US20030083656A1 - Tissue separator assembly and method - Google Patents

Tissue separator assembly and method Download PDF

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Publication number
US20030083656A1
US20030083656A1 US10/045,657 US4565701A US2003083656A1 US 20030083656 A1 US20030083656 A1 US 20030083656A1 US 4565701 A US4565701 A US 4565701A US 2003083656 A1 US2003083656 A1 US 2003083656A1
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United States
Prior art keywords
tissue
assembly
distal
shaft
separator element
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Abandoned
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US10/045,657
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English (en)
Inventor
George Morrison
William Dubrul
Robert Laird
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Artemis Medical Inc
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US10/045,657 priority Critical patent/US20030083656A1/en
Priority to US10/374,584 priority patent/US20030204188A1/en
Publication of US20030083656A1 publication Critical patent/US20030083656A1/en
Assigned to ARTEMIS MEDICAL, INC. reassignment ARTEMIS MEDICAL, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LAIRD, ROBERT
Priority to US11/434,632 priority patent/US7846159B2/en
Assigned to GENERAL ELECTRIC CAPITAL CORPORATION, AS AGENT reassignment GENERAL ELECTRIC CAPITAL CORPORATION, AS AGENT SECURITY AGREEMENT Assignors: ARTEMIS MEDICAL, INC.
Priority to US13/865,611 priority patent/US9211130B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/148—Probes or electrodes therefor having a short, rigid shaft for accessing the inner body transcutaneously, e.g. for neurosurgery or arthroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00867—Material properties shape memory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A61B2017/22061—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation for spreading elements apart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A61B2017/2212—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having a closed distal end, e.g. a loop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A61B2017/2215—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having an open distal end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00601—Cutting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1475—Electrodes retractable in or deployable from a housing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
    • A61B2090/3908—Soft tissue, e.g. breast tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/02—Devices for expanding tissue, e.g. skin tissue

Definitions

  • tissue separator assembly including the proximal end assembly, typically a handle, and catheter assembly extending from the proximal end assembly.
  • the catheter assembly includes a shaft and an elongate tissue separator element, a distal part of which is movable between a retracted state and an outwardly extending, operational state.
  • the proximal end assembly includes a first driver coupled to the tissue separator element and constructed to (1) to move the tissue separator element from the retracted state to the operational state, and (2) automatically rotate the tissue separator element about the axis, whereby a tissue section is separable from the surrounding tissue by the moving tissue separator element.
  • tissue separator assembly including the proximal end assembly, typically a handle, and catheter assembly extending from the proximal end assembly.
  • the catheter assembly includes a shaft and an elongate tissue separator element, a distal part of which is movable between a retracted state and an outwardly bowed, operational state.
  • An energy source is selectively coupled to the tissue separator element.
  • the proximal end assembly includes a first driver coupled to the tissue separator element and constructed to (1) to move the tissue separator element from the retracted state to the operational state, and (2) automatically rotate the tissue separator element about the axis, whereby a tissue section is separable from the surrounding tissue by the moving tissue separator element.
  • the catheter assembly also includes a tissue holding element at the distal portion of the shaft movable from a retracted condition to an extended, tissue engaging condition so to help secure a separated tissue section to the catheter assembly.
  • the catheter assembly further includes a tubular braided element at the distal portion of the shaft movable to a radially expanded state so to surround the tissue separator element and any separated tissue section.
  • the proximal end assembly also includes a second driver coupled to the holding element and to the tubular braided element. The second driver is constructed to move the holding element to the extended, tissue engaging condition and move the tubular braided element to the distal, radially expanded state.
  • tissue separator assembly including the proximal end assembly, typically a handle, and catheter assembly extending from the proximal end assembly.
  • the catheter assembly includes a shaft and a movable tissue separator element.
  • the proximal end assembly includes a first driver coupled to the tissue separator element and constructed to drive the tissue separator element through tissue to separate a tissue section from surrounding tissue.
  • the catheter assembly also includes a tissue holding element at the distal portion of the shaft movable from a retracted condition to an extended, tissue engaging condition so to help secure a separated tissue section to the catheter assembly.
  • the catheter assembly further includes a tubular braided element at the distal portion of the shaft movable to a radially expanded state so to surround the tissue separator element and any separated tissue section.
  • the proximal end assembly also includes a second driver coupled to the holding element and to the tubular braided element. The second driver is constructed to move the holding element to the extended, tissue engaging condition and move the tubular braided element to the distal, radially expanded state.
  • a further aspect of the invention is directed to a method for creating a tissue section within surrounding tissue.
  • the method includes positioning a distal end of a catheter assembly at a target location within a patient.
  • An elongate tissue separator element, at the distal end of the catheter assembly, is moved to an outwardly extending, operational state.
  • the separator element is automatically rotated about the axis, following at least the start of the separator element moving step, so to separate a tissue section from surrounding tissue.
  • the method may also include moving a tissue holding element, located at the distal end of the catheter assembly, from a retracted condition to an extended, tissue engaging condition. Further, the method may include surrounding the separated tissue section with a tubular braided element.
  • a still further aspect of the invention is directed to a method for creating a tissue section within surrounding tissue.
  • the method includes positioning a distal end of the catheter assembly at a target location within a breast of a patient.
  • An elongate tissue separator element, at the distal end of the catheter assembly is moved to a radially extended, outwardly bowed, operational state. Energy is supplied to the separator element.
  • the separator element is automatically rotated about the axis, following at least the start of the separator element moving step, so to separate a tissue section from surrounding tissue.
  • a tissue holding element, located at the distal end of the catheter assembly is moved from a retracted condition to an extended, tissue engaging condition.
  • the separated tissue section is surrounded by a tubular braided element by moving the tubular braided element, located at the distal end of the catheter assembly, from a proximal, radially contracted state to a distal, radially expanded state following the automatically rotating step.
  • FIG. 1 is a partially schematic overall view of a tissue separator assembly made according to the invention with portions of the handle removed for clarity;
  • FIG. 1A is a simplified cross-sectional view taken along line 1 A- 1 A of FIG. 1 showing the engagement of a pin within a slot in the lead nut mounted to the lead screw;
  • FIG. 2 is schematic view of portions of the drive elements of the assembly of FIG. 1;
  • FIG. 3 is a simplified cross-sectional view of the catheter assembly taken along line 3 - 3 of FIG. 1;
  • FIG. 4 is an oblique view of the housing half of FIG. 1 together with the drive screw, drive nut and an L-shaped actuator connected to and movable with the drive nut;
  • FIGS. 5 and 6 show the handle and catheter assembly of FIG. 1 after the actuator has moved from the position of FIG. 1 and the actuator extension has pushed the separator wire pusher screw in a distal direction causing the separator wire to move radially outwardly;
  • FIG. 7 is a simplified the end view of the block and the pusher screw just after the pusher screw has exited the slot in the block showing the off-vertical orientation of the pusher screw;
  • FIG. 8 illustrates the proximal end of the lead screw, which is visible from outside the housing, and a rotary position indicator marked thereon corresponding to the position of the separator wire in FIG. 10;
  • FIGS. 9 and 10 illustrate the structure of FIGS. 5 and 6 after the drive screw has moved the actuator distally causing the lead nut to rotate the lead screw, catheter shaft and separator wire therewith about 540 degrees to create a separated tissue section;
  • FIGS. 11 and 12 illustrate the manual actuation of tissue section holding elements
  • FIG. 13 is a simplified view of certain of the components of FIG. 12;
  • FIG. 14 is a cross-sectional view of the catheter taken along line 14 - 14 of FIG. 13;
  • FIGS. 15 and 16 illustrate the manual actuation of a tubular braided element to surround the separated tissue section
  • FIG. 17 is a simplified view of certain of the components of FIG. 16.
  • FIGS. 1 and 2 illustrate a tissue separator assembly 10 used to separate target tissue from surrounding tissue, typically within a patient's breast. The removal of target tissue may be for diagnostic or therapeutic purposes.
  • the assembly 10 includes a catheter assembly 12 extending from a handle 14 . Introduction of catheter assembly 12 into the patient, typically through the skin, is preferably aided by the use of, for example, a trocar or an RF tip to provide a suitable path through the tissue.
  • a stepper motor 16 is connected to handle 14 by a drive drive cable 18 and a drive cable connector 20 mounted to the handle housing 22 . Note that in the figures only one-half of handle housing 22 is shown; the other housing half is substantially similar.
  • RF energy is supplied to catheter assembly 12 from an RF source 24 , along drive cable 18 and to the interior of handle 14 .
  • a controller 26 controls the operation of stepper motor 16 as well as RF source 24 , such as speed of operation and energy level. Controller 26 also receives appropriate feedback signals from handle 14 and catheter assembly 12 , such as tissue temperature, resistance force signals, rotary orientation, and so forth.
  • Drive cable 18 is connected to and rotates a drive screw 28 rotatably mounted within handle 14 at a fixed axial location by drive screw supports 30 , 32 .
  • a drive nut 34 is threadably mounted to drive screw 28 .
  • An L-shaped actuator 36 is secured to drive nut 34 .
  • Actuator 36 see FIG. 4, includes a generally horizontal base portion 38 and a generally vertical upright portion 40 sized and configured to move within handle 14 parallel to the axis of drive screw 28 . Therefore, rotation of drive screw 28 by stepper motor 16 causes actuator 36 to slide within housing 22 from the initial position of FIG. 1 to the position of FIG. 10. Reverse and reciprocating movement is also possible.
  • Catheter assembly 12 includes in introducer sheath 42 mounted to and extending from housing 22 .
  • Catheter assembly 12 also includes an actuator tube 43 , discussed below with reference to FIGS. 14 - 17 , passing through sheath 42 and a shaft 44 passing through tube 43 .
  • Shaft 44 has a distal portion 46 extending distally of the distal end 48 of sheath 42 and a proximal portion 50 extending into the interior of handle 14 .
  • Proximal portion 50 is secured to and rotates with a lead screw 52 .
  • shaft 44 rotates with lead screw 52 .
  • Lead screw 52 is mounted within housing 22 in a manner so that it can rotate but not move axially within housing 22 .
  • a tissue separator device 54 extends along shaft 44 and has a separator wire portion 56 secured to the distal end 58 of shaft 44 .
  • the separator wire 56 is positioned externally of distal portion 46 .
  • the majority of tissue separator device 54 is in the form of a wire and extends through an axial bore 60 formed in shaft 44 .
  • the separator device 54 has a radially extending pusher screw 62 at its proximal end.
  • the proximal end of shaft 44 has an axially extending slot 64 , see FIG. 2, through which pusher screw 62 extends. Accordingly, pushing pusher screw 62 distally, that is to the left in the figures, causes tissue separator wire 56 to move outwardly from its radially contracted condition of FIG.
  • wire 56 is supplied with RF energy from RF source 24 .
  • Other applications of energy such as mechanical reciprocation or mechanical vibration, can also be used.
  • the axial movement of pusher screw 62 is caused by the axial movement of actuator 36 .
  • Actuator 36 has an extension 66 extending distally from upright portion 40 .
  • Extension 66 has a downwardly formed distal end 68 aligned with pusher screw 62 .
  • the initial axial movement of actuator 40 caused by the rotation of drive screw 28 by stepper motor 16 , closes a small gap 70 (see FIG. 2) between distal end 68 and pusher screw 62 . This small gap permits the initiation of an electrosurgical arc prior to the outwardly radial movement of separator wire 56 .
  • Continued distal movement of actuator 36 moves pusher screw 62 distally causing separator wire 56 to bow outwardly to the position of FIGS. 5 and 6.
  • FIGS. 5 and 6 show the use of a support block 72 , which is a part of housing 22 , to support the distal end of lead screw 52 and the proximal end of shaft 44 .
  • Support block 72 has an axially extending slot 74 , see FIGS. 5 and 7, which initially houses pusher screw 62 .
  • pusher screw 62 exits slot 74 and the distal end 68 of extension 66 , which has a chamfered face, causes pusher screw 62 , along with shaft 44 , to begin rotating to the off-vertical position of FIG. 7.
  • upright portion 40 of actuator 36 closes gap 73 (see FIG.
  • Assembly 10 is configured so that shaft 44 rotates about 540 degrees to ensure a tissue section 80 is completely separated from the surrounding tissue by the passage of separator wire 56 through the tissue.
  • the radial position of separator wire 56 can be easily determined by looking at the proximal end 82 of lead screw 52 , which is exposed through housing 22 . See FIG. 8.
  • Proximal end 82 has a rotary position indicator 84 formed thereon corresponding to the rotary position of separator wire 56 .
  • Assembly 10 also includes a T-pusher device 86 having a pair of pusher tabs 88 extending laterally outwardly from slots formed in housing 22 . See FIGS. 11 - 13 . After shaft 44 has completed its rotation, the user begins pushing tabs 88 distally. This causes an extension 90 of device 86 to rotate a flipper cam 92 about a pivot pin 94 ; flipper cam 92 is connected to the proximal ends of a pair of tissue section holding elements 96 . Holding elements 96 are in the form of wires passing through axial bores 98 formed in shaft 44 as shown in FIG. 3.
  • holding elements 96 are preformed hook wires 100 , preferably made of a shape memory material such as nitinol, which pass through openings formed in distal portion 46 of shaft 44 and engage separated tissue section 80 to help secure tissue section 80 to distal portion 46 of shaft 44 .
  • a shape memory material such as nitinol
  • Device 86 includes a distal end 102 connected to the proximal end of actuator tube 43 .
  • the movement of device 86 causes tube 43 to move distally within introducer sheath 42 .
  • a tubular braided element 104 see FIGS. 14 - 17 , secured to the distal end of actuator tube 43 , is still fully housed within sheath 42 .
  • Further distal movement of device 86 causes tubular braided element 104 to extend outwardly past distal end 48 of sheath 42 to the position of FIGS. 15 - 17 .
  • tubular braided element 104 The purpose of tubular braided element 104 is to surround separated tissue section 80 by passing along the dissection plane between the separated tissue section and the surrounding tissue.
  • the open outer end 106 of element 104 naturally expands radially as it is pushed axially through the tissue.
  • shaft 44 has an outwardly tapered guide surface 108 , formed on a guide element 110 , positioned adjacent to distal end 48 of introducer shaft 42 .
  • Guide element 110 has a slot in its proximal surface into which the proximal end of separator wire 56 passes when in the radially expanded condition of FIG. 9; this helps to keep separator wire 56 from folding over during rotation.
  • outer end 106 of tubular braided element 104 could include a drawstring or other type of closure element.
  • the separated tissue section 80 now substantially enclosed within tubular braided element 104 and secured to distal portion 46 of shaft 44 by hook wires 100 , may be removed from the patient.
  • separated tissue section 80 retains most if not all of its physical integrity once removed from the patient. Also, the use of tubular braided element 104 , especially when it is sealed or otherwise impermeable to the passage of material, helps to reduce the possibility of seeding diseased tissue along the tissue tract during removal of separated tissue section 80 .
  • a target tissue localization device such as disclosed in U.S. Pat. No. 6,179,860, may be incorporated into assembly 10 ; such a localization device would be deployed, as indicated by dashed lines 112 in FIG. 1 and localization device actuator shaft 114 in FIG. 18, after placement of distal portion 46 of shaft 44 at the target site and would be used to help stabilize the assembly and also help contain, in conjunction with a tubular braided element 104 , separated tissue section 80 .
  • Lead screw 52 could be hollow to permit actuator shaft 114 , or other medical devices, to pass therethrough and into a lumen within shaft 44 .
  • stepper motor 16 drive screw 28 and drive nut 34
  • other driving mechanisms such as spring driven drivers with appropriately configured escape mechanisms and/or movement damping devices, could be used.
  • shaft 44 does not begin to rotate until after separator wire 56 has reached its fully radially extended state. In some situations it may be desired to begin rotating shaft 44 before and/or during the outward movement of separator wire 56 .

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Otolaryngology (AREA)
  • Pathology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Surgical Instruments (AREA)
US10/045,657 2000-06-05 2001-11-07 Tissue separator assembly and method Abandoned US20030083656A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/045,657 US20030083656A1 (en) 2000-11-07 2001-11-07 Tissue separator assembly and method
US10/374,584 US20030204188A1 (en) 2001-11-07 2003-02-25 Tissue separating and localizing catheter assembly
US11/434,632 US7846159B2 (en) 2000-11-07 2006-05-15 Tissue separating and localizing catheter assembly
US13/865,611 US9211130B2 (en) 2000-06-05 2013-04-18 Tissue separating catheter assembly and method

Applications Claiming Priority (2)

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US24641300P 2000-11-07 2000-11-07
US10/045,657 US20030083656A1 (en) 2000-11-07 2001-11-07 Tissue separator assembly and method

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US10/374,584 Continuation-In-Part US20030204188A1 (en) 2000-06-05 2003-02-25 Tissue separating and localizing catheter assembly

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US20030083656A1 true US20030083656A1 (en) 2003-05-01

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US10/212,467 Expired - Fee Related US7150712B2 (en) 2000-11-07 2002-08-05 Target tissue localization assembly and method

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US10/212,467 Expired - Fee Related US7150712B2 (en) 2000-11-07 2002-08-05 Target tissue localization assembly and method

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EP (1) EP1341435A4 (zh)
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040167511A1 (en) * 2003-02-25 2004-08-26 Artemis Medical, Inc. Tissue separating catheter assembly and method
US20050038462A1 (en) * 1998-04-08 2005-02-17 Senorx, Inc. Dilation devices and methods for removing tissue specimens
US20060293654A1 (en) * 2000-11-07 2006-12-28 Artemis Medical, Inc. Tissue separating and localizing catheter assembly
US20080294361A1 (en) * 2007-05-24 2008-11-27 Popp Shane M Intelligent execution system for the monitoring and execution of vaccine manufacturing
US9642645B2 (en) 2013-03-13 2017-05-09 Boston Scientific Scimed, Inc. Tissue cutting devices and methods
US20230181187A1 (en) * 2021-08-20 2023-06-15 Covidien Lp Small diameter linear surgical stapling apparatus

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US8795332B2 (en) 2002-09-30 2014-08-05 Ethicon, Inc. Barbed sutures
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
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