US20100191138A1 - Breath condensate collector - Google Patents

Breath condensate collector Download PDF

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Publication number
US20100191138A1
US20100191138A1 US12/670,432 US67043208A US2010191138A1 US 20100191138 A1 US20100191138 A1 US 20100191138A1 US 67043208 A US67043208 A US 67043208A US 2010191138 A1 US2010191138 A1 US 2010191138A1
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Prior art keywords
breath
chamber
condensate
wand
condensate collector
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Abandoned
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US12/670,432
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English (en)
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George Lee Bulbrook
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Exhalation Technology Ltd
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Individual
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Assigned to EQUINE HEALTHCARE LIMITED reassignment EQUINE HEALTHCARE LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BULBROOK, GEORGE LEE
Publication of US20100191138A1 publication Critical patent/US20100191138A1/en
Assigned to EXHALATION TECHNOLOGY LTD reassignment EXHALATION TECHNOLOGY LTD CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: EQUINE HEALTHCARE LIMITED
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals

Definitions

  • This invention concerns apparatus for the collection of breath condensate and also apparatus specifically for collection of breath condensate from animals, especially horses and humans.
  • a breath condensate collector comprising: a chamber having a breath inlet port, an air inlet port and an outlet port; a one-way valve, located in said air inlet port, to allow flow of air into the chamber, whilst resisting flow of air or breath out of the chamber; a sample collector, adapted to receive air from the chamber outlet, and having air exhaust means; cooling means, to promote, in use, condensation of vapour from breath entering the sample collector; and characterised by the feature that the flow path from the breath inlet port to the sample collector is unimpeded by a valve.
  • FIG. 1 The device consists essentially of a tube 1 with a side-arm 2 . Within the tube are two one-way valves, 3 and 4 , located either side of the side arm.
  • the side arm acts as a mouthpiece, and may be specifically shaped to assist sealing by a user's lips. During use, a patient inserts the mouthpiece into their mouth, and is instructed to breathe through their mouth (rather than nose).
  • the valve arrangement allows air to pass through the lower one-way valve, 4 , with the upper valve, 3 , remaining closed, as indicated in FIG. 1( a ).
  • the lower valve 4 closes, and the upper valve opens, causing the air to pass through the upper portion of the tube 1 .
  • Breath condensate then collects on the inner surface of the tube 1 , from where it may be harvested. Cooling may be applied to the outside of the tube, 1 , to promote condensation.
  • the upper valve 3 is of a so-called “duckbill” configuration—a generally dome-shaped configuration, made of a rubber-like material, and having a slit at the domed end, forming a pair of lip-like structures. This is illustrated in cross-section in FIG. 1 .
  • the duckbill valve In its relaxed state, the duckbill valve is in a closed configuration. A decreased pressure within the dome of the valve, as would be experienced during inhalation tends to maintain this closed configuration. An increased pressure within the dome, as would be experienced during exhalation against the now closed second valve, 4 , causes the valve to open.
  • devices of this nature require the user to consciously breathe through their mouths, rather than through their nose. Again, when used with informed and cooperative users this is usually not problematic, but can become problematic where communication with the patient, or subject, is difficult.
  • devices of this nature are relatively complex, and require multiple one-way valves, located within the body of a narrow tube, in order to function. This tends to increase manufacture costs.
  • the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and where the sample collector comprises a partially lidded dish.
  • Samples will collect in both the chamber and the sample collector. Samples in the chamber will be condensate rich; Samples in the sample collector will be aerosol rich.
  • partially lidded dish it is meant that the area of the opening of the dish is less than the cross sectional area of the dish's interior immediately beneath the opening.
  • the partially lidded dish is advantageous over fully open receptacles in that when air flows into the dish, it will not immediately deflect back out of the dish again. Instead, a large proportion of the breath will hit the inside of the lid. Unable to vacate the sample collector, it is caused to swirl around. Such swirling will lead to the deposition of more condensate and aerosol from the breath, into the dish itself. This gives a larger sample, and may also have more diagnostic value, since parts of the sample more easily carried by the air will be more likely to settle in the dish.
  • the partially lidded dish is further advantageous in relation to open dishes in that it provides a smaller target for contamination.
  • the invention is further advantageous in that both the chamber and the sample collector may be used to collect condensate.
  • the invention provides a breath collection apparatus, having two sample collection recipients: one with a collection surface substantially parallel to the flow of breath for collection of a sample primarily comprising breath condensate and a second recipient with a collection surface substantially perpendicular to the flow of breath (such that the breath flow impinges on the collection surface thereby causing breath borne aerosol droplets to impact on the collection surface) for collection of sample containing condensate and enriched with breath—borne aerosol.
  • both samples may be collected almost simultaneously, via one exhalation from the subject. This is quicker, and this speed is useful when the very act of procuring the sample is putting an animal under stress.
  • the chamber is cylindrical.
  • At least a part of the chamber is tapered.
  • the tapered chamber is particularly advantageous in that it disrupts air passing down it, creating turbulent rather than laminar flow conditions. This has two subsidiary advantages in itself.
  • the first is that the turbulence tends to cause more condensate and aerosol to drop out of the air.
  • the second is that turbulent flow leads to the formation of a thinner boundary layer on the inside of the tube, which itself increases condensation.
  • At least a part of the inner surface of the chamber comprises a hydrophobic material.
  • hydrophobic material will encourage the condensate to form droplets, rather than spread out and “wet” the surface. This will lead to faster and more effective collecting of condensate from the chamber.
  • At least part of the inner surface of the sample collector comprises a hydrophobic material.
  • hydrophobic material will encourage the condensate to form droplets, rather than spread out and “wet” the surface. This will lead to faster and more effective collecting of condensate from the sample collector.
  • the cooling means comprises a Peltier device.
  • a Peltier device provides a manner of controlling the temperature of a sample collector placed adjacent to it, to a high degree of precision.
  • a second advantage is that the Peltier device will tend to cool for longer than other means, such as a gel wrapper or the provision of cold—retentive materials.
  • the Peltier device provides its own means for displacing heat—it is integral to the condensate collector and is not reliant on external sources for cooling. This will be of particular utility to the travelling veterinarian, for example, who may need to take samples of condensate on an ad hoc basis, and away from the external refrigeration means that would be required to cool other cooling means to the requisite temperature.
  • the breath condensate collector further comprises a wand.
  • a wand in the apparatus, as the wand may be used to collect condensate from the chamber and the sample collector.
  • the wand is tapered.
  • the wand will be of advantage in that when held correctly, the taper will encourage the condensate to run along the wand and form at the tip, allowing for ease of collection.
  • the wand is resiliently deformable.
  • the resiliently deformable wand will deform to match the profile of the inside of the condensate collector, allowing the wand to scrape or wipe in a quicker and more comprehensive fashion, covering more of the surface area per motion.
  • the surface of the wand is hydrophobic.
  • Making the surface of the wand hydrophobic will encourage the formation of droplets on the wand, which will enhance the efficiency with which a large droplet can be formed at the end of the wand.
  • That the wand is hydrophobic will further encourage the travel of the droplets to the tip of the wand.
  • the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and wherein the chamber is cylindrical.
  • the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and wherein the chamber is tapered
  • the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and wherein the chamber comprises a hydrophobic material.
  • the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and wherein at least part of the inner surface of the sample collector comprises a hydrophobic material.
  • the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and wherein the cooling means comprises a Peltier device.
  • the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector; and a wand.
  • the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector; and a tapered wand.
  • the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector; and a resiliently deformable wand.
  • the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector; and a hydrophobic wand.
  • FIG. 1 shows a cross sectional view of the prior art.
  • FIG. 2 shows a side elevation view of a breath collection device.
  • FIG. 3 shows a cross-sectional side view of a partially lidded dish.
  • FIG. 4 shows a plan view of the device.
  • FIG. 5 shows a plan view of a disposable tube.
  • FIG. 6 shows an elevational view of a wand.
  • FIG. 7 shows an elevational view of a chamber.
  • FIG. 8 shows a further elevational view of a chamber.
  • FIG. 9 shows a further elevational view of a chamber.
  • FIG. 10 shows a further elevational view of a chamber.
  • FIG. 11 shows a further elevational view of a chamber.
  • FIG. 12 shows a cross sectional view of a chamber and a dish, illustrating a wand in use.
  • FIG. 13 shows a cross sectional view of a chamber and a dish, illustrating a wand in use.
  • FIG. 2 shows a breath condensate collector generally indicated by 10 .
  • This embodiment is made largely of polypropylene and aluminium, both of which are robust and easy to clean.
  • the device 10 has a chamber 12 , with a breath inlet port 14 and an outlet port 16 .
  • the chamber 12 is cylindrical and has a circular cross section.
  • the chamber also has a tapered portion 18 .
  • Other embodiments need not be cylindrical.
  • the chamber 12 may be entirely tapered or not tapered at all.
  • a particularly advantageous shape for the chamber 12 is a frusto-conical shape or similar, since I resiliently deformable wand may easily be designed to match the profile of the taper of the inner surface of such a chamber 12 .
  • the inlet port 14 is furthest away from the sample collector, which is a partially lidded dish 110 , while the outlet port 16 is near to the partially lidded dish 110 .
  • the chamber 12 fits frictionally inside the breath condensate collector 10 . It may alternatively be held in place by supplementary attachment means. In this embodiment, the chamber 12 is removable.
  • the entire inside of the chamber 12 is coated with a hydrophobic material.
  • a hydrophobic material This may be a material of the polytetrafluoroethylene (PTFE) family such as TeflonTM, made by E. I. du Pont de Nemours and Company of 1007 Market St. Wilmington, Del. 19898, USA, or comprise a siliconised surface or any other material or combination of materials known to the skilled man.
  • the material may be part of the chamber 12 itself or the chamber 12 may be made from it. It may cover all or part of the inside of the chamber 12 .
  • the chamber 12 may be partially or entirely transparent.
  • the chamber 12 is reusable and it is made of plastics. It is so fashioned that it may be easily cleaned between uses. Reusable chambers may also be fashioned of stainless steel or composite materials. Alternatively, disposable cardboard or plastics chambers may be appropriate.
  • FIG. 3 shows a partially lidded dish 110 .
  • the dish comprises a dish portion 22 and a partial lid portion 124 defining an aperture. These two portions 22 124 are inseparable in some embodiments. In others, the partial lid portion 124 may be detached from the dish portion 22 .
  • the entire inside of the dish 110 is coated with a hydrophobic material. This may be a material of the polytetrafluoroethylene (PTFE) family, or comprise a siliconised surface or any other material or combination of materials known to the skilled man. In other embodiments, it need not be a coating—the dish 110 can be made from the material. Equally, it is not necessary that the entire surface be made or coated in a hydrophobic material—only part of it may be coated.
  • PTFE polytetrafluoroethylene
  • the partially lidded dish feature is also of particular advantage over the syringe used in GB2427686 in that the partially lidded dish has a smaller surface area than the syringe and is therefore easier to cool.
  • the partial lid portion 24 is transparent.
  • the dish portion 22 is made of aluminium, in order to effect good heat transfer.
  • the partially lidded dish, 110 placed in the condensate receiving position within the breath condensate collector 10 . It is inside a recess (not shown). It is retained there by any retention means known to the skilled man, although a frictional fit may suffice.
  • the partially lidded dish 110 is positioned so that its aperture faces the outlet port 16 . In circumstances where the breath condensate collector 10 is positioned in such a way that its longest axis runs along a substantially horizontal plane, the partial lid feature 24 will serve to stop the condensate from coming out of the aperture, because the inside of the partial lid feature 24 forms a reservoir with the inner surface of the partially lidded dish 110 .
  • the ideal placement of the partially lidded dish 110 in relation to the outlet port 18 is to have each facing the other, the outlet port 16 being so sized that condensate travelling down it will be directed into the partially lidded dish 110 and so placed so as to be substantially aligned with the aperture formed by the partial lid. In this embodiment there is a distance of about 2 mm between the outlet port 16 and the partial lid portion 124 . Other placements are envisaged, but this is the optimal placement. If the outlet port 16 , was inside the dish 110 , the flow of air into the dish 110 would serve to dry any condensate collected, thus robbing it of at least part of its diagnostic value. If the outlet port 16 was further away from the partially lidded dish 110 , there would be two problems.
  • the first would be that of improperly directed condensate, which may at least be messy, and at most the possible carrier of infectious matter or otherwise dangerous.
  • the second would be that the flow of air would be prone to making a whistling sound upon contact with the partially lidded dish 110 .
  • the whistling may startle or otherwise disconcert the horse, thus hampering the collection of condensate or endangering the people collecting it.
  • the collector 10 further features cooling means 112 to promote in use condensation of vapour from breath entering the collection condensate vessel.
  • said cooling means 112 comprises a Peltier device, having a cooling surface 114 and heat dissipating fins 116 of which six can be seen.
  • the cooling surface 114 is so arranged as to be in operable communication with the partially lidded dish 110 on a flat or curved plane, and may follow the profile of the partially lidded dish 110 .
  • the device is powered by conventional means (not shown), and is rechargeable. It may be attached to a power source via a recharge point 118 which in this embodiment is situated in a recess 120 .
  • the employment of a Peltier device 112 dispenses with the need for external cooling means, making it particularly useful for the travelling vet, or someone who is otherwise without separate refrigeration means.
  • the Peltier device 112 is operated via an on/off switch 122 , but may alternatively be operated by a switch actuated by the placement or removal of the lidded dish 110 in the recess (not shown).
  • cooling means such as a pre-cooled metallic element or a cooling jacket may be substituted.
  • FIG. 4 shows the invention 10 . It has a partially lidded dish 110 , in a recess 44 .
  • the recess 44 is so fashioned as to bring the partially lidded dish 110 , into abutment with the cooling surface 46 of the Peltier device 112 .
  • the fascia 410 is transparent and removable, being attached by screws 412 . This increases the visibility of parts under the fascia 410 and allows easy cleaning of the device.
  • the device also has an LED 414 , which in this embodiment shines green when the device is on, and flashes red when it is running out of power.
  • FIG. 5 shows, for human use, a disposable, cylindrical, open-ended tube made, for example, of cardboard, which may be connected to the inlet port 14 of a device 10 to facilitate a user blowing into a device without ever having to place the device itself into the mouth, with evident hygiene benefits.
  • FIG. 6 shows a wand, 60 .
  • the wand 60 is tapered, resiliently deformable and of a hydrophobic material, although in other embodiments, it might feature only a selection of these features, or none at all.
  • the dimensions of the wand are optimised so that it can best be used to remove condensate attached to the sides of a chamber, being operated by the user with a motion which could be described as “scraping” or “wiping”
  • This embodiment of the wand 60 has a deformation profile of such attributes that when, in use, force is applied to the wand 60 it deforms in such a way as to mimic the curvature of the chamber or sample collector of the device. This will enable the wand 60 to be used to scrape the condensate more quickly and effectively. Having got the condensate onto the wand 60 , the provision of hydrophobic material encourages the condensate to form in beads on the wand 60 . The taper will then encourage droplets on a wand 60 which is held so that the thin end is pointing substantially downwards to travel towards the tip.
  • FIG. 7 shows a chamber 70 . It has an open-ended frusto-conical profile, so as to work synergistically with a wand.
  • FIG. 8 shows another chamber 80 . It has a flange 82 , allowing for the attachment of further items, such as, for example, filtration devices or deformable plastic masks.
  • FIG. 9 shows a further chamber 90 . It is cylindrical and open-ended. It has a raised, tapered inlet 92 which may act as a flange.
  • FIG. 10 shows a still further chamber 1000 .
  • the chamber 1000 may be connected to a mask, adapted to fit over one or more nostrils of an animal.
  • the mask (not shown) is specifically adapted to fit over a horse's nostril.
  • the mask has generally cylindrical symmetry.
  • Known devices for breath collection rely on a user putting the device in their mouth and breathing out, into the device, through the mouth rather than the nose.
  • the provision of a mask adapted to receive exhaled breath from the nostrils overcomes this problem.
  • a suitable mask might fit over both the nose and the mouth.
  • FIG. 11 shows a still further chamber 1100 with an integral mask 1102 of the type described above.
  • the mask 1102 is resiliently deformable and designed so as to fit the contours of an animal's nostril and provide an airtight seal.
  • the mask 1102 is resiliently deformable so that if more than one attempt is required to fit the mask over the nostril, the mask will spring back into shape between attempts. The mask may also, therefore, be used again with a different animal.
  • FIG. 12 shows a method by which a chamber 12 , shown here in cross-section, is wiped or scraped of condensate 1202 using a wand 60 .
  • This is the second method of collection possible with this device, the first method being that outlined above, wherein the subject breathes down the chamber 12 and into the partially lidded dish 110 .
  • This second method facilitates collection of condensate with a lower aerosol quotient, whereas the first method facilitates collection of condensate with a higher aerosol quotient.
  • a dish 1204 Here the chamber 12 has been detached from the device 10 .
  • the wand 60 is placed inside the chamber 12 .
  • FIG. 13 shows a wand 60 being manipulated (manipulation means not shown) so that it deforms to form a substantial contact with the inner wall of the chamber 12 .
  • Condensate 1202 lining the chamber 12 will be forced off it by the contact of the wand 60 as it is wiped around the inside of the chamber and will be manipulated into the dish 1204 . It will be encouraged to flow down the wand 60 if the wand 60 is tapered and/or has a hydrophobic surface.
  • the condensate 1202 will tend to form a droplet 1302 , which when force is applied to it may drop into a conveniently placed dish 1204 .
  • the chamber 12 need not be detached from the device 10 in order for condensate to be collected.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Investigating Or Analysing Biological Materials (AREA)
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US12/670,432 2007-07-24 2008-06-06 Breath condensate collector Abandoned US20100191138A1 (en)

Applications Claiming Priority (3)

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GB0714424.9 2007-07-24
GB0714424A GB2451249A (en) 2007-07-24 2007-07-24 A breath condensate collector
PCT/GB2008/001954 WO2009013450A1 (en) 2007-07-24 2008-06-06 Breath condensate collector

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US15/169,891 Continuation US9968281B2 (en) 2007-07-24 2016-06-01 Breath condensate collector

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US15/169,891 Active US9968281B2 (en) 2007-07-24 2016-06-01 Breath condensate collector

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AU (1) AU2008278896B2 (https=)
CA (1) CA2694186C (https=)
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DK (1) DK2173250T3 (https=)
ES (1) ES2604257T3 (https=)
GB (1) GB2451249A (https=)
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US20100241019A1 (en) * 2009-03-18 2010-09-23 Cardinal Health 207, Inc. Exhaled breath condensate biometric marker measurement apparatus and method
JP2019512687A (ja) * 2016-03-08 2019-05-16 ユニバーシティ オブ ノーサンブリア アット ニューキャッスル 呼気凝縮液の採取装置及びその部品のキット
US20220175272A1 (en) * 2019-03-31 2022-06-09 Agscent Pty Ltd Biological sample capturing device

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US11083440B2 (en) * 2016-06-13 2021-08-10 Jmdfnp, Inc. Strep throat test apparatus
GB201704367D0 (en) 2017-03-20 2017-05-03 Exhalation Tech Ltd A breath condensate analyser
GB2566453B (en) * 2017-09-12 2021-01-13 Univ Of Northumbria At Newcastle Impactor for aerosol component collection
GB201818584D0 (en) 2018-11-14 2018-12-26 Exhalation Tech Limited A device to measure breath humidity
WO2020145896A1 (en) * 2019-01-11 2020-07-16 National University Of Singapore Sample collection device
US12031982B2 (en) 2020-04-19 2024-07-09 John J. Daniels Using exhaled breath condensate for testing for a biomarker of COVID-19
US12369816B2 (en) 2020-04-19 2025-07-29 John J. Daniels Mask-based diagnostic system using exhaled breath condensate
US12533047B2 (en) 2020-04-19 2026-01-27 John J. Daniels Mask-based diagnostic system using exhaled breath condensate
US12442726B2 (en) 2020-04-19 2025-10-14 John J. Daniels Mask-based testing system for detecting biomarkers in exhaled breath condensate, aerosols and gases
JP2024536778A (ja) * 2021-09-20 2024-10-08 ヴォスビオ，インコーポレーテッド 生物学的試料の捕捉および処理のためのデバイス、方法およびキット

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WO2009013450A1 (en) 2009-01-29
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AU2008278896A1 (en) 2009-01-29
US9968281B2 (en) 2018-05-15
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CA2694186A1 (en) 2009-01-29
GB2451249A9 (en) 2009-03-04
AU2008278896B2 (en) 2014-09-25
SI2173250T1 (sl) 2017-06-30
ES2604257T3 (es) 2017-03-06
PT2173250T (pt) 2016-11-14
EP2173250A1 (en) 2010-04-14
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HUE030682T2 (en) 2017-05-29
HRP20161472T1 (hr) 2017-01-27

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