US11872124B2 - Temperature-control during crimping of an implant - Google Patents
Temperature-control during crimping of an implant Download PDFInfo
- Publication number
- US11872124B2 US11872124B2 US18/125,350 US202318125350A US11872124B2 US 11872124 B2 US11872124 B2 US 11872124B2 US 202318125350 A US202318125350 A US 202318125350A US 11872124 B2 US11872124 B2 US 11872124B2
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- crimping
- bath
- aperture
- port
- state
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Links
- 238000002788 crimping Methods 0.000 title claims abstract description 185
- 239000007943 implant Substances 0.000 title claims abstract description 47
- 230000007246 mechanism Effects 0.000 claims abstract description 57
- 230000007704 transition Effects 0.000 claims abstract description 6
- 210000003709 heart valve Anatomy 0.000 claims description 8
- 230000002792 vascular Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 description 30
- 238000000034 method Methods 0.000 description 14
- 238000007789 sealing Methods 0.000 description 10
- 229910000734 martensite Inorganic materials 0.000 description 9
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 7
- 229910001000 nickel titanium Inorganic materials 0.000 description 6
- 230000008878 coupling Effects 0.000 description 5
- 238000010168 coupling process Methods 0.000 description 5
- 238000005859 coupling reaction Methods 0.000 description 5
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910001566 austenite Inorganic materials 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000013529 heat transfer fluid Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/9522—Means for mounting a stent or stent-graft onto or into a placement instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/9522—Means for mounting a stent or stent-graft onto or into a placement instrument
- A61F2/9524—Iris-type crimpers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/9522—Means for mounting a stent or stent-graft onto or into a placement instrument
- A61F2/9525—Means for mounting a stent or stent-graft onto or into a placement instrument using a funnel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B21—MECHANICAL METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
- B21D—WORKING OR PROCESSING OF SHEET METAL OR METAL TUBES, RODS OR PROFILES WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
- B21D39/00—Application of procedures in order to connect objects or parts, e.g. coating with sheet metal otherwise than by plating; Tube expanders
- B21D39/04—Application of procedures in order to connect objects or parts, e.g. coating with sheet metal otherwise than by plating; Tube expanders of tubes with tubes; of tubes with rods
- B21D39/048—Application of procedures in order to connect objects or parts, e.g. coating with sheet metal otherwise than by plating; Tube expanders of tubes with tubes; of tubes with rods using presses for radially crimping tubular elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49863—Assembling or joining with prestressing of part
- Y10T29/49865—Assembling or joining with prestressing of part by temperature differential [e.g., shrink fit]
Definitions
- Some applications of the present invention relate in general to the application of heat-transfer fluid to work-pieces during their preparation. More specifically, some applications of the present invention relate to the cooling of a Nitinol frame of a prosthetic heart valve or vascular stent during crimping.
- SMAs shape memory alloys
- SMA-based medical devices may possess shape memory in that they can be reformed from an original, austenitic configuration to a second, martensitic configuration by lowering their temperature, and subsequently restored to their original austenitic configuration, by elevating their temperature.
- an SMA device in its original shape and size, is cooled to its martensitic state, and subsequently deformed, it will retain its deformed shape and size. Upon warming of the SMA device to its austenitic state, the device will recover its original shape and size.
- SMAs has been shown to be particularly useful in the context of implants percutaneously implanted into a patient's cardiovascular system, including prosthetic heart valves. Due to the relatively narrow diameter of the vascular system via which prosthetic heart valves are frequently delivered, it is often desirable to deliver the implant in a crimped state, achieved while the implant is in its martensitic configuration. When the implant is exposed to physiological temperatures, the implant undergoes transformation to its austenitic configuration. The thermoelastic expansion enabled by the implant's transformation to its austenitic configuration may be controlled mechanically by housing the implant within a sleeve of a delivery tool. The regulated release of the implant from the housing enables the gradual return of the implant to its original shape and size upon delivery to the desired anatomical location.
- the present invention is directed to apparatus and methods for temperature control during crimping of a medical implant.
- an SMA device in its original shape and size, is cooled to its martensitic state, and subsequently deformed, it will retain its deformed shape and size. Upon warming of the SMA device to its austenitic state, the device will recover its original shape and size. Since implants comprising SMAs, such as nickel titanium (Nitinol), are more easily deformed while in their martensitic state, it is therefore desirable to crimp such an implant while cooled below its transition temperature. Such crimping of a cooled SMA implant reduces a likelihood of damaging the implant or delivery tool during the crimping and loading processes.
- aspects of the present invention include apparatus and methods for crimping a frame of an SMA implant while the SMA implant is at least partially submerged in a cooled liquid that maintains the SMA implant in its martensitic state.
- the submersion of the frame of an SMA implant during crimping is achieved by disposition of a crimping device within a bath of the cooled liquid.
- Some aspects of the present invention include alignment of the crimping aperture with a port in a side-wall of the bath, enabling advancing a delivery tool that comprises a shaft and a housing at a distal end of the shaft, housing-first, through the port, at least until the housing reaches the aperture, crimping the frame onto the delivery tool by actuating the crimping mechanism.
- a seal configured to maintain sealing as the housing and the shaft pass through the port during the advancing.
- apparatus for crimping a frame of an implant including:
- the crimping mechanism has a thickness
- the bath has an internal width that is 16-24 cm greater than the thickness of the crimping mechanism.
- the receptacle is a recess, configured to snugly receive the portion of the crimping device.
- the bath defines the recess in the floor, and the recess is shaped to receive at least a portion of the base.
- a height of the aperture is within 1 cm of a height of the port.
- the bath is shaped to receive the crimping device in a pre-defined rotational orientation of the crimping device with respect to the bath.
- a rotational position of the aperture is within 5 degrees of a rotational position of the port.
- the receptacle and the portion of the crimping device are cooperatively shaped to inhibit, in the assembled state, rotation of the crimping device out of the pre-defined rotational orientation.
- the port defines a channel, and includes a seal that reversibly closes the channel.
- the channel has an internal diameter of 6-15 mm.
- the apparatus includes a delivery tool that includes a shaft and a housing at a distal end of the shaft, the delivery tool being advanceable, housing-first, through the port, at least until the housing reaches the aperture, and the seal is configured to maintain sealing as the housing and the shaft pass through the port during the advancing.
- the external portion of the port defines a screw thread
- the cap defines a complementary screw thread
- the cap is securable to the external portion of the port by being screwed onto the external portion of the port.
- the apparatus includes an implant, the implant including a tubular frame that: (i) circumscribes a longitudinal axis, (ii) defines a radial diameter, and (iii) has a crimped state and a non-crimped state, in which the radial diameter of the frame in the crimped state is smaller than the radial diameter of the frame in the non-crimped state.
- the implant is a prosthetic heart valve or vascular stent.
- the internal width of the bath is less than 5 cm greater than the working diameter of the crimping device.
- the internal width of the bath is less than 2 cm greater than the working diameter of the crimping device.
- the internal width of the bath is 1-10 mm greater than the working diameter of the crimping device.
- the handle is below the side-wall height in both the open state and the narrowed state.
- the handle is temporarily elevated above the side-wall height.
- apparatus for crimping a frame of an implant including a crimping assembly, the crimping assembly including:
- the one or more side-walls include a port-defining side-wall, and the port-defining side-wall defines a port between outside of the bath and inside of the bath, the port being aligned with the crimping aperture of the crimping device.
- an aperture-height of the aperture is within 1 cm of a port-height of the port.
- a rotational position of the aperture is within 5 degrees of a rotational position of the port.
- the port defines a channel, and includes a seal that reversibly closes the channel.
- the channel has an internal diameter of 6-15 mm.
- the apparatus includes a delivery tool that includes a shaft and a housing at a distal end of the shaft, the delivery tool being advanceable, housing-first, through the port, at least until the housing reaches the aperture, and the seal is configured to maintain sealing as the housing and the shaft pass through the port during the advancing.
- the external portion of the port defines a screw thread
- the cap defines a complementary screw thread
- the cap is securable to the external portion of the port by being screwed onto the external portion of the port.
- the apparatus includes an implant, the implant including a tubular frame that: (i) circumscribes a longitudinal axis, (ii) defines a radial diameter, and (iii) has a crimped state and a non-crimped state, in which the radial diameter of the frame in the crimped state is smaller than the radial diameter of the frame in the non-crimped state.
- the implant is a prosthetic heart valve or vascular stent.
- the crimping mechanism has a thickness
- the bath has an internal width that is 16-24 cm greater than the thickness of the crimping mechanism.
- the internal width of the bath is less than 5 cm greater than the working diameter of the crimping device.
- the internal width of the bath is less than 2 cm greater than the working diameter of the crimping device.
- the internal width of the bath is 1-10 mm greater than the working diameter of the crimping device.
- the handle is below the side-wall height in both the open state and the narrowed state.
- the handle is temporarily elevated above the side-wall height.
- method for crimping an expandable frame including:
- introducing the cooled liquid into the bath includes introducing the cooled liquid into the bath while the liquid has a temperature of between ⁇ 2 and 12 degrees C.
- the method includes introducing, into the bath, a frozen portion of the liquid.
- the method includes, prior to crimping the frame, immersing the frame in the cooled liquid in the bath for at least 10 seconds.
- the method includes, prior to crimping the frame, immersing the frame in the cooled liquid in the bath for between 30 seconds and 10 minutes.
- the crimping mechanism has a first side and a second side
- inserting the expandable frame includes manually inserting the frame to within the crimping aperture facilitated by placing a first hand within the bath on the first side of the crimping mechanism, and a second hand within the bath on the second side of the crimping mechanism.
- actuating the crimping mechanism includes revolving a handle about halfway circumferentially around the crimping mechanism, and revolving the handle causes transitioning of the crimping aperture from an open state to a narrowed state.
- the method includes, prior to revolving the handle, grasping the handle while aperture is in its open state and the handle is disposed in the liquid.
- actuating the crimping mechanism includes transitioning the crimping aperture into the narrowed state by revolving the handle such that the handle enters the liquid.
- the port includes an external portion outside of the bath, and the method further includes:
- fastening the cap to the external portion of the port includes screwing the cap onto the external portion of the port, sealing the port.
- screwing the cap onto the external portion of the port further includes pushing the plurality of plugs into the gap between the shaft and the external portion of the port.
- the method includes forming a crimping assembly in which the crimping mechanism is held securely within the bath, and the crimping aperture is below the side-wall height, by placing the crimping device into the bath, and coupling the crimping device to the bath.
- forming the crimping assembly includes coupling the crimping device to the bath such that the port is aligned with the aperture.
- forming the crimping assembly includes coupling the crimping device to the bath such that a rotational position of the aperture is within 5 degrees of a rotational position of the port.
- forming the crimping assembly includes coupling the crimping device to the bath such that an aperture-height of the aperture is within 1 cm of a port-height of the port.
- the method includes threading the frame onto the part of the delivery tool.
- threading the frame onto the part of the delivery tool includes threading the frame onto the part of the delivery tool subsequently to inserting the part of the delivery tool through the port into the bath.
- apparatus for crimping a frame of an implant including:
- FIGS. 1 A-C are schematic illustrations of a crimping assembly, comprising a crimping device and a bath, in accordance with some applications of the invention
- FIGS. 2 A-E are schematic illustrations showing a crimping assembly being used in combination with a delivery tool to crimp a frame of an implant, in accordance with some applications of the invention
- FIG. 3 is a schematic illustration of a seal connected by a cap to an external portion of a port, in accordance with some applications of the invention
- FIGS. 4 A-E are schematic illustrations showing the use of a delivery tool with a cap, the port, and a plurality of plugs, in accordance with some applications of the invention
- FIG. 5 is a schematic illustration showing sealing of the port around a delivery tool shaft, in accordance with some applications of the invention.
- FIGS. 6 A-B are schematic illustrations showing use of the crimping device disposed within the bath, in accordance with some applications of the invention.
- FIGS. 1 A-C are schematic illustrations of a crimping assembly 10 , comprising a crimping device 20 and a bath 28 , in accordance with some applications of the invention.
- Crimping device 20 comprises a base 22 , and a crimping mechanism 24 that defines a crimping aperture 26 having an open state shown in FIGS. 2 B, 2 C & 6 A , as well as a narrowed state shown in FIGS. 2 D and 6 B .
- Bath 28 has a floor 30 , and one or more side-walls 32 extending upward from the floor to a side-wall height D 34 .
- side-wall height D 34 is the height to which bath 28 is fillable with a liquid, e.g., the lowest height of the one or more side-walls.
- Bath 28 defines a receptacle 18 that is shaped to receive a portion of crimping device 20 , such that the crimping device is held securely by the bath 28 .
- FIGS. 1 A- 2 E show crimping assembly 10 in its assembled state, in which crimping device 20 is disposed within bath 28 , and is held securely by the bath.
- the aperture 26 is below side-wall height D 34 .
- the receptacle 18 is a recess in floor 30 of bath 28 , and the recess is shaped to snugly receive base 22 of crimping device 20 .
- bath 28 includes a port-defining side-wall 36 , which defines a port 38 that defines a channel 50 between outside of the bath and inside of the bath.
- port 38 is aligned with crimping aperture 26 .
- a height D 35 of the aperture may be within 1 cm of a height D 33 of the port.
- port 38 may be disposed in a rotational position of the aperture that is within 5 degrees of a rotational position of the port 38 . This alignment typically places channel 50 and aperture 26 along a co-linear axis 40 ( FIG. 1 A ).
- crimping assembly 10 comprises two or more separable components, which undergo assembly prior to use.
- bath 28 and crimping device 20 may be provided as separate components, which are assembled prior to use, e.g., by the operator or by a technician.
- assembly 10 is typically assembled by introducing a portion of the crimping device (e.g., base 22 ) into receptacle 18 ( FIG. 1 A ).
- bath 28 is shaped to receive crimping device 20 in a pre-defined rotational orientation of the crimping device with respect to the bath, and receptacle 18 and the portion of the crimping device (e.g., base 22 ) are cooperatively shaped to inhibit, in the assembled state, rotation of the crimping device 20 from the pre-defined rotational orientation.
- receptacle 18 may define a protrusion 52
- device 20 e.g., base 22 thereof
- notch 54 or vice versa
- crimping assembly 10 may be provided pre-assembled, with crimping device 20 already secured within bath 28 .
- device 20 does not comprise a distinct base 22 .
- the pre-assembled crimping assembly is typically as described hereinabove.
- FIGS. 6 A-B are schematic illustrations of crimping assembly 10 , in accordance with some applications of the invention.
- Crimping mechanism 24 has a working radius D 80 from the center of aperture 26 to the end of handle 25 .
- handle 25 revolves about halfway circumferentially around mechanism 24 (i.e., with respect to aperture 26 ). Therefore, crimping mechanism 24 defines a working diameter D 82 , defined as twice working radius D 80 .
- Bath 28 has an internal width D 84 , measured at height D 33 , typically transverse to axis 40 .
- internal width D 84 is greater than working diameter D 82 .
- D 84 is less than 10 cm greater than D 82 , (e.g., less than 5 cm greater, less than 2 cm greater, e.g., 1-10 mm greater).
- Crimping mechanism 24 has a thickness D 88 .
- Thickness D 88 is typically 2-5 cm (e.g., 2-3 cm).
- bath 28 has another internal width D 86 , measured at height D 33 , measured along axis 40 .
- width D 86 is sufficiently great that an operator may place a hand on each side of crimping mechanism 24 in order to load the implant onto the tool. Therefore, for some applications, width D 86 is greater than thickness D 88 plus 8-15 cm (e.g., 10-15 cm) on each side of crimping mechanism 24 .
- Internal widths D 84 and D 88 are both typically 20-40 cm (e.g., 25-35 cm).
- bath 28 is generally circular, and diameters D 84 and D 88 are generally equal to each other (e.g., within 10 percent of each other, such as identical to each other).
- FIGS. 2 A-E are schematic illustrations showing crimping assembly 10 being used in combination with a delivery tool 42 to crimp a frame 56 of an implant 58 , in accordance with some applications of the invention.
- implant 58 FIG. 2 B
- Frame 56 is typically a shape-memory alloy such as nickel titanium (Nitinol).
- Nitinol nickel titanium
- the co-linear axis 40 of port 38 and crimping aperture 26 enables advancement of a delivery tool 42 ( FIG. 2 B ), which as depicted may include a shaft 44 and housing 46 , through port 38 , at least until housing 46 reaches aperture 26 .
- Port 38 typically comprises an external portion 78 that is outside the bath.
- port 38 defines channel 50 having an internal diameter of 6-15 mm (e.g., 6-10 mm or 10-15 mm), and comprises a seal 48 that reversibly closes the channel (detailed in FIG. 2 E ) configured to maintain sealing as housing 46 and shaft 44 pass through channel 50 during the advancing.
- a cooled liquid 60 within bath 28 maintains frame 56 at a cool temperature during crimping of the frame.
- Liquid 60 typically has a temperature of between ⁇ 2 and 12 degrees C. (e.g., 4-10 degrees C.).
- a portion 61 of liquid 60 may be frozen.
- frozen liquid (e.g., saline ice) 60 a may also be added, in order to maintain liquid 60 at its cool temperature throughout the duration of the crimping of frame 56 .
- FIG. 2 A shows assembly 10 prior to introduction of tool 42 or implant 58 .
- FIG. 2 A shows liquid 60 having been introduced into bath 28 prior to insertion of tool 42 , but the liquid may alternatively be introduced after insertion of the tool.
- FIGS. 2 B and 2 C depict advancement of tool 42 into crimping aperture 26 , such that frame 56 is disposed within the crimping aperture and immersed within cooled liquid 60 .
- Frame 56 may be allowed to cool for a period of time while immersed in cooled liquid 60 , prior to crimping. This period of time may typically last greater than 10 seconds (e.g., greater than 30 seconds) and/or less than 10 minutes (e.g., between 30 seconds and 10 minutes, such as 2-10 minutes).
- FIG. 10 seconds e.g., greater than 30 seconds
- 10 minutes e.g., between 30 seconds and 10 minutes, such as 2-10 minutes.
- FIG. 2 D shows contraction of crimping aperture 26 upon frame 56 , crimping frame 56 while immersed in cooled liquid 60 . Since implants comprising SMAs such as Nitinol are more easily deformed while in their martensitic state, it is therefore desirable to crimp such an implant while cooled below its transition temperature. Cooling of an SMA implant during crimping, which reduces a likelihood of damaging the implant or delivery tool during the crimping and loading processes, is achieved by disposition of crimping device 20 within a bath of the cooled liquid as shown in FIGS. 2 C and 2 D .
- FIG. 2 E shows retraction of tool 42 through channel 50 of port 38 , with implant 58 disposed within housing 46 . Enlarged inset of FIG. 2 E shows passage of tool shaft 44 through seal 48 , while the seal prevents leakage of cooled liquid 60 .
- liquid 60 is typically suitable for introduction into the subject, e.g., being sterile, non-toxic, and/or isotonic.
- liquid 60 may be sterile saline. It is to be noted that the crimping of implant 58 while immersed in cooled liquid 60 , as described above, may reduce or obviate the need for subsequent flushing of air from the implant.
- the “heights” described herein are all heights above the same reference point, e.g., floor 30 .
- FIGS. 3 , 4 A -E, and 5 are schematic illustrations showing the sealing of port 38 during advancing of housing 46 and shaft 44 of delivery tool 42 through the port.
- Some embodiments of the device include one or more washers 62 , 66 , and 68 fitted a first sealing nut 64 and a second sealing nut 70 ( FIG. 3 ).
- Port 38 may be secured to port-defining side-wall 36 using screws (e.g., as shown), an adhesive, and/or any other suitable securing means.
- Delivery tool housing 46 is advanced through a cap 74 (i.e., through an opening defined in the cap) ( FIG. 4 A ). Subsequently, housing 46 is advanced through port 38 ( FIG. 4 B ). Optionally, a plurality of plugs 72 are subsequently arranged into a ring that circumscribes shaft 44 and is disposed in an annular gap 76 between the shaft and external portion 78 of port 38 ( FIGS. 4 C-D ).
- cap 74 is fastened to external portion 78 of port 38 ( FIG. 4 E ).
- an interior portion of cap 74 may be shaped to define threading, and cap 74 may be secured to port 38 by being screwed onto the port.
- cap 74 onto external portion 78 pushes plugs 72 into gap 76 .
Abstract
Description
-
- a crimping device including (i) a base, and (ii) a crimping mechanism that defines a crimping aperture;
- a bath having a floor, the bath (i) defining a receptacle that is shaped to receive a portion of the crimping device, and (ii) having one or more side-walls, the one or more side-walls:
- extending upward from the floor to a side-wall height, and
- including a port-defining side-wall, wherein the port-defining side-wall defines a port between outside of the bath and inside of the bath;
- the apparatus having an assembled state in which the portion of the crimping device has been received by the receptacle,
- wherein, in the assembled state:
- the crimping device is held securely by the bath,
- the aperture is below the side-wall height, and
- the port is aligned with the crimping aperture.
- wherein, in the assembled state:
-
- a first element selected from the group consisting of: the receptacle, and the portion of the crimping device is shaped to define a protrusion,
- another element selected from the group is shaped to define a notch, and
- the protrusion and the notch inhibit the rotation of the crimping device out of the pre-defined rotational orientation by, in the assembled state, the protrusion being disposed within the notch.
-
- the port includes an external portion outside of the bath,
- the external portion of the port is dimensioned such that, while the shaft extends through the port, an annular gap is defined around the shaft, between the shaft and the external portion of the port,
- the apparatus further includes a cap and a plurality of plugs,
- the cap (i) defines an opening through which the housing is advanceable, and (ii) is securable to the external portion of the port,
- the plurality of plugs are shaped to be formable into a ring that circumscribes the shaft, and that fits snugly within in the gap.
-
- the crimping mechanism has a first side and first side, and
- the bath has an internal width sufficient to allow a human operator to simultaneously place a first hand inside the bath on the first side of the crimping mechanism, and a second hand inside the bath on the second side of the crimping mechanism.
-
- the crimping aperture has an open state and a narrowed state,
- the crimping device further includes a handle, the crimping mechanism being actuatable by moving the handle circumferentially around the crimping mechanism, and
- actuation of the crimping mechanism transitions the crimping aperture from its open state to its narrowed state.
-
- the crimping device has a working diameter, defined between a first position of an end of the handle when the crimping aperture is in its open state, and a second position of the end of the handle when the aperture is in its narrowed state, and
- the bath has an internal width that is greater than the working diameter.
-
- a bath having a floor, and one or more side-walls extending upward from the floor to a side-wall height; and
- a crimping mechanism that defines a crimping aperture, the crimping mechanism attached to the bath such that the crimping aperture is disposed within the bath below the side-wall height.
-
- the port includes an external portion outside of the bath,
- the external portion of the port is dimensioned such that, while the shaft extends through the port, an annular gap is defined around the shaft, between the shaft and the external portion of the port,
- the apparatus further includes a cap and a plurality of plugs,
- the cap (i) defines an opening through which the housing is advanceable, and (ii) is securable to the external portion of the port,
- the plurality of plugs are shaped to be formable into a ring that circumscribes the shaft, and that fits snugly within in the gap.
-
- the crimping mechanism has a first side and first side, and
- the bath has an internal width sufficient to allow a human operator to simultaneously place a first hand inside the bath on the first side of the crimping mechanism, and a second hand inside the bath on the second side of the crimping mechanism.
-
- the crimping aperture has an open state and a narrowed state,
- the crimping device further includes a handle, the crimping mechanism being actuatable by moving the handle circumferentially around the crimping mechanism, and
- actuation of the crimping mechanism transitions the crimping aperture from its open state to its narrowed state.
-
- the crimping device has a working diameter, defined between a first position of an end of the handle when the crimping aperture is in its open state, and a second position of the end of the handle when the aperture is in its narrowed state, and
- the bath has an internal width that is greater than the working diameter.
-
- introducing a cooled liquid into a bath, the bath having a floor and one or more side-walls, at least one of the side-walls being a port-defining side-wall that defines a port from inside the bath to outside the bath;
- inserting at least a part of a delivery tool through the port into the bath,
- inserting the expandable frame, disposed on the part of the delivery tool, to a crimping aperture of a crimping mechanism disposed within and coupled to the bath; and
- while (i) the frame remains disposed within the aperture, and (ii) the frame is at least partially submerged in the liquid, crimping the frame onto the delivery tool by actuating the crimping mechanism.
-
- prior to inserting the part of the delivery tool through the port into the bath, passing the part of the delivery tool through a cap; and
- subsequently to inserting the part of the delivery tool through the port into the bath, fastening the cap to the external portion of the port.
-
- the delivery tool includes a shaft,
- inserting at least the part of the delivery tool through the port into the bath includes positioning the shaft through the port,
- the method further includes, prior to securing the cap to the external portion of the port, arranging a plurality of plugs into a ring that circumscribes the shaft and is disposed in a gap between the shaft and the external portion of the port, and
- fastening the cap to the external portion of the port includes securing the ring of plugs within the gap.
-
- a crimping device including (i) a base, and (ii) a crimping mechanism that defines a crimping aperture;
- a bath having a floor, the bath (i) defining a receptacle that is shaped to receive a portion of the crimping device, and (ii) having one or more side-walls, the one or more side-walls:
- extending upward from the floor to a side-wall height, and
- including a port-defining side-wall, wherein the port-defining side-wall defines a port between outside of the bath and inside of the bath;
- the apparatus having an assembled state in which the portion of the crimping device has been received by the receptacle,
- wherein, in the assembled state:
- the crimping device is held securely by the bath,
- the aperture is below the side-wall height, and
- the port is aligned with the crimping aperture.
- wherein, in the assembled state:
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US18/125,350 US11872124B2 (en) | 2018-01-10 | 2023-03-23 | Temperature-control during crimping of an implant |
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GB1800399.6 | 2018-01-10 | ||
GBGB1800399.6A GB201800399D0 (en) | 2018-01-10 | 2018-01-10 | Temperature-control during crimping of an implant |
GB1800399 | 2018-01-10 | ||
PCT/IL2018/051122 WO2019138400A1 (en) | 2018-01-10 | 2018-10-21 | Temperature-control during crimping of an implant |
US202016760147A | 2020-04-29 | 2020-04-29 | |
US18/125,350 US11872124B2 (en) | 2018-01-10 | 2023-03-23 | Temperature-control during crimping of an implant |
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US16/760,147 Continuation US11633277B2 (en) | 2018-01-10 | 2018-10-21 | Temperature-control during crimping of an implant |
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US18/125,350 Active US11872124B2 (en) | 2018-01-10 | 2023-03-23 | Temperature-control during crimping of an implant |
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US20200352760A1 (en) | 2020-11-12 |
US20230293293A1 (en) | 2023-09-21 |
CN111587098A (en) | 2020-08-25 |
CN111587098B (en) | 2023-11-28 |
GB201800399D0 (en) | 2018-02-21 |
US11633277B2 (en) | 2023-04-25 |
CA3085103A1 (en) | 2019-07-18 |
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EP3737335A1 (en) | 2020-11-18 |
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