6217585B1 (en) * 1996-08-16 2001-04-17 Converge Medical, Inc. Mechanical stent and graft delivery system
US5855602A (en) * 1996-09-09 1999-01-05 Shelhigh, Inc. Heart valve prosthesis
US5749890A (en) * 1996-12-03 1998-05-12 Shaknovich; Alexander Method and system for stent placement in ostial lesions
US6605112B1 (en) * 1996-12-18 2003-08-12 Venpro Corporation Device for regulating the flow of blood through the blood system
US6908481B2 (en) * 1996-12-31 2005-06-21 Edwards Lifesciences Pvt, Inc. Value prosthesis for implantation in body channels
US6171335B1 (en) * 1997-01-24 2001-01-09 Aortech Europe Limited Heart valve prosthesis
US5855597A (en) * 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US6245102B1 (en) * 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
US5925063A (en) * 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6221091B1 (en) * 1997-09-26 2001-04-24 Incept Llc Coiled sheet valve, filter or occlusive device and methods of use
US6569196B1 (en) * 1997-12-29 2003-05-27 The Cleveland Clinic Foundation System for minimally invasive insertion of a bioprosthetic heart valve
US6174327B1 (en) * 1998-02-27 2001-01-16 Scimed Life Systems, Inc. Stent deployment apparatus and method
US6350277B1 (en) * 1999-01-15 2002-02-26 Scimed Life Systems, Inc. Stents with temporary retaining bands
US6425916B1 (en) * 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US6210408B1 (en) * 1999-02-24 2001-04-03 Scimed Life Systems, Inc. Guide wire system for RF recanalization of vascular blockages
US6231602B1 (en) * 1999-04-16 2001-05-15 Edwards Lifesciences Corporation Aortic annuloplasty ring
US6440164B1 (en) * 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US7018406B2 (en) * 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US20060167543A1 (en) * 1999-12-31 2006-07-27 Bailey Steven R Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6733525B2 (en) * 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
US7374571B2 (en) * 2001-03-23 2008-05-20 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of manufacture
US20030050694A1 (en) * 2001-09-13 2003-03-13 Jibin Yang Methods and apparatuses for deploying minimally-invasive heart valves
US20040039436A1 (en) * 2001-10-11 2004-02-26 Benjamin Spenser Implantable prosthetic valve
US6730118B2 (en) * 2001-10-11 2004-05-04 Percutaneous Valve Technologies, Inc. Implantable prosthetic valve
US7510575B2 (en) * 2001-10-11 2009-03-31 Edwards Lifesciences Corporation Implantable prosthetic valve
US7393360B2 (en) * 2001-10-11 2008-07-01 Edwards Lifesciences Pvt, Inc. Implantable prosthetic valve
US6893460B2 (en) * 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US20030100939A1 (en) * 2001-11-23 2003-05-29 Mindguard Ltd. Expandable delivery appliance particularly for delivering intravascular devices
US20060149350A1 (en) * 2003-06-05 2006-07-06 Flowmedica, Inc. Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens
US20050177224A1 (en) * 2004-02-11 2005-08-11 Fogarty Thomas J. Vascular fixation device and method
US20060025857A1 (en) * 2004-04-23 2006-02-02 Bjarne Bergheim Implantable prosthetic valve
US20080154355A1 (en) * 2006-12-22 2008-06-26 Netanel Benichou Implantable prosthetic valve assembly and method of making the same

Cited By (254)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9364354B2 (en) 2000-03-27 2016-06-14 Neovasc Medical Ltd Methods for treating abnormal growths in the body using a flow reducing implant
US8790398B2 (en) 2002-01-04 2014-07-29 Colibri Heart Valve Llc Percutaneously implantable replacement heart valve device and method of making same
US9554898B2 (en) 2002-01-04 2017-01-31 Colibri Heart Valve Llc Percutaneous prosthetic heart valve
US8900294B2 (en) 2002-01-04 2014-12-02 Colibri Heart Valve Llc Method of controlled release of a percutaneous replacement heart valve
US9125739B2 (en) 2002-01-04 2015-09-08 Colibri Heart Valve Llc Percutaneous replacement heart valve and a delivery and implantation system
US9610158B2 (en) 2002-01-04 2017-04-04 Colibri Heart Valve Llc Percutaneously implantable replacement heart valve device and method of making same
US9186248B2 (en) 2002-01-04 2015-11-17 Colibri Heart Valve Llc Percutaneously implantable replacement heart valve device and method of making same
US9744059B2 (en) 2003-11-19 2017-08-29 Neovasc Medical Ltd. Vascular implant
USD732666S1 (en) * 2005-05-13 2015-06-23 Medtronic Corevalve, Inc. Heart valve prosthesis
US9872769B2 (en) 2006-12-05 2018-01-23 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US9351830B2 (en) 2006-12-05 2016-05-31 Valtech Cardio, Ltd. Implant and anchor placement
US20090030506A1 (en) * 2007-07-24 2009-01-29 Biotronik Vi Patent Ag Endoprosthesis and method for manufacturing same
US9730792B2 (en) 2007-09-13 2017-08-15 Georg Lutter Truncated cone heart valve stent
US9078749B2 (en) 2007-09-13 2015-07-14 Georg Lutter Truncated cone heart valve stent
US9254192B2 (en) 2007-09-13 2016-02-09 Georg Lutter Truncated cone heart valve stent
US9095433B2 (en) 2007-09-13 2015-08-04 Georg Lutter Truncated cone heart valve stent
US9636221B2 (en) 2007-09-26 2017-05-02 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9351828B2 (en) 2007-09-26 2016-05-31 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9241794B2 (en) 2007-09-26 2016-01-26 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US8425593B2 (en) 2007-09-26 2013-04-23 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US8845721B2 (en) 2007-09-26 2014-09-30 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9549815B2 (en) 2007-09-26 2017-01-24 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9414911B2 (en) 2007-09-26 2016-08-16 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9693859B2 (en) 2007-09-26 2017-07-04 St. Jude Medical, Llc Collapsible prosthetic heart valves
US9545307B2 (en) 2007-09-26 2017-01-17 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9345571B1 (en) 2007-09-26 2016-05-24 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9532868B2 (en) 2007-09-28 2017-01-03 St. Jude Medical, Inc. Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
US8784481B2 (en) 2007-09-28 2014-07-22 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US9364321B2 (en) 2007-09-28 2016-06-14 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US9289290B2 (en) 2007-09-28 2016-03-22 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US9820851B2 (en) 2007-09-28 2017-11-21 St. Jude Medical, Llc Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
US9615921B2 (en) 2007-09-28 2017-04-11 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US8628566B2 (en) * 2008-01-24 2014-01-14 Medtronic, Inc. Stents for prosthetic heart valves
US20090292350A1 (en) * 2008-01-24 2009-11-26 Medtronic, Inc. Stents for Prosthetic Heart Valves
US9333100B2 (en) 2008-01-24 2016-05-10 Medtronic, Inc. Stents for prosthetic heart valves
US9173737B2 (en) 2008-04-23 2015-11-03 Medtronic, Inc. Stented heart valve devices
US8323336B2 (en) 2008-04-23 2012-12-04 Medtronic, Inc. Prosthetic heart valve devices and methods of valve replacement
US20090281618A1 (en) * 2008-04-23 2009-11-12 Medtronic, Inc. Prosthetic Heart Valve Devices and Methods of Valve Replacement
US9827090B2 (en) 2008-04-23 2017-11-28 Medtronic, Inc. Prosthetic heart valve devices and methods of valve replacement
US20100036479A1 (en) * 2008-04-23 2010-02-11 Medtronic, Inc. Stented Heart Valve Devices
US9351832B2 (en) 2008-07-15 2016-05-31 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US9675449B2 (en) 2008-07-15 2017-06-13 St. Jude Medical, Llc Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US9351831B2 (en) 2008-07-15 2016-05-31 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US9220594B2 (en) 2008-07-15 2015-12-29 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US8808356B2 (en) 2008-07-15 2014-08-19 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US9289296B2 (en) 2008-07-15 2016-03-22 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US9681949B2 (en) 2008-07-15 2017-06-20 St. Jude Medical, Llc Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US9456896B2 (en) 2008-09-29 2016-10-04 Edwards Lifesciences Cardiaq Llc Body cavity prosthesis
US9597183B2 (en) 2008-10-01 2017-03-21 Edwards Lifesciences Cardiaq Llc Delivery system for vascular implant
US9301840B2 (en) 2008-10-10 2016-04-05 Edwards Lifesciences Corporation Expandable introducer sheath
US9713530B2 (en) 2008-12-22 2017-07-25 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US9636224B2 (en) 2008-12-22 2017-05-02 Valtech Cardio, Ltd. Deployment techniques for annuloplasty ring and over-wire rotation tool
US9277994B2 (en) 2008-12-22 2016-03-08 Valtech Cardio, Ltd. Implantation of repair chords in the heart
US9011530B2 (en) 2008-12-22 2015-04-21 Valtech Cardio, Ltd. Partially-adjustable annuloplasty structure
US9662209B2 (en) 2008-12-22 2017-05-30 Valtech Cardio, Ltd. Contractible annuloplasty structures
US9561104B2 (en) 2009-02-17 2017-02-07 Valtech Cardio, Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US9333074B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9333073B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery method
US20140309731A1 (en) * 2009-04-15 2014-10-16 Cardiaq Valve Technologies, Inc. Vascular implant
US9339378B2 (en) * 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9585747B2 (en) * 2009-04-15 2017-03-07 Edwards Lifesciences Cardiaq Llc Vascular implant
US9339379B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9339380B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant
US20130144380A1 (en) * 2009-04-15 2013-06-06 Cardiaq Valve Technologies, Inc. Vascular implant and delivery system
US9474606B2 (en) 2009-05-04 2016-10-25 Valtech Cardio, Ltd. Over-wire implant contraction methods
US9119719B2 (en) 2009-05-07 2015-09-01 Valtech Cardio, Ltd. Annuloplasty ring with intra-ring anchoring
US9504569B2 (en) * 2009-08-28 2016-11-29 Medtronic 3F Therapeutics, Inc. Transapical delivery device and method of use
US20110106246A1 (en) * 2009-08-28 2011-05-05 Malewicz Andrzej M Transapical delivery device and method of use
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US9480560B2 (en) 2009-09-29 2016-11-01 Edwards Lifesciences Cardiaq Llc Method of securing an intralumenal frame assembly
US20120283757A1 (en) * 2009-10-29 2012-11-08 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9011520B2 (en) * 2009-10-29 2015-04-21 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9414921B2 (en) 2009-10-29 2016-08-16 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9180007B2 (en) 2009-10-29 2015-11-10 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
US9622861B2 (en) 2009-12-02 2017-04-18 Valtech Cardio, Ltd. Tool for actuating an adjusting mechanism
US9717591B2 (en) 2009-12-04 2017-08-01 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8926691B2 (en) 2009-12-04 2015-01-06 Edwards Lifesciences Corporation Apparatus for treating a mitral valve
US9433500B2 (en) 2009-12-04 2016-09-06 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8986373B2 (en) 2009-12-04 2015-03-24 Edwards Lifesciences Corporation Method for implanting a prosthetic mitral valve
US8585755B2 (en) 2009-12-04 2013-11-19 Edwards Lifesciences Corporation Prosthetic apparatus for implantation at mitral valve
US9084676B2 (en) 2009-12-04 2015-07-21 Edwards Lifesciences Corporation Apparatus for treating a mitral valve
US8961596B2 (en) 2010-01-22 2015-02-24 4Tech Inc. Method and apparatus for tricuspid valve repair using tension
US9307980B2 (en) 2010-01-22 2016-04-12 4Tech Inc. Tricuspid valve repair using tension
US8475525B2 (en) 2010-01-22 2013-07-02 4Tech Inc. Tricuspid valve repair using tension
US9241702B2 (en) 2010-01-22 2016-01-26 4Tech Inc. Method and apparatus for tricuspid valve repair using tension
US20110208298A1 (en) * 2010-02-24 2011-08-25 Medtronic Ventor Technologies Ltd Mitral Prosthesis and Methods for Implantation
US9072603B2 (en) 2010-02-24 2015-07-07 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
WO2011106544A1 (en) 2010-02-24 2011-09-01 Medtronic Ventor Technologies Ltd Mitral prosthesis
WO2011106533A1 (en) 2010-02-24 2011-09-01 Medtronic Ventor Technologies Ltd Mitral prosthesis
US20110208297A1 (en) * 2010-02-24 2011-08-25 Medtronic Ventor Technologies Ltd. Mitral Prosthesis and Methods for Implantation
US8926692B2 (en) * 2010-04-09 2015-01-06 Medtronic, Inc. Transcatheter prosthetic heart valve delivery device with partial deployment and release features and methods
US20110251675A1 (en) * 2010-04-09 2011-10-13 Medtronic, Inc. Transcatheter Prosthetic Heart Valve Delivery Device With Partial Deployment and Release Features and Methods
US9770329B2 (en) 2010-05-05 2017-09-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9241790B2 (en) 2010-05-05 2016-01-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9248014B2 (en) 2010-05-05 2016-02-02 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9795476B2 (en) 2010-06-17 2017-10-24 St. Jude Medical, Llc Collapsible heart valve with angled frame
US9119738B2 (en) 2010-06-28 2015-09-01 Colibri Heart Valve Llc Method and apparatus for the endoluminal delivery of intravascular devices
US9375312B2 (en) 2010-07-09 2016-06-28 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9132009B2 (en) 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
US9017399B2 (en) 2010-07-21 2015-04-28 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US8814931B2 (en) 2010-08-24 2014-08-26 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and methods for transcatheter heart valve delivery systems
US9545308B2 (en) 2010-08-24 2017-01-17 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and methods for transcatheter heart valve delivery systems
US9039759B2 (en) 2010-08-24 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Repositioning of prosthetic heart valve and deployment
US9615924B2 (en) 2010-09-17 2017-04-11 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and methods for transcatheter heart valve delivery
US8778019B2 (en) 2010-09-17 2014-07-15 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and method for transcatheter heart valve delivery
USD654170S1 (en) 2010-09-20 2012-02-14 St. Jude Medical, Inc. Stent connections
USD654169S1 (en) 2010-09-20 2012-02-14 St. Jude Medical Inc. Forked ends
USD653342S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Stent connections
USD660433S1 (en) 2010-09-20 2012-05-22 St. Jude Medical, Inc. Surgical stent assembly
USD653341S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Surgical stent
US9827091B2 (en) 2010-09-20 2017-11-28 St. Jude Medical, Cardiology Division, Inc. Valve leaflet attachment in collapsible prosthetic valves
USD660432S1 (en) 2010-09-20 2012-05-22 St. Jude Medical, Inc. Commissure point
USD653343S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Surgical cuff
USD660967S1 (en) 2010-09-20 2012-05-29 St. Jude Medical, Inc. Surgical stent
USD652926S1 (en) 2010-09-20 2012-01-24 St. Jude Medical, Inc. Forked end
USD648854S1 (en) 2010-09-20 2011-11-15 St. Jude Medical, Inc. Commissure points
US9011527B2 (en) 2010-09-20 2015-04-21 St. Jude Medical, Cardiology Division, Inc. Valve leaflet attachment in collapsible prosthetic valves
USD684692S1 (en) 2010-09-20 2013-06-18 St. Jude Medical, Inc. Forked ends
USD652927S1 (en) 2010-09-20 2012-01-24 St. Jude Medical, Inc. Surgical stent
WO2012054776A1 (en) 2010-10-21 2012-04-26 Medtronic Inc Mitral bioprosthesis with low ventricular profile
US9192466B2 (en) 2010-10-21 2015-11-24 Medtronic, Inc. Mitral bioprosthesis with low ventricular profile
US9737400B2 (en) 2010-12-14 2017-08-22 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
US9770331B2 (en) 2010-12-23 2017-09-26 Twelve, Inc. System for mitral valve repair and replacement
US9421098B2 (en) 2010-12-23 2016-08-23 Twelve, Inc. System for mitral valve repair and replacement
WO2012101190A1 (en) * 2011-01-25 2012-08-02 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Implant device
EP2478868A1 (en) * 2011-01-25 2012-07-25 The Provost, Fellows, Foundation Scholars, and the other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Implant device
US9545309B2 (en) 2011-02-01 2017-01-17 St. Jude Medical, Cardiology Divisions, Inc. Repositioning of prosthetic heart valve and deployment
US9775707B2 (en) 2011-02-01 2017-10-03 St. Jude Medical, Cardiology Division, Inc. Repositioning of prosthetic heart valve and deployment
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9713529B2 (en) 2011-04-28 2017-07-25 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
EP2529701A1 (en) * 2011-06-01 2012-12-05 Nvt Ag Cardiac valve prosthesis deployment system
CN103702635A (en) * 2011-06-01 2014-04-02 Nvt股份公司 Cardiac valve prosthesis deployment system
US9125740B2 (en) 2011-06-21 2015-09-08 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9572662B2 (en) 2011-06-21 2017-02-21 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9585751B2 (en) 2011-06-21 2017-03-07 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9579196B2 (en) 2011-06-21 2017-02-28 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US8940044B2 (en) 2011-06-23 2015-01-27 Valtech Cardio, Ltd. Closure element for use with an annuloplasty structure
EP2734157A4 (en) * 2011-07-21 2015-06-17 4Tech Inc Method and apparatus for tricuspid valve repair using tension
WO2013011502A3 (en) * 2011-07-21 2013-05-10 4Tech Inc. Method and apparatus for tricuspid valve repair using tension
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9387078B2 (en) 2011-08-05 2016-07-12 Mitraltech Ltd. Percutaneous mitral valve replacement and sealing
US9480559B2 (en) * 2011-08-11 2016-11-01 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US20140214159A1 (en) * 2011-08-11 2014-07-31 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US9833315B2 (en) 2011-08-11 2017-12-05 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US9867701B2 (en) 2011-08-18 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Devices and methods for transcatheter heart valve delivery
US9039757B2 (en) 2011-10-19 2015-05-26 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9034032B2 (en) 2011-10-19 2015-05-19 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9295552B2 (en) 2011-10-19 2016-03-29 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9034033B2 (en) 2011-10-19 2015-05-19 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9775709B2 (en) 2011-11-04 2017-10-03 Valtech Cardio, Ltd. Implant having multiple adjustable mechanisms
US9265608B2 (en) 2011-11-04 2016-02-23 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
US9724192B2 (en) 2011-11-08 2017-08-08 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US9827092B2 (en) * 2011-12-16 2017-11-28 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
US20130172978A1 (en) * 2011-12-16 2013-07-04 Tendyne Holdings Inc. Tethers for Prosthetic Mitral Valve
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US9066800B2 (en) * 2012-03-28 2015-06-30 Medtronic, Inc. Dual valve prosthesis for transcatheter valve implantation
US9011515B2 (en) * 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
US9566152B2 (en) * 2012-04-19 2017-02-14 Caisson Interventional, LLC Heart valve assembly and methods
US9427316B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US9427315B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US20150209138A1 (en) * 2012-04-19 2015-07-30 Caisson Interventional, LLC Heart valve assembly and methods
US20130282114A1 (en) * 2012-04-19 2013-10-24 Caisson Interventional, LLC Heart valve assembly systems and methods
US9345573B2 (en) * 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US8961594B2 (en) 2012-05-31 2015-02-24 4Tech Inc. Heart valve repair system
US9554902B2 (en) 2012-06-28 2017-01-31 St. Jude Medical, Cardiology Division, Inc. Leaflet in configuration for function in various shapes and sizes
US9289292B2 (en) 2012-06-28 2016-03-22 St. Jude Medical, Cardiology Division, Inc. Valve cuff support
US9693861B2 (en) 2012-06-29 2017-07-04 St. Jude Medical, Cardiology Division, Inc. Leaflet attachment for function in various shapes and sizes
US9615920B2 (en) 2012-06-29 2017-04-11 St. Jude Medical, Cardiology Divisions, Inc. Commissure attachment feature for prosthetic heart valve
US9241791B2 (en) 2012-06-29 2016-01-26 St. Jude Medical, Cardiology Division, Inc. Valve assembly for crimp profile
US9808342B2 (en) 2012-07-03 2017-11-07 St. Jude Medical, Cardiology Division, Inc. Balloon sizing device and method of positioning a prosthetic heart valve
US9283072B2 (en) 2012-07-25 2016-03-15 W. L. Gore & Associates, Inc. Everting transcatheter valve and methods
US9675454B2 (en) 2012-07-30 2017-06-13 Tendyne Holdings, Inc. Delivery systems and methods for transcatheter prosthetic valves
US9510946B2 (en) 2012-09-06 2016-12-06 Edwards Lifesciences Corporation Heart valve sealing devices
US9414918B2 (en) 2012-09-06 2016-08-16 Edwards Lifesciences Corporation Heart valve sealing devices
US9295549B2 (en) 2012-10-12 2016-03-29 St. Jude Medical, Cardiology Division, Inc. Valve holder and loading integration
WO2014059064A1 (en) * 2012-10-12 2014-04-17 St. Jude Medical, Cardiology Division, Inc. Valve holder and loading integration
US9801721B2 (en) 2012-10-12 2017-10-31 St. Jude Medical, Cardiology Division, Inc. Sizing device and method of positioning a prosthetic heart valve
CN102961199A (en) * 2012-11-30 2013-03-13 宁波健世生物科技有限公司 Anti-displacement pulmonary valve stent
US9730793B2 (en) 2012-12-06 2017-08-15 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
US9737398B2 (en) 2012-12-19 2017-08-22 W. L. Gore & Associates, Inc. Prosthetic valves, frames and leaflets and methods thereof
US9144492B2 (en) 2012-12-19 2015-09-29 W. L. Gore & Associates, Inc. Truncated leaflet for prosthetic heart valves, preformed valve
US9827089B2 (en) 2012-12-19 2017-11-28 W. L. Gore & Associates, Inc. Methods for improved prosthetic heart valve with leaflet shelving
US9101469B2 (en) 2012-12-19 2015-08-11 W. L. Gore & Associates, Inc. Prosthetic heart valve with leaflet shelving
US9398952B2 (en) 2012-12-19 2016-07-26 W. L. Gore & Associates, Inc. Planar zone in prosthetic heart valve leaflet
WO2014110082A2 (en) 2013-01-08 2014-07-17 Medtronic CV Luxembourg S.a.r.l. Method of treating paravalvular leakage after prosthetic valve implantation
US9693865B2 (en) 2013-01-09 2017-07-04 4 Tech Inc. Soft tissue depth-finding tool
US9788948B2 (en) 2013-01-09 2017-10-17 4 Tech Inc. Soft tissue anchors and implantation techniques
US9681952B2 (en) 2013-01-24 2017-06-20 Mitraltech Ltd. Anchoring of prosthetic valve supports
US9655719B2 (en) 2013-01-29 2017-05-23 St. Jude Medical, Cardiology Division, Inc. Surgical heart valve flexible stent frame stiffener
US9314163B2 (en) 2013-01-29 2016-04-19 St. Jude Medical, Cardiology Division, Inc. Tissue sensing device for sutureless valve selection
US9186238B2 (en) 2013-01-29 2015-11-17 St. Jude Medical, Cardiology Division, Inc. Aortic great vessel protection
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9844435B2 (en) 2013-03-01 2017-12-19 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve replacement
US9480563B2 (en) 2013-03-08 2016-11-01 St. Jude Medical, Cardiology Division, Inc. Valve holder with leaflet protection
US9867697B2 (en) 2013-03-12 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for a paravalvular leak protection
US9339274B2 (en) 2013-03-12 2016-05-17 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak occlusion device for self-expanding heart valves
US9687341B2 (en) 2013-03-12 2017-06-27 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for paravalvular leak protection
US9398951B2 (en) 2013-03-12 2016-07-26 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for paravalvular leak protection
US9636222B2 (en) 2013-03-12 2017-05-02 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak protection
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9326856B2 (en) 2013-03-14 2016-05-03 St. Jude Medical, Cardiology Division, Inc. Cuff configurations for prosthetic heart valve
US9131982B2 (en) 2013-03-14 2015-09-15 St. Jude Medical, Cardiology Division, Inc. Mediguide-enabled renal denervation system for ensuring wall contact and mapping lesion locations
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
WO2014141239A1 (en) * 2013-03-14 2014-09-18 4Tech Inc. Stent with tether interface
US9486306B2 (en) 2013-04-02 2016-11-08 Tendyne Holdings, Inc. Inflatable annular sealing device for prosthetic mitral valve
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
WO2014168655A1 (en) * 2013-04-12 2014-10-16 St. George Medical, Inc. Mitral heart valve prosthesis and associated delivery catheter
FR3004336A1 (en) * 2013-04-12 2014-10-17 St George Medical Inc Prothese mitral heart valve catheter and release combines
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
WO2014201384A1 (en) * 2013-06-14 2014-12-18 The Regents Of The University Of California Transcatheter mitral valve
WO2014203171A1 (en) * 2013-06-17 2014-12-24 Heldman Alan Prosthetic heart valve with linking element and methods for implanting same
US9445894B2 (en) 2013-06-17 2016-09-20 Alan W. HELDMAN Prosthetic heart valve with linking element and methods for implanting same
EP3010448A4 (en) * 2013-06-17 2017-03-01 Alan Heldman Prosthetic heart valve with linking element and methods for implanting same
US9597181B2 (en) 2013-06-25 2017-03-21 Tendyne Holdings, Inc. Thrombus management and structural compliance features for prosthetic heart valves
US9668856B2 (en) 2013-06-26 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Puckering seal for reduced paravalvular leakage
USD730521S1 (en) 2013-09-04 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Stent with commissure attachments
USD730520S1 (en) 2013-09-04 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Stent with commissure attachments
US9867611B2 (en) 2013-09-05 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Anchoring studs for transcatheter valve implantation
US9050188B2 (en) 2013-10-23 2015-06-09 Caisson Interventional, LLC Methods and systems for heart valve therapy
US9421094B2 (en) 2013-10-23 2016-08-23 Caisson Interventional, LLC Methods and systems for heart valve therapy
US9526611B2 (en) 2013-10-29 2016-12-27 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US9668857B2 (en) 2013-11-06 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
US9700409B2 (en) 2013-11-06 2017-07-11 St. Jude Medical, Cardiology Division, Inc. Reduced profile prosthetic heart valve
US9549818B2 (en) 2013-11-12 2017-01-24 St. Jude Medical, Cardiology Division, Inc. Pneumatically power-assisted tavi delivery system
US9597185B2 (en) 2013-12-19 2017-03-21 St. Jude Medical, Cardiology Division, Inc. Leaflet-cuff attachments for prosthetic heart valve
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
US9867556B2 (en) 2014-02-07 2018-01-16 St. Jude Medical, Cardiology Division, Inc. System and method for assessing dimensions and eccentricity of valve annulus for trans-catheter valve implantation
US9763778B2 (en) 2014-03-18 2017-09-19 St. Jude Medical, Cardiology Division, Inc. Aortic insufficiency valve percutaneous valve anchoring
US9610157B2 (en) 2014-03-21 2017-04-04 St. Jude Medical, Cardiology Division, Inc. Leaflet abrasion mitigation
US9668858B2 (en) 2014-05-16 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve with paravalvular leak sealing ring
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9855140B2 (en) 2014-06-10 2018-01-02 St. Jude Medical, Cardiology Division, Inc. Stent cell bridge for cuff attachment
US9801720B2 (en) 2014-06-19 2017-10-31 4Tech Inc. Cardiac tissue cinching
US9808201B2 (en) 2014-08-18 2017-11-07 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
US9737264B2 (en) 2014-08-18 2017-08-22 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
JP2016067931A (en) * 2014-09-26 2016-05-09 エヌヴィーティー アーゲー Implantable device for treating heart valve counter-flow
US9839517B2 (en) 2014-09-26 2017-12-12 Nvt Ag Implantable device for treating mitral valve regurgitation
US9750607B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9750606B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9750605B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US20170100240A1 (en) * 2015-10-12 2017-04-13 Horizon Scientific Corp. Mitral Valve Assembly
US9872765B2 (en) * 2015-10-12 2018-01-23 Venus Medtech (Hangzhou) Inc Mitral valve assembly
EP3231393A1 (en) 2016-04-13 2017-10-18 Christian Vallbracht Minimally invasive implantable mitral and tricuspid valve
WO2017189276A1 (en) * 2016-04-29 2017-11-02 Medtronic Vascular Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
USD802765S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
USD802766S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
USD802764S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element
US9883943B2 (en) 2016-08-29 2018-02-06 Valtech Cardio, Ltd. Implantation of repair devices in the heart

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