Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
  • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
  • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P13/00—Drugs for disorders of the urinary system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P13/00—Drugs for disorders of the urinary system
  • A61P13/12—Drugs for disorders of the urinary system of the kidneys
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P27/00—Drugs for disorders of the senses
  • A61P27/02—Ophthalmic agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P27/00—Drugs for disorders of the senses
  • A61P27/02—Ophthalmic agents
  • A61P27/06—Antiglaucoma agents or miotics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
  • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
  • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
  • A61P9/12—Antihypertensives
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
  • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Definitions

• the present invention relates to novel substituted piperidines, to processes for their preparation and to the use of the compounds as medicaments, in particular as renin inhibitors.
• Piperidine derivatives for use as medicaments are disclosed, for example, by WO 97/09311.
• renin inhibition there is still a need for highly potent active ingredients.
• the improvement of the pharmacokinetic properties is at the forefront. These properties directed to better bioavailability are, for example, absorption, metabolic stability, solubility or lipophilicity.
• the invention therefore provides substituted piperidines of the general formulae (I) and (II)
• R is C 2-8 -alkenyl, C 1-8 -alkyl, C 2-8 -alkynyl, C 0-8 -alkyl-carbonyl-amino-C 1-8 -alkyl, C 3-8 -cycloalkyl-C 0-8 -alkyl, C 1-8 -alkyl-sulfonyl-C 1-8 -alkyl, optionally N-mono- or N,N-di-C 1-8 -alkylated carbamoyl-C 0-8 -alkyl, optionally O—C 1-8 -alkylated carboxyl-C 0-8 -alkyl, optionally N and/or N′ mono-, di- or tri-C 1-8 -alkylated ureido-C 1-8 -alkyl or heterocyclylcarbonyl-C 0-8 -alkyl, each of said radicals may be substituted, preferably by 1-4 C 1-8 -alkoxy,
• R 1 is aryl or heterocyclyl
• R 2 is acenaphthyl, cyclohexyl, diazinyl, furyl, imidazolyl, naphthyl, oxadiazolyl, oxazolyl, phenyl, pyrazinyl, pyridyl, pyrimidinyl, pyrrolyl, oxopyridinyl, tetrazolyl, thienyl, or triazolyl, each of said radicals may be substituted by 1-3 C 1-8 -alkanoyloxy-C 1-8 -alkyl, C 2-8 -alkenyloxy, C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxycarbonyl, C 1-8 -alk
• T1, T2, T3 and T4 are each independently
• bonds starting from (b)-(t) lead to a saturated or aromatic carbon atom of the adjacent group if the bond starts from a heteroatom, and where not more than two (b)-(f) groups, three (g)-(h) groups and one (i)-(t) group are present;
• R 3 is hydrogen, hydroxyl, C 1-8 -alkoxy or C 2-8 -alkenyloxy
• R 4 is hydrogen, C 2-8 -alkenyl, C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkyl, optionally (N—C 1-8 -alkyl)-C 1-8 -alkoxycarbonyl-amino-C 1-8 -alkoxy, optionally (N—C 1-8 -alkyl)-C 1-8 -alkylcarbonyl-amino-C 1-8 -alkoxy, optionally (N-mono- or N,N-di-C 1 -C 8 -alkyl)-amino-C 1-8 -alkoxy, benzyl, C 3-8 -cycloalkyloxy, C 3-8 -cycloalkyloxy-C 1-8 -alkoxy, heterocyclyl-C 0-8 -alkoxy, heterocyclyloxy-C 1-8
• R 5 and R 6 are each independently hydrogen, C 1-8 -alkyl, C 2-8 -alkenyl, aryl-C 1-8 -alkyl or acyl, or, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered heterocyclic ring which may contain an additional nitrogen, oxygen or sulfur atom or a —SO— or —SO 2 — group, and the additional nitrogen atom may optionally be substituted by C 1-8 -alkyl radicals;
• R 7 and R 8 together with the carbon atom to which they are bonded, are a 3-7-membered ring which may contain one or two —O— or —S— atoms or —SO— or —SO 2 — groups;
• R 9 is hydrogen, C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkyl, acyl or arylalkyl;
• R 10 is carboxyalkyl, alkoxycarbonylalkyl, alkyl or hydrogen
• R 11 is hydrogen or C 1-8 -alkyl
• R 12 is hydrogen or C 1-8 -alkyl
• Q is ethylene or is absent (formula I) or is ethylene or methylene (formula II);
• U is hydrogen, C 1-8 -alkyl, cyano, optionally substituted C 3-8 -cycloalkyl, aryl or heterocyclyl;
• W is oxygen or sulfur
• X is a bond, oxygen or sulfur, or is a >CH—R 11 , >CHOR 9 , —O—CO—, >CO, >C ⁇ NOR 10 , —O—CHR 11 — or —O—CHR 11 —CO—NR 9 — group and the bond starting from an oxygen or sulfur atom leads to a saturated carbon atom of the Z group or to R 1 ;
• Z is C 1-8 -alkylene, C 2-8 -alkenylene, hydroxy-C 1-8 -alkylidene, —O—, —S—, —O-alk-, —S-alk-, -alk-O—, -alk-S— or -alk-NR 9 —, where alk is C 1-8 -alkylene; and where
• R 2 contains an L1-T1-L2-T2-L3-T3-L4-T4-L5-U substituent or R 4 is a substituent other than hydrogen as defined above;
• n 0 or 1
• n 0 or 1
• alkyl and alkoxy radicals which may be linear or branched, are C 1-8 -alkyl and C 1-8 -alkoxy radicals such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, hexyl, and methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, sec-butoxy and tert-butoxy respectively, in addition C 0 -alkoxy designates —O—.
• C 1-8 -alkylenedioxy radicals are preferably methylenedioxy, ethylenedioxy and propylenedioxy.
• Examples of C 1-8 -alkanoyl radicals, which may be linear or branched, are acetyl, propionyl and butyryl.
• Cycloalkyl is a saturated, cyclic hydrocarbon radical having 3-12 carbon atoms, i.e. cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, bicyclo[2.2.1]heptyl, cyclooctyl, bicyclo[2.2.2]octyl and adamantyl.
• C 1-8 -alkylene radicals which may be linear or branched, are, for example, methylene, ethylene, propylene, 2-methylpropylene, 2-methylbutylene, 2-methylbutyl-2-ene, butyl-2-ene, butyl-3-ene, propyl-2-ene, tetra-, penta- and hexamethylene.
• C 2-8 -alkenylene radicals which may be linear or branched, are, for example, vinylene and propenylene.
• C 2-8 -alkynylene radicals which may be linear or branched, are, for example, ethynylene; acyl radicals are alkanoyl radicals, preferably C 1-8 -alkanoyl radicals, or aroyl radicals such as benzoyl.
• Aryl denotes mono- or polycyclic aromatic radicals which may be mono- or polysubstituted, for example phenyl, substituted phenyl, naphthyl, substituted naphthyl, tetrahydronaphthyl or substituted tetrahydronaphthyl.
• substituents on such aryl radicals or on heterocyclyl radicals are C 1-8 -alkyl, trifluoromethyl, trifluoromethoxy, nitro, amino, C 2-6 -alkenyl, C 1-8 -alkoxy, C 1-8 -alkylsulfinyl, C 1-8 -alkylcarbonyloxy, hydroxyl, halogen, cyano, carbamoyl, carboxyl and C 1-8 -alkylenedioxy, and also phenyl, phenoxy, phenylthio, phenyl-C 1-8 -alkyl or phenyl-C 1-8 -alkoxy each optionally substituted by halogen, C 1-8 -alkyl, C 1-8 -alkoxy or dihydroxy-C 1-8 -alkylaminocarbonyl.
• substituents on aryl or on heterocyclyl radicals are oxo, C 1-8 -alkoxycarbonylphenyl, hydroxy-C 1-8 -alkylphenyl, benzyloxy, pyridylcarbonylamino-C 1-8 -alkyl, C 2-6 -alkenyloxy, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy-C 1-8 -alkyl, hydroxy-C 1-8 -alkoxy, di-C 1-8 -alkylamino, 2,3-dihydroxypropoxy, 2,3-dihydroxypropoxy-C 1-8 -alkoxy, 2,3-dimethoxypropoxy, methoxybenzyloxy, hydroxybenzyloxy, phenethyloxy, methylenedioxybenzyloxy, dioxolanyl-C 1-8 -alkoxy, cyclopropyl
• heterocyclyl denotes a saturated or unsaturated, 4-8-membered, particularly preferably 5- or 6-membered, monocyclic ring system, a saturated or unsaturated, 7-12-membered, particularly preferably 9- or 10-membered, bicyclic ring system and also a saturated or unsaturated, 7-12-membered tricyclic ring system, in each case having from 1 to 4 nitrogen and/or 1 or 2 sulfur or oxygen atoms and comprising an N, O or S atom in at least one ring, it also being possible for additional N, O or S atoms to be present in the same ring.
• Said radicals may be unsubstituted or substituted one or more times, e.g. once or twice.
• substituents are (in the case of unsaturated heterocyclyl radicals) alkyl, hydroxyl, alkoxy, cyano, oxide, nitrogen, halogen, and substituents as defined above for aryl radicals, or (in the case of saturated heterocyclyl radicals) alkyl and alkoxy.
• heterocyclyl radicals are pyridyl, thienyl, pyrazinyl, triazolyl, imidazolyl, benzothiazolyl, furyl, pyranyl, tetrahydropyranyl, azetidinyl, pyrimidinyl, morpholinyl, quinazolinyl, quinolyl, quinoxalinyl, isoquinolyl, tetrahydroquinolyl, tetrahydroisoquinolyl, benzo[b]thienyl, isobenzofuranyl, benzoimidazolyl, 2-oxobenzoimidazolyl, oxazolyl, thiazolyl, indolyl, 2-oxo-1H-quinolinyl, 2H-chromenyl, 2-oxo-2H-chromenyl, 1,1a,2,7b-tetrahydro-cyclopropa[c]chromenyl, 2-oxo
• substituted heterocyclyl radicals are nitrobenzothiazolyl, phenyltetrazolyl, phenyloxadiazolyl, phenylpiperidinyl, phenylpiperazinyl, phenylpyrrolidinyl, thienyloxadiazolyl, furanyloxadiazolyl, benzyloxadiazolyl or phenyloxazolyl.
• substituted heterocyclyl radicals are dioxolanyl, dioxanyl, dithiolanyl, dithianyl, pyrrolidinyl, piperidinyl, piperazinyl, 4-methyl-piperazinyl, morpholinyl, thiomorpholinyl, 2-hydroxymethylpyrrolidinyl, 3-hydroxypyrrolidinyl, 3,4-dihydroxypyrrolidinyl, 4-hydroxypiperidinyl, 4-oxopiperidinyl, 3,5-dimethylmorpholinyl, 4,4-dioxothiomorpholinyl, 4-oxothiomorpholinyl, 2,6-dimethylmorpholinyl, tetrahydropyranyl, 2-oxoimidazolidinyl, 2-oxooxazolidinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 2-oxo-[1,3]oxazinyl, 2-oxoazepanyl
• the aryl, aroyl and heterocyclyl radicals may additionally be substituted by heterocyclylalkyl, heterocyclylalkoxy, heterocyclylalkoxyalkyl or heterocyclyl for example piperidinoalkyl, piperidinoalkoxy, piperidinoalkoxyalkyl, morpholinoalkyl, morpholinoalkoxy, morpholinoalkoxyalkyl, piperazinoalkyl, piperazinoalkoxy, piperazinoalkoxy, piperazinoalkoxyalkyl, [1,2,4]-triazol-1-ylalkyl, [1,2,4]-triazol-1-ylalkoxy, [1,2,4]-triazol-4-ylalkyl, [1,2,4]-triazol-4-ylalkoxy, [1,2,4]-oxadiazol-5-ylalkyl, [1,2,4]oxadiazol-5-ylalkoxy,
• Examples of 5- and 6-membered heterocyclic rings represented by NR 5 R 6 are pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, 2-hydroxymethylpyrrolidinyl, 3-hydroxypyrrolidinyl, 3,4-dihydroxypyrrolidinyl, 4-hydroxypiperidinyl, 4-oxopiperidinyl, 3,5-dimethylmorpholinyl, 4,4-dioxothiomorpholinyl, 4-oxothiomorpholinyl, 2,6-dimethylmorpholinyl, 2-oxoimidazolidinyl, 2-oxooxazolidinyl, 2-oxopyrrolidinyl, 2-oxo-[1,3]oxazinyl, 2-oxotetrahydropyrimidinyl and the like.
• Examples of 3-7-membered rings represented by CR 7 R 8 are cyclopentyl, cyclohexyl, cycloheptyl, 1,3-dioxolanyl, 1,3-dioxanyl, 1,3-dithiolanyl and 1,3-dithianyl.
• polyhydroxyalkyl denotes C 1-7 -alkyl radicals which may be substituted by 2-6 hydroxyl groups, for example glyceryl, arabityl, sorbityl, etc.
• Halogen or halo denotes, for example, fluorine, chlorine or bromine, or a radical singly, multiply or fully substituted by fluorine, chlorine or bromine.
• Salts are primarily the pharmaceutically usable or nontoxic salts of compounds of the formula (I) or formula (II).
• pharmaceutically useable salts encompasses salts with inorganic or organic acids, such as hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid, phosphoric acid, citric acid, formic acid, maleic acid, acetic acid, succinic acid, tartaric acid, methanesulfonic acid, p-toluenesulfonic acid and the like.
• Salts of compounds having salt-forming groups are in particular acid addition salts, salts with bases, or, in the presence of a plurality of salt-forming groups, in some cases also mixed salts or internal salts.
• Such salts are formed, for example, from compounds of the formula (I) or formula (II) with an acidic group, for example a carboxyl or sulfo group, and are, for example, the salts thereof with suitable bases-such as non-toxic metal salts derived from metals of group Ia, Ib, IIa and IIb of the Periodic Table of the Elements, for example alkali metal, in particular lithium, sodium, or potassium, salts, alkaline earth metal salts, for example magnesium or calcium salts, and also zinc salts and ammonium salts, including those salts which are formed with organic amines, such as optionally hydroxy-substituted mono-, di- or trialkylamines, in particular mono-, di- or tri(lower alkyl)amines, or with quaternary ammonium bases, e.g.
• suitable bases such as non-toxic metal salts derived from metals of group Ia, Ib, IIa and IIb of the Periodic Table of the Elements, for
• methyl-, ethyl-, diethyl- or triethylamine mono-, bis- or tris(2-hydroxy(lower alkyl))amines, such as ethanol-, diethanol- or triethanolamine, tris(hydroxymethyl)methylamine or 2-hydroxy-tert-butylamine, N,N-di(lower alkyl)-N-(hydroxy(lower alkyl))amine, such as N,N-di-N-dimethyl-N-(2-hydroxyethyl)amine, or N-methyl-D-glucamine, or quaternary ammonium hydroxides such as tetrabutylammonium hydroxide.
• the compounds of the formula I having a basic group, for example an amino group may form acid addition salts, for example with suitable inorganic acids, e.g. hydrohalic acid such as hydrochloric acid, hydrobromic acid, sulfuric acid with replacement of one or both protons, phosphoric acid with replacement of one or more protons, e.g. orthophosphoric acid or metaphosphoric acid, or pyrophosphoric acid with replacement of one or more protons, or with organic carboxylic, sulfonic or phosphonic acids or N-substituted sulfamic acids, e.g.
• suitable inorganic acids e.g. hydrohalic acid such as hydrochloric acid, hydrobromic acid, sulfuric acid with replacement of one or both protons, phosphoric acid with replacement of one or more protons, e.g. orthophosphoric acid or metaphosphoric acid, or pyrophosphoric acid with replacement of one or more protons, or with organic carboxylic, sulfonic or phosphonic acids or N-
• Salts obtained may be converted to other salts in a manner known per se, acid addition salts, for example, by treating with a suitable metal salt such as a sodium, barium or silver salt, of another acid in a suitable solvent in which an inorganic salt which forms is insoluble and thus separates out of the reaction equilibrium, and base salts by release of the free acid and salt reformation.
• a suitable metal salt such as a sodium, barium or silver salt
• the compounds of the formula (I) and (II), including their salts, may also be obtained in the form of hydrates or include the solvent used for the crystallization.
• the compounds of the formulae (I) and (II) also include those compounds in which one or more atoms are replaced by their stable, non-radioactive isotopes; for example a hydrogen atom by deuterium.
• the compounds of the formulae (I) or (II) may be prepared in a similar manner to the preparation processes disclosed in the literature.
• Preferred procedures for the preparation of optically pure compounds of the formula (I) or (II) consist of the construction of the requisite multiply-substituted piperidine scaffolds and their precursors via either (i) a chiral aza-Diels-Alder reaction of an imine derivative with a diene (see Chemistry-A European Journal 2000, 6(13), 2435-2448 and references cited therein) [Scheme 1] or (ii) condensation of a chiral amino acid derivative with Meldrum's acid followed by cyclisation (see Journal of Organic Chemistry 2004, 69(1), 130-141 and references cited therein) [Scheme 2].
• amine e.g. triethylamine
• This amine component may either be present in the commercially available diene (e.g. Danishefsky's diene from Aldrich) or added exogenously. Details on the specific preparation variants can be taken from the examples.
• the compounds of the formula (I) or formula (II) have at least three asymmetric carbon atoms and may therefore be in the form of optically pure diastereomers, diastereomeric mixtures, diastereomeric racemates, mixtures of diastereomeric racemates or as meso compounds.
• the invention encompasses all of these forms. Diastereomeric mixtures, diastereomeric racemates or mixtures of diastereomeric racemates may be separated by customary procedures, for example by column chromatography, thin-layer chromatography, HPLC and the like.
• the compounds of the formulae (I) or (II) may also be prepared in optically pure form.
• the separation into antipodes can be effected by procedures known per se, either preferably at an earlier synthetic stage by salt formation with an optically active acid, for example (+)- or ( ⁇ )-mandelic acid and separation of the diastereomeric salts by fractional crystallization, or preferably at a relatively late stage by derivatizing with a chiral auxiliary building block, for example (+)- or ( ⁇ )-camphanoyl chloride, and separation of the diastereomeric products by chromatography and/or crystallization and subsequent cleavage of the bonds to give the chiral auxiliary.
• the pure diastereomeric salts and derivatives may be analysed to determine the absolute configuration of the piperidine present with common spectroscopic procedures, and X-ray spectroscopy on single crystals constitutes a particularly suitable procedure.
• the configuration at individual chiral centres in a compound of the formulae (I) or (II) may be inverted selectively.
• the configuration of asymmetric carbon atoms which bear nucleophilic substituents, such as amino or hydroxyl may be inverted by second-order nucleophilic substitution, if appropriate after conversion of the bonded nucleophilic substituent to a suitable nucleofugic leaving group and reaction with a reagent which introduces the original substituents, or the configuration at carbon atoms having hydroxyl groups can be inverted by oxidation and reduction, analogously to the process in the European patent application EP-A-0 236 734.
• the reactive functional modification of the hydroxyl group and subsequent replacement thereof by hydroxyl with inversion of configuration is also advantageous.
• the compounds of the formulae (I) or (II) also include compounds where one or more atoms are replaced by their stable, non-radioactive isotopes (for example hydrogen by deuterium).
• Prodrug derivatives of the compounds described in the present context are derivatives thereof which, on in vivo application, release the original compound by a chemical or physiological process.
• a prodrug may be converted to the original compound, for example, when a physiological pH is attained or by enzymatic conversion.
• Prodrug derivatives may, for example, be esters of freely available carboxylic acids, S- and O-acyl derivatives of thiols, alcohols or phenols, and the acyl group is as defined in the present context.
• ester derivatives which are converted by solvolysis in physiological medium to the original carboxylic acid
• a certain compound in this invention also encompasses its prodrug derivative and salt form, where these are possible and appropriate.
• Preferred inventive compounds are those of the general formulae (IA) or (IIA)
• R, R 1 , R 2 , R 3 , R 4 , Q, W, X and Z, n and m are each as defined above for the compounds of the formulae (I) and (II).
• a further, preferred group of compounds of the formula (I) or (II), or more preferably of the formula (IA) or (IIA), are compounds where
• R is C 2-8 -alkenyl, C 1-8 -alkyl, C 2-8 -alkynyl, C 0-8 -alkyl-carbonyl-amino-C 1-8 -alkyl, C 3-8 -cycloalkyl-C 0-8 -alkyl, C 1-8 -alkyl-sulfonyl-C 0-8 -alkyl, optionally N-mono- or N,N-di-C 1-8 -alkylated carbamoyl-C 0-8 -alkyl, optionally O—C 1-8 -alkylated carboxyl-C 0-8 -alkyl, optionally N and/or N′ mono-, di- or tri-C 1-8 -alkylated ureido-C 0-8 -alkyl or heterocyclylcarbonyl-C 0-8 -alkyl, each of said radicals may be substituted, preferably by 1-4 C 1-8 -alk
• R 1 is aryl or heterocyclyl
• R 2 is phenyl, cyclohexyl, tetrazolyl, naphthyl or acenaphthyl, each of said radicals may be unsubstituted or substituted, preferably by 1-3 C 1-8 -alkanoyloxy-C 1-8 -alkyl, C 2-8 -alkenyloxy, C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxycarbonyl, C 1-8 -alkoxycarbonyloxy-C 1-8 -alkyl, C 1-8 -alkyl, carboxy-C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkylsulfanyl, C 1-8 -alkylsul
• L1, L2, L3, L4 and L5 are each independently a bond, C 1-8 -alkylene, C 2-8 -alkenylene or C 2-8 -alkynylene, C 3-8 -cycloalkene or are absent;
• T1, T2, T3 and T4 are each independently
• bonds starting from (b)-(t) lead to a saturated or aromatic carbon atom of the adjacent group if the bond starts from a heteroatom, and where not more than two (b)-(f) groups, three (g)-(h) groups and one (i)-(t) group are present;
• R 3 is hydrogen, hydroxyl, C 1-8 -alkoxy or C 2-8 -alkenyloxy
• R 4 is hydrogen, C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkyl, optionally (N—C 1-8 -alkyl)-C 1-8 -alkoxycarbonyl-amino-C 1-8 -alkoxy, optionally (N—C 1-8 -alkyl)-C 1-8 -alkylcarbonyl-amino-C 1-8 -alkoxy, optionally (N-mono- or N,N-di-C 1 -C 8 -alkyl)-amino-C 1-8 -alkoxy, C 3-8 -cycloalkyloxy, C 3-8 -cycloalkyloxy-C 1-8 -alkoxy, heterocyclyl-C 0-8 -alkoxy, heterocyclyloxy-C 1-8 -alkoxy, hydroxy, oxo or hydroxy
• R 5 and R 6 are each independently hydrogen, C 1-8 -alkyl or acyl, or, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered heterocyclic ring which may contain an additional nitrogen, oxygen or sulfur atom;
• R 7 and R 8 together with the carbon atom to which they are bonded, are a 3-7-membered ring which may contain one or two —O— or —S— atoms;
• R 9 is hydrogen, C 1-8 -alkyl, acyl or arylalkyl
• U is hydrogen, C 1-8 -alkyl, C 3-8 -cycloalkyl, cyano, aryl or heterocyclyl;
• Q is ethylene or is absent (formula (I)) and is ethylene or methylene (formula (II));
• X is a bond, oxygen, sulfur or is a >CHR 11 , >CHOR 9 , —O—CO—, >CO or —O—CH—R 11 —CO—NR 9 — group;
• W is oxygen or sulfur if R 3 is hydrogen
• Z is C 1-8 -alkylene or -alk-O—
• n 0 or 1
• n 0 or 1
• R radicals are C 1-8 -alkyl, C 0-8 -alkyl-carbonyl-amino-C 1-8 -alkyl, C 1-8 -alkyl-sulfonyl-C 1-8 -alkyl, optionally N-mono- or N,N-di-C 1-8 -alkylated carbamoyl-C 0-8 -alkyl, optionally N and/or N′ mono-, di- or tri-C 1-8 -alkylated ureido-C 0-8 -alkyl, heterocyclyl-C 0-8 -alkyl, or heterocyclylcarbonyl-C 0-8 -alkyl, each of said radicals may be substituted, preferably by 1-4 C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkoxycarbonyl-(N—C 1-8 -alkyl)-amino, C 1
• R 1 radicals are phenyl and phenyl substituted by 1-3 radicals selected from C 1-8 -alkyl, C 1-8 -alkoxy, halogen, hydroxyl, hydroxy-C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkylsulfinyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, carboxyl, C 1-8 -alkoxycarbonyl, C 1-8 -alkoxy-C 1-8 -alkoxy-C 1-8 -alkyl, C 0-6 -alkylcarbonylamino, C 0-6 -alkylcarbonylamino-C 1-8 -alkyl, C 0-6 -alkylcarbonylamino-C 1-8 -alkoxy, (N—C 1-8 -alkyl)-C 0-6 -alkylcarbonylamino-C 1-8
• R 1 radicals which are likewise preferred are benzofuranyl, benzoimidazolyl, 4H-benzo[1,4]oxazinyl, benzooxazolyl, 2- and 5-benzo[b]thienyl, 3,4-dihydro-2H-benzo[1,4]oxazinyl, 1,3-dihydroindolyl, 2,3-dihydroindolyl, indazolyl, indolyl,1H-quinolinyl, 2H-chromenyl, 1,1a,2,7b-tetrahydrocyclopropa[c]chromenyl, 1a,7b-dihydro-1H-cyclopropa[c]chromenyl, 6- and 7-isoquinolyl, pyridyl, pyrimidinyl, 6- and 7-quinazolinyl, 6- and 7-quinolyl, 6-quinoxalinyl, 6- and 7-tetrahydroisoquinoly
• R 1 radicals are phenyl, pyridyl, 3-C 1-8 -alkylindolyl, benzofuranyl, 4H-benzo[1,4]oxazin-3-onyl, 3,4-dihydro-2H-benzo[1,4]oxazinyl, 3,4-dihydro-2H-benzo[1,4]thiazinyl, 3,3-di-C 1-8 -alkyl-1,3-dihydroindol-2-onyl, 3,3-di-C 1-8 -alkyl-1,3-dihydroindolyl, indazolyl, indolyl, 1H-quinolinyl, 2H-chromenyl, 1,1a,2,7b-tetrahydro-cyclopropa[c]chromenyl, 1a,7b-dihydro-1H-cyclopropa[c]chromenyl, and spiro[cyclopropane
• R 1 radicals are phenyl, pyridyl, or a bicyclic heterocyclyl, consisting of a phenyl-ring annulated to a 5-6 membered, saturated or unsaturated, heteocyclic ring, having from 1 to 3 nitrogen and/or 1 sulfur or oxygen atoms, such as 4H-benzo[1,4]oxazin-3-on-6-yl, 3,4-dihydro-2H-benzo[1,4]oxazin-6-yl, 3,4-dihydro-2H-benzo[1,4]thiazin-6-yl, 2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl, 2,2-dimethyl-4H-benzo[1,4]oxazin-3-on-6-yl, 4,4-dimethyl-1,4-dihydrobenzo[d][1,3]oxazin-2-on-8-yl, 3,3-
• R 2 radicals are phenyl and phenyl substituted by halogen, hydroxyl, cyano, trifluoromethoxy, trifluoromethyl, C 2-8 -alkenyloxy, C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 l-alkyl, C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkylsulfanyl, C 1-8 -alkylsulfanyl, C 1-8 -alkylsulfanyl-C 1-8 -alkyl, C 1-8 -alkylsulfanyl-C 1-8 -alkoxy, C 1-8 -alkylsulfanyl-C 1-8 -alkoxy, C 1-8 -alkylsulfanyl
• R 2 radicals which are likewise preferred are phenyl and halophenyl substituted by an L1-T1-L2-T2-L3-T3-L4-T4-L5-U radical where L1 and L2 are preferably absent or C 1-8 -alkylene and L3 is absent and U is hydrogen, C 1-8 -alkyl, C 3-8 -cycloalkyl, phenylpiperidinyl, phenylpiperazinyl, phenylpyrrolidinyl, phenyl, is phenyl or phenylpyrrolidinyl each substituted by C 1-8 -alkyl, C 1-8 -alkoxy, C 1-8 -alkylthio, C 1-8 -alkylsulfinyl, C 1-8 -alkylenedioxy, halogen, benzoyl-C 1-8 -alkyl, halogen-C 1-8 -alkyl, C 1-8 -alkanoyl
• R 2 radicals are unsubstituted phenyl and phenyl and halo phenyl each substituted by C 2-8 -alkenyloxy, C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkyl-amino-C 1-8 -alkyl, C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkylsulfanyl, C 1-8 -alkylsulfanyl, C 1-8 -alkylsulfanyl-C 1-8 -alkyl, C 1-8 -alkylsulfanyl-C 1-8 -alkoxy, C 1-8 -alkylsulfanyl-C 1
• R 2 radicals are phenyl and halophenyl each substituted by C 2-8 -alkenyloxy, C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkyl-amino-C 1-8 -alkyl, C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkylsulfanyl, C 1-8 -alkylsulfanyl, C 1-8 -alkylsulfanyl-C 1-8 -alkyl, C 1-8 -alkylsulfanyl-C 1-8 -alkoxy, C 1-8 -alkylsulfanyl-C 1-8 -alkoxy, C 1-8 -
• R 2 radicals are phenyl and halophenyl each substituted as defined above whereby at least one substituent is in the para-position relative to the bond of R 2 to the rest of the molecule.
• Preferred substituents—in the para-position relative to the bond of R 2 to the rest of the molecule—on R 2 are fluoro, ethyl, propyl, butyl, isobutyl, pentyl, methylsulfanyl, 2-methoxyethylsulfanyl, 3-methoxypropylsulfanyl, 4-methoxybutylsulfanyl, 4-methoxy-3-methyl-butylsulfanyl, allyloxy, methoxy, ethoxy, propoxy, 4-methoxybutoxy, 3-methoxypropoxy, 2-methoxyethoxy, 3-cyclopropyloxypropoxy, (2-methoxy-cyclopropyl)methoxymethyl, (2-methoxymethyl-cyclopropy
• Examples of preferred X radicals are oxygen, methylene, —O—CH 2 —CO—NH—, —O—CH 2 —CO—N(CH 3 )— and —O—CH(CH 3 )—CO—NH—.
• X particularly preferred for X are, a bond, methylene and oxygen.
• Particularly preferred Z radicals are alkylene, —(CH 2 ) 1-2 —O— and —CH(CH 3 )—;
• a group of very particularly preferred compounds of the formula (I) or (II), or more preferably of the formula (IA) or (IIA), are compounds where
• R is C 1-8 -alkyl, C 0-8 -alkyl-carbonyl-amino-C 1-8 -alkyl, C 1-8 -alkyl-sulfonyl-C 1-8 -alkyl, optionally N-mono- or N,N-di-C 1-8 -alkylated carbamoyl-C 0-8 -alkyl, optionally N and/or N′ mono-, di- or tri-C 1-8 -alkylated ureido-C 0-8 -alkyl, heterocyclyl-C 0-8 -alkyl, or heterocyclylcarbonyl-C 0-8 -alkyl, each of said radicals may be substituted, preferably by 1-4 C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkoxycarbonyl-(N—C 1-8 -alkyl)-amino, C 1-8 -
• R 1 is phenyl, pyridyl, 4H-benzo[1,4]oxazin-3-on-6-yl, 3,4-dihydro-2H-benzo[1,4]oxazin-6-yl, 3,4-dihydro-2H-benzo[1,4]thiazin-6-yl, 2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl, 2,2-dimethyl-4H-benzo[1,4]oxazin-3-on6-yl, 4,4-dimethyl-1,4-dihydrobenzo[d][1,3]oxazin-2-on-8-yl, 3,3-dimethyl-1,3-dihydroindol-2-on-6-yl, 3,3-dimethyl-1,3-dihydroindol-2-on-7-yl, 3,3-dimethyl-1,3-dihydroindol-6-yl, 3-methyl
• R 2 is phenyl or halophenyl each substituted by C 2-8 -alkenyloxy, C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy, C 1-8 -alkoxy-C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkyl-amino-C 1-8 -alkyl, C 1-8 -alkyl, C 1-8 -alkoxy-C 1-8 -alkylsulfanyl, C 1-8 -alkylsulfanyl, C 1-8 -alkylsulfanyl-C 1-8 -alkyl, C 1-8 -alkylsulfanyl-C 1-8 -alkoxy, C 1-8 -alkylsulfanyl-C 1-8 -alkoxy, C 1-8 -alky
• Preferred substituents—in the para-position relative to the bond of R 2 to the rest of the molecule—on R 2 are fluoro, ethyl, propyl, butyl, isobutyl, pentyl, methylsulfanyl, 2-methoxyethylsulfanyl, 3-methoxypropylsulfanyl, 4-methoxybutylsulfanyl, 4-methoxy-3-methyl-butylsulfanyl, allyloxy, methoxy, ethoxy, propoxy, 4-methoxybutyloxy, 3-methoxypropoxy, 2-methoxyethoxy, 3-cyclopropyloxypropoxy, (2-methoxy-cyclopropyl)methoxymethyl, (2-methoxymethyl-cyclopropyl)methoxymethyl, 3-methylsulfanylpropoxy, methoxymethyl, 2-methoxyethoxymethyl, 3-methoxypropoxymethyl, 2-methyl-3-methylsulfanyl-prop
• R 3 is hydrogen
• R 4 is hydrogen
• X is a bond, methylene or oxygen
• Z is alkylene, —(CH 2 ) 1-2 —O— and —CH(CH 3 )—;
• n 1.
• the compounds of the formulae (I) and (II), or preferably of the formula (IA) or (IIA), and their pharmaceutically useable salts have inhibiting action on the natural enzyme renin.
• the latter passes from the kidneys into the blood and there brings about the cleavage of angiotensinogen to form the decapeptide angiotensin I which is then cleaved in the lung, the kidneys and other organs to the octapeptide angiotensin II.
• Angiotensin II increases the blood pressure both directly by arterial constriction and indirectly by the release of the hormone aldosterone which inhibits the release of the sodium ion from the adrenal glands, which is associated with a rise in the extracellular liquid volume.
• This rise can be attributed to the action of angiotensin II itself or of the heptapeptide angiotensin III formed therefrom as a cleavage product.
• Inhibitors of the enzymatic activity of renin bring about a reduction in the formation of angiotensin I and, as a consequence thereof, the formation of a smaller amount of angiotensin II.
• the reduced concentration of this active peptide hormone is the immediate cause of the hypotensive action of renin inhibitors.
• One experimental procedure of detecting the action of renin inhibitors is by means of in vitro tests, in which the reduction of the formation of angiotensin I in different systems (human plasma, purified human renin together with synthetic or natural renin substrate) is measured.
• the compounds of examples 10, 12, 21, 33, 40, 53, and 120 inhibit the formation of angiotensin I with IC 50 values in the range of about 10 ⁇ 5 to about 10 ⁇ 7 mol/l.
• renin inhibitors bring about a blood pressure decrease.
• Human renin differs from renin of other species.
• primates marmosets, Callithrixjacchus
• human renin and primate renin are substantially homologous in the enzymatically active region.
• One in vivo test which is used is as follows: the test compounds are tested on normotensive marmosets of both genders and having a body weight of about 350 g which are conscious, able to move freely and in their normal cages Blood pressure and heart rate are measured using a catheter in the descending aorta and recorded radiometrically.
• the endogenous release of renin is stimulated by the combination of a 1-week low-salt diet with a single intramuscular injection of furosemide (5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid). (5 mg/kg). 16 hours after the injection of furosemide, the test substances are administered either directly into the femoral artery by means of an injection cannular or into the stomach by gavage as a suspension or solution, and their effect on blood pressure and heart rate was evaluated.
• the compounds of the present invention effectively reduce blood pressure in the in vivo test described at doses of about 0.003 to about 0.3 mg/kg i.v. and at doses of about 0.3 to about 30 mg/kg p.o.
• the compounds of the formulae (I) or (II), or preferably of the formula (IA) or (IIA), and their pharmaceutically useable salts may find use as medicaments, for example in the form of pharmaceutical preparations.
• the pharmaceutical preparations may be administered enterally, such as orally, for example in the form of tablets, coated tablets, sugar-coated tablets, hard and soft gelatine capsules, solutions, emulsions or suspensions, nasally, for example in the form of nasal sprays, rectally, for example in the form of suppositories, or transdermally, for example in the form of ointments or patches.
• the administration may also be parenteral, such as intramuscular or intravenous, for example in the form of injection solutions.
• the compounds of the formulae (I) or (II), or preferably of the formula (IA) or (IIA), and pharmaceutically useable salts thereof may be processed with pharmaceutically inert, inorganic or organic excipients.
• excipients used for example for tablets, coated tablets and hard gelatine capsules, may be lactose, corn starch, or derivatives thereof, talc, stearic acid or salts thereof etc.
• Suitable excipients for soft gelatine capsules are, for example, vegetable oils, waxes, fats, semisolid and liquid polyols, etc.
• Suitable excipients for preparing solutions and syrups are, for example, water, polyols, sucrose, invert sugar, glucose, etc.
• Suitable excipients for injection solutions are, for example, water, alcohols, polyols, glycerol, vegetable oils, bile acids, lecithin, etc.
• Suitable excipients for suppositories are, for example, natural or hardened oils, waxes, fats, semisolid or liquid polyols, etc.
• the pharmaceutical preparations may additionally also comprise preservatives, solubilizers, viscosity-increasing substances, stabilizers, wetting agents, emulsifiers, sweeteners, colorants, flavourings, salts for altering the osmotic pressure, buffers, coatings or antioxidants. They may also comprise other therapeutically valuable substances.
• the present invention further provides the use of the compounds of the formulae (I) or (II), or preferably of the formula (IA) or (IIA), and the pharmaceutically useable salts thereof, in the treatment or prevention of hypertension and heart failure, and also glaucoma, cardiac infarction, kidney failure and restenoses of mammals, especially of human beings.
• the compounds of the formulae (I) or (II), or preferably of the formula (IA) or (IIA), and the pharmaceutically useable salts thereof, may also be administered in combination with one or more agents having cardiovascular action, for example ⁇ - and ⁇ -blockers such as phentolamine, phenoxybenzamine, prazosin, terazosin, tolazine, atenolol, metoprolol, nadolol, propranolol, timolol, carteolol etc.; vasodilators such as hydralazine, minoxidil, diazoxide, nitroprusside, flosequinan etc.; calcium antagonists such as amrinone, bencyclan, diltiazem, fendiline, flunarizine, nicardipine, nimodipine, perhexilene, verapamil, gallopamil, nifedipine etc.; ACE
• the dose may vary within wide limits and has of course to be adapted to the individual circumstances in each individual case.
• the reaction mixture is quenched by addition of 10 ml of methanol and concentrated under reduced pressure.
• the title compound is obtained from the residue by means of flash chromatography (SiO 2 60F).
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• reaction mixture is allowed to warm to 0° C., stirred for 30 minutes at this temperature and cooled to ⁇ 10° C., followed by the addition of 20 ml of a solution of diazomethane in diethyl ether (1.5%).
• the reaction mixture is allowed to warm to room temperature overnight, diluted with tert.-butyl methyl ether and the organic phase is washed with an aqueous solution of saturated sodium bicarbonate, dried over sodium sulfate and concentrated under reduced pressure to afford the title compound after flash chromatography (SiO 2 60F) as a yellow oil.
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• reaction mixture is stirred for 5 hours, diluted with tert-butyl methyl ether, washed with 1N hydrochloric acid and the organic phase is dried over sodium sulfate. The organic phase is concentrated under reduced pressure and the residue is purified by flash chromatography (SiO 2 60F) to afford the title compound as a slightly brown oil.
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• reaction mixture is worked up after 3 hours by quenching with 1N aqueous potassium bisulfate solution and extracting with tert-butyl methyl ether (3 ⁇ ). The combined organic layers are washed with brine, dried over sodium sulfate and concentrated under reduced pressure. The residue is purified by flash chromatography (SiO 2 60F) to afford the title compound as a turbid yellow oil.
• reaction mixture is worked up after 3.5 hours by quenching with solid magnesium sulfate to decompose any excess diazomethane, filtering and concentrating under reduced pressure to afford the crude title compound as a pale yellow solid with was used in the next step without any further purification.
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• methanesulfonic acid (R)-2-[(2R,4R,5R)-4-(4-methoxy-phenyl)-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl-piperidin-2-yl]-1-methyl-ethyl ester (from example 38b) is reacted with the sodium salt of pyrazole to afford the title compound as a colourless solid.
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• reaction mixture is diluted with 1M aqueous sodium bicarbonate (50 ml), extracted with tert-butyl methyl ether and the organic phase is separated and dried over sodium sulfate. The organic phase is concentrated under reduced pressure and the residue is purified by flash chromatography (SiO 2 60F) to afford the title compound as a colourless oil.
• the starting material is prepared as follows:
• the starting material is prepared as follows:
• a freshly prepared solution of diazomethane/diethylether (from Diazald®) is added dropwise to a solution of 0.201 g of 6-[(3R,4R,6S)-4-(4-methoxy-phenyl)-6-[(R)-2-(1H-tetrazol-5-yl)-butyl]-1-(toluene-4-sulfonyl)-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine (from example 64a) in 8 ml of methanol at 0° C.
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• the starting materials are prepared as follows:
• the starting material is prepared as follows:
• the starting materials are prepared as follows:
• reaction mixture is stirred for 2 hours, followed by the addition of 0.32 ml of triethylamine, 178 mg of 4-toluenesulfonyl chloride and 7 mg of 4-N-dimethylaminopyridine.
• the reaction mixture is heated to 50° C. for 4 hours and subsequently washed with 1N hydrochloric acid solution and extracted with dichloromethane. The organic phases are combined, dried and concentrated under reduced pressure. The residue is purified by flash chromatography (SiO 2 60 F) to afford the title compound as a yellow oil.

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