US20100051552A1 - In-line sensors for dialysis applications - Google Patents

In-line sensors for dialysis applications Download PDF

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Publication number
US20100051552A1
US20100051552A1 US12/200,488 US20048808A US2010051552A1 US 20100051552 A1 US20100051552 A1 US 20100051552A1 US 20048808 A US20048808 A US 20048808A US 2010051552 A1 US2010051552 A1 US 2010051552A1
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United States
Prior art keywords
dialysis
water
sensor
sensing
dialysis solution
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Abandoned
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US12/200,488
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English (en)
Inventor
Justin B. Rohde
William W. Han
Elizabeth A. Everitt
Michael E. Hogard
Ying-Cheng Lo
Erin M. Copeland
William P. Burns
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Baxter Healthcare SA
Baxter International Inc
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Baxter Healthcare SA
Baxter International Inc
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Priority to US12/200,488 priority Critical patent/US20100051552A1/en
Assigned to BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC. reassignment BAXTER HEALTHCARE S.A. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BURNS, WILLIAM P., COPELAND, ERIN M., EVERITT, ELIZABETH A., HAN, WILLIAM W., HOGARD, MICHAEL E., LO, YING-CHENG, ROHDE, JUSTIN B.
Priority to JP2011525031A priority patent/JP5684127B2/ja
Priority to ES09789836T priority patent/ES2394911T3/es
Priority to CA2733511A priority patent/CA2733511A1/en
Priority to BRPI0917238A priority patent/BRPI0917238A2/pt
Priority to PCT/US2009/047591 priority patent/WO2010024963A1/en
Priority to MX2011002196A priority patent/MX2011002196A/es
Priority to EP09789836A priority patent/EP2320969B1/en
Priority to CN200980133542.3A priority patent/CN102131533B/zh
Priority to PL09789836T priority patent/PL2320969T3/pl
Publication of US20100051552A1 publication Critical patent/US20100051552A1/en
Priority to US15/941,278 priority patent/US11400193B2/en
Priority to US17/878,412 priority patent/US20220362445A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1603—Regulation parameters
    • A61M1/1605—Physical characteristics of the dialysate fluid
    • A61M1/1607—Physical characteristics of the dialysate fluid before use, i.e. upstream of dialyser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/166—Heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/1674—Apparatus for preparing dialysates using UV radiation sources for sterilising the dialysate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
    • A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A61M1/287—Dialysates therefor

Definitions

  • This patent relates generally to medical fluid delivery systems and methods. More particularly, this patent discloses systems, methods and apparatuses for microelectromechanical systems (MEMS) sensors for sensing and measuring species in fluids involved in dialysis, such as peritoneal dialysis fluid, hemodialysis fluid, and blood.
  • MEMS microelectromechanical systems
  • Renal failure produces several physiological impairments and difficulties.
  • the balance of water, minerals and the excretion of daily metabolic load is no longer possible and toxic end products of nitrogen metabolism (urea, creatinine, uric acid, and others) can accumulate in blood and tissue.
  • Kidney failure and reduced kidney function have been treated with dialysis. Dialysis removes waste, toxins and excess water from the body that would otherwise have been removed by normal functioning kidneys. Dialysis treatment for replacement of kidney functions is critical to many people because the treatment is life saving.
  • Hemodialysis and peritoneal dialysis are two types of dialysis therapies used commonly to treat loss of kidney function.
  • a hemodialysis (“HD”) treatment utilizes the patient's blood to remove waste, toxins and excess water from the patient.
  • the patient is connected to a hemodialysis machine and the patient's blood is pumped through the machine.
  • Catheters or needles are inserted into the patient's veins and arteries, or an artificial graft so blood can flow to and from the hemodialysis machine.
  • the blood passes through a dialyzer of the machine, which removes waste, toxins and excess water from the blood.
  • the cleaned blood is returned to the patient.
  • a large amount of dialysate for example about 120 liters, is consumed to dialyze the blood during a single hemodialysis therapy.
  • Hemodialysis treatment lasts several hours and is generally performed in a treatment center about three or four times per week.
  • HF hemofiltration
  • substitution or replacement fluid to the extracorporeal circuit during treatment (typically ten to ninety liters of such fluid). That substitution fluid and the fluid accumulated by the patient in between treatments is ultrafiltered over the course of the HF treatment, providing a convective transport mechanism that is particularly beneficial in removing middle and large molecules.
  • HDF Hemodiafiltration
  • hemodiafiltration is another blood treatment modality that combines convective and diffusive clearances.
  • HDF uses dialysate to flow through a dialyzer, similar to standard hemodialysis, providing diffusive clearance.
  • substitution solution is provided directly to the extracorporeal circuit, providing convective clearance.
  • Peritoneal dialysis uses a dialysis solution, referred to as dialysate, which is infused into a patient's peritoneal cavity via a catheter.
  • the dialysate contacts the peritoneal membrane of the peritoneal cavity. Waste, toxins and excess water pass from the patient's bloodstream, through the peritoneal membrane and into the dialysate due to diffusion and osmosis, i.e., an osmotic gradient occurs across the membrane.
  • the spent dialysate is drained from the patient, removing waste, toxins and excess water from the patient. This cycle is repeated.
  • CAPD continuous ambulatory peritoneal dialysis
  • APD automated peritoneal dialysis
  • CFPD continuous flow peritoneal dialysis
  • CAPD is a manual dialysis treatment.
  • the patient manually connects an implanted catheter to a drain, allowing spent dialysate fluid to drain from the peritoneal cavity.
  • the patient then connects the catheter to a bag of fresh dialysate, infusing fresh dialysate through the catheter and into the patient.
  • the patient disconnects the catheter from the fresh dialysate bag and allows the dialysate to dwell within the peritoneal cavity, wherein the transfer of waste, toxins and excess water takes place.
  • the patient repeats the manual dialysis procedure, for example, four times per day, each treatment lasting about an hour.
  • Manual peritoneal dialysis requires a significant amount of time and effort from the patient, leaving ample room for improvement.
  • APD Automated peritoneal dialysis
  • CAPD Automated peritoneal dialysis
  • APD machines perform the cycles automatically, typically while the patient sleeps.
  • APD machines free patients from having to manually perform the treatment cycles and from having to transport supplies during the day.
  • APD machines connect fluidly to an implanted catheter, to a source or bag of fresh dialysate and to a fluid drain.
  • APD machines pump fresh dialysate from a dialysate source, through the catheter, into the patient's peritoneal cavity, and allow the dialysate to dwell within the cavity, and allow the transfer of waste, toxins and excess water to take place.
  • the source can be multiple sterile dialysate solution bags.
  • APD machines pump spent dialysate from the peritoneal cavity, though the catheter, to the drain. As with the manual process, several drain, fill and dwell cycles occur during APD. A “last fill” may occur at the end of CAPD and APD, which remains in the peritoneal cavity of the patient until the next treatment.
  • Both CAPD and APD are batch type systems that send spent dialysis fluid to a drain.
  • Tidal flow systems are modified batch systems. With tidal flow, instead of removing all of the fluid from the patient over a longer period of time, a portion of the fluid is removed and replaced after smaller increments of time.
  • Continuous flow, or CFPD, systems may clean or regenerate spent dialysate instead of discarding it.
  • the systems pump fluid into and out of the patient, through a loop.
  • Dialysate flows into the peritoneal cavity through one catheter lumen and out another catheter lumen.
  • the fluid exiting the patient passes through a reconstitution device that removes waste from the dialysate, e.g., via a urea removal column that employs urease to enzymatically convert urea into ammonia.
  • the ammonia is then removed from the dialysate by adsorption prior to reintroduction of the dialysate into the peritoneal cavity. Additional sensors are employed to monitor the removal of ammonia.
  • CFPD systems are typically more complicated than batch systems.
  • the dialysis fluid including the water used to make the dialysis fluid.
  • the purity of the incoming water is obviously important. In home situations, there is typically no control or monitoring of the water from a city main or from a person's well.
  • the dialysis fluid may be useful to at least check its complete composition, at least to insure that the proper fluid is being used. At present this cannot be done without taking a sample to a lab for testing and analysis. If more than one type of fluid is being used for peritoneal or other dialysis treatment, it may be useful to check the composition of each container, to insure that the proper containers have been procured and are connected correctly to the peritoneal dialysis machine.
  • Dialysis fluid may be used in more than one pass, i.e., hemodialysis fluid may be routed more than once through the dialyzer before it is filtered or purified and peritoneal dialysis fluid may also be used in multi-pass therapies.
  • hemodialysis fluid may be routed more than once through the dialyzer before it is filtered or purified and peritoneal dialysis fluid may also be used in multi-pass therapies.
  • Using a plurality of standard sensors at one or more points in the fluid circuits would be very expensive and would also occupy space that is not available at the bedside of the patient, whether in a home-care or even in an institutional-care setting.
  • MEMS sensors are used to sense and quantify analytes of interest in dialysis fluid and in water for use in dialysis fluid.
  • the MEMS sensors are useful in dialysis fluid intended for both peritoneal dialysis and hemodialysis.
  • a system for preparing dialysis fluid includes a first purification vessel which includes a purification medium for water, and a device for pumping or measuring the water.
  • the system also includes a heater for heating the water and a mixing chamber configured for receiving water from the device and for mixing the water with a concentrate to form a fresh dialysis solution.
  • a filter for filtering the fresh dialysis solution is provided, as well as a microelectromechanical systems (MEMS) sensor that is placed in fluid communication with an output from a vessel selected from the first purification vessel, the heater, the mixing chamber and the filter.
  • MEMS microelectromechanical systems
  • a system for preparing dialysis fluid in a second embodiment, includes a first purification cartridge that includes a purification medium for water, and also includes a heater for heating water received from the first purification cartridge.
  • the system also includes first and second pumps for pumping and metering first and second concentrates, and a mixing chamber configured for receiving the first and second concentrates from the first and second pumps and for mixing the first and second concentrates.
  • the mixing chamber is used to mix the water with the first and second concentrates to form a fresh dialysis solution.
  • the system further includes a filter for filtering the fresh dialysis solution, and a microelectromechanical systems (MEMS) sensor placed in fluid communication with an output of a vessel selected from the first purification vessel, the heater, the mixing chamber and the filter, wherein the MEMS sensor is suitable for sensing at least two substances in a stream selected from the group consisting of water from the first purification cartridge, the fresh dialysis solution and the filtered dialysis solution.
  • MEMS microelectromechanical systems
  • a method for preparing dialysis solution includes the steps of furnishing a supply of water and purifying the water in at least one pass through a purification medium. The method also includes the steps of heating the water and adding the water to at least one dialysis concentrate to form a dialysis solution. In addition, the method includes the steps of filtering the dialysis solution and sensing at least two characteristics of the water with a microelectromechanical systems (MEMS) sensor.
  • MEMS microelectromechanical systems
  • a method of preparing dialysis solution includes the steps of furnishing a supply of water and spent dialysate and purifying the water and the spent dialysate in at least one pass through a purification medium.
  • the purification medium may be in one vessel or more than vessel, as described below.
  • the method also includes the steps of heating the water and adding the water and at least one dialysis concentrate to form a dialysis solution.
  • the method includes filtering the formed dialysis solution and sensing at least two characteristics of a stream selected from the group consisting of the water, the formed dialysis solution and the spent dialysis solution, using a microelectromechanical systems (MEMS) sensor.
  • MEMS microelectromechanical systems
  • a method of purifying dialysis solution includes the steps of furnishing a supply of spent dialysate and purifying the spent dialysate in at least one pass through a purification medium in a vessel to form a purified dialysate.
  • the method also includes the steps of filtering the spent dialysate to form a filtered dialysate, and sensing at least two characteristics of a stream selected from the group consisting of the spent dialysate, the purified dialysate and the filtered dialysate. The characteristics are sensed with a microelectromechanical systems (MEMS) sensor.
  • MEMS microelectromechanical systems
  • Another embodiment is a method for performing dialysis.
  • the method includes the steps of providing a dialysis machine and a supply of dialysis fluid and also includes the steps of sensing and determining a composition of the dialysis fluid with a MEMS sensor.
  • the MEMS sensor is suitable for sensing and detecting at least two ions in the dialysis fluid.
  • the method also includes the steps of performing dialysis on a patient using the dialysis fluid, and sensing and determining a composition of the dialysis fluid after the step of performing dialysis, using a MEMS sensor.
  • the method includes the steps of purifying the dialysis fluid after the step of performing dialysis, and sensing and determining a composition of the dialysis fluid after the step of purifying with a MEMS sensor.
  • the method includes a step of reusing the dialysis fluid if the composition of the dialysis fluid after the step of purifying is suitable for dialysis.
  • FIG. 1 is a schematic view of a first system for purifying water or spent dialysis solution before hemodialysis
  • FIG. 2 is a schematic view of a second system for purifying water or spent dialysis solution before hemodialysis
  • FIG. 3 is a schematic view of a third system for purifying water and preparing dialysis solution, directed more to peritoneal dialysis;
  • FIG. 4 is a schematic view of a system for purifying water and preparing dialysis solution, especially for peritoneal dialysis;
  • FIG. 5 is a perspective view of a hemodialysis machine with a system for treating, purifying, and reusing spent dialysate;
  • FIG. 6 is a schematic view of a system for preparing dialysis solution using MEMS sensors.
  • MEMS sensors are used in embodiments of the present invention to detect and quantify analytes of interest in dialysis fluids.
  • MEMS sensors are capable of detecting numerous properties and species in a variety of aqueous fluids. These fluids include water, dialysis fluid, spent dialysis fluid and even blood.
  • the properties include pH, conductivity, temperature, oxidation-reduction potential and total hardness.
  • Species include ammonia or ammonium, total dissolved solids (TDS), carbonate, bicarbonate, calcium, magnesium, sodium, potassium, chloride and others.
  • a MEMS sensor includes a substrate with a plurality of electrode sensor elements adapted to measure relevant species of an aqueous analyte.
  • the sensor elements include, for example, electrodes and selective membranes. These elements, together with any support circuitry required to drive the sensor element, make up the complete sensor.
  • the substrate can include a plurality of electrodes covered by ion-selective membranes and an amperometric sensor including a working electrode and a counter electrode.
  • the substrate, including the sensor elements is connected to an analyzer capable of calculating one or more desired properties, such as the disinfection index of a water sample.
  • the substrate includes additional sensor elements configured to measure additional species.
  • These element may include an ammonia sensor, an oxygen sensor, or a sensor for a mutagenic species, such as an immunosensor or a DNA probe. Sensors may also be used to detect and quantify additional physical properties, such as temperature, conductivity and oxidation-reduction potential.
  • Exemplary sensors can be fabricated on silicon substrates. They may alternatively be fabricated on other types of substrates such as, for example, ceramic, glass, SiO 2 , or plastic, using conventional processing techniques. Exemplary sensors can also be fabricated using combinations of such substrates situated proximate to one another. For example, a silicon substrate having some sensor components (e.g., sensing elements) can be mounted on a ceramic, SiO 2 , glass, plastic or other type of substrate having other sensor components. These other sensor components may include sensing elements, one or more reference electrodes, or both. Conventional electronics processing techniques can be used to fabricate and interconnect such composite devices. These techniques are also described in U.S. Pat. No. 4,743,954 and U.S. Pat. No. 5,102,526, which are hereby incorporated herein by reference.
  • the sensors can utilize micro-array sensor chip technology on a silicon platform.
  • ion-selective electrode-based sensor elements can be implemented in a silicon-based embodiment, such as that as described by Brown, “Solid-state Liquid Chemical Sensors” (Miniaturized Analytical Devices Microsymposium, Chemistry Forum, 1998, pp. 120-126), the disclosure of which is hereby incorporated herein by reference.
  • Alternative silicon-based sensor devices, and the manners in which such devices can be fabricated, are described in U.S. Pat. No. 4,743,954 (“Integrated Circuit for a Chemical-Selective Sensor with Voltage Output”), U.S. Pat. No.
  • sensors for use in systems disclosed herein can be fabricated using known lithographic, dispensing and screen printing techniques. These include conventional microelectronics processing techniques. These techniques can provide sensors having sensing elements with micro-sized features integrated at the chip level, and can be integrated with low-cost electronics, such as ASICs (application specific integrated circuits). Such sensors and electronics can be manufactured at low cost, thereby enabling wide distribution of such sensors for general use.
  • the sensor may be a MEMS sensor as sold by Sensicore, Inc., Ann Arbor, Mich., U.S.A.
  • MEMS microelectromechanical systems
  • MEMS sensors may be used in many aspects of dialysis fluid preparation and processing to ensure patient safety, comfort, economy and convenience, as well as treatment efficacy.
  • the economy and convenience arise from the use at home of the embodiments described below, as well as many other embodiments that are not described here, but will be obvious to those having skill in dialysis arts.
  • FIG. 1 illustrates a first embodiment of a system 10 for preparing fresh dialysis solution from spent dialysate using MEMS sensors to sense, measure, and report various characteristics of the dialysate.
  • dialysis fluid enters from a source 11 of dialysis fluid, such as the effluent from a spent dialysate pump that forms part of a hemodialysis machine.
  • FIG. 1 depicts a plurality of sensors 13 , located at several points around the system 10 . The intent is not to suggest that a sensor is needed at every point depicted, but rather to demonstrate the plurality of locations where a sensor may advantageously be placed.
  • Each sensor 13 includes a power source 132 , such as a battery, a sensing element 134 with a working portion 136 , and optionally, a module 138 for remote communication, such as to a controller of the system.
  • the power source may be furnished by electrical wiring from a controller of the hemodialysis machine, or from another power source, such as a convenience outlet or a modular power supply for a series of MEMS sensors.
  • Sensor element 134 is a MEMS sensor and working portion 136 includes the circuitry necessary to process signals from the sensor and convert them to useful information. These signals may be sent to a controller of the hemodialysis machine via wired connections, or the MEMS sensor may include a remote communications capability.
  • the signal processing circuitry and wireless transmitter or radio 138 are small and compact, and are easily placed into the sensor housing at the sensing site.
  • One suitable remote communications module is a wireless module in accord with the ZigBee/IEEE 805.15.4 standard. This is a standard for a very low power radio system with a very limited range, about 10-20 feet.
  • the senor 13 optionally includes a power supply and may also include an ADC converter to convert analog data from the sensing element into digital data. The digital data is thus formatted, at least by the sensor, before transmission to the controller of the hemodialysis machine or other extracorporeal processing machine controller.
  • MEMS sensors include sensors which may be placed in-line between one vessel and a succeeding vessel, and also include sensors which may be placed within a vessel, such as a processing vessel or cartridge, or a storage vessel. Many MEMS sensors are capable of detecting many species of ions or contaminants, and some are also capable of sensing and relaying a temperature, pH (as in hydrogen or hydronium ion concentration), conductivity, total dissolved solids (TDS), and so forth.
  • system 10 includes a source 11 of water or spent dialysis fluid, with a MEMS sensor 13 placed at the source for monitoring characteristics of the incoming water or fluid.
  • a first processing vessel 12 such as a bed of activated carbon or charcoal, is placed downstream of the source 11 .
  • the bed of activated carbon or charcoal is excellent for removing a number of contaminants, including small particles and also including heavy metals, chlorine, chloramines, and organics, among others.
  • the bed of activated carbon or charcoal is relatively non-selective in the types of contaminants removed.
  • a second processing vessel 12 or bed of activated carbon or charcoal may be used, with a second sensor 13 placed downstream of the second vessel.
  • vessel 14 for purification of the water or spent dialysate may be used, with a fourth sensor downstream of vessel 14 .
  • This vessel may include any desired purification substance, and may include a single adsorbent or more than one layer of different adsorbents.
  • Vessel 14 may include a layer of urease and zirconium phosphate for converting urea into ammonium ions and then removing the ammonium by forming ammonium phosphate. Alternatively, or in addition, there may be a layer of zirconium oxide for removing phosphates or sulfates.
  • Vessel 14 may also include an ion exchange resin suitable for exchanging ions of waste substance for ions that are desirable in dialysis solutions, such as calcium or magnesium ions, and also bicarbonate or acetate ions.
  • the ion exchange resin may include filtering beds of carbon or charcoal before or after, or before and after, the resin itself. These supplemental beds also help to purify the final product, whether water for making dialysate or refreshed dialysate for service to the patient.
  • the rejuvenated dialysis fluid leaves vessel 14 , it is routed to the dialysate side of a dialyzer 16 , used for hemodialysis.
  • a dialyzer may be compared to a shell-and-tube heat exchanger, with the dialysate on the shell side and the blood of the patient running through the tube side counter-current to the dialysis fluid.
  • the dialysis fluid enters through inlet port 162 and leaves through dialysis fluid outlet port 164 , where an additional MEMS sensor may sense and measure a variety of species within the exiting dialysis fluid. Once the dialysis fluid leaves through outlet port 164 , it may be disposed of or may be sent again to be filtered and purified for another pass.
  • the other side of the dialyzer is connected to the patient's blood.
  • Blood enters through the inlet header 166 , flows through many hundred or thousand tiny porous tubes, and then leaves through the outlet header 168 .
  • the tiny porous tubes allow water and toxic substances in the blood, such as creatinine and urea, to flow from the blood side to the dialysis solution side.
  • electrolytes and bicarbonate buffer may flow from the dialysis solution side to the blood side.
  • the cleansed blood is then sent to an air detector or air trap before returning to the patient.
  • An additional sensor 13 may be used to check the composition of the incoming blood for contaminants or other species near inlet header 166 .
  • An additional sensor 17 may be used to check for contaminants or other species near outlet header 168 .
  • Sensor 17 may be tuned for different species than sensor 13 , for example, measuring pH, phosphates or urea, may be very important to determine the condition of the cleansed blood as it is returned to the patient.
  • FIG. 2 A second embodiment of a system 20 that advantageously uses MEMS sensors is depicted in FIG. 2 .
  • System 20 includes first and second purifying vessels 22 , which may be small cartridges rather than gallon-size vessels.
  • a MEMS sensor 23 senses and measures levels of the desired contaminants or species, as described above.
  • the reverse-osmosis filter 27 may be equipped with a MEMS sensor 23 that includes a temperature sensor, for proper operation of the reverse-osmosis filter.
  • the MEMS sensor may also include one or more sensors that monitor specific ions or substances, such as ammonia or ammonium, total dissolved solids (TDS), Ca ++ , Mg ++ , Na + , K + , Cl ⁇ , and so forth.
  • TDS total dissolved solids
  • the system may include a UV-light generator 26 , wherein the light generated is cidal to bacteria and other harmful microorganisms.
  • the light may be used to dissociate chloride ion from nitrogen atoms in chloramine molecules, thus removing chloramines from the water or dialysis fluid.
  • Ultraviolet light for these applications is typically UV-C, with a wavelength from about 180-290 nm. Lamps with a wavelength of about 185 nm or about 254 nm are preferred. Without being bound to any particular theory, it is believed that UV light penetrates the outer cell walls of microorganisms, where it passes through the cell body, reaches the DNA and alters the genetic material, and is thus cidal to the microorganism. Other desired wavelengths may be used.
  • Dialyzer 28 has a dialysis fluid inlet 282 and a dialysis fluid outlet 284 , each of which may also be equipped with a MEMS sensor 23 .
  • Dialyzer 28 has a blood inlet header 286 and a blood outlet header 288 opposite the inlet header.
  • the composition of the blood at the outlet may be sensed and monitored by a MEMS sensor 29 that is tuned, as above, for a particular component or property of the blood that is important, such as pH, phosphate, or urea.
  • the patient or a caregiver may take special note of the sensor readings from sensor 29 and from the last sensor 23 at the dialysis fluid outlet 284 . Readings of the composition or the state of the blood is important to gauge whether the dialysis treatment is working and whether dialysis should be continued as is or whether some modification to the patient's prescription may be needed, whether dialysis fluid, duration or frequency of the treatment, and so forth. Of course, a comparable result may also be achieved by analyzing the composition of the spent dialysis fluid, since the waste that leaves the patient's body must either remain in the dialyzer or enter the dialysis fluid. The condition of the spent dialysis fluid is thus important.
  • the fluid has toxic components within certain high ranges, it may be expedient not to re-use any part of the fluid and to instead replace it with fresh dialysis fluid. If the range is more reasonable, a user or caregiver may decide to recycle and refresh at least part of the spent fluid, rather than sending it to drain.
  • the composition of the spent dialysate also provides information on the efficacy of the dialysis therapy, albeit not as precisely as monitoring the patient's blood. While not depicted in FIG. 2 , it is understood that there may be one or more metering pumps or flow meters to control the flow of dialysis fluid to and from dialyzer 28 or any of the process vessels or cartridges upstream of dialyser 28 . It should be understood that many of the techniques and much of the equipment described above may be applicable to both hemodialysis and peritoneal dialysis applications.
  • FIG. 3 A system 30 designed for peritoneal dialysis is depicted in FIG. 3 .
  • System 30 accepts water or spent dialysate fluid from a source 31 , such as a water tap or an outlet from a patient yielding spent dialysate.
  • the system includes at least one vessel 32 for purifying the water or spent dialysate.
  • first vessel 32 may include activated carbon or charcoal, or may include more than one layer for selectively or non-selectively adsorbing impurities or wastes from either water or from spent dialysis fluid.
  • the system includes a MEMS sensor 33 , as discussed above.
  • the spent dialysis fluid or water is sent to a dialysis fluid preparation system 34 , of which one embodiment is described below in FIG. 6 .
  • the dialysis fluid preparation system may simply be a container with a known quantity of concentrate of known composition.
  • system 34 may be a flexible container with a known volume (liquid) or a known mass (solid) of a known concentrate for a single component dialysis solution, e.g., a dialysis lactate solution.
  • a dialysis lactate solution typically contains electrolytes, lactate, and glucose.
  • the water source 31 and necessary controls, such as a control valve in series with the water source of the vessel 32 are used to admit the proper amount of water to system 34 , where the components are mixed and dissolved to form the desired solution.
  • the amount of water or spent dialysate admitted may be measured, for example, by monitoring a positive-displacement pump for the fluid or water, or an accurate positive-displacement meter in series with the in-flow Alternatively, the amount of water or fluid can be controlled by weighing the mass admitted, e.g., by placing container 34 on a weigh scale, mass cell, or other device.
  • dialysis solution preparation may include heating or pressurization, or both heating and pressurization, and hence at least one temperature sensor or temperature element and at least one pressure sensor or pressure element may be used in the dialysis fluid preparation.
  • the resulting dialysis solution is checked at least once after its preparation by MEMS sensor 35 .
  • the fresh dialysis fluid is stored in at least one container 36 and its temperature is sensed and monitored by at least one temperature element or temperature sensor.
  • the dialysis fluid is pumped via pump 37 through a filter 38 , which routes the impurities to a drain and sends the purified filtrate to a peritoneal dialysis machine 39 .
  • the contents of the fluid may be checked by an additional MEMS sensor 35 at the input to the peritoneal dialysis machine.
  • the peritoneal dialysis machine may operate in one or more modes to route dialysis fluid to the peritoneum of the patient for a dwell period, or for a continuous flow-through mode, or other mode.
  • the dialysis fluid may be routed to the patient P through the inlet lumen 391 of a two-lumen catheter, as shown.
  • the dialysis fluid is routed from the patient through the outlet lumen 392 of a two lumen catheter.
  • the make-up of the spent dialysis fluid returned from the patient may be checked by an additional MEMS sensor 33 for the parameters discussed above.
  • System 40 includes a water source 41 , which may be a municipal water source, or other water source, or may be a source of spent dialysate.
  • a first filter or treatment vessel 42 is intended to remove impurities such as described above, the filter followed by a first MEMS sensor 43 .
  • the purified water or dialysis fluid is then routed to a system 44 for producing dialysis fluid, one embodiment of which is depicted below in FIG. 6 .
  • temperature and pressure elements may advantageously be used in preparation of dialysis fluid from concentrates.
  • the composition of the resulting dialysis fluid is sensed and checked at a second MEMS sensor 43 , as the dialysis fluid is routed to one or more storage containers 45 , where the temperature may be monitored by one or more temperature elements to ensure safe storage.
  • the dialysis fluid When the dialysis fluid is needed, it is pumped by pump 46 to a peritoneal dialysis machine 47 , and then to and from the patient by a catheter with two lumens, input lumen 471 and output lumen 472 .
  • the spent dialysate is routed to a reverse osmosis filter 48 , with the waste routed to a drain.
  • first and second vessels or filters 49 a, 49 b which may be used to remove contaminants, as described above, or may be used with ion exchange resins to remove contaminants and add desirable components.
  • An electro-deionization process unit may also be used to remove ionic contaminants.
  • An ultrafilter 49 c is used to filter the solution and to route waste to the drain.
  • MEMS sensors 13 , 29 may be used as indicated, such as after the dialysate is returned from the patient, and after the treatment vessels or filters, and the ultrafilter. MEMS sensors 13 , 29 and 43 may be the same or may be tuned or capable of sensing different species, different ions, or different substances, as desired and as explained above.
  • FIG. 5 depicts a home hemodialysis system 50 with a water or dialysate recycling system 52 as described above.
  • System 50 includes an incoming city water tap 51 to a water or dialysate recycling system 52 , which also includes a drain 59 for waste water.
  • Fresh dialysis fluid is sent through tubing 53 to a storage container S adjacent hemodialysis machine H with dialyzer 54 .
  • the patient P has a vascular access site 55 for an arterial needle A N and a venous needle V N .
  • the patient P is connected to the hemodialysis machine H via tubing 56 .
  • Spent dialysis fluid is returned to the recycling system 52 via tubing 57 .
  • the MEMS sensors 13 described above may be used at several points in system 50 .
  • One or more sensors 13 may be deployed within the dialysate recycling system 52 , for instance, to check on the incoming water from source 51 or the returned dialysate from tubing 57 .
  • a decision is made whether to send the returned dialysate to the drain 59 or to reuse the dialysate by cleaning, filtering, and replenishing the dialysate.
  • a second MEMS sensor may be used to monitor the quality and composition of the dialysate sent to, or stored in, dialysis fluid storage container S.
  • another MEMS sensor 13 may be deployed within hemodialysis machine H to monitor the composition of the returned dialysate or species within the patient's blood. As discussed above, this sensor can help the patient or the caregiver determine whether the dialysis process is changing the appropriate parameters of the blood or the dialysis fluid, thus giving an indication of whether the therapy is working as effectively as desired.
  • FIG. 6 A system for preparing dialysis fluid from concentrate using make-up water or cleansed dialysis fluid is depicted in FIG. 6 .
  • One system 60 for producing dialysate is depicted in FIG. 6 .
  • System 60 receives water from water source 61 and passes the water through one or more purification vessels 61 a, 61 b, as described above.
  • MEMS sensors 13 are used to sense and report the sensed quantities of impurities or other components of the water as it flows from the first and second vessels.
  • the water passes through control valve 61 c and is heated, if desired, using in-line heater 61 d.
  • the heated water flows through lines 61 e, 61 f to A and B concentrate pumps 62 , 63 , for pumping concentrate respectively from reservoirs 62 a, 63 a.
  • the pumps are positive displacement pumps, such as gear pumps, vane pumps, or piston pumps, to pump precise amounts of A or B concentrate.
  • One embodiment uses small ceramic piston pumps, available from Fluid Metering, Inc., Long Island, N.Y., U.S.A. Other pumps may be used.
  • Other embodiments use proportioning or ratiometric pumps, whose flow of A or B concentrate may be set, and which thereafter pump A and B concentrate in a ratio proportional to the water metered out by the pumps.
  • the pumps may be controlled by a feedback loop that includes a MEMS conductivity monitor.
  • the concentrate pump is sped up if the conductivity at the conductivity sensor 64 e is too low or is slowed if the conductivity at the probe is too high. Since the characteristic volumes of the concentrate pumps are known, there are limits on the amount of cycling needed to produce a stable dialysis solution.
  • a controller for the system keeps track of the amounts of concentrate pumped, and also keeps track of the amount of incoming water and A concentrate that is pumped, thus keeping precisely proportioned flows.
  • a concentrate pump 62 pumps A concentrate to mixing vessel 64 through line 62 a, the vessel not filled but retaining an air gap at its top, while the correct ratio of water also flows to the vessel through line 61 f.
  • the mixture is deaerated by spraying using precision metering pump 64 a, nozzle 64 c, and air trap 64 b.
  • Other embodiments such as a simple restriction creating a starved intake to pump 64 a, could be substituted for the sprayer to remove the air from the solution.
  • the mixture is monitored by temperature sensor 64 d and MEMS conductivity sensor 64 e.
  • Vessel 64 includes a level sensor L.
  • the deaerated acid mixture is then sent to the B mix chamber 65 , where B concentrate from the B concentrate pump through line 63 b is added, in this case in-line.
  • the B mix chamber 65 is equipped with a second MEMS sensor 66 to monitor the composition of the finished dialysis solution.
  • This sensor can check the conductivity of the finished solution, and may also check other parameters or qualities of the solution.
  • a WaterPointTM 870 Sensor from Sensicore, Inc., may be used to check several parameters, including conductivity, pH, temperature, total dissolved solids (TDS, based on sodium ions), calcium, magnesium, total hardness, carbonate alkalinity, and other parameters. Many of these are very useful to a patient or to a caregiver preparing dialysis solution, since these measurements are directly related to the quality and make-up of the dialysis solution.
  • this MEMS sensor can also sense and report general water quality, such as the concentrations of total and free ammonia (related to urea in the dialysate), chlorine, and chloramines.
  • general water quality such as the concentrations of total and free ammonia (related to urea in the dialysate), chlorine, and chloramines.
  • Other embodiments may use more than two concentrates, and the system may be changed to use a separate pump to pull the proper amount from each container of concentrate. Any of these systems may thus prepare a customized solution or prescription for each patient.
  • the MEMS sensors may be used to monitor and control the process, as well as the final product, in any of these embodiments.
  • the dialysis solution is then pumped by supply pump 67 through filter 67 a, to remove particles larger than 150 micrometers.
  • Control valve 68 controls the flow of dialysis solution from system 60 . If the correct level of continuity has not been achieved, the freshly-prepared dialysis solution may be recycled as desired through the filter and the mixing chamber, as shown, until the proper mixing and purity has been achieved.
  • the dialysis solution can then be pumped through a final filter, endotoxin filter 69 , and checked by final MEMS sensor 13 after the filter, on its way to a storage container or for use.
  • the endotoxin filter is intended to remove bacteria, such as E. coli and P. aeruginosa, as well as endotoxins. This filter could be an ultrafilter such as those made by Medica SRL, Mirandola, Italy, or from Nipro Corp., Osaka, Japan.
  • dialysis solutions may be used, including those requiring an osmotic agent, such as a small amount of dextrose, glucose, sodium or potassium polyacrylate, or mixtures of these, or other components.
  • an osmotic agent such as a small amount of dextrose, glucose, sodium or potassium polyacrylate, or mixtures of these, or other components.
  • These solutions are prepared in generally similar ways, some embodiments using powders, some using concentrates, some using solutions. Any such embodiments, including MEMS sensors, are intended to fall within the scope of the present invention.
  • Embodiments using powders may require a conventional stirred-tank vessel, or vessel suitable for mixing powders using a stirrer or using flow, often turbulent flow, to insure a good mixing. For home use, this may be any suitable mixer capable of maintaining and preserving sterility, when used with the MEMS sensors described above.
  • MEMS sensors that are capable of sensing and quantifying organic materials. These sensors work in the same manner as the other MEMS sensors, but operate by detecting analytes that are associated with an organic substance rather than an inorganic ion, such as ammonium or chlorine. These MEMS sensors are, or will be, capable of sensing total organic carbon (TOC), and also specific substances, such as urea, creatinine, ⁇ 2 -microglobulin, heparin, and glucose or other sugar or osmotic agent in the dialysis fluid. MEMS sensors could also be used to detect levels of bacteria, endotoxins, and viruses in the water or spent dialysis fluid. In addition, MEMS sensors may be used to detect analytes of interest in the blood, such as proteins in general, including albumin, free hemoglobin and hematocrit.

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US12/200,488 US20100051552A1 (en) 2008-08-28 2008-08-28 In-line sensors for dialysis applications
PL09789836T PL2320969T3 (pl) 2008-08-28 2009-06-17 Układ do wytwarzania płynu dializacyjnego
MX2011002196A MX2011002196A (es) 2008-08-28 2009-06-17 Sensores en linea para aplicaciones de dialisis.
ES09789836T ES2394911T3 (es) 2008-08-28 2009-06-17 Sistema para la preparación de un fluido de diálisis
CA2733511A CA2733511A1 (en) 2008-08-28 2009-06-17 In-line sensors for dialysis applications
BRPI0917238A BRPI0917238A2 (pt) 2008-08-28 2009-06-17 sensores em linha para aplicações de diálises
PCT/US2009/047591 WO2010024963A1 (en) 2008-08-28 2009-06-17 In-line sensors for dialysis applications
JP2011525031A JP5684127B2 (ja) 2008-08-28 2009-06-17 透析用途のためのインラインセンサ
EP09789836A EP2320969B1 (en) 2008-08-28 2009-06-17 A system for preparing dialysis fluid
CN200980133542.3A CN102131533B (zh) 2008-08-28 2009-06-17 用于透析应用的线路中的传感器
US15/941,278 US11400193B2 (en) 2008-08-28 2018-03-30 In-line sensors for dialysis applications
US17/878,412 US20220362445A1 (en) 2008-08-28 2022-08-01 In-line sensors for dialysis applications

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WO2010024963A1 (en) 2010-03-04
EP2320969B1 (en) 2012-09-05
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CN102131533B (zh) 2015-11-25
PL2320969T3 (pl) 2013-05-31
US20180221555A1 (en) 2018-08-09
JP5684127B2 (ja) 2015-03-11
US20220362445A1 (en) 2022-11-17
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EP2320969A1 (en) 2011-05-18
CN102131533A (zh) 2011-07-20

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