US20040168694A1 - Whole smoke exposure apparatus - Google Patents

Whole smoke exposure apparatus Download PDF

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Publication number
US20040168694A1
US20040168694A1 US10/793,774 US79377404A US2004168694A1 US 20040168694 A1 US20040168694 A1 US 20040168694A1 US 79377404 A US79377404 A US 79377404A US 2004168694 A1 US2004168694 A1 US 2004168694A1
Authority
US
United States
Prior art keywords
smoke
chamber
exposure apparatus
exposure
culture medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/793,774
Other languages
English (en)
Inventor
Yasuo Fukano
Mutsuaki Suzuki
Maiko Ide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Tobacco Inc
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of US20040168694A1 publication Critical patent/US20040168694A1/en
Priority to US12/830,160 priority Critical patent/US20100273246A1/en
Assigned to JAPAN TOBACCO INC. reassignment JAPAN TOBACCO INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FUKANO, YASUO, IDE, MAIKO, SUZUKI, MUTSUAKI
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24C—MACHINES FOR MAKING CIGARS OR CIGARETTES
    • A24C5/00—Making cigarettes; Making tipping materials for, or attaching filters or mouthpieces to, cigars or cigarettes
    • A24C5/32—Separating, ordering, counting or examining cigarettes; Regulating the feeding of tobacco according to rod or cigarette condition
    • A24C5/34—Examining cigarettes or the rod, e.g. for regulating the feeding of tobacco; Removing defective cigarettes
    • A24C5/3406—Controlling cigarette combustion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture

Definitions

  • this warm keeping means for example, a circulating device which keeps a constant temperature by circulating an isothermal medium can be used.
  • this temperature to be kept is 35° C. to 40° C.
  • discharge pipe lines P 15 to which the three chambers 10 are connected are merged into one line at a predetermined position and connected to the discharge tube pump 17 .
  • the tube pump 17 is connected to the culture medium discharge tank 16 through a pipe line.
  • the seal member 34 is formed from a sterile member, and hence contamination of the culture medium or cell-adhered surface due to fungi can be prevented.
  • Each chamber has a function of measuring and controlling a pressure even at the time of exposure to smoke. This makes it possible to prevent pressure changes occurring in each operation from influencing the cell.
  • the inlet 37 is formed above the outlet 38 , and the lower portion of the chamber 10 tapers off and inclines toward the outlet 38 . This makes it possible to quickly and efficiently replace the culture medium in each chamber 10 .

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Exposure And Positioning Against Photoresist Photosensitive Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
US10/793,774 2001-09-28 2004-03-08 Whole smoke exposure apparatus Abandoned US20040168694A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/830,160 US20100273246A1 (en) 2001-09-28 2010-07-02 Whole smoke exposure apparatus

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001303668 2001-09-28
JP2001-303668 2001-09-28
PCT/JP2002/003399 WO2003031946A1 (fr) 2001-09-28 2002-04-04 Dispositif d'exposition a la fumee

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/003399 Continuation WO2003031946A1 (fr) 2001-09-28 2002-04-04 Dispositif d'exposition a la fumee

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/830,160 Continuation US20100273246A1 (en) 2001-09-28 2010-07-02 Whole smoke exposure apparatus

Publications (1)

Publication Number Publication Date
US20040168694A1 true US20040168694A1 (en) 2004-09-02

Family

ID=19123723

Family Applications (2)

Application Number Title Priority Date Filing Date
US10/793,774 Abandoned US20040168694A1 (en) 2001-09-28 2004-03-08 Whole smoke exposure apparatus
US12/830,160 Abandoned US20100273246A1 (en) 2001-09-28 2010-07-02 Whole smoke exposure apparatus

Family Applications After (1)

Application Number Title Priority Date Filing Date
US12/830,160 Abandoned US20100273246A1 (en) 2001-09-28 2010-07-02 Whole smoke exposure apparatus

Country Status (6)

Country Link
US (2) US20040168694A1 (ja)
EP (1) EP1431746B1 (ja)
JP (1) JP3788988B2 (ja)
CA (1) CA2458470C (ja)
TW (1) TWI243651B (ja)
WO (1) WO2003031946A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101884569A (zh) * 2010-06-04 2010-11-17 浙江大学 用于建立慢性阻塞性肺病模型的烟雾暴露装置
US20110212515A1 (en) * 2008-10-06 2011-09-01 Ulrich Mohr Culture/exposure device, in particular for cell and/or bacteria cultures
US9598666B2 (en) 2011-10-31 2017-03-21 British American Tobacco (Investments) Limited Fluid distribution in a sample exposure device

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005012130A1 (de) * 2005-03-16 2006-09-28 Borgwaldt Technik Gmbh Verfahren und Vorrichtung zum Erzeugen von Rauchgas-Gemischen
DE102007030413A1 (de) * 2007-06-29 2009-01-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Untersuchung der Wirkung eines gasförmigen Mediums auf ein biologisches Prüfsystem unter Verwendung eines extrazellulären Metabolisierungssystems sowie Vorrichtung zur Durchführung des Verfahrens
EP2586321A1 (en) 2011-10-28 2013-05-01 Philip Morris Products S.A. Aerosol dilution for automatic smoking machine
DE102011118958B4 (de) * 2011-11-20 2023-08-24 Pieter Van Weenen & Co. Gmbh The House Of Innovation Verteilervorrichtung für eine Probenexpositionsanordnung
US9588105B1 (en) 2013-03-15 2017-03-07 The United States Of America As Represented By The Secretary Of The Air Force Portable in vitro multi-well chamber for exposing airborne nanomaterials at the air-liquid interface using electrostatic deposition
DE102013109450B4 (de) 2013-08-30 2015-04-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Expositionsapparat
FR3022632B1 (fr) * 2014-06-23 2016-07-15 Phode Sciences Machine de test de dispositifs de diffusion d'un produit diffusable
DE102014119037B4 (de) 2014-12-18 2023-12-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Expositionsvorrichtung
US20200209219A1 (en) * 2017-07-17 2020-07-02 Philip Morris Products S.A. Simulated respiratory tract
CN110358677B (zh) * 2018-04-10 2021-11-23 北京慧荣和科技有限公司 同源多浓度细胞暴露系统
JP2021078446A (ja) * 2019-11-20 2021-05-27 株式会社島津製作所 共培養装置及び共培養方法
JP7469577B2 (ja) 2020-10-14 2024-04-17 国立保健医療科学院長 煙草エアロゾル曝露装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065669A (en) * 1960-07-19 1962-11-27 American Cyanamid Co Tissue culture chamber
US4748124A (en) * 1984-10-30 1988-05-31 E. I. Du Pont De Nemours And Company Compartmentalized cell-culture device and method
US20060099706A1 (en) * 2002-05-24 2006-05-11 Massey Elan D Exposure device

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19526533C2 (de) * 1995-07-20 1997-06-05 Fraunhofer Ges Forschung Expositionsvorrichtung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065669A (en) * 1960-07-19 1962-11-27 American Cyanamid Co Tissue culture chamber
US4748124A (en) * 1984-10-30 1988-05-31 E. I. Du Pont De Nemours And Company Compartmentalized cell-culture device and method
US20060099706A1 (en) * 2002-05-24 2006-05-11 Massey Elan D Exposure device

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110212515A1 (en) * 2008-10-06 2011-09-01 Ulrich Mohr Culture/exposure device, in particular for cell and/or bacteria cultures
US9096824B2 (en) 2008-10-06 2015-08-04 Ulrich Mohr Culture/exposure device, in particular for cell and/or bacteria cultures
CN101884569A (zh) * 2010-06-04 2010-11-17 浙江大学 用于建立慢性阻塞性肺病模型的烟雾暴露装置
US9598666B2 (en) 2011-10-31 2017-03-21 British American Tobacco (Investments) Limited Fluid distribution in a sample exposure device

Also Published As

Publication number Publication date
EP1431746A4 (en) 2008-05-14
WO2003031946A1 (fr) 2003-04-17
CA2458470C (en) 2013-09-24
JP3788988B2 (ja) 2006-06-21
US20100273246A1 (en) 2010-10-28
EP1431746A1 (en) 2004-06-23
EP1431746B1 (en) 2012-03-14
JPWO2003031946A1 (ja) 2005-01-27
CA2458470A1 (en) 2003-04-17
TWI243651B (en) 2005-11-21

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Legal Events

Date Code Title Description
AS Assignment

Owner name: JAPAN TOBACCO INC., JAPAN

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FUKANO, YASUO;SUZUKI, MUTSUAKI;IDE, MAIKO;REEL/FRAME:027814/0262

Effective date: 20040223

STCB Information on status: application discontinuation

Free format text: ABANDONED -- AFTER EXAMINER'S ANSWER OR BOARD OF APPEALS DECISION