US20040243018A1 - Apparatus and method for determining adequacy of electrode-to-skin contact and electrode quality for bioelectrical measurements - Google Patents

Apparatus and method for determining adequacy of electrode-to-skin contact and electrode quality for bioelectrical measurements Download PDF

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US20040243018A1
US20040243018A1 US10/724,458 US72445803A US2004243018A1 US 20040243018 A1 US20040243018 A1 US 20040243018A1 US 72445803 A US72445803 A US 72445803A US 2004243018 A1 US2004243018 A1 US 2004243018A1
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electrode
measurement
body part
voltage
electrodes
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Leslie Organ
Kenneth Smith
Joel Ironstone
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Z Tech Canada Inc
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Z Tech Canada Inc
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Publication of US20040243018A1 publication Critical patent/US20040243018A1/en
Assigned to MMW FINANCIAL INC. reassignment MMW FINANCIAL INC. SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: Z-TECH (CANADA) INC.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4312—Breast evaluation or disorder diagnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0041—Detection of breast cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531—Measuring skin impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6843—Monitoring or controlling sensor contact pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00026—Conductivity or impedance, e.g. of tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/0016—Energy applicators arranged in a two- or three dimensional array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06—Measuring instruments not otherwise provided for
    • A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
    • A61B2090/065—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension for measuring contact or contact pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0219—Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/276—Protection against electrode failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
    • A61B5/282—Holders for multiple electrodes

Definitions

  • This invention relates to medical diagnosis of disease and specifically relates to diagnosis of disease using electrical impedances of body parts.
  • the onset of disease is often accompanied by physical changes in a body part. Some physical changes, while not discernible by a patient, can be detected with appropriate diagnostic equipment, often at a relatively early stage of the disease. For example, the electrical impedance of a human breast can have diagnostic value.
  • Tetrapolar impedance measurements are associated with injecting current between so called current injection electrodes and measuring a voltage drop between associated electrodes.
  • the differences between corresponding homologous impedance measurements in the two body parts are compared in a variety of ways that allows the calculation of metrics that can serve either as an indicator of the presence of disease or to localize the disease to a specific breast quadrant or sector.
  • Electrodes array having a plurality of electrodes in contact with the skin covering the underlying breast tissue. If one or more electrodes have lost contact with the skin, or if the contact with the skin is poor, errors can arise in the electrical measurements that then yield erroneous impedances.
  • the present invention provides a method to determine both if there is electrode contact with the skin, and, if there is such contact, what the quality of that contact is.
  • the method involves making bipolar measurements of the impedance.
  • ⁇ is the frequency at which the voltage (and current) oscillates
  • C is the capacitance of the circuit.
  • phase associated with a body part of a patient at a particular frequency can be found by making bipolar measurements. By comparing the phase, at one or several frequencies, to expected values, a decision can be made as to whether the electrode is in suitable contact with the skin on the body part.
  • bipolar measurement is better for determining adequacy of electrode-to-skin contact (herein referred to as either “contact” or “electrode contact”) because a poor contact result can be isolated to one or both electrodes.
  • phase instead of the magnitude is advantageous because a) impedance magnitude varies greatly from person to person, b) stray capacitance in the system can cause a smaller observed impedance value than would be expected from the high open-circuit value associated with a disconnected electrode, and c) sweat or some other substance could allow a low impedance to be registered even though the current traversing the skin is reduced because of poor electrode contact.
  • Measuring the phase at different frequencies allows this measure to be even more precise because it can identify if excessive oil or other materials obstruct the skin-electrode interface.
  • the expected value for human skin at each of these frequencies is considered. With multiple frequencies, the measured ratio between measured impedance values at different frequencies can be compared to the expected values oh human skin.
  • the system includes an electrode array containing a plurality of electrodes capable of being electrically coupled to the body part, and a first measurement unit for making an electrode assessment measurement for the electrode array.
  • the system also includes an electrode assessment module for determining whether the plurality of electrodes are suitably coupled to the body part based on the electrode assessment measurement.
  • the system further includes a second measurement unit for making a diagnosis measurement with the electrode array, and an electrical property module for obtaining an electrical property, such as electrical impedance, of the body part based on the diagnosis measurement.
  • a diagnosis module utilizes the electrical property to diagnose the possibility of disease.
  • the plurality of electrodes includes a current injection electrode pair and an associated voltage measurement electrode pair that are applied to the body part.
  • One current injection electrode of the current injection electrode pair and one proximal voltage measurement electrode of the voltage measurement electrode pair are used by the first measurement unit to make a bipolar measurement.
  • the electrode assessment module can include a phase module for obtaining a phase, ⁇ , from the bipolar measurement, whose absolute value is given by
  • the electrode assessment module may further include a contact module for determining that at least one of the current injection electrode and the voltage measurement electrode is not in electrical contact with the body part if the phase is outside a threshold range.
  • I is the current and V is a resultant voltage measured during the bipolar measurement
  • a quality module for determining quality of electrical contact of the current injection electrode and the voltage measurement electrode with the body part based on the magnitude.
  • the electrode assessment module may include a) a phase module for obtaining a phase that is a function of a capacitive reactance, at a particular frequency, and a resistance, associated with the body part, and for obtaining other phases at other frequencies, and b) a contact module for determining that at least one of the current injection electrode and the voltage measurement electrode is not in electrical contact with the body part based on the phase at the particular frequency and the other phases at the other frequencies.
  • the plurality of electrodes mentioned above can include n CI current injection electrode pairs and n CI associated voltage measurement electrode pairs that are applied to the body part.
  • the second measurement unit injects a first current between a first pair of the n CI current injection electrode pairs, measures the resultant voltage difference V 1 M between the voltage measurement electrode pair associated with the first current injection electrode pair, and repeats the preceding two steps of current injection and voltage difference measurement with the other electrode pairs until all n CI voltage differences, ⁇ V 1 M , V 2 M , . . . , V n CI M ⁇ are obtained.
  • the electrical property module is an impedance module that uses the n CI voltage differences to obtain associated measured impedances, ⁇ Z 1 M , Z 2 M , . . . , Z n CI M ⁇ , where Z j M is the measured impedance between the voltage electrodes associated with the jth current injection electrode pair.
  • the system can then further include a diagnosis module for utilizing the measured impedances, ⁇ Z 1 M , Z 2 M , . . . , Z n CI M ⁇ to diagnose the possibility of disease.
  • the system may also include a graphical user interface to indicate a status of the coupling between the plurality of electrodes and the body part.
  • the present invention describes a system and/or method for measuring an electrical property, such as impedance, in a living tissue that includes an electrode array, first and second measurement units, an electrode assessment module, and an electrical property module, which are described in more detail below.
  • FIG. 1 shows a block diagram of the system for diagnosing the possibility of disease, according to the teachings of the present invention
  • FIG. 2A shows the electrode array of FIG. 1.
  • FIG. 2B shows a side view of a schematic of a particular current injection electrode pair and an associated voltage measurement electrode pair on the electrode array of FIG. 1.
  • FIG. 3 shows the electrode assessment module of FIG. 1.
  • FIG. 4 shows a graphical user interface (GUI) that illustrates the status of the skin-electrode contact, according to the teachings of the present invention.
  • GUI graphical user interface
  • FIG. 5 shows a block diagram of a system for measuring a voltage in a body part, according to the teachings of the present invention.
  • FIGS. 6 A-D shows modes of the controller switching unit of FIG. 5.
  • FIG. 7 shows a hybrid mode of the controller switching unit of FIG. 5.
  • FIG. 8 shows electrical connections in a particular tetrapolar impedance measurement that employs the system of FIG. 5.
  • FIGS. 9A and 9B show the multiplexer of FIG. 5.
  • FIG. 10 shows a diagnostic system that includes an internal load in addition to the components of FIG. 5.
  • FIG. 11 shows one embodiment of the controller switching unit, according to the principles of the present invention.
  • FIG. 1 shows a system 100 for diagnosing the possibility of disease in a body part.
  • the system 100 includes an electrode array 102 containing a plurality of electrodes 104 capable of being electrically coupled to the body part.
  • the system 100 also includes a first measurement unit 106 , an electrode assessment module 108 , a second measurement unit 110 , an electrical property module 112 and a diagnosis module 114 .
  • the plurality of electrodes 104 are applied to the body part to obtain an electrical property of the body part, such as impedance, to diagnose disease.
  • the plurality of electrodes 104 have to be electrically connected to the body part.
  • adhesive means (not shown) can be used to connect the electrodes 104 to the skin on the body part of a subject.
  • the electrode conductive material generally a hydrogel, can also have adhesive properties.
  • the combined adhesive means can fail, resulting in an electrode that is not in proper electrical contact with the body part.
  • the first measurement unit 106 utilizes the electrode array 102 to make an electrode assessment measurement.
  • the electrode assessment module 108 determines whether the plurality of electrodes 104 are adequately coupled to the body part based on the electrode assessment measurement, as described in more detail below.
  • the second measurement unit 110 can then utilize the electrode array 102 to make a diagnosis measurement.
  • the electrical property module 112 obtains an electrical property of the body part, such as an impedance of the body part, based on the diagnosis measurement.
  • the diagnosis module 114 diagnoses the possibility of disease based on the electrical property. For example, cancer may change the impedance of the body part, a fact that can be exploited by the diagnosis module 114 to diagnose the possible presence of cancer.
  • FIG. 2A shows the electrode array 102 of FIG. 1.
  • the electrode array 102 includes the plurality of electrodes 104 that are applied to the body part.
  • the plurality of electrodes 104 include current injection electrodes 120 and voltage measurement electrodes 122 (two of these electrodes are labeled for simplicity).
  • the electrode array 102 contains several arms 123 (one arm is labeled for simplicity). Each arm includes a current injection electrode and a voltage measurement electrode.
  • the arm 125 includes a particular current injection electrode 124 and voltage measurement electrode 126 .
  • current injection and “voltage measurement” refer to their use during tetrapolar measurement, as used in this invention for the diagnosis stage.
  • an inner pair of electrodes is provided on some of the array arms 123 .
  • One particular inner set of electrodes 128 i and 130 i is located on arm 127 . By positioning the inner set of electrodes partway on the array arms, these electrodes are placed closer to the nipple area of the breast, thus allowing better detection of cancers in the periareolar area of the breast.
  • FIG. 2B shows a side view of the particular current injection electrode 124 and the voltage measurement electrode 126 on the arm 125 . Also shown in FIG. 2B is another arm 127 of the electrode array 102 having another current injection electrode 128 and voltage measurement electrode 130 .
  • a single electrode is used for both current injection and voltage measurement.
  • current is injected between electrodes 124 and 126 , and voltage is measured between electrodes 124 and 126 . More specifically, current is injected through electrode 124 into the body part, then is received from the body part through electrode 126 . The resultant voltage difference between electrodes 124 and 126 is measured by a voltmeter 131 .
  • the first measurement unit 106 is used to make the bipolar impedance measurement between electrodes 124 and 126 , yielding a reactance X C and a resistance R
  • the result of this bipolar measurement is used to assess whether the electrodes on the arm 125 are suitably coupled to the body part before a tetrapolar measurement is performed to diagnose disease.
  • adjacent electrodes 124 and 126 are used to perform the bipolar measurements. This choice is dictated by the fact that a measurement is more likely to yield predominantly electrode-to-skin contact impedance if the distance between the two electrodes used is very small.
  • FIG. 3 shows the electrode assessment module 108 of FIG. 1.
  • the electrode assessment module 108 includes a phase module 132 , a magnitude module 134 , a contact module 136 and a quality module 138 .
  • the phase module 132 obtains a phase ⁇ from the bipolar measurement according to
  • the contact module 136 uses the phase calculated by the phase module 132 to determine whether at least one of the electrodes 124 and 126 does not make adequate electrical contact with the body part. In particular, if the phase lies outside a threshold range, then the electrodes 124 and/or 126 fails to make adequate electrical contact with the skin.
  • a useful index for this determination is the ratio X C /R, with X C /R ⁇ 0.80 at 50 kHz indicating failed contact.
  • the relationship between the phases at each frequency is used to make the contact determination. Particularly, as frequency increases, the phase of the impedance reduces. If the measured phase at one frequency is larger than a measured phase at a lower frequency, something other than skin is making contact.
  • the magnitude module 134 obtains an impedance magnitude
  • the quality module 138 uses the magnitude
  • the first measurement unit 106 makes bipolar measurements that allow the electrode assessment module 108 to determine a) whether the electrodes 124 and 126 are in adequate contact with the skin, as ascertained from the phase information and b) whether the conductive quality of the hydrogel component of electrodes 124 and 126 has been maintained or has deteriorated, as ascertained from the impedance magnitude. It should be understood that the electrode-to-skin contact of other electrodes can also be assessed. For this purpose, another bipolar measurement can be performed using another two electrodes on another arm of the electrode array to provide information about the suitability of the contact, and so on.
  • FIG. 4 shows a graphical user interface (GUI) that illustrates the status of the electrode-to-skin contact.
  • GUI graphical user interface
  • a display 150 shows two representations 152 and 154 of electrode arrays 102 , the representation 152 of the right breast array and the representation 154 of the left breast array.
  • Each electrode array representation has twelve arms 156 .
  • each electrode array representation has sixteen arms.
  • the colour of the circles 158 indicates which electrodes have been ascertained to be in contact with the skin.
  • a red circle indicates an inadequate contact
  • a blue circle indicates an adequate one.
  • Other indicators are possible, such as flashing circles representing inadequate contacts.
  • white circles represent electrodes making adequate contact
  • black circles represent those that are not. This determination is made by the contact module 136 .
  • the quality module 138 furnishes its information at the bottom of the display.
  • a bar 160 is shown with various levels of electrode quality with, in this example, three usable level—excellent, Good, and Pass—and one unacceptable level—Replace. If the quality is excellent, for example, then the word “Excellent” is highlighted on the bar 160 .
  • Both electrode contact and quality information are made available to the user administering the diagnostic examination in real time.
  • the user can take immediate steps to rectify a poor electrode-to-skin contact, or replace a deteriorated electrode, before proceeding with the diagnostic testing.
  • the ability to display real time information is a direct result of using bipolar measurements for making the status determination.
  • bipolar measurements one measurement relates to one electrode pair, and only the number of measurements as there air pairs is required to refresh the display. If tetrapolar measurements were used to make the contact determination, each measurement would include four electrodes and many sets of measurements per pair would be required to make the contact determination. Performing all of these measurements would take much longer.
  • the display 150 shown can be a computer or television monitor. In other embodiments, LED lights can signal electrode status.
  • the system 100 can proceed to the diagnosis stage.
  • the second measurement unit 110 injects a first current between a first pair of the n CI current injection electrode pairs, and then measures the resultant voltage difference V 1 M between a voltage measurement electrode pair.
  • current travels from a current injection electrode of a first arm to a current injection electrode of a second arm, then the voltage difference is measured between the voltage measurement electrodes of the same two arms.
  • current can flow between electrodes 124 and 128 .
  • the associated resultant voltage is measured between electrodes 126 and 130 .
  • n CI current injections are possible with an equal number of associated voltage measurements.
  • n CI current injections are possible with an equal number of associated voltage measurements.
  • the impedance module 112 uses the n CI voltage differences to obtain associated measured impedances, ⁇ Z 1 M , Z 2 M , . . . , Z n C IM ⁇ where Z j M is the measured impedance between the voltage electrodes associated with the jth current injection electrode pair.
  • the diagnosis module 114 utilizes the measured impedances, ⁇ Z 1 M , Z 2 M , . . . , Z n CI M ⁇ to diagnose the possibility of disease.
  • U.S. Pat. No. 6,122,544 describes a method that compares impedances between homologous body parts. In this method, the impedance of a body part of a patient is compared to the impedance of the homologous body part of the same patient. A difference between these two impedances could signal disease.
  • the system 100 employs both tetrapolar and bipolar measurements to assess the quality of electrode contact.
  • a diagnostic system 1000 capable of both these types of measurements will now be described.
  • FIG. 5 shows a system 1000 for measuring a voltage in a body part 110 , such as a human breast.
  • the system 1000 includes N body leads 120 .
  • the N body leads 120 are ordered from 1 to N for reference.
  • the system 1000 also includes a multiplexing unit 140 having a multiplexer 160 , a first MX lead 180 , a second MX lead 200 , a third MX lead 220 and a fourth MX lead 240 .
  • the system 1000 further includes a controller switching unit 260 having a first switch 280 connected to the multiplexer 160 by the first MX lead 180 and the second MX lead 200 , a second switch 300 connected to the multiplexer 160 by the third MX lead 220 and the fourth MX lead 240 , a current input lead 320 connected to the first switch 280 , a current output lead 340 connected to the second switch 300 , a first voltage lead 360 connected to the first switch 280 , and a second voltage lead 380 connected to the second switch 300 .
  • the controller switching unit 260 also includes a controller 390 .
  • the system 1000 further includes an impedance module 400 and a diagnosis module 420 .
  • FIG. 5 Also shown in FIG. 5 is an optional second set of leads 440 that can be used when making measurements on a second homologous body part 460 .
  • the description below is directed mainly to an impedance measurement on the one body part 110 with the set of N leads 120 , but it should be understood that the discussion could be analogously expanded to include an impedance measurement on the second homologous body part 460 with the second set of leads 440 .
  • the principles of the present invention can be applied to diagnosis of disease by making electrical measurements on a single body part, or by making measurements on a homologous pair of body parts. When making measurements on only a single body part, the results can be compared to standard results obtained from population studies, for example, to diagnose disease. When using a homologous pair of body parts, the results of one body part can be compared to the results of the homologous body part of the same patient, as described in U.S. Pat. No. 6,122,544.
  • the N body leads 120 electrically connect the multiplexing unit 140 to the body part 110 .
  • Each of the N body leads 120 includes a wire capable of carrying a current and an electrode to attach to the body part 110 .
  • a current conducting gel can act as an interface between the electrode and the skin covering the body part 110 .
  • the multiplexing unit 140 and the controller switching unit 260 allow a current to flow through the body part 110 between any two body leads, n 1 and n 2 , of the N body leads 120 , and a resultant voltage to be measured between any two body leads, n 3 and n 4 of the N body leads 120 , where n 1 ⁇ n 2 and n 3 ⁇ n 4 , but where n 1 , n 2 , n 3 and n 4 need not otherwise be distinct.
  • the impedance module 400 generates current that is injected into the current input lead 320 and then delivered to the body part.
  • the current output lead 340 receives the current from the body part.
  • the first voltage lead 360 and the second voltage lead 380 are used to measure the resultant voltage between these leads 360 and 380 .
  • the impedance module 400 uses this voltage, together with the known current injected into the current input lead 320 , to calculate a corresponding impedance, which may then be used by the diagnosis module 420 to diagnose disease.
  • N is even and the multiplexer 160 can electrically connect the first MX lead 180 and the fourth MX lead 240 to a first set of N/2 of the N leads, and the second MX lead 200 and the third MX lead 220 to a second set of the other N/2 leads.
  • the first set of N/2 leads are exclusively used to inject current into and receive current from the body part.
  • the second set of N/2 leads are then exclusively used to measure resultant voltages in tetrapolar measurements. This configuration limits the number of impedances that can be measured.
  • the second set of N/2 leads can also be used to inject and receive current, and the first set can be used to measure resultant voltages.
  • the system 1000 can furnish a greater number of impedances.
  • the system can make both tetrapolar and bipolar measurements.
  • the added benefits arise from the functionality of the controller switching unit 260 .
  • the system 1000 can force current to flow through the body part 110 between any two body leads, n 1 and n 2 , of the N body leads 120 , and a resultant voltage to be measured between any two body leads, n 3 and n 4 of the N body leads 120 , where n 1 ⁇ n 2 and n 3 ⁇ n 4 .
  • FIGS. 6 A-D show several states of the switches 280 and 300 resulting in different modes of the controller switching unit 260 of the system of FIG. 5. These states of the switches 280 and 300 are controlled by the controller 390 .
  • current is injected into the first MX lead 180 and received by the fourth MX lead 240 . While this current travels through the body part 110 , a resultant voltage is measured between the second MX lead 200 and the third MX lead 220 . This measurement is tetrapolar because current is forced to flow between two leads and the resultant voltage is measured between two other leads.
  • FIGS. 6A and 6B the first switch 280 and the second switch 300 are both in tetrapolar states since, for each of the switches 280 and 300 , two distinct MX leads are involved in the impedance measurement.
  • the controller switching unit 260 is said to be in a tetrapolar mode.
  • FIGS. 6A and 6B correspond to tetrapolar modes.
  • the current input lead 320 is electrically connected to exactly one of the first MX lead 180 and the second MX lead 200 and the first voltage lead 360 is electrically connected to the other one of the first MX lead 180 and the second MX lead 200 ; likewise, the current output lead 340 is electrically connected to exactly one of the third MX lead 220 and the fourth MX lead 240 and the second voltage lead 380 is connected to the other one of the third MX lead 220 and the fourth MX lead 240 .
  • the two tetrapolar modes shown in FIGS. 6A and 6B do not exhaust all the tetrapolar modes.
  • the controller switching unit 260 is also in a tetrapolar mode.
  • the controller switching unit 260 is in a tetrapolar mode when n 1 , n 2 , n 3 and n 4 are distinct, where n 1 and n 2 are leads from among the N leads 120 used to inject current into and receive current from the body part 110 , and n 3 and n 4 are leads used to measure the resultant voltage.
  • FIG. 6C current is injected into the first MX lead 180 and received by the fourth MX lead 240 . While this current travels through the body part 110 , a resultant voltage is measured between the first MX lead 180 and the fourth MX lead 240 .
  • the second and third MX leads 200 and 220 are electrically unconnected to any of the N body leads 120 during this measurement. This measurement is bipolar because the pair of electrodes used for measuring a voltage is also used for current flow.
  • FIG. 6D current is injected into the second MX lead 200 and received by the third MX lead 220 .
  • the resultant voltage is measured between the same two leads 200 and 220 .
  • the first and fourth MX leads 180 and 240 are electrically unconnected during this measurement. This measurement is also bipolar.
  • FIGS. 6C and 6D the first switch 280 and the second switch 300 are both in bipolar states since, for each of the switches 280 and 300 , only one MX lead is involved in the impedance measurement.
  • the controller switching unit 260 is said to be in a bipolar mode.
  • FIGS. 6C and 6D correspond to bipolar modes.
  • the current input lead 320 and the first voltage lead 360 are electrically connected to each other and to exactly one of the first MX lead 180 and the second MX lead 200
  • the current output lead 340 and the second voltage lead 380 are electrically connected to each other and to exactly one of the third MX lead 220 and the fourth MX lead 240 .
  • the two modes shown in FIGS. 6C and 6D do not exhaust all bipolar modes.
  • FIG. 7 shows a hybrid mode of the controller switching unit 260 of FIG. 5.
  • the first switch 280 is in a tetrapolar state and the second switch 300 is in a bipolar state.
  • n 1 ⁇ n 3 and n 2 n 4
  • the lead n is electrically connected to the first MX lead 180 or to the fourth MX lead 240 via the multiplexer 160 .
  • the lead n 2 is connected to whichever of first MX lead 180 and the fourth MX lead 240 is not connected to the lead n 1 .
  • the lead n 3 is connected to the second MX lead 200 or the fourth MX lead 240 , and the lead n 4 is connected to whichever of the second MX lead 200 and the fourth MX lead 240 is not connected to the n 3 lead.
  • the third MX lead 220 is electrically unconnected during this hybrid measurement.
  • FIG. 8 shows electrical connections in a particular tetrapolar impedance measurement that employs the system 1000 of FIG. 5.
  • N 32.
  • the second set of leads 440 is also not shown in the FIG. 8 .
  • All the electrodes 1-5 of the first set can be electrically connected to the first and fourth MX leads 180 and 240 , and all the electrodes 6-10 of the second set can be connected to the second and third MX leads 200 and 220 via the multiplexer 160 .
  • the electrodes 2 and 5 are used to measure the resultant voltage.
  • current is generated by the impedance module 400 and sent to the current input lead 320 . From there, the current travels to the first MX lead 180 via the first switch 280 and from there to the electrode 6 via the multiplexer 160 . The current next travels through the body part 110 to the electrode 9 and then through the multiplexer 160 to the fourth MX lead 240 . The current then flows to the current output lead 340 via the second switch 300 and then back to the impedance module 400 . The resultant voltage is measured between the first and second voltage leads 360 and 380 , which corresponds to the voltage between the electrodes 2 and 5.
  • the first voltage lead 360 is connected to the electrode 2 via the first switch 280 and the multiplexer 160
  • the second voltage lead 380 is electrically connected to the electrode 5 via the second switch 300 and the multiplexer 160 .
  • the controller 390 controls the states of the switches 280 and 300 and the multiplexing states in the multiplexer 160 that determine through which leads current flows and which leads are used to measure voltage.
  • FIG. 9A shows the multiplexer 160 of FIG. 5 in an embodiment in which a body part is being compared to a homologous body part.
  • the multiplexer 160 includes a first body part multiplexer 520 that includes a first body part A multiplexer unit 540 and a first body part B multiplexer unit 560 .
  • the multiplexer 160 also includes a second body part multiplexer 580 that includes a second body part A multiplexer unit 600 and a second body part B multiplexer unit 620 .
  • the first body part A multiplexer unit 540 is connected to the first MX lead 180 and the fourth MX lead 240 .
  • the first body part B multiplexer unit 560 is connected to the second MX lead 200 and the third MX lead 220 .
  • the second body part A multiplexer unit 600 is also connected to the first MX lead 180 and the fourth MX lead 240
  • the second body part B multiplexer unit 620 is also connected to the second MX lead 200 and the third MX lead 220 .
  • the first body part multiplexer 520 is used for multiplexing electrical signals to the first body part of the homologous pair.
  • the first body part A multiplexer unit 540 and B multiplexer unit 560 are both capable of multiplexing current and voltage signals to and from the N leads 120 .
  • the second body part multiplexer 580 is used for multiplexing electrical signals to the homologous body part.
  • the second body part A multiplexer unit 600 and B multiplexer unit 620 are both capable of multiplexing current and voltage signals to and from the N leads 120 , as described below.
  • FIG. 9B shows the first body part A multiplexer unit 540 of FIG. 9A.
  • the multiplexer unit 540 includes four one-to-N/4 multiplexers 640 , 660 , 680 and 700 . These, for example, can be model number MAX4051ACPE manufactured by MAXIMTM.
  • the N/4 multiplexer current leads 720 connect the multiplexer 640 to the multiplexer 680
  • N/4 multiplexer current leads 740 connect the multiplexers 660 and 700 .
  • the leads 720 and 740 are connected to the first N/2 of the N leads 120 .
  • the multiplexers 640 , 660 , 680 and 700 each have a configurable one bit “inhibit state” and log 2 (N/4) bit “control state.”
  • the inhibit state can be either off (0) or on (1) and determines whether current can flow through the respective multiplexer 640 , 660 , 680 or 700 .
  • the inhibit state of the multiplexer 640 is 1 (on) and the state of the multiplexer 660 is (0,0,0,1), where the first bit is for the inhibit state, and the last three bits identify which lead of multiplexer 660 is being activated, then current destined for the breast is directed to the tenth lead, provided the states of the switches 280 and 300 connect the current input lead 320 to the first MX lead 180 , as previously described.
  • this lead 180 when the multiplexer 660 is in the state (0,0,0,1), measures the resultant voltage with the tenth lead.
  • a similar binary code for the multiplexers 680 and 700 dictates through which one of the first 16 electrodes of the 32 leads 120 current is received from the breast, provided the states of the switches 280 and 300 connect the current output lead 340 to the fourth MX lead 240 . If the fourth MX lead 240 is not connected to the current output lead 340 , but is connected to the second voltage lead 220 , then the fourth MX lead 240 is used for measuring the resultant voltage, provided the inhibit state of the multiplexer 680 or the multiplexer 700 is off.
  • the B multiplexer unit 560 is similar to the A multiplexer unit 540 in that it has four one-to-N/4 multiplexers analogous to 640 , 660 , 680 and 700 .
  • the one-to-N/4 multiplexers are capable of connecting with the second and third MX leads 200 and 220 , instead of the first and fourth MX leads 180 and 240 .
  • the inhibit and control states determine which electrode from among the other N/2 electrodes is used to deliver current or measure voltage.
  • the inhibit and control states are set by the controller 390 with a shift-register and/or a computer.
  • a direct digital stream can be sent to the shift register for this purpose.
  • the function of the second body part multiplexer 580 is analogous to that of the first body part multiplexer 520 and therefore need not be described further.
  • FIG. 10 shows a diagnostic system 820 that includes an internal load 840 in addition to the components described above in relation to FIG. 5.
  • the internal load 840 is electrically connected to the first MX lead 180 , the second MX lead 200 , the third MX lead 220 and the fourth MX lead 240 .
  • the internal load 840 is used for at least one of internal testing of the system 820 and varying the measurement range of the system 820 .
  • the internal load 840 can be connected to the impedance module 400 in a tetrapolar mode or in a bipolar mode.
  • the internal load 840 has a known impedance and therefore can be used to test the diagnostic system 820 .
  • the internal load 840 can be used to change the measurement range of the system 820 .
  • the system 820 is capable of measuring larger impedances than would otherwise be possible. If the resistance of the internal load 840 is R int and is in parallel, the measured resistance R is given by
  • R load is the resistance of the load. Consequently, the measured resistance is reduced from the value without the internal load, thereby increasing the measurement range of the system 840 .
  • the switches 280 and 300 allow current to flow between various pairs of electrodes on a body part, and resultant voltage to be measured between various pairs of electrodes, as described above with reference to FIGS. 5-10.
  • FIG. 11 another embodiment of the controller switching unit is shown that can be used to achieve the states of FIGS. 6 A-D using a different electrical circuit topology.
  • the controller switching unit 900 of FIG. 11 includes a first switch 920 and a second switch 940 .
  • the current input lead 320 , the current output lead 340 , the first voltage lead 360 and the second voltage lead 380 split to connect to both the first and second switches 920 and 940 .
  • the switches 920 and 940 can be turned on or off and can be used to make tetrapolar and bipolar measurements. With only one of the switches 920 and 940 on, a tetrapolar measurement can be made. With both switches 920 and 940 on, a bipolar measurement can be made. For example, when the first switch 920 is on, and the second switch is off, the resultant functionality corresponds to that of FIG. 6A, albeit achieved with a different circuit topology. In this example, current flows from the impedance module 400 along the current input lead 320 , through the first switch 920 , and then to the first MX lead 180 . From there, the current proceeds to the multiplexer 160 .
  • the resultant functionality corresponds to that of FIG. 6B.
  • current from the impedance module 400 travels along the current input lead 320 , across the second switch 940 , then jumps to the second MX lead 200 .
  • Current is received along the third MX lead 220 , from where it jumps to the current output lead 340 via the second switch 940 .
  • the voltage is measured between the first and fourth MX leads 180 and 240 with the use of the first and second voltage leads 360 and 380 .
  • the first and second switches 920 and 940 are both on, which corresponds to FIG. 6C or 6 D. Precisely to which of these two figures this example corresponds is determined by the inhibit states of the multiplexer 160 . For example, if the inhibit states of both of the one-to-N/4 multiplexers 640 and 660 are on, then bipolar measurements are performed with the second set of N/2 electrodes.
  • the controller switching unit 900 also includes an internal load switch 1080 that is connected to the internal load 840 .
  • the controller switching unit 900 and the internal load 840 are used to test the system and to increase the measurement range, as described above.

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US20040158167A1 (en) 2004-08-12

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