US20050154353A1 - Positive displacement flush syringe - Google Patents

Positive displacement flush syringe Download PDF

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Publication number
US20050154353A1
US20050154353A1 US10/754,870 US75487004A US2005154353A1 US 20050154353 A1 US20050154353 A1 US 20050154353A1 US 75487004 A US75487004 A US 75487004A US 2005154353 A1 US2005154353 A1 US 2005154353A1
Authority
US
United States
Prior art keywords
stopper
plunger
barrel
distal
detent position
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/754,870
Other languages
English (en)
Inventor
Thomas Alheidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Priority to US10/754,870 priority Critical patent/US20050154353A1/en
Priority to ES18158817T priority patent/ES2809398T3/es
Priority to EP04815300.1A priority patent/EP1703930B1/en
Priority to JP2006549315A priority patent/JP4794463B2/ja
Priority to ES04815300.1T priority patent/ES2671333T3/es
Priority to BRPI0418352A priority patent/BRPI0418352B8/pt
Priority to PCT/US2004/043203 priority patent/WO2005070484A1/en
Priority to EP18158817.9A priority patent/EP3345640B1/en
Assigned to BECTON, DICKINSON AND COMPANY reassignment BECTON, DICKINSON AND COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ADAM-ALHEIDT, THOMAS
Publication of US20050154353A1 publication Critical patent/US20050154353A1/en
Priority to US11/862,257 priority patent/US20080021414A1/en
Priority to US12/166,632 priority patent/US8574202B2/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features
    • A61M2005/1403—Flushing or purging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
    • A61M2005/31506—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit formed as a single piece, e.g. moulded
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31516—Piston or piston-rod constructions, e.g. connection of piston with piston-rod reducing dead-space in the syringe barrel after delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31523—Piston or piston-rod constructions, e.g. connection of piston with piston-rod for reducing reflux
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3135—Syringe barrels characterised by constructional features of the proximal end

Definitions

  • the I.V. line refers to the system containing a VAD, tubing set with clamp and may terminate with a port or valve.
  • the most common types of I.V. ports are covered by pierceable septums or pre-slit septums and are known in the art and sometimes referred to as “PRN” from the Latin pro re nata meaning “as the need arises”.
  • the septum is preferably made of rubber or another elastomeric material, which permits insertion of a sharp needle cannula in order to infuse fluids or to withdraw fluids from the catheter. Upon withdrawal of the needle cannula the septum seals itself.
  • the positive displacement valves were not designed to compensate for the worst-case syringe stopper induced reflux.
  • the stopper When using a traditional syringe assembly containing an elastomeric stopper, the stopper is often compressed when it contacts the distal end of the syringe barrel at the completion of the flush procedure. If the user releases the pressure on the plunger after the flush solutions is delivered, the compressed stopper may expand back to its normal size drawing fluid back into the catheter. This fluid is referred to as syringe stopper induced reflux.
  • Traditional syringe assemblies were designed to accurately deliver medications. Traditional syringe assemblies supplied by various suppliers may appear similar but can vary significantly in terms of performance especially stopper induced reflux. Because the catheter is inserted into the patient the users cannot see the reflux when it occurs and therefore cannot take corrective actions to address a potential problem.
  • the present invention is directed to a syringe assembly for use in flush applications.
  • the syringe assembly has structure to provide an additional positive displacement of flush solution after the flush solution has been substantially delivered from the cavity in the syringe barrel through the application of an additional distally-directed force to the plunger.
  • Structure for positively displacing additional fluid after the stopper has contacted the distal wall of the barrel comprises the stopper including a distal end having a distal surface and a proximal end having a cavity therein defining an inside surface.
  • the distal end of the plunger is connected to the stopper by a complementary detent structure defining a first detent position and a second detent position.
  • the stopper may include a conically-shaped distal surface and a complementary conically-shaped inside surface of the barrel distal wall wherein the total included angle of the inside surface of the barrel at the distal wall is preferably greater than the total included angle of the stopper distal surface.
  • the stopper may include a distally-directed projection on the distal end of the stopper shaped to fit in the passageway when the plunger and the stopper are engaged in the second detent position.
  • the inside surface of the stopper may include a proximally-directed protuberance configured to contact the distal tip of the plunger when the plunger and the stopper are engaged in the second detent position.
  • the syringe assembly may be configured so that the inside surface of the stopper includes a first discontinuity, and a second discontinuity located distally from the first discontinuity.
  • the distal end of the plunger includes a discontinuity positioned so that when the stopper and the plunger are in the first detent position the plunger discontinuity engages the first discontinuity in the stopper, and when the stopper and the plunger are in the second detent position, the plunger discontinuity engages the second discontinuity in the stopper.
  • the discontinuity on the plunger may be a raised projection and the raised projection may be shaped like an annular ring or flange.
  • the first discontinuity in the stopper may be a recess for containing the discontinuity on the plunger such as an annular recess.
  • the first discontinuity may also be an inwardly directed projection and the plunger discontinuity a recess for accepting the projection.
  • the syringe assembly may further include a needle assembly including a cannula having a proximal end, a distal end, and a lumen therethrough.
  • a hub having an open proximal end containing a cavity and a distal end attached to the proximal end of the cannula so that the lumen is in fluid communication with the cavity of the hub.
  • the needle assembly is removably attached to the tip of the barrel through engagement of the tip to the cavity of the hub so that the lumen is in fluid communication with the chamber of the barrel.
  • the syringe assembly may further include a spring between the distal tip of the plunger and the distal end of the plunger.
  • the spring is configured to compress when the plunger moves to the second detent position with respect to the stopper.
  • the syringe assembly may also include the barrel and plunger having complementary detent structures defining a primary detent position and a secondary detent position to hold the position of the plunger relative to the barrel.
  • the primary detent position being positioned to engage when fluid has been delivered from the chamber and the stopper is in contact with the distal wall.
  • the secondary detent position is configured to engage upon application of an additional distally directed force to the plunger after the stopper has made contact with the distal wall.
  • the complementary detent structure between the barrel and the plunger can include the barrel having a first discontinuity and a second discontinuity located distally from the first discontinuity, and a proximal end of the plunger including a discontinuity positioned so that when the plunger and the barrel are in the primary detent position the plunger discontinuity engages the first barrel discontinuity and when the plunger and the barrel are in the secondary detent position the proximal plunger discontinuity engages the secondary barrel discontinuity.
  • FIG. 1 is a perspective view of a syringe assembly of the present invention.
  • FIG. 3 is an enlarged partial cross-sectional side elevation view of the distal end of the syringe assembly of FIG. 2 .
  • FIG. 4 is an enlarged partial cross-sectional side elevational view of the distal end of the syringe assembly shown at the completion of flush solution delivery.
  • FIG. 6 is a side-elevational view illustrating the syringe assembly in use with a catheter injection site.
  • FIG. 8 is a partially cross-sectioned side-elevational view of an alternative syringe assembly of the present invention.
  • FIG. 13 is an enlarged partial cross-sectional side-elevational view of the syringe assembly of FIG. 12 shown after completion of the flush solution delivery and after application of an additional distally directed force to the plunger.
  • a cannula 43 includes a proximal end 44 , a distal end 45 and a lumen 46 therethrough.
  • the distal end of the cannula may include a sharp tip or a blunt tip 47 as shown.
  • the cannula may be connected directly to the tip of the syringe barrel to establish fluid communication between the lumen and the chamber.
  • the cannula may be part of a needle assembly 42 including a hub 49 having an open proximal end 50 containing a cavity 51 and a distal end 52 attached to the proximal end of the cannula so that lumen of the cannula is in fluid communication with the cavity.
  • the cavity of the hub can be removably frictionally engaged to the tip of the barrel.
  • the stopper further includes a distal end 61 having a conically shaped distal surface 62 thereon.
  • Conically-shaped distal surface 62 has a total included angle B as illustrated in FIG. 4 .
  • total included angle A of the inside surface of the barrel at the distal wall is preferably greater than the total included angle B of the conically-shaped distal surface of the stopper in this embodiment.
  • the structure for moving fluid distally in the passageway after fluid has been delivered from the chamber includes the stopper being connected to the plunger by a complementary detent structure defining a first detent position and a second detent position.
  • the detent structure is configured so that a distally directed force F applied to the plunger after fluid has been delivered from the chamber causes the plunger to move distally with respect to the stopper from the first detent position to the second detent position so that a distal tip 55 on the distal end of the plunger contacts inside surface 60 of the stopper forcing part of the distal end of the stopper into passageway 32 to move fluid distally in the passageway.
  • the distal end of the stopper is preferably shaped to include a distally directed projection 63 on the distal end of the stopper to fit in passageway 32 when the plunger and the stopper are engaged in the second detent position as best illustrated in FIG. 5 .
  • the inside surface of the stopper preferably includes a proximally direct protuberance 64 configured to contact distal tip 55 of the plunger when the plunger and the stopper are engaged in the second detent position.
  • the inside surface of the stopper includes a first discontinuity and a second discontinuity located distally from the first discontinuity.
  • the distal end of the plunger includes a discontinuity position so that when the stopper and the plunger are in the first detent position the plunger discontinuity engages the first discontinuity in the stopper and when the stopper and the plunger are in the second detent position, the plunger discontinuity engages the second discontinuity in the stopper.
  • the discontinuity at the distal end of the plunger is at least one raised projection.
  • the at least one raised projection is two raised projections configured in the shape of annular rings 70 .
  • the first discontinuity in the stopper is preferably at least one recess for containing the raised projection on the distal end of the plunger.
  • the at least one recess includes two recesses which are annularly-shaped recesses 65 .
  • the second discontinuity in the stopper is preferably at least one recess and in this case includes two annularly-shaped recesses 67 .
  • the stopper may be made of any material suitable for providing sealing characteristics while under compression.
  • the stopper may be made of thermoplastic elastomers, natural rubber, synthetic rubber or thermoplastic materials and combinations thereof.
  • the plunger in this embodiment is preferably made of material which is more rigid than the stopper such as polypropylene, polyethylene and the like.
  • syringe assembly 20 is connected to a needle assembly and filled with flush solution using known methods.
  • the flush solution may be any solution intended for flushing or maintaining the performance of VAD's. It is preferred that the flush solution be selected from the group consisting of saline flush solution and heparin lock flush solution. These solutions are known in the art and readily available.
  • An example of a saline flush solution is 0.9% Sodium Chloride USP for injection.
  • An example of a heparin lock flush solution is 0.9% Sodium Chloride with 100 USP units of Heparin Sodium per ml or 10 USP units of Heparin Sodium per ml.
  • the syringe with needle assembly attached is used to pierce the pierceable septum or a blunt cannula may be inserted into a pre-split septum of a vial or the neck of a glass ampule containing flush solution, and the flush solution is drawn into the syringe barrel by pulling plunger flange 56 in the proximal direction while holding barrel 21 , to draw fluid through the needle cannula into fluid chamber 25 .
  • flush syringes may be pre-filled with flush solution during the manufacturing of the syringe using sterile filling methods.
  • Such prefilled syringes may be supplied with a tip cap, such as tip cap 36 releasably connected to tip 31 sealing passageway 32 .
  • the tip cap is formed of material selected from a group of thermoplastic materials and elastomeric materials such as natural and synthetic rubber, thermoplastic elastomers, or combinations thereof.
  • I.V. set 73 comprises an I.V. site 74 which includes a housing 75 having a hollow interior 76 and a septum 77 at its proximal end.
  • An I.V. line 79 having a conduit therethrough extends from the distal end of the housing.
  • the I.V. site may be a valve having structure for accepting the syringe barrel tip and being activated by the insertion of the tip to establish fluid communication with the catheter, such as the valve taught in U.S. Pat. No. 6,171,287.
  • Blunt tip 47 of cannula 43 may be inserted through pre-split septum 77 of I.V. set 73 .
  • a sharp tip of a needle cannula may be used to pierce a septum that is not pre-split, or the tip of the barrel may be engaged with a valve in the IV site.
  • This establishes fluid communication between the interior 76 of the I.V. set and the chamber of the syringe barrel.
  • the syringe barrel 21 is preferably held via finger grips 53 . Pressure is then applied to flange 56 of the plunger, for example by a thumb, in the distal direction. This moves plunger 37 having the stopper 41 on its distal end forcing the liquid such as flush solution 71 in chamber 25 out of the chamber, through cannula 43 and into interior 76 of the I.V. set and then through I.V. line 79 .
  • the positive displacement of fluid in the passageway in a distal direction will help prevent reflux while the I.V. line is being clamped and the syringe is being removed. After the I.V. line is clamped, the empty syringe assembly may be removed from the I.V. set.
  • FIG. 7 shows an alternative simplified I.V. set to illustrate a flush procedure without a needle assembly.
  • I.V. set 173 comprises an I.V. site 174 which includes a housing 175 having a hollow interior 176 and a luer fitting 178 at its proximal end.
  • An I.V. line 1 79 having a conduit therethrough extends from the distal end of the housing.
  • T he example illustrated in FIG. 7 is simplified to demonstrate the invention. In most cases a luer fitting such as luer fitting 178 would be part of a one-way valve in the I.V. set. The elongate tip of the barrel is inserted and engaged with the luer fitting to establish fluid communication between interior 176 of the I.V.
  • a detent structure is configured so that a directed force F applied to the plunger after fluid has been delivered from the chamber causes the plunger to move distally with respect to the stopper from the first detent position to the second detent position so that a distal tip 155 on the distal end of the plunger contacts the inside surface of the stopper forcing part of the distal end of the stopper into the passageway to move fluid distally in the passageway.
  • spring 180 is positioned between distal tip 155 and the distal end of the plunger rod. The spring is configured to compress when the plunger moves to the second detent position with respect to the stopper.
  • the harder metal will enhance the grip of the sharp ends of the projections to resist proximal motion of the plunger with respect to the barrel.
  • the flexible element may be circularly shaped like a flexible flange so that the sharp edge can go up to 360 degrees around the plunger.
  • one or more projections may radiate from the proximal end of the stopper so long as the net result is the restraint of the motion of the plunger with respect to the barrel. Discontinuities such as recesses and/or projections may also be placed in the barrel to enhance the function of the radial projections.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US10/754,870 2004-01-09 2004-01-09 Positive displacement flush syringe Abandoned US20050154353A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US10/754,870 US20050154353A1 (en) 2004-01-09 2004-01-09 Positive displacement flush syringe
BRPI0418352A BRPI0418352B8 (pt) 2004-01-09 2004-12-21 conjunto de seringa de lavagem
EP04815300.1A EP1703930B1 (en) 2004-01-09 2004-12-21 Positive displacement flush syringe
JP2006549315A JP4794463B2 (ja) 2004-01-09 2004-12-21 正圧排出用フラッシュ注射器
ES04815300.1T ES2671333T3 (es) 2004-01-09 2004-12-21 Jeringa de enjuague de desplazamiento positivo
ES18158817T ES2809398T3 (es) 2004-01-09 2004-12-21 Jeringa de enjuague de desplazamiento positivo
PCT/US2004/043203 WO2005070484A1 (en) 2004-01-09 2004-12-21 Positive displacement flush syringe
EP18158817.9A EP3345640B1 (en) 2004-01-09 2004-12-21 Positive displacement flush syringe
US11/862,257 US20080021414A1 (en) 2004-01-09 2007-09-27 Positive displacement flush syringe
US12/166,632 US8574202B2 (en) 2004-01-09 2008-07-02 Positive displacement flush syringe

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/754,870 US20050154353A1 (en) 2004-01-09 2004-01-09 Positive displacement flush syringe

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/862,257 Division US20080021414A1 (en) 2004-01-09 2007-09-27 Positive displacement flush syringe
US12/166,632 Continuation US8574202B2 (en) 2004-01-09 2008-07-02 Positive displacement flush syringe

Publications (1)

Publication Number Publication Date
US20050154353A1 true US20050154353A1 (en) 2005-07-14

Family

ID=34739460

Family Applications (3)

Application Number Title Priority Date Filing Date
US10/754,870 Abandoned US20050154353A1 (en) 2004-01-09 2004-01-09 Positive displacement flush syringe
US11/862,257 Abandoned US20080021414A1 (en) 2004-01-09 2007-09-27 Positive displacement flush syringe
US12/166,632 Expired - Lifetime US8574202B2 (en) 2004-01-09 2008-07-02 Positive displacement flush syringe

Family Applications After (2)

Application Number Title Priority Date Filing Date
US11/862,257 Abandoned US20080021414A1 (en) 2004-01-09 2007-09-27 Positive displacement flush syringe
US12/166,632 Expired - Lifetime US8574202B2 (en) 2004-01-09 2008-07-02 Positive displacement flush syringe

Country Status (6)

Country Link
US (3) US20050154353A1 (https=)
EP (2) EP1703930B1 (https=)
JP (1) JP4794463B2 (https=)
BR (1) BRPI0418352B8 (https=)
ES (2) ES2809398T3 (https=)
WO (1) WO2005070484A1 (https=)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060178625A1 (en) * 1998-07-29 2006-08-10 Becton, Dickinson And Company Single use syringe
US20060195063A1 (en) * 1998-07-29 2006-08-31 Becton, Dickinson And Company Splatter prevention mechanism for a syringe
WO2007019164A1 (en) * 2005-08-03 2007-02-15 Becton Dickinson And Company Splatter prevention mechanism for a syringe
US20070213670A1 (en) * 2006-03-09 2007-09-13 Gabel Jonathan B Endoscopic applicator
US20080082055A1 (en) * 2006-09-29 2008-04-03 Tyco Healthcare Group Lp Detachable plunger rod syringe
US20080300550A1 (en) * 2007-06-04 2008-12-04 Becton, Dickinson And Company Positive displacement stopper for a pre-filled syringe
US20090005759A1 (en) * 2007-06-27 2009-01-01 Tyco Healthcare Group Lp Positive displacement fluid lock port
US20090163876A1 (en) * 2007-12-20 2009-06-25 Tyco Healthcare Group Lp Cap Assembly for Use With a Prefilled Lock Solution Syringe
US20100280461A1 (en) * 2009-04-30 2010-11-04 Axel Forstreuter Drug delivery device for delivery of a medicament
US20110034882A1 (en) * 2007-06-04 2011-02-10 Becton, Dickinson And Company Stoppers Used in Pre-filled Syringes
WO2011026931A1 (en) * 2009-09-07 2011-03-10 Sanofi-Aventis Deutschland Gmbh Drive mechanism for drug delivery device
US20120209179A1 (en) * 2006-02-09 2012-08-16 Dean Kamen Patch-sized fluid delivery systems and methods
US20120271245A1 (en) * 2011-04-21 2012-10-25 Achan Jr Leonard Malleable stopper for a syringe
US20130102994A1 (en) * 2011-08-31 2013-04-25 Martin J. Gibler Sealing arrangement for syringe
WO2015150646A1 (fr) * 2014-04-02 2015-10-08 Aptar Stelmi Sas Ensemble de seringue anti-reflux
US9233208B2 (en) 2012-11-29 2016-01-12 Becton, Dickinson And Company Methods and apparatus for disinfecting and reflux prevention flush syringe assembly
US9302049B2 (en) 2012-08-20 2016-04-05 Becton, Dickinson And Company Medical devices for blood reflux prevention and methods of use
FR3032124A1 (fr) * 2015-02-04 2016-08-05 Pascal Freydier Seringue
CN106132461A (zh) * 2014-03-20 2016-11-16 大和特殊硝子株式会社 注射器
AU2014277859B2 (en) * 2010-04-05 2017-03-09 Becton, Dickinson And Company Stoppers used in pre-filled syringes
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EP3345640A3 (en) 2018-07-25
ES2809398T3 (es) 2021-03-04
JP4794463B2 (ja) 2011-10-19
EP3345640B1 (en) 2020-06-10
ES2671333T3 (es) 2018-06-06
JP2007517589A (ja) 2007-07-05
BRPI0418352B8 (pt) 2021-06-22
EP1703930A1 (en) 2006-09-27
US20080021414A1 (en) 2008-01-24
EP3345640A2 (en) 2018-07-11
US8574202B2 (en) 2013-11-05
BRPI0418352B1 (pt) 2015-11-10
EP1703930B1 (en) 2018-02-28
WO2005070484A1 (en) 2005-08-04
BRPI0418352A (pt) 2007-05-08
US20080262439A1 (en) 2008-10-23

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