US20080294155A1 - Radiation Applicator and Method of Radiating Tissue - Google Patents

Radiation Applicator and Method of Radiating Tissue Download PDF

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Publication number
US20080294155A1
US20080294155A1 US12/158,831 US15883106A US2008294155A1 US 20080294155 A1 US20080294155 A1 US 20080294155A1 US 15883106 A US15883106 A US 15883106A US 2008294155 A1 US2008294155 A1 US 2008294155A1
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Prior art keywords
ferrule
applicator
sleeve
microwave applicator
inner conductor
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Abandoned
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US12/158,831
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English (en)
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Nigel Cronin
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Microsulis Ltd
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Microsulis Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/02—Radiation therapy using microwaves
    • A61N5/04—Radiators for near-field treatment
    • A61N5/045—Radiators for near-field treatment specially adapted for treatment inside the body
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00029—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids open
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A61B2018/00077—Electrical conductivity high, i.e. electrically conducting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A61B2018/00083—Electrical conductivity low, i.e. electrically insulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00172—Connectors and adapters therefor
    • A61B2018/00178—Electrical connectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/183—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves characterised by the type of antenna
    • A61B2018/1838—Dipole antennas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/1869—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument interstitially inserted into the body, e.g. needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/1892—Details of electrical isolations of the antenna

Definitions

  • the present invention relates generally to medical technology, and more specifically to microwave radiation applicators and methods of thermal ablative treatment of tissue using radiated microwaves.
  • Thermal ablative therapies may be defined as techniques that intentionally decrease body tissue temperature (hypothermia) or intentionally increase body tissue temperature (hyperthermia) to temperatures required for cytotoxic effect, or to other therapeutic temperatures depending on the particular treatment.
  • Microwave thermal ablation relies on the fact that microwaves form part of the electromagnetic spectrum causing heating due to the interaction between water molecules and the microwave radiation. The heat being used as the cytotoxic mechanism.
  • Treatment typically involves the introduction of an applicator into tissue, such as tumors. Microwaves are released from the applicator forming a field around its tip. Heating of the water molecules occurs in the radiated microwave field produced around the applicator, rather than by conduction from the probe itself. Heating is therefore not reliant on conduction through tissues, and cytotoxic temperature levels are reached rapidly.
  • Microwave thermal ablative techniques are useful in the treatment of tumors of the liver, brain, lung, bones, etc.
  • U.S. Pat. No. 4,494,539 discloses a surgical operation method using microwaves, characterized in that microwaves are radiated to tissue from a monopole type electrode attached to the tip of a coaxial cable for transmitting microwaves. Coagulation, hemostasis or transaction is then performed on the tissue through the use of the thermal energy generated from the reaction of the microwaves on the tissue. In this way, the tissue can be operated in an easy, safe and bloodless manner. Therefore, the method can be utilized for an operation on a parenchymatous organ having a great blood content or for coagulation or transaction on a parenchymatous tumor. According to the method, there can be performed an operation on liver cancer, which has been conventionally regarded as very difficult.
  • a microwave radiation applicator is also disclosed.
  • U.S. Pat. No. 6,325,796 discloses a microwave ablation assembly and method, including a relatively thin, elongated probe having a proximal access end, and an opposite distal penetration end adapted to penetrate into tissue.
  • the probe defines an insert passage extending therethrough from the access end to the penetration end thereof.
  • An ablation catheter includes a coaxial transmission line with an antenna device coupled to a distal end of the transmission line for generating an electric field sufficiently strong enough to cause tissue ablation.
  • the coaxial transmission line includes an inner conductor and an outer conductor separated by a dielectric material. A proximal end of the transmission line is coupled to a microwave energy source.
  • the antenna device and the transmission line each have a transverse cross-sectional dimension adapted for sliding receipt through the insert passage while the elongated probe is positioned in the tissue. Such sliding advancement continues until the antenna device is moved to a position beyond the penetration end and further into direct contact with the tissue.
  • a drawback with the existing techniques include the fact that they are not optimally mechanically configured for insertion into, and perforation of, the human skin, for delivery to a zone of soft tissue to be treated.
  • known radiation applicator systems do not have the heightened physical rigidity that is desirable when employing such techniques.
  • some radiation applicators made available heretofore do not have radiation emitting elements for creating a microwave field pattern optimized for the treatment of soft tissue tumors.
  • a dipole microwave applicator for emitting microwave radiation into tissue, the assembly comprising: an outer conductor having an end; an inner conductor disposed within the outer conductor, and including a section that extends outwardly beyond the end of the outer conductor; a ferrule disposed at the end of the outer conductor, and having a sleeve portion that surrounds a portion of the outwardly extending section of the inner conductor; and a dielectric tip surrounding the sleeve portion of the ferrule and the outwardly extending section of the inner conductor, whereby the sleeve portion of the ferrule and at least a portion of the outwardly extending section of the inner conductor operate as corresponding arms of the dipole microwave applicator.
  • the present invention is directed to a microwave applicator for ablating tissue.
  • the applicator is a dipole microwave antenna that transmits microwave radiation into the tissue being treated.
  • the applicator is formed from a thin coaxial cable having an inner conductor surrounded by an insulator, which is surrounded by an outer conductor or shield. The end of the coaxial cable is trimmed so that a portion of the insulator and inner conductor extend beyond the outer conductor, and a portion of the inner conductor extends beyond the insulator.
  • the applicator further includes a tubular ferrule defining an aperture therethrough.
  • One end of the ferrule is attached to the outer conductor, while the other end, which forms a sleeve, extends out beyond the end of the insulator and around a portion of the extended inner conductor.
  • a step is preferably formed on the outer surface of the ferrule between its two ends.
  • a solid spacer having a central bore to receive the inner conductor abuts an end of the ferrule and surrounds the extended inner conductor.
  • a tuning element is attached to the end of the extended inner conductor, and abuts an end of the spacer opposite the ferrule. The tuning element faces the step in the ferrule, and the step and the tuning element are both sized and shaped to cooperate in balancing and tuning the applicator.
  • a hollow tip formed from a dielectric material, has an open end and a closed end.
  • the tip encloses the tuning element, the spacer, and the extended inner conductor.
  • the tip also encloses the sleeve of the ferrule, thus defining outer surface of the ferrule that is surrounded by the dielectric tip.
  • the open end of the tip preferably abuts the step in the ferrule.
  • a rigid sleeve surrounds the coaxial cable and extends away from the ferrule opposite the tip.
  • the sleeve, which abuts the step of the ferrule opposite the tip has an inner diameter that is larger than the coaxial cable, thereby defining an annular space between the outside of the coaxial cable and the inner surface of the sleeve.
  • the sleeve further includes one or more drainage holes, which permit fluid communication between the annular space around the coaxial cable and the outside of the applicator.
  • microwave energy from a source is applied to the coaxial cable, and is conveyed to the tip.
  • the portion of the inner conductor that extends beyond the end of the ferrule forms one arm of the dipole, and emits microwave radiation.
  • the microwave energy flowing along the inner conductor of the coaxial cable and in the aperture of the ferrule induces a current to flow along the outer surface of the sleeve of the ferrule that is surrounded by the tip.
  • This causes microwave radiation to be emitted from the sleeve of the ferrule, which operates as the second arm of the dipole.
  • microwave energy is emitted along a substantial length of the applicator, rather than being focused solely from the tip.
  • a cooling fluid is introduced from a source into the annular space defined by the outside of the coaxial cable and the inside of the sleeve.
  • the cooling fluid flows along this annular space, and absorbs heat from the coaxial cable.
  • the cooling fluid after having absorbed heat from the coaxial cable, then exits the annular space through the one or more drainage holes in the sleeve, and perfuses adjacent tissue.
  • the closed end of the tip is preferably formed into a blade or point so that the Microwave applicator may be inserted directly into the tissue being treated.
  • the tip, ferrule, and rigid sleeve moreover, provide strength and stiffness to the applicator, thereby facilitating its insertion into tissue.
  • the present invention further provides a method of treating target tissue, such as a tumor, the tumor being formed of, and/or being embedded within, soft tissue.
  • the method includes inserting the microwave applicator into the tumor, and supplying electromagnetic energy to the applicator, thereby radiating electromagnetic energy into the tumor.
  • FIG. 1 is a schematic, partial cross-sectional view of a radiation applicator in accordance with one embodiment of the invention
  • FIG. 2A shows an axial cross-section
  • FIG. 2B shows an end elevation of the radiating tip of the radiation applicator of FIG. 1 ;
  • FIG. 3 shows a partial transverse cross-section of the tube of the radiation applicator of FIG. 1 ;
  • FIG. 4A shows a transverse cross-section
  • FIG. 4B shows an axial cross-section of the tuning washer of the radiation applicator of FIG. 1 ;
  • FIG. 5A shows an axial cross-section
  • FIG. 5B shows an end elevation of the ferrule of the radiation applicator of FIG. 1 ;
  • FIG. 6A shows an axial cross-section
  • FIG. 6B shows a transverse cross-section of a handle section that may be attached to the radiation applicator of FIG. 1 ;
  • FIG. 7 illustrates the portion of coaxial cable that passes through the tube of the radiation applicator of FIG. 1 ;
  • FIG. 8 is a plot of S 11 against frequency for the radiation applicator of FIG. 1 ;
  • FIG. 9A illustrates the E-field distribution
  • FIG. 9B illustrates the SAR values around the radiation applicator of FIG. 1 , in use;
  • FIGS. 10A-E show a preferred sequential assembly of the radiation applicator of FIG. 1 ;
  • FIG. 11 schematically illustrates a treatment system employing the radiation applicator of FIG. 1 ;
  • FIG. 12 is an exploded, perspective view of another embodiment of the present invention.
  • FIGS. 13-18 show a preferred sequential assembly of the radiation applicator of FIG. 12 ;
  • FIG. 19 is a schematic, partial cross-sectional view of the radiation applicator of FIG. 12 .
  • FIG. 1 is a schematic, partial cross-sectional view of a radiation applicator in accordance with one embodiment of the invention.
  • the radiation applicator generally designated 102 , includes a distal end portion of a coaxial cable 104 that is used to couple to a source (not shown) of microwaves, a copper ferrule 106 , a tuning washer 108 attached on the end 110 of the insulator part of the coaxial cable 104 , and a tip 112 .
  • the applicator 102 further includes a metal tube 114 . Tube 114 is rigidly attached to the ferrule 106 .
  • An annular space 116 is defined between the outer conductor 118 of the cable 104 and the inner surface of the tube 114 , enabling cooling fluid to enter (in the direction of arrows A), contact the heated parts of the applicator 102 and exit in the direction of arrows B through radial holes 120 in the tube 114 , thereby extracting heat energy from the radiation applicator 102 .
  • the washer 108 is soldered to a small length 122 of the central conductor 124 of the cable 104 that extends beyond the end 110 of the insulator 126 of the cable 104 .
  • the ferrule 106 is soldered to a small cylindrical section 128 of the outer conductor 118 of the cable 104 .
  • the tube 114 which is preferably stainless steel, but may be made of other suitable materials, such as titanium or any other medical grade material, is glued to the ferrule 106 by means of an adhesive, such as Loctite 638 retaining compound, at the contacting surfaces thereof, indicated at 130 and 132 .
  • the tip 112 is also glued preferably, using the same adhesive, on the inner surfaces thereof, to corresponding outer surfaces of the ferrule 106 and the insulation 126 .
  • the applicator 102 When assembled, the applicator 102 forms a unitary device that is rigid and stable along its length, which may be of the order of 250 or so millimeters including tube 114 , thereby making the applicator 102 suitable for insertion into various types of soft tissue.
  • the space 116 and holes 120 enable cooling fluid to extract heat from the applicator 102 through contact with the ferrule 106 , the outer conductor 118 of the cable 104 and the end of the tube 114 .
  • the ferrule 106 assists, among other things, in assuring the applicator's rigidity.
  • the exposed end section 134 of cable 104 from which the outer conductor 118 has been removed, in conjunction with the dielectric tip 112 are fed by a source of radiation of predetermined frequency.
  • the exposed end section 134 and dielectric tip 112 operate as a radiating antenna for radiating microwaves into tissue for therapeutic treatment.
  • the applicator 102 operates as a dipole antenna, rather than a monopole device, resulting in an emitted radiation pattern that is highly beneficial for the treatment of certain tissues, such as malignant or tumorous tissue, due to its distributed, spherical directly heated area.
  • FIG. 2A shows an axial cross-section
  • FIG. 2B shows an end elevation of the tip 112 of the radiation applicator 102 of FIG. 1
  • the tip 112 has inner cylindrical walls 202 , 204 , and abutting walls 206 , 208 , for receiving and abutting the washer 108 and the ferrule 106 , respectively, during assembly.
  • the tip 112 is made of zirconia ceramic alloy. More preferably, it is a partially stabilized zirconia (PSZ) having yttria as the stabilizing oxidizing agent. Even more preferably, the tip 112 is made of Technox 2000, which is a PSZ commercially available from Dynamic Cerarnic Ltd.
  • the transverse dimensions of the applicator 102 are relatively small.
  • the diameter of applicator 102 is preferably less than or equal to about 2.4 mm.
  • the tip 112 is designed to have dimensions, and be formed of the specified material, so as to perform effective tissue ablation at the operating microwave frequency, which in this case is preferably 2.45 Gigahertz (GHz).
  • the applicator 102 of the present invention is thus well adapted for insertion into, and treatment of, cancerous and/or non-cancerous tissue of the liver, brain, lung, veins, bone, etc.
  • the tip 112 is preferably coated with a non-stick layer such as silicone or paralene, to facilitate movement of the tip 112 relative to tissue.
  • a non-stick layer such as silicone or paralene
  • FIG. 3 shows a partial transverse cross-section of the tube 114 .
  • the tube 114 is preferably made of stainless steel.
  • the tube 114 is preferably made from 13 gauge thin wall 304 welded hard drawn (WHD) stainless steel.
  • the tube 114 is also approximately 215 mm in length.
  • two sets of radial holes 120 , 120 ′ are provided at 12 mm and 13 mm, respectively, from the end 302 of the tube 114 .
  • These radial holes 120 , 120 ′ permit the exit of cooling fluid.
  • two sets of holes are shown, one, three, four or more sets of holes may be provided, in variants of the illustrated embodiment.
  • the holes 120 , 120 ′ are of 0.5 mm diameter, but it will be appreciated that this diameter may be quite different, e.g. any thing in the range of approximately 0.1 to 0.6 mm, depending on the number of sets of holes and/or the number of holes per set, in order to provide an effective flow rate.
  • the illustrated distance from the end 302 is 12 or 13 mm, in alternative embodiments, this distance may range from 3 mm to 50 mm from the end 302 , in order to control the length of track that requires cauterization.
  • the tube 114 may be omitted.
  • the treatment may comprise delivering the applicator to the treatment location, e.g., to the tumorous tissue, by suitable surgical or other techniques.
  • the applicator may be left in place inside the tumor, the access wound closed, and a sterile connector left at the skull surface for subsequent connection to the microwave source for follow-up treatment at a later date.
  • FIG. 5A shows an axial cross-section
  • FIG. 5B shows an end elevation of the ferrule 106 .
  • the ferrule 106 is preferably made of copper, and is preferably gold plated to protect against any corrosive effects of the cooling fluid.
  • the ferrule 106 may be produced by conventional machining techniques, such as CNC machining.
  • FIG. 6A shows an axial cross-section
  • FIG. 6B shows a transverse cross-section at line B-B of a handle section 602 that may be attached to the tube 114 of the radiation applicator 102 .
  • the handle section 602 is preferably made from the same material as the tube 114 , i.e., stainless steel.
  • the handle section 602 includes a forward channel 604 enabling insertion of the tube 114 , and a rear channel 606 enabling insertion of the coaxial cable 104 during assembly.
  • a transverse port 608 having an internal thread 610 enables the connection, through a connector, to a source of cooling fluid, discussed later.
  • the connector may be formed from plastic.
  • FIG. 7 illustrates the portion of coaxial cable 104 that passes through the tube 114 .
  • the cable 104 suitably comprises a low-loss, coaxial cable such as SJS070LL-253-Strip cable.
  • a connector 702 preferably a SMA female type connector permits connection of the cable 104 to a microwave source (not shown), or to an intermediate section of coaxial cable (not shown) that, in turn, connects to the microwave source.
  • the tube 114 is then slid over the cable 104 .
  • the ferrule 106 is slid over the cable 104 ( FIG. 10C ), and fixedly attached to the tube 114 and to the cable 104 , as described earlier.
  • the washer 108 is attached to the inner conductor 124 by soldering, as shown in FIG. 1D .
  • the tip 112 is slid over the cable 104 and part of the ferrule 106 , and affixed thereto, as described earlier.
  • the completed applicator is shown in FIG. 10E . This results in a construction of great rigidity and mechanical stability.
  • radiation applicator 102 is a dipole antenna.
  • the portion of the inner conductor 124 that extends beyond the ferrule 106 operates as one arm of the dipole antenna.
  • the transmission of microwave energy along the inner conductor 124 and in the aperture of the ferrule induces a current to flow on that portion of the outer surface of the ferrule 106 that is located underneath the tip 112 .
  • This induced current causes this enclosed, outer surface of the ferrule 106 to emit microwave radiation, thereby forming a second arm of the dipole antenna.
  • the bipolar configuration of the applicator effectively spreads the microwave radiation that is being transmitted by the applicator 102 along a greater transverse, i.e., axial, length of the antenna 102 , rather than focusing the radiation transmission solely from the tip 112 of the applicator 102 .
  • the applicator 102 of the present invention may be operated at much higher power levels, e.g., up to approximately 80 Watts, than prior art designs.
  • FIG. 12 is an exploded, perspective view of an alternative radiation applicator 1202 .
  • the applicator 1202 includes a coaxial cable 1204 having an outer conductor 1206 that surrounds an insulator 1208 that, in turn, surrounds an inner or central conductor 1210 .
  • the applicator 1202 further includes a ferrule 1212 .
  • the ferrule 1212 is generally tubular shaped so as to define an aperture therethrough, and has first and second ends 1212 a , 1212 b .
  • the ferrule 1212 also has three parts or sections.
  • the closed end 1232 may be formed into a cutting element, such as a trocar point or a blade, to cut or pierce tissue.
  • Applicator 1202 also includes a rigid sleeve 1234 .
  • the sleeve 1234 has an inner diameter that is slightly larger than outer diameter of the coaxial cable 1204 . As described below, an annular space is thereby defined between the outer surface of the coaxial cable 1204 and the inner surface of the sleeve 1234 .
  • the sleeve 1234 further includes one or more drainage holes 1236 that extend through the sleeve.
  • FIGS. 13-18 illustrate a preferred assembly sequence of the applicator 1202 .
  • the coaxial cable 1204 is trimmed so that there is a length “m” of insulator 1208 that extends beyond an end 1206 a of the outer conductor 1206 , and a length “l” of inner conductor 1210 that extends beyond an end 1208 a of the insulator 1208 .
  • the ferrule 1212 slides over the exposed inner conductor 1210 and over the exposed insulator 1208 such that the first section 1214 surrounds the outer conductor 1206 , and the second and third sections 1216 , 1218 surround the exposed portion of the insulator 1208 .
  • the spacer 1220 is slid over the exposed portion of the inner conductor 1210 , and is brought into contact with the second end 1212 b of the ferrule 1212 .
  • the spacer 1220 is not fixedly attached to the ferrule 1212 or the inner conductor 1210 .
  • the spacer 1220 is sized so that a small portion 1210 a ( FIG. 15 ) of the inner conductor 1210 remains exposed.
  • the tuning element 1224 is then slid over this remaining exposed portion 1210 a of the inner conductor 1210 .
  • the tuning element 1224 is preferably fixedly attached to the inner conductor 1210 , e.g., by soldering. The tuning element 1224 , in cooperation with the ferrule 1212 , thus hold the spacer 1220 in place.
  • the sleeve 1234 is slid over the coaxial cable 1234 , and up over the first section 1214 of the ferrule 1212 .
  • the sleeve 1234 abuts the step 1216 in the ferrule 1212 opposite the tip 1226 .
  • the tip 1226 , second section 1216 of the ferrule 1212 , and sleeve 1234 all preferably have the same outer diameter, thereby giving the applicator 1202 a smooth outer surface.
  • FIG. 19 is a schematic, partial cross-sectional view of the radiation applicator 1202 .
  • the insulator 1208 extends partially through the inside of the ferrule 1212 .
  • the end 1208 a of the insulator 1208 is disposed a predetermined distance back from the second end 1212 b of the ferrule 1212 .
  • the inner conductor 1210 extends completely through and beyond the ferrule 1212 .
  • the sleeve 1234 slides over and is bonded to the first section 1214 of the ferrule 1212 .
  • the inside diameter of the sleeve 1234 is greater than the outside diameter of the coaxial cable 1204 , thereby defining an annular space 1238 between the outside of the coaxial cable 1204 and the inside of the sleeve 1234 .
  • Cooling fluid such as saline
  • the cooling fluid absorbs heat from the coaxial cable that feeds radiation to applicator 1202 .
  • the cooling fluid is then discharged through holes 1236 in the sleeve 1234 , as shown by arrows B.
  • the holes 1236 are placed far enough behind the closed end 1232 of the tip 1226 such that the discharged cooling fluid does not enter that portion of the tissue that is being heated by the radiation applicator 1202 . Instead, the discharged cooling fluid preferably perfuses tissue outside of this heated region. Depending on the tissue to be treated, a suitable distance between the closed end 1232 of the tip 1226 and the holes 1236 may be approximately 30 mm.
  • a first end 1220 a of the spacer 1220 abuts the second end 1212 b of the ferrule 1212 , while a second end 1220 b of the spacer 1220 abuts the tuning element 1224 .
  • a space designated generally 1240 , is defined within the ferrule 1212 between the end 1208 a of the insulator and the second end 1212 b of the ferrule.
  • this space 1240 is filled with air.
  • the space may be filled with other materials, such as a solid dielectric, or it may be evacuated to form a vacuum.
  • the inside surface of the tip 1226 preferably conforms to the shape of the tuning element 1224 , the spacer 1220 , and the third section 1218 of the ferrule 1212 so that there are no gaps formed along the inside surface of the tip 1226 .
  • operation of the radiation applicator 1202 causes a current to be induced on the outer surface of the third section 1218 of the ferrule 1212 , which is enclosed within the dielectric material of the tip 1226 .
  • This induced current results in microwave energy being radiated from this surface of the ferrule 1212 , thereby forming one arm of the dipole.
  • the section of the inner conductor 1210 that extends beyond the ferrule 1212 is the other arm of the dipole.
  • Both the length of the inner conductor 1210 that extends beyond the ferrule 1212 , and the length of the third section 1218 of the ferrule 1212 , which together correspond to the two arms of the dipole, are chosen to be approximately 1 ⁇ 4 of the wavelength in the dielectric tip 1226 , which in the illustrative embodiment is approximately 6 mm. Nonetheless, those skilled in the art will understand that other factors, such as tissue permittivity, the action of the tuning element, etc., will affect the ultimate lengths of the dipole arms. For example, in the illustrative embodiment, the two arms are approximately 5 mm in length.
  • the tuning element 1224 moreover, cooperates with the second section or step 1216 of the ferrule to balance the radiation being emitted by the two arms of the dipole.
  • the size and shape of the tuning element 1224 and the step 1216 are selected such that the coherent sum of the microwave power reflected back toward the cable at the aperture of the ferrule is minimized. Techniques for performing such design optimizations are well-known to those skilled in the relevant art.
  • the radiation applicator 1202 is attached to a source of microwave radiation in a similar manner as described above in connection with the applicator 102 of FIG. 1 .
  • the coaxial cable is also attached to a source of cooling fluid in a similar manner as described above.
  • the present invention it is the dielectric tip, ferrule and stainless steel sleeve that cooperate to provide the necessary stiffness and mechanical strength for the applicator to be used in treatment procedures.
  • the applicator does not rely on the coaxial cable for any of its strength. Indeed, a flexible coaxial cable, having little or no rigidity, could be used with the radiation applicator of the present invention.

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US12/158,831 2006-01-03 2006-12-15 Radiation Applicator and Method of Radiating Tissue Abandoned US20080294155A1 (en)

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GB0600018A GB2434314B (en) 2006-01-03 2006-01-03 Microwave applicator with dipole antenna
PCT/EP2006/012144 WO2007076924A2 (en) 2006-01-03 2006-12-15 Radiation applicator and method of radiating tissue

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AU2006332213A1 (en) 2007-07-12
KR20080092402A (ko) 2008-10-15
WO2007076924A3 (en) 2007-08-30
CN101631506B (zh) 2011-12-28
EP1968469A2 (en) 2008-09-17
GB0600018D0 (en) 2006-02-08
CN101631506A (zh) 2010-01-20
JP2009521967A (ja) 2009-06-11
AU2006332213B2 (en) 2013-01-10
GB2434314B (en) 2011-06-15
GB2434314A (en) 2007-07-25
TW200740407A (en) 2007-11-01
US9907613B2 (en) 2018-03-06
WO2007076924A2 (en) 2007-07-12
BRPI0620875A2 (pt) 2011-11-29
US20070203551A1 (en) 2007-08-30
JP5318581B2 (ja) 2013-10-16
EP1968469B8 (en) 2017-01-11
CA2635316A1 (en) 2007-07-12
US20160262832A1 (en) 2016-09-15
IL192469A0 (en) 2009-02-11
EP1968469B1 (en) 2016-11-02

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