US20030192791A1 - Closure device for a medical container - Google Patents
Closure device for a medical container Download PDFInfo
- Publication number
- US20030192791A1 US20030192791A1 US10/418,058 US41805803A US2003192791A1 US 20030192791 A1 US20030192791 A1 US 20030192791A1 US 41805803 A US41805803 A US 41805803A US 2003192791 A1 US2003192791 A1 US 2003192791A1
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- US
- United States
- Prior art keywords
- closure device
- opening
- container
- passage
- syringe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
- B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
- B65D51/2807—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
- B65D51/2814—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2055—Connecting means having gripping means
Definitions
- the present invention generally relates to containers, such as vials or ampoules, for holding and transferring injectable solutions to a syringe. More specifically, the present invention relates to a closure device for such containers.
- injection solutions are kept in sterile glass vials or ampoules, which are closed off by a suitable seal, such as a rubber stopper or an aluminum foil.
- a suitable seal such as a rubber stopper or an aluminum foil.
- Such solutions are injected into a patient by means of a syringe.
- syringes There are many different forms of syringes that are presently available for use by the medical professions.
- One particular design difference between various syringes is the manner in which the open end of the syringe is shaped to accommodate a hypodermic needle.
- the two most popular forms of needle fittings are the friction fit fitting (such as the Luer Slip fitting), and the combination of screw thread and friction engagement fitting (such as the Luer Lock fitting).
- a broad channeled needle is attached to the fitting at the open end of the syringe. This needle is used to penetrate the seal, so that the solution in the vial can be transferred to the syringe. Following transfer, this broad channeled needle is removed from the syringe and replaced with a narrower channeled needle suitable for injecting the solution into the patient. It will be appreciated that this procedure is costly and complicated since it necessitates the use of a number of separate components. Furthermore, since solution transfer for injection into humans requires scrupulous sterilizing of components, this practice requires separate sterilizing measures to be taken at each step.
- a closure member is mounted on a stopper fitted in a neck portion of a container holding a solution.
- the closure member includes an axial passage, which extends between first and second openings, the second opening being adapted to receive the end of a syringe.
- a piercing member is arranged in the passage with a piercing tip at the first opening adjacent to the stopper. The piercing member is arranged such that it is displaced to penetrate the stopper when the end of a syringe is received in the second opening. After penetration of the stopper, the solution can be transferred to the syringe through a channel defined in the piecing member, without the need for any broad channeled needle on the syringe itself.
- U.S. Pat. No. 5 740 654 discloses an assembly intended for extemporaneous preparation of solutions and suspensions of a solid active product, the product being enclosed in a container sealed by a stopper fitted in a neck portion thereof.
- the stopper has an axial channel covered by a thin operculum fixed on the outside face of the stopper.
- a separate connection member is first attached to the neck portion, whereupon a compressible flask holding a liquid product and having a pointed tip portion is opened and screwed into the connection member such that the tip portion of the flask penetrates the operculum, thereby establishing fluid communication between the flask and the container.
- the liquid By compressing the flask, the liquid is caused to pass into the container, where it is mixed with the active product. Then, the flask is repeatedly compressed to transfer the solution back to the container, from where it can be transferred by a syringe, as discussed by way of introduction.
- This known device includes several components, and exhibits an increased risk of contamination. The use of the device involves several separate steps before the solution can be injected into a patient. Separate sterilizing measures must be taken at each step.
- the object of the invention is to solve or alleviate at least some of the problems described above.
- the passage is formed such that a substance can be confined therein, two different substances can be separately enclosed in one and the same packaging and be mixed with each other immediately prior to injection.
- a medical practitioner can access the contents of the container and introduce, and preferably engage, the end of a syringe in the second opening of the closure device. Since both substances enter the syringe from the passage in the closure device, they will be mixed automatically, in the syringe and/or in a chamber defined in the passage connecting the first and second openings.
- the inventive closure device both minimizes the need for sterilization and obviates the need for two different needles.
- the inventive closure device comprises a minimum of parts and is of cost-effective construction.
- the container might contain a unit dose of the first substance. If another unit dose of the second substance is confined in the passage of the closure device, the invention provides the further advantage that the first and second substances will be automatically mixed in known and precise proportions.
- the closure device is of unitary or one-piece construction.
- the closure device is formed to replace commonly used seals, such as rubber stoppers or aluminum foils, fitted to the neck portion of the container.
- the closure device holding the second substance is mounted onto an existing conventional seal, such as a rubber stopper or a foil, on the container holding the first substance.
- the penetration means preferably comprises a hollow needle for facilitated penetration of the stopper.
- a non resealable cap is provided at the second portion to seal the second opening. This allows the medical practitioner to access the contents of the container by simply removing the cap to expose the second opening.
- the second end portion comprises a Luer fitting near the second opening, the fitting being adapted for direct fluid tight engagement with the open end of a syringe.
- the penetration means is provided in the passage such that, when the end of a syringe is inserted into the second opening, the penetration means is displaced towards the first opening to penetrate the sealing means that closes off the first opening of the device.
- the penetration means is enclosed in a sterile and confined space, minimizing the need for additional sterilization steps during use of the inventive closure device.
- the penetration means has a cutting element in the shape of an arc extending over more than 180° and less than 360°. Such a cutting element will provide a clean non-closed cut in the foil and minimize the risk of cut-away foil portions falling into the container.
- the cutting element is connected to a stem which extends to the second opening for engagement with the end of the syringe, the periphery of the stem being provided with one or more longitudinal grooves to define a flow path in the passage of the closure device.
- the closure device as such is displaceable towards the container to establish fluid communication between the passage holding the second substance and the container holding the first substance.
- the penetration means has a first end with a cutting element adapted to rupture the sealing means, a second end sealingly fitted to the first opening, and an internal channel in fluid communication with the first and second ends thereof.
- the closure device when mounted on the neck portion of the container, the closure device can be displaced towards the container such that the cutting element ruptures the sealing means, thereby establishing fluid communication between the passage and the container and allowing for confined mixing of the first and second substances.
- the sealing means is attached to the first end of the penetration means to close off the internal channel, and indirectly the first opening.
- FIG. 1 a is a cross-sectional view of a closure device according to the first aspect of the invention
- FIGS. 1 b - 1 d is a perspective view, an elevated side view, and a bottom plan view, respectively, of the penetration means of FIG. 1 a.
- FIG. 2 is a cross-sectional view of a variant of the closure device of FIGS. 1 a - 1 d.
- FIGS. 3 a - 3 b is a perspective view and a cross-sectional view, respectively, of a closure device according to the second aspect of the invention.
- FIGS. 1 a - 1 d there is shown a first embodiment of the inventive closure device according to the first aspect.
- the closure device is attached to a neck portion 1 of a container 2 , thereby enclosing an injectable solution therein.
- the container 2 or at least the neck portion 1 thereof, is generally made of a non-collapsible material, such as glass.
- the closure device of the first embodiment has a body 3 comprising an engaging portion 4 , which is adapted to mate with and engage the inner periphery of the neck portion 1 .
- the engaging portion 4 is joined with a shell portion 5 .
- a spigot 6 extends from the shell portion 5 to a distal end 7 .
- a flat grip 8 is connected to the distal end 7 via a weakened portion 9 , which has a smaller wall thickness than the distal end 7 .
- a passage 10 is formed within the body 3 and extends from a proximate opening 11 defined in an end surface 12 of the engaging portion 4 to a distal opening 13 defined in the distal end 7 , where the passage 10 is closed off by the grip 8 .
- the spigot 6 defines a fitting for engagement with the open end of a syringe (not shown), in this case a Luer Slip fitting, in which the interior of the spigot 6 is adapted to mate with and frictionally engage the outer periphery of the end of the syringe, thereby allowing for a temporary fluid tight engagement therewith.
- a foil 30 preferably of aluminum or aluminum laminate, is attached to the body 3 of the closure device to close off the passage 10 at the end surface 12 of the body 3 .
- the closed passage 10 holds a liquid substance, to be mixed with the injection solution in the container 2 , as will be explained below.
- the passage 10 consists of a smaller-diameter conduit 31 , which is defined in the spigot 6 , and a larger-diameter chamber 32 , which is defined in the engaging portion 4 and in the shell portion 5 .
- the chamber 32 opens in the end surface 12 and defines the opening 11 therein.
- a pusher 33 which is shown in more detail in FIGS. 1 b - 1 d , is slidingly arranged in the passage 10 .
- the pusher 33 is preferably of one-piece construction of a material that is compatible with the fluids in the container and the passage, respectively.
- the pusher 33 comprises an elongate shaft 34 and a plate 35 at a first end thereof.
- Elongate recesses 37 extend between the ends of the shaft 34 .
- the outer periphery of the plate 35 is shaped to be snugly received in the chamber 32 .
- the plate 35 is provided with through holes 39 connecting the opposite sides of the plate.
- the plate 35 On the side facing away from the shaft 34 , the plate 35 carries an arcuate cutting edge 40 extending essentially in parallel to the perimeter of the plate 35 .
- the cutting edge 40 forms an arc extending over more than 180° and less than 360°.
- the cutting edge 40 comprises an axial projection 41 facilitating penetration of the foil 30 .
- the pusher 33 is arranged with the cutting edge 40 adjacent to the foil 30 sealing the opening 11 .
- the shaft 34 extends through the chamber 32 and into the conduit 31 , such that the second end of the shaft 34 is arranged close to the opening 13 .
- the arcuate cutting edge 40 will form a correspondingly arcuate cut in the foil 30 . This cut will define a tongue that can be automatically folded into the container 2 without coming loose, thereby minimizing the risk of cut-away foil portions falling into the container 2 .
- the user grasps the flat grip 8 and tears it off at the weakened portion 9 , thereby exposing the distal opening 13 at the distal end 7 . Then, the end of a syringe (not shown) is introduced in the distal opening 13 to abuttingly engage with the pusher 33 . As the end of the syringe is brought into fluid tight engagement with the Luer fitting formed in the spigot 6 , the cutting edge 40 of the pusher 33 will be automatically driven through the foil 30 to establish fluid communication between the syringe and the container 2 via the passage 10 .
- the first embodiment allows two different substances to be separately enclosed in one and the same packaging and mixed with each other immediately prior to injection. Since both substances enter the syringe through the opening 13 , they will be mixed automatically, in the syringe and/or in the chamber 32 .
- a hypodermic needle can be attached to the end of the syringe for injecting the solution into a patient.
- the end of the syringe can be brought to direct engagement with an intravenous cannula or the like.
- the body 3 of the closure device in the embodiment shown in FIG. 1 a is formed in one piece, preferably by injection moulding, of a plastic material, preferably a nonrigid material such as polyethylene or polypropylene.
- a plastic material preferably a nonrigid material such as polyethylene or polypropylene.
- the pusher 33 is first inserted into the body 3 through the opening 11 in the body 3 .
- a liquid substance is filled into the passage 10 through the opening 11 .
- the foil 30 is attached to the body 3 to provide a unitary closure device which can be attached to a filled container 2 in a subsequent step.
- containers 2 that conventionally are sealed with rubber stoppers, only minor modification of the sealing equipment is required to replace the rubber stopper with the closure device. Further, standard filling equipment can be used.
- the container can be filled with a solution of any drug which is suitable for injection but is particularly advantageous for use with sterilizable anaesthetic or anaesthetization agents, such as propofol or other drugs which are used under conditions where the demands for easy handling and sterility is high.
- the inventive closure device is most suited for use with substances that, for example in order not to exhibit reduced potency, should be mixed immediately prior to injection into a patient.
- propofol which is commonly used both as anaesthetic and as sedative drug. Injection of propofol is frequently associated with pain on intravenous administration. The pain can be reduced by addition of a pH-lowering substance, such as HCl, or a local anaesthetic, such as lidocaine or ropivacaine.
- a pH-lowering substance such as HCl
- a local anaesthetic such as lidocaine or ropivacaine.
- FIG. 2 A second embodiment of a closure device according to the first aspect of the invention is shown in FIG. 2, albeit only in an operative position. As compared with FIG. 1, like elements have been given like reference numerals and a detailed description of such elements will not be repeated.
- the closure device of the second embodiment has a body 3 comprising an engaging portion 4 , a shell portion 5 , and a spigot 6 , the interrelationship of which is described above with reference to FIG. 1.
- a stopper 20 preferably of resilient material such as rubber, is fitted in the neck portion 1 of the container 2 to confine a substance therein.
- a recess is formed in the top surface of the stopper 20 to facilitate penetration thereof.
- a sealing means in the form of a thin foil 30 is attached to the body 3 of the closure device to close off the proximal opening 11 and thus the passage 10 .
- a pusher 33 ′ is arranged in the passage 10 of the closure device of the second embodiment.
- One end portion 35 ′ of the pusher 33 ′ has the shape of a broad channeled needle, i.e. a hollow needle with a central channel 39 ′.
- the sharp tip 40 ′ on one end of the needle 35 ′ is arranged adjacent to the stopper 20 .
- the opposite end of the needle 35 ′ is attached to a shaft 34 ′ (not shown in detail) of similar construction as the shaft 34 in the first embodiment (see FIGS. 1 b and 1 c ).
- the pusher 33 ′ is a long broad channeled needle which extends into the conduit 31 and has lateral perforations communicating the interior channel 39 ′ with the chamber 32 .
- the needle might be connected to an annular gasket which is slidingly arranged in the conduit 31 to seal a space defined between the needle and the walls of the conduit 31 .
- the gasket can guide the needle in the conduit 31 and provide a surface for engagement with the end of the syringe S.
- the stopper 20 it is also conceivable to fixedly attach the stopper 20 to the body 3 , for example by means of glue or the like, thereby closing off the proximate opening 11 and forming a unit that can be directly fitted in the neck portion 1 of the container 2 .
- the foil 30 can be omitted.
- the second embodiment is essentially identical to the first embodiment, and a description thereof will not be repeated. In essence, the second embodiment confers similar advantages as the first embodiment.
- FIGS. 3 a - 3 b An embodiment of a second aspect of the inventive closure device will now be described with reference to FIGS. 3 a - 3 b .
- like elements have been given like reference numerals, and a detailed description of such elements will not be repeated.
- the closure device in FIGS. 3 a - 3 b has a body 3 comprising an engaging portion 4 , a shell portion 5 , and a spigot 6 , the interrelationship of which is described above with reference to FIG. 1.
- the passage 10 consists of a smaller-diameter conduit 31 , which is defined in the spigot 6 , and a larger-diameter chamber 32 , which is defined in the shell portion 5 .
- the chamber 32 opens in the end surface 12 and defines the proximal opening 11 therein.
- a hollow needle 35 ′ with an internal channel 39 ′ is sealingly fitted in the opening 11 and extends to a sharp tip 40 ′.
- the sheath 30 ′ indirectly closes off the opening 11 and confines a liquid substance in the passage 10 .
- the distal opening 13 is sealed off by a foil 8 .
- the engaging portion 4 of the closure device comprises two parallel extensions 4 ′ for snap-fit engagement with the neck portion of a container, which holds an injection solution and is closed off by a conventional seal, such as a stopper or a foil.
- a conventional seal such as a stopper or a foil.
- the body 3 of the closure device shown in FIGS. 3 a - 3 b is a two-piece construction, preferably formed by injection moulding of a plastic material, preferably a nonrigid material such as polyethylene or polypropylene. More specifically, the body 3 is formed by joining a lid part, including the spigot 6 and a peripheral flange at one end thereof, to a sleeve part, including the shell portion 5 and the engaging portion 4 . The lid part is engaged with the sleeve part at the open end thereof, thereby forming a non-releasable peripheral snap-fit joint 60 .
- the two-piece construction reduces manufacturing costs in that the lid part can be produced with narrow tolerances, as required by the Luer fitting, whereas the sleeve part can be produced with wider tolerances.
- the snap-fit joint 60 could be incorporated in any one of the embodiments of the invention.
- the sheath 30 ′ is slipped on the needle 35 ′, whereupon a liquid substance is filled into the passage 10 through the spigot 6 . Then, the foil 8 is attached to seal the distal opening 7 , thereby providing a unitary closure device that can be attached to a filled container in a subsequent step.
- the user pushes the closure device towards the container to drive the tip 40 ′ of the needle 35 ′ through the seal of the container.
- the extensions 4 ′ align the needle 35 ′ perpendicularly to the seal for controlled penetration of the seal.
- the tip 40 ′ simultaneously penetrates the sheath 30 ′ to establish fluid communication between the passage 10 and the container.
- the user grasps the grip portion 8 ′ and removes the foil 8 to expose the distal opening 13 .
- the end of a syringe (not shown) is introduced in the distal opening 13 and brought into fluid tight engagement with the Luer fitting formed in the spigot 6 .
- the solution will flow into the chamber 32 , where it at least partly mixes with the liquid substance contained therein, before leaving the chamber 32 through the conduit 31 .
- closure device is formed integrally with the container.
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/418,058 US20030192791A1 (en) | 1999-07-07 | 2003-04-18 | Closure device for a medical container |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9902610A SE9902610D0 (sv) | 1999-07-07 | 1999-07-07 | Förslutningsanordning vid medicinsk behållare |
SE9902610-6 | 1999-07-07 | ||
US67781700A | 2000-09-29 | 2000-09-29 | |
US10/418,058 US20030192791A1 (en) | 1999-07-07 | 2003-04-18 | Closure device for a medical container |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE2000/001445 Continuation WO2001003641A1 (en) | 1999-07-07 | 2000-07-05 | Closure device for a medical container |
US67781700A Continuation | 1999-07-07 | 2000-09-29 |
Publications (1)
Publication Number | Publication Date |
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US20030192791A1 true US20030192791A1 (en) | 2003-10-16 |
Family
ID=20416420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/418,058 Abandoned US20030192791A1 (en) | 1999-07-07 | 2003-04-18 | Closure device for a medical container |
Country Status (15)
Country | Link |
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US (1) | US20030192791A1 (zh) |
EP (1) | EP1198216A1 (zh) |
JP (1) | JP2003504120A (zh) |
KR (1) | KR20020028204A (zh) |
CN (1) | CN1433293A (zh) |
AU (1) | AU770228B2 (zh) |
BR (1) | BR0012248A (zh) |
CA (1) | CA2375538A1 (zh) |
IL (1) | IL147152A0 (zh) |
MX (1) | MXPA01013442A (zh) |
NO (1) | NO20020035L (zh) |
NZ (1) | NZ516099A (zh) |
SE (1) | SE9902610D0 (zh) |
WO (1) | WO2001003641A1 (zh) |
ZA (1) | ZA200110226B (zh) |
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US20080009809A1 (en) * | 2005-04-26 | 2008-01-10 | Industrie Borla S.P.A. | Device for administering medical liquids and method for the manufacturing thereof |
US20080290060A1 (en) * | 2005-10-07 | 2008-11-27 | Rainer Ammann | Closure |
US20100116699A1 (en) * | 2007-05-31 | 2010-05-13 | Joseph Sorenson | Supplement compartment for beverage container |
US20110144596A1 (en) * | 2008-09-12 | 2011-06-16 | Jms Co., Ltd. | Spout and liquid container with spout |
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USD750768S1 (en) | 2014-06-06 | 2016-03-01 | Anutra Medical, Inc. | Fluid administration syringe |
DE102014226900A1 (de) * | 2014-12-23 | 2016-06-23 | B. Braun Melsungen Ag | Verschlusskappensystem für ein medizinisches Fluidspeicherbehältnis |
US9387151B2 (en) | 2013-08-20 | 2016-07-12 | Anutra Medical, Inc. | Syringe fill system and method |
USD763433S1 (en) | 2014-06-06 | 2016-08-09 | Anutra Medical, Inc. | Delivery system cassette |
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US7533671B2 (en) | 2003-08-08 | 2009-05-19 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US7691151B2 (en) | 2006-03-31 | 2010-04-06 | Spiration, Inc. | Articulable Anchor |
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AU2009203557B2 (en) * | 2008-01-09 | 2014-02-20 | Novartis Ag | Unitary withdrawal spike unit suitable for factory fitting |
WO2010109612A1 (ja) * | 2009-03-25 | 2010-09-30 | 株式会社モリモト医薬 | 医薬組成物容器 |
US8630908B2 (en) | 2011-11-02 | 2014-01-14 | Avery Dennison Corporation | Distributed point of sale, electronic article surveillance, and product information system, apparatus and method |
EP3359116B1 (de) * | 2015-10-09 | 2021-04-07 | Fresenius Kabi Deutschland GmbH | Deckel für ein behältnis zur aufnahme einer enteralen nährstofflösung |
FR3087336B1 (fr) * | 2018-10-19 | 2024-03-22 | Coradin Sas | Dispositif de connexion temporaire de deux recipients |
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US4067440A (en) * | 1975-05-21 | 1978-01-10 | Tuboplast France | Packaging container for the extemporaneous preparation of multi-component solutions |
US4244467A (en) * | 1978-06-05 | 1981-01-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Device for the extemporaneous preparation of a solution under sterile conditions |
US4346820A (en) * | 1979-05-02 | 1982-08-31 | Sigma-Tau Industrie Farmaceutiche Riunite | Apparatus for mixing and dispersing two substances under sterile conditions |
US4643309A (en) * | 1982-02-08 | 1987-02-17 | Astra Lakemedel Ab | Filled unit dose container |
US5740654A (en) * | 1996-03-04 | 1998-04-21 | Semco | Packaging assembly for freeze-dried preparations |
US5782345A (en) * | 1995-12-04 | 1998-07-21 | Laboratorios Cusi, S.A. | Pharmaceutical bottle of two separate substances with mixing device, dosed application and assembly process thereof |
US6098795A (en) * | 1997-10-14 | 2000-08-08 | Mollstam; Bo | Device for adding a component to a package |
US6105760A (en) * | 1997-10-14 | 2000-08-22 | Mollstam; Bo | Two-compartment package |
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CA2252404A1 (en) * | 1996-04-22 | 1997-10-30 | Abbott Laboratories | Container closure system |
FR2753624B1 (fr) * | 1996-09-25 | 1999-04-16 | Biodome | Dispositif de connexion, en particulier entre un recipient avec bouchon perforable et une seringue |
US6003566A (en) * | 1998-02-26 | 1999-12-21 | Becton Dickinson And Company | Vial transferset and method |
-
1999
- 1999-07-07 SE SE9902610A patent/SE9902610D0/xx unknown
-
2000
- 2000-07-05 EP EP20000946723 patent/EP1198216A1/en not_active Withdrawn
- 2000-07-05 CN CN00810031A patent/CN1433293A/zh active Pending
- 2000-07-05 IL IL14715200A patent/IL147152A0/xx unknown
- 2000-07-05 NZ NZ516099A patent/NZ516099A/en unknown
- 2000-07-05 WO PCT/SE2000/001445 patent/WO2001003641A1/en not_active Application Discontinuation
- 2000-07-05 AU AU60437/00A patent/AU770228B2/en not_active Ceased
- 2000-07-05 BR BR0012248A patent/BR0012248A/pt not_active IP Right Cessation
- 2000-07-05 MX MXPA01013442A patent/MXPA01013442A/es unknown
- 2000-07-05 CA CA 2375538 patent/CA2375538A1/en not_active Abandoned
- 2000-07-05 KR KR1020027000121A patent/KR20020028204A/ko not_active Application Discontinuation
- 2000-07-05 JP JP2001508925A patent/JP2003504120A/ja active Pending
-
2001
- 2001-12-12 ZA ZA200110226A patent/ZA200110226B/xx unknown
-
2002
- 2002-01-04 NO NO20020035A patent/NO20020035L/no not_active Application Discontinuation
-
2003
- 2003-04-18 US US10/418,058 patent/US20030192791A1/en not_active Abandoned
Patent Citations (8)
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US4067440A (en) * | 1975-05-21 | 1978-01-10 | Tuboplast France | Packaging container for the extemporaneous preparation of multi-component solutions |
US4244467A (en) * | 1978-06-05 | 1981-01-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Device for the extemporaneous preparation of a solution under sterile conditions |
US4346820A (en) * | 1979-05-02 | 1982-08-31 | Sigma-Tau Industrie Farmaceutiche Riunite | Apparatus for mixing and dispersing two substances under sterile conditions |
US4643309A (en) * | 1982-02-08 | 1987-02-17 | Astra Lakemedel Ab | Filled unit dose container |
US5782345A (en) * | 1995-12-04 | 1998-07-21 | Laboratorios Cusi, S.A. | Pharmaceutical bottle of two separate substances with mixing device, dosed application and assembly process thereof |
US5740654A (en) * | 1996-03-04 | 1998-04-21 | Semco | Packaging assembly for freeze-dried preparations |
US6098795A (en) * | 1997-10-14 | 2000-08-08 | Mollstam; Bo | Device for adding a component to a package |
US6105760A (en) * | 1997-10-14 | 2000-08-22 | Mollstam; Bo | Two-compartment package |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2005049444A1 (en) * | 2003-11-24 | 2005-06-02 | Guido Rossi Merighi | Monodose food pack |
US20080009809A1 (en) * | 2005-04-26 | 2008-01-10 | Industrie Borla S.P.A. | Device for administering medical liquids and method for the manufacturing thereof |
US7625359B2 (en) * | 2005-04-26 | 2009-12-01 | Industrie Borla S.P.A. | Device for administering medical liquids and method for the manufacturing thereof |
US20080290060A1 (en) * | 2005-10-07 | 2008-11-27 | Rainer Ammann | Closure |
US9522098B2 (en) | 2006-05-25 | 2016-12-20 | Bayer Healthcare, Llc | Reconstitution device |
US8562582B2 (en) | 2006-05-25 | 2013-10-22 | Bayer Healthcare Llc | Reconstitution device |
US20100116699A1 (en) * | 2007-05-31 | 2010-05-13 | Joseph Sorenson | Supplement compartment for beverage container |
US20110144596A1 (en) * | 2008-09-12 | 2011-06-16 | Jms Co., Ltd. | Spout and liquid container with spout |
US20110180566A1 (en) * | 2008-10-16 | 2011-07-28 | Jms Co., Ltd. | Spout and liquid container with spout |
USD738494S1 (en) * | 2013-03-05 | 2015-09-08 | Ikashmore Pty Ltd | Blood collection safety device |
WO2014202600A1 (en) * | 2013-06-18 | 2014-12-24 | Corporació Sanitària Parc Taulí | Container and method for the storage and extemporaneous reconstitution of a mixture of compounds in fixed proportions |
USD742742S1 (en) * | 2013-07-26 | 2015-11-10 | ViCap Systems Europe Asia AG | Drink flask cap insert |
US9387151B2 (en) | 2013-08-20 | 2016-07-12 | Anutra Medical, Inc. | Syringe fill system and method |
US9393177B2 (en) | 2013-08-20 | 2016-07-19 | Anutra Medical, Inc. | Cassette assembly for syringe fill system |
US9579257B2 (en) | 2013-08-20 | 2017-02-28 | Anutra Medical, Inc. | Haptic feedback and audible output syringe |
US10010483B2 (en) | 2013-08-20 | 2018-07-03 | Anutra Medical, Inc. | Cassette assembly for syringe fill system |
US10010482B2 (en) | 2013-08-20 | 2018-07-03 | Anutra Medical, Inc. | Syringe fill system and method |
USD763433S1 (en) | 2014-06-06 | 2016-08-09 | Anutra Medical, Inc. | Delivery system cassette |
USD774182S1 (en) | 2014-06-06 | 2016-12-13 | Anutra Medical, Inc. | Anesthetic delivery device |
USD750768S1 (en) | 2014-06-06 | 2016-03-01 | Anutra Medical, Inc. | Fluid administration syringe |
DE102014226900A1 (de) * | 2014-12-23 | 2016-06-23 | B. Braun Melsungen Ag | Verschlusskappensystem für ein medizinisches Fluidspeicherbehältnis |
DE102014226900B4 (de) * | 2014-12-23 | 2017-10-26 | B. Braun Melsungen Ag | Verschlusskappensystem für ein medizinisches Fluidspeicherbehältnis |
Also Published As
Publication number | Publication date |
---|---|
NO20020035D0 (no) | 2002-01-04 |
AU770228B2 (en) | 2004-02-19 |
AU6043700A (en) | 2001-01-30 |
ZA200110226B (en) | 2003-03-12 |
CA2375538A1 (en) | 2001-01-18 |
NO20020035L (no) | 2002-01-04 |
CN1433293A (zh) | 2003-07-30 |
KR20020028204A (ko) | 2002-04-16 |
BR0012248A (pt) | 2002-03-26 |
JP2003504120A (ja) | 2003-02-04 |
SE9902610D0 (sv) | 1999-07-07 |
WO2001003641A1 (en) | 2001-01-18 |
IL147152A0 (en) | 2002-08-14 |
NZ516099A (en) | 2003-07-25 |
EP1198216A1 (en) | 2002-04-24 |
MXPA01013442A (es) | 2002-07-02 |
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Legal Events
Date | Code | Title | Description |
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STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO PAY ISSUE FEE |