US20100061932A1 - Peptides useful as cell-penetrating peptides - Google Patents
Peptides useful as cell-penetrating peptides Download PDFInfo
- Publication number
- US20100061932A1 US20100061932A1 US12/159,226 US15922606A US2010061932A1 US 20100061932 A1 US20100061932 A1 US 20100061932A1 US 15922606 A US15922606 A US 15922606A US 2010061932 A1 US2010061932 A1 US 2010061932A1
- Authority
- US
- United States
- Prior art keywords
- peptide
- seq
- amino acid
- acid sequence
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
Definitions
- the peptides according to the present invention form a complex together with a cargo molecule.
- cargo molecule may be any cargo molecule as defined herein.
- the complex can be either a covalent or a non-covalent complex comprising at least one peptide according to the present invention and at least one cargo molecule. It is also within in the present invention that the complex comprises more than one peptide according to the present invention, i. e. a plurality of such peptides, whereby the plurality of the peptides may comprise a plurality of the same or of different peptides. Also, the complex according to the present invention may also comprise more than one cargo molecule, whereby the plurality of the cargo molecules may comprise a plurality of the same or of different cargo molecules.
- compositions according to the present invention may also be formulated as a depot preparation.
- Such long acting formulations may be administered by implantation (for example subcutaneously or intramuscularly) or by intramuscular injection.
- the compositions may be formulated with suitable polymeric or hydrophobic materials (for example as an emulsion in an acceptable oil), or as part of a solid or semi-solid implant that may or may not be auto-degrading in the body, or ion exchange resins, or one or more components of the composition can be formulated as sparingly soluble derivatives, for example, as a sparingly soluble salt.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05028755 | 2005-12-30 | ||
EP05028755.6 | 2005-12-30 | ||
PCT/EP2006/010271 WO2007076904A1 (en) | 2005-12-30 | 2006-10-25 | Peptides useful as cell-penetrating peptides |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/010271 A-371-Of-International WO2007076904A1 (en) | 2005-12-30 | 2006-10-25 | Peptides useful as cell-penetrating peptides |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/557,706 Division US9403884B2 (en) | 2005-12-30 | 2012-07-25 | Peptides useful as cell-penetrating peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
US20100061932A1 true US20100061932A1 (en) | 2010-03-11 |
Family
ID=37491778
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/159,226 Abandoned US20100061932A1 (en) | 2005-12-30 | 2006-10-25 | Peptides useful as cell-penetrating peptides |
US13/557,706 Active 2028-03-11 US9403884B2 (en) | 2005-12-30 | 2012-07-25 | Peptides useful as cell-penetrating peptides |
US14/955,696 Abandoned US20160151504A1 (en) | 2005-12-30 | 2015-12-01 | Peptides useful as cell-penetrating peptides |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/557,706 Active 2028-03-11 US9403884B2 (en) | 2005-12-30 | 2012-07-25 | Peptides useful as cell-penetrating peptides |
US14/955,696 Abandoned US20160151504A1 (en) | 2005-12-30 | 2015-12-01 | Peptides useful as cell-penetrating peptides |
Country Status (16)
Country | Link |
---|---|
US (3) | US20100061932A1 (ja) |
EP (1) | EP1966240B3 (ja) |
JP (1) | JP5264502B2 (ja) |
KR (1) | KR101317100B1 (ja) |
CN (1) | CN101395180B (ja) |
AT (1) | ATE501169T1 (ja) |
AU (1) | AU2006332193B2 (ja) |
BR (1) | BRPI0620806B8 (ja) |
CA (1) | CA2646833C (ja) |
DE (1) | DE602006020617D1 (ja) |
ES (1) | ES2361621T7 (ja) |
IL (1) | IL192131A (ja) |
MX (1) | MX2008008548A (ja) |
PL (1) | PL1966240T6 (ja) |
SI (1) | SI1966240T1 (ja) |
WO (1) | WO2007076904A1 (ja) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100322862A1 (en) * | 2009-06-22 | 2010-12-23 | Burnham Institute For Medical Research | Methods and compositions using peptides and proteins with c-terminal elements |
WO2012118778A1 (en) | 2011-02-28 | 2012-09-07 | Sanford-Burnham Medical Research Institute | Truncated car peptides and methods and compositions using truncated car peptides |
WO2012166585A2 (en) | 2011-05-31 | 2012-12-06 | Airware, Inc. | Re-calibration of ab ndir gas sensors |
WO2013052058A1 (en) * | 2011-10-07 | 2013-04-11 | Morehouse School Of Medicine | Antimicrobial compositions and methods of use thereof |
CN103169982A (zh) * | 2011-12-23 | 2013-06-26 | 中国科学院上海药物研究所 | 生物活性肽修饰的纳米银及其制备方法和用途 |
US8669226B2 (en) | 2011-10-07 | 2014-03-11 | Morehouse School Of Medicine | Antimicrobial compositions and methods of use thereof |
RU2575603C2 (ru) * | 2010-07-30 | 2016-02-20 | Куревак Гмбх | Получение комплексов нуклеиновых кислот и поперечно сшитых дисульфидными связями катионных компонентов, предназначенных для трансфекции и иммуностимуляции |
US9724422B2 (en) | 2010-11-26 | 2017-08-08 | Evonik Roehm Gmbh | Human lactoferrin derived peptide for use as an antigen masking agent |
WO2018204392A1 (en) | 2017-05-02 | 2018-11-08 | Stanford Burnham Prebys Medical Discovery Institute | Tumor associated monocyte/macrophage binding peptide and methods of use thereof |
US10179801B2 (en) | 2011-08-26 | 2019-01-15 | Sanford-Burnham Medical Research Institute | Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides |
WO2020161602A1 (en) | 2019-02-04 | 2020-08-13 | University Of Tartu | Bi-specific extracellular matrix binding peptides and methods of use thereof |
US10793603B2 (en) * | 2015-02-27 | 2020-10-06 | Josho Gakuen Educational Foundation | Polysaccharide derivative having membrane-permeable peptide chain |
US11052053B2 (en) | 2018-05-08 | 2021-07-06 | Evonik Operations Gmbh | Nanoparticle comprising a bio-resorbable polyester, a hydrophilic polymer and an acylated human lactoferrin-derived peptide |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005051366A1 (de) | 2005-10-25 | 2007-04-26 | Degussa Gmbh | Drug Delivery Systeme |
EP2050461A1 (en) * | 2007-10-19 | 2009-04-22 | PharmaSurgics in Sweden AB | Peptides based on the sequence of human lactoferrin and their use |
EP2090584A1 (en) * | 2008-02-13 | 2009-08-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Identification of a novel cysteine-rich cell penetrating peptide |
CA2716565C (en) * | 2008-02-28 | 2017-09-12 | Toray Industries, Inc. | Pharmaceutical composition for transnasal administration |
CN102686603B (zh) * | 2009-12-14 | 2014-12-17 | 国立大学法人北海道大学 | 对脂质膜结构体赋予细胞透过能力和/或增强脂质膜结构体的细胞透过能力的肽、以及含有与这些肽结合了的脂质作为构成脂质的具有细胞透过能力或细胞透过能力得到增强的脂质膜结构体 |
WO2011084061A1 (en) | 2010-01-08 | 2011-07-14 | Universitair Medisch Centrum St. Radboud | Cpp (cell penetrating peptide) and its uses |
FR2955773B1 (fr) * | 2010-02-01 | 2017-05-26 | Commissariat A L'energie Atomique | Complexe moleculaire de ciblage des antigenes vers les cellules presentatrices d'antigene et ses applications pour la vaccination |
CN102091036A (zh) * | 2011-01-10 | 2011-06-15 | 中国药科大学 | 一种含有抗肿瘤药物的复合脂质体及其制备方法和用途 |
CN102174078A (zh) * | 2011-01-10 | 2011-09-07 | 中国药科大学 | 肿瘤细胞选择性穿膜肽的应用 |
CN102153629B (zh) * | 2011-01-20 | 2013-07-24 | 华中科技大学 | 一种短肽及其应用 |
CN102988295B (zh) * | 2011-09-09 | 2015-07-29 | 复旦大学 | 一种穿膜肽修饰的纳米粒及其制备方法 |
CN102993296A (zh) * | 2011-09-14 | 2013-03-27 | 广州格拉姆生物科技有限公司 | 牛乳铁蛋白肽及其制备方法 |
DE102011055229A1 (de) | 2011-11-10 | 2013-05-16 | Evonik Degussa Gmbh | Verfahren zur Bereitstellung von Regelleistung mit einem Energiespeicher unter Ausnutzung von Toleranzen bei der Bestimmung der Frequenzabweichung |
DE102011055231A1 (de) * | 2011-11-10 | 2013-05-16 | Evonik Industries Ag | Verfahren zur Bereitstellung von Regelleistung |
CN110251682B (zh) | 2011-11-24 | 2022-12-06 | 苏州宝时得电动工具有限公司 | 多肽序列设计及其在多肽介导的siRNA传递中的应用 |
CN103382217B (zh) * | 2012-12-11 | 2015-05-27 | 任发政 | 穿膜肽和药物组合物及其制备方法和应用 |
US9642895B2 (en) | 2013-08-12 | 2017-05-09 | 3M Innovative Properties Company | Peptides for enhancing transdermal delivery |
WO2015075747A1 (en) * | 2013-11-19 | 2015-05-28 | Council Of Scientific And Industrial Research | Cell-penetrating peptide for biomolecule delivery |
KR102532559B1 (ko) | 2013-12-12 | 2023-05-16 | 라이프 테크놀로지스 코포레이션 | 형질감염을 개선하는 막 투과 펩타이드 및 조성물 그리고 이들을 사용하는 방법 |
CN103784406A (zh) * | 2014-01-20 | 2014-05-14 | 同济大学 | 一种偶联穿膜肽和mmp酶切位点的纳米颗粒 |
KR101647804B1 (ko) * | 2015-06-24 | 2016-08-11 | 한국과학기술연구원 | 신규 세포투과 펩타이드 및 이의 용도 |
CN108456254B (zh) * | 2017-02-20 | 2021-06-01 | 中国科学院上海药物研究所 | 一种tcs-穿膜肽-肿瘤蛋白酶底物肽融合蛋白、其制备方法和用途 |
CN108101966B (zh) * | 2017-12-26 | 2020-10-27 | 暨南大学 | 基于细胞穿膜肽的氧化还原敏感多肽及其在疫苗载体中的应用 |
CN111499759B (zh) * | 2019-01-31 | 2022-12-20 | 上海科技大学 | 一种具有细胞穿膜性的锌指蛋白-乳铁蛋白融合蛋白质及其制备与应用 |
CN110078834B (zh) * | 2019-05-05 | 2021-07-30 | 华中科技大学 | 一种类短肽、辅助透膜剂及其应用 |
WO2021093881A1 (zh) * | 2019-11-14 | 2021-05-20 | 上海鑫湾生物科技有限公司 | 用于调控酸性环境免疫应答的组合物、其制备方法和用途 |
WO2023186757A1 (en) | 2022-03-30 | 2023-10-05 | Evonik Operations Gmbh | Formulations composed of cationic lipids and poly(lactic-co-glycolic acid) for the delivery of polynucleotides into cells |
WO2024079331A1 (en) * | 2022-10-13 | 2024-04-18 | Stichting Radboud Universitair Medisch Centrum | A complex comprising a cargo and a targeting moiety binding intelectin-1 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5304633A (en) * | 1990-09-07 | 1994-04-19 | Morinaga Milk Industry Co., Ltd. | Fragments of lactoferrin having potent antimicrobial activity |
US5741957A (en) * | 1989-12-01 | 1998-04-21 | Pharming B.V. | Transgenic bovine |
US5804555A (en) * | 1992-08-07 | 1998-09-08 | Morinaga Milk Industry Co., Ltd. | Antioxidant |
US6399570B1 (en) * | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
US6890902B2 (en) * | 1998-08-28 | 2005-05-10 | Alpharma As | Cytotoxic modified lactoferrin peptides |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0533838T3 (da) | 1990-06-11 | 1998-02-23 | Nexstar Pharmaceuticals Inc | Nukleinsyreligander |
JP3312946B2 (ja) * | 1993-03-04 | 2002-08-12 | 雪印乳業株式会社 | ウイルス感染・増殖抑制剤 |
ES2188985T3 (es) | 1996-08-30 | 2003-07-01 | Jens Peter Furste | Seleccion enantiomerica y evolucion enantiomerica de acidos nucleicos. |
US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
US5989912A (en) | 1996-11-21 | 1999-11-23 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
SE9804614A0 (en) * | 1998-07-06 | 2000-01-07 | A+ Science Invest Ab | New peptides and use thereof |
US6423509B1 (en) * | 1998-07-15 | 2002-07-23 | Samyang Genex Corporation | Pichia pastoris strain for producing lactoferrin and methods of use |
WO2000004132A1 (en) * | 1998-07-15 | 2000-01-27 | Samyang Genex Corporation | Mass production method of lactoferrin polypeptide from yeast and useful microorganism thereof |
DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
PT2796553T (pt) | 2000-03-30 | 2019-09-27 | Massachusetts Inst Technology | Mediadores de interferência de arn específicos de sequência de arn |
RU2197987C2 (ru) * | 2000-07-07 | 2003-02-10 | Закрытое акционерное общество "АСГЛ-Исследовательские Лаборатории" | Носитель чужеродной генетической информации для генной терапии |
-
2006
- 2006-10-25 DE DE602006020617T patent/DE602006020617D1/de active Active
- 2006-10-25 JP JP2008547861A patent/JP5264502B2/ja active Active
- 2006-10-25 US US12/159,226 patent/US20100061932A1/en not_active Abandoned
- 2006-10-25 AT AT06806526T patent/ATE501169T1/de active
- 2006-10-25 BR BRPI0620806A patent/BRPI0620806B8/pt active IP Right Grant
- 2006-10-25 SI SI200631008T patent/SI1966240T1/sl unknown
- 2006-10-25 KR KR1020087015786A patent/KR101317100B1/ko active IP Right Grant
- 2006-10-25 CN CN200680049953.0A patent/CN101395180B/zh active Active
- 2006-10-25 CA CA2646833A patent/CA2646833C/en active Active
- 2006-10-25 ES ES06806526T patent/ES2361621T7/es active Active
- 2006-10-25 WO PCT/EP2006/010271 patent/WO2007076904A1/en active Application Filing
- 2006-10-25 AU AU2006332193A patent/AU2006332193B2/en active Active
- 2006-10-25 MX MX2008008548A patent/MX2008008548A/es active IP Right Grant
- 2006-10-25 EP EP06806526A patent/EP1966240B3/en active Active
- 2006-10-25 PL PL06806526T patent/PL1966240T6/pl unknown
-
2008
- 2008-06-12 IL IL192131A patent/IL192131A/en active IP Right Grant
-
2012
- 2012-07-25 US US13/557,706 patent/US9403884B2/en active Active
-
2015
- 2015-12-01 US US14/955,696 patent/US20160151504A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5741957A (en) * | 1989-12-01 | 1998-04-21 | Pharming B.V. | Transgenic bovine |
US6066725A (en) * | 1989-12-01 | 2000-05-23 | Pharming B.V. | Production of recombinant polypeptides by bovine species and transgenic methods |
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Also Published As
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KR20080091120A (ko) | 2008-10-09 |
CA2646833C (en) | 2019-07-30 |
US20130108662A1 (en) | 2013-05-02 |
AU2006332193A1 (en) | 2007-07-12 |
CN101395180A (zh) | 2009-03-25 |
PL1966240T3 (pl) | 2011-08-31 |
SI1966240T1 (sl) | 2011-06-30 |
ES2361621T7 (es) | 2012-06-14 |
CN101395180B (zh) | 2016-06-22 |
MX2008008548A (es) | 2008-09-10 |
KR101317100B1 (ko) | 2013-10-15 |
EP1966240B3 (en) | 2011-12-28 |
BRPI0620806B1 (pt) | 2017-12-05 |
EP1966240A1 (en) | 2008-09-10 |
DE602006020617D1 (de) | 2011-04-21 |
ES2361621T3 (es) | 2011-06-20 |
JP5264502B2 (ja) | 2013-08-14 |
AU2006332193B2 (en) | 2012-06-28 |
ATE501169T1 (de) | 2011-03-15 |
WO2007076904A1 (en) | 2007-07-12 |
PL1966240T6 (pl) | 2012-05-31 |
BRPI0620806A2 (pt) | 2011-11-22 |
JP2009521908A (ja) | 2009-06-11 |
US20160151504A1 (en) | 2016-06-02 |
US9403884B2 (en) | 2016-08-02 |
IL192131A0 (en) | 2008-12-29 |
EP1966240B1 (en) | 2011-03-09 |
BRPI0620806B8 (pt) | 2022-07-05 |
IL192131A (en) | 2011-10-31 |
CA2646833A1 (en) | 2007-07-12 |
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