US20020125166A1 - Cassette stack having cassettes for histological preparations - Google Patents

Cassette stack having cassettes for histological preparations Download PDF

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Publication number
US20020125166A1
US20020125166A1 US10/093,312 US9331202A US2002125166A1 US 20020125166 A1 US20020125166 A1 US 20020125166A1 US 9331202 A US9331202 A US 9331202A US 2002125166 A1 US2002125166 A1 US 2002125166A1
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US
United States
Prior art keywords
stack
cassettes
cassette
cassette stack
magazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/093,312
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English (en)
Inventor
Andreas Laudat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leica Biosystems Nussloch GmbH
Original Assignee
Leica Microsystems Nussloch GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leica Microsystems Nussloch GmbH filed Critical Leica Microsystems Nussloch GmbH
Assigned to LEICA MICROSYSTEMS NUSSLOCH GMBH reassignment LEICA MICROSYSTEMS NUSSLOCH GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LAUDAT, ANDREAS
Publication of US20020125166A1 publication Critical patent/US20020125166A1/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates

Definitions

  • the invention concerns a cassette stack having individual cassettes, arranged one above another and connected detachably to one another.
  • the cassettes of a stack of this kind serve as containers for histological specimens. The latter are exposed in the container, for preparation of the section, to a subsequent chemical process for fixing and to a process for embedding. In order to distinguish the cassettes, they are manually or automatically labeled.
  • GB 2 235 163 A discloses a printing system for labeling the cassettes. In this printing system, the cassettes must be individually loaded into a stack magazine.
  • cassettes are usually packaged loose in plastic bags when supplied commercially, and must then be laboriously introduced “by hand” into such stack magazines.
  • GB 2 304 704 A mentions a prepackaged stack magazine, “Packing, containing a stack of tissue processing cassettes,” for a special printer in which a high level of packaging complexity is effected.
  • cassette stack in which the cassettes have a special groove on both long sides.
  • a continuous ribbon is guided in the grooves in order to attach the cassettes to one another.
  • the ribbon reliably retains the cassettes, each cassette must nevertheless be equipped with a special groove, so that this approach is limited to a specific cassette type. It has also proven in practical use to be difficult to remove the ribbon from the cassette stack.
  • connection of the individual plastic cassettes is accomplished either via an adhesive tape that is applied on one of the lateral surfaces and/or via a weld seam on at least one of the lateral surfaces.
  • connection of the individual plastic cassettes is accomplished either via an adhesive tape that is applied on one of the lateral surfaces and/or via a weld seam on at least one of the lateral surfaces.
  • the cassettes which have a rectangularly configured bottom surface having peripheral shaped-on lateral surfaces, are arranged in the cassette stack with a displacement with respect to one another in the longitudinal direction of the cassettes. This has the advantage that the corners of the cassette cannot jam against one another.
  • the cassettes are arranged at an angle of at least 20° with respect to horizontal when the cassette stack extends in a vertical direction. This also has the advantage that the stack is easier to introduce into the stack magazine. Cassettes positioned obliquely inside the stack magazine are mechanically easier to remove, and do not jam against one another.
  • At least one adhesive tape is arranged on at least one of the lateral surfaces of the cassette stack; it is of course possible, for stability reasons, to arrange two or more adhesive tapes on one side or also one adhesive tape on each of two or more sides. These adhesive tapes are selected in such a way that they can be pulled off the cassette in residue-free fashion.
  • the adhesive tape is also characterized by being configured so that at any desired point it can be severed and/or partially pulled off the cassette stack. Different stack magazines can thus be loaded individually.
  • This weld seam is produced by a heatable tool, preferably a heated wire. With this wire, adjacent cassettes, which preferably are made of polyoxymethylene, are welded to one another at adjacent points.
  • This spot-type connection can be produced very easily and economically, and requires absolutely no additional packaging or attachment materials.
  • the stack magazine of the printing system has on one side a slot for pulling the adhesive tape off the cassette stack.
  • the cassettes must be introduced obliquely into the stack magazine, and are stacked therein in that oblique position. This has the advantage that the cassettes cannot jam against one another with their corners, and thus ensures reliable mechanical removal of the cassettes.
  • the cassette stack is configured to be obliquely insertable into the stack magazine. It has proven to be advantageous if the cassettes are arranged in the cassette stack at an angle of at least 20° relative to horizontal, and in the stack magazine at an angle of at least 15° relative to a bottom of the stack magazine.
  • FIG. 1 is a side view of the cassette stack with adhesive tape applied
  • FIG. 2 is a perspective view of the cassette stack with adhesive tape applied
  • FIG. 3 is a side view of the cassette stack with a weld seam applied
  • FIG. 4 is a perspective view of the cassette stack with a weld seam applied
  • FIG. 5 is a side view of the stack magazine with the cassette stack inserted.
  • FIG. 6 is a plan view of the stack magazine.
  • FIG. 1 shows a cassette stack 1 having multiple cassettes 2 arranged one above another.
  • Cassettes 2 have a rectangular bottom surface 6 and are equipped with shaped-on and peripheral lateral surfaces 7 . These cassettes 2 serve to receive histological preparations that, for section preparation, pass through a chemical process.
  • Cassettes 2 are arranged with a displacement with respect to one another in their longitudinal direction.
  • Cassettes 2 are furthermore arranged in cassette stack 1 such that the bottom surface 6 of each cassette 2 is at an angle of approximately 20° relative to horizontal when the cassette stack 1 extends in a vertical stack direction.
  • the individual cassettes 2 of the stack 1 are detachably connected to one another by way of an adhesive tape 4 . This adhesive tape 4 can be removed later from the cassette stack in residue-free fashion.
  • FIG. 2 shows cassette stack 1 of FIG. 1 in a perspective depiction, with adhesive tape 4 applied. It is clear from this depiction that cassettes 2 are arranged in inclined fashion and with a displacement with respect to one another.
  • FIG. 3 analogous to FIG. 1, shows cassette stack 1 , the adhesive tape here having been replaced by a weld seam 5 .
  • the respective adjacent cassettes 2 are connected in spot fashion to one another.
  • two weld seams 5 arranged parallel to one another are provided on one lateral surface 7 . It may also be sufficient, however, if only one weld seam 5 is provided on lateral surfaces 7 , or if one weld seam 5 is arranged on each of two or three lateral surfaces 7 . It is simply necessary to ensure that cassette stack 1 can be reliably transported, and that the individual cassettes 2 can later be detached from one another.
  • FIG. 4 shows a perspective view of cassette stack 1 with the two weld seams 5 .
  • FIG. 5 shows a side view of a stack magazine 3 having a slot 8 provided in a lateral wall thereof.
  • a cassette stack 1 is introduced into stack magazine 3 at an oblique angle of approximately 15°.
  • the individual cassettes 2 lie obliquely with respect to the bottom of the stack magazine, and are arranged at an offset from one another. This has the advantage that the individual corners of cassettes 2 cannot jam against one another, thus ensuring that cassettes 2 reliably slide along when the bottommost cassette 2 of stack 1 is removed.
  • Cassette 1 is depicted here still having adhesive tape 4 arranged on it. The latter can, after the introduction of cassette stack 1 into stack magazine 3 , be pulled off and removed through slot 8 in stack magazine 3 .
  • FIG. 6 shows a plan view of stack magazine 3 , which has a shorter bottom surface 9 longitudinally from front to back than bottom surface 6 of cassette 2 . This ensures that cassettes 2 are always arranged inside stack magazine 3 at an oblique angle of at least 15° relative to the bottom surface 9 of the stack magazine when they are allowed to shift slightly upon removal of adhesive tape 4 and/or weld seam(s) 5 .
  • the invention is not limited to the exemplary embodiments described; to the contrary, any desired connection combinations of weld seams and/or adhesive strips can be provided on the lateral surfaces of the cassettes.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Stackable Containers (AREA)
  • Packages (AREA)
  • Packaging Of Annular Or Rod-Shaped Articles, Wearing Apparel, Cassettes, Or The Like (AREA)
  • Packaging Frangible Articles (AREA)
  • Ink Jet (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
US10/093,312 2001-03-09 2002-03-07 Cassette stack having cassettes for histological preparations Abandoned US20020125166A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE20104158U DE20104158U1 (de) 2001-03-09 2001-03-09 Kassettenstapel mit Kassetten für histologische Präparate
DE20104158.8 2001-03-09

Publications (1)

Publication Number Publication Date
US20020125166A1 true US20020125166A1 (en) 2002-09-12

Family

ID=7954100

Family Applications (1)

Application Number Title Priority Date Filing Date
US10/093,312 Abandoned US20020125166A1 (en) 2001-03-09 2002-03-07 Cassette stack having cassettes for histological preparations

Country Status (8)

Country Link
US (1) US20020125166A1 (de)
EP (1) EP1238706B1 (de)
JP (1) JP4031653B2 (de)
CN (1) CN1254311C (de)
AT (1) ATE276831T1 (de)
CA (1) CA2375593A1 (de)
DE (2) DE20104158U1 (de)
ES (1) ES2229055T3 (de)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059281A1 (en) * 2001-09-06 2003-03-27 Uwe Kiene Delivery device for cassettes and/or specimen slides for histological preparations in a printing system
US20050152809A1 (en) * 2004-01-08 2005-07-14 Hunnell Jack E. Unitary assembly of biological specimen support articles, and apparatus for dispensing individual biological specimen support articles therefrom
US20050183391A1 (en) * 2004-02-19 2005-08-25 Chouinard Richard J. Wrap device to facilitate handling of stacked slides or other stackable flat objects
US20100220162A1 (en) * 2006-01-20 2010-09-02 Phoenix Contact Gmbh & Co. Kg Method and apparatus for printing objects, in particular plastic parts
US20150241325A1 (en) * 2014-02-26 2015-08-27 CellPath Ltd. Histology cassette stack
WO2017136401A1 (en) * 2016-02-01 2017-08-10 Bioventures, Llc Dual-purpose biopsy collection container and tissue processing cassette

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013020114A1 (de) 2013-12-06 2015-06-11 Kabe-Labortechnik Gmbh Kassettenstapel aus einzelnen Kassetten, vorzugsweise zur Aufnahme von Präparaten für Laboranalysen
DE202018102561U1 (de) 2018-05-08 2018-05-22 Kabe-Labortechnik Gmbh Kassettenstapel aus einzelnen Kassetten, vorzugsweise zur Aufnahme von Präparaten für Laboranalysen
JP7252649B2 (ja) * 2019-11-15 2023-04-05 株式会社常光 印字装置
GB2593532A (en) 2020-03-27 2021-09-29 Shandon Diagnostics Ltd A stack of histology cassettes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4890765A (en) * 1988-01-05 1990-01-02 Habley Medical Technology Corp. Storage container for blood collection devices
US6176383B1 (en) * 1999-08-24 2001-01-23 3088081 Canada Inc. Biological specimen cassette
US6676901B1 (en) * 1997-10-17 2004-01-13 Mitsubishi Gas Chemical Company, Inc. Oxygen indicator package equipped with oxygen indicator and method for manufacturing the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343579A (en) * 1979-09-07 1982-08-10 Signode Corporation Nail stack
GB8915140D0 (en) * 1989-06-30 1989-08-23 Lamb Raymond A Device for marking supports for laboratory samples
ES2066697B1 (es) * 1992-12-29 1995-08-16 Azkoyen Ind Sa Perfeccionamientos introducidos en columnas expendedoras automaticas de productos.
US5511690A (en) * 1993-05-20 1996-04-30 Medical Laboratory Automation, Inc. Automated feeder system and apparatus
US6098839A (en) * 1998-05-07 2000-08-08 Triangle Biomedical Sciences, Inc. Article dispensing assembly

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4890765A (en) * 1988-01-05 1990-01-02 Habley Medical Technology Corp. Storage container for blood collection devices
US6676901B1 (en) * 1997-10-17 2004-01-13 Mitsubishi Gas Chemical Company, Inc. Oxygen indicator package equipped with oxygen indicator and method for manufacturing the same
US6176383B1 (en) * 1999-08-24 2001-01-23 3088081 Canada Inc. Biological specimen cassette

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059281A1 (en) * 2001-09-06 2003-03-27 Uwe Kiene Delivery device for cassettes and/or specimen slides for histological preparations in a printing system
US6814257B2 (en) * 2001-09-06 2004-11-09 Leica Microsystems Nussloch Gmbh Delivery device for cassettes and/or specimen slides for histological preparations in a printing system
US20050152809A1 (en) * 2004-01-08 2005-07-14 Hunnell Jack E. Unitary assembly of biological specimen support articles, and apparatus for dispensing individual biological specimen support articles therefrom
US7507379B2 (en) * 2004-01-08 2009-03-24 Triangle Biomedical Sciences, Inc. Unitary assembly of biological specimen support articles, and apparatus for dispensing individual biological specimen support articles therefrom
US20050183391A1 (en) * 2004-02-19 2005-08-25 Chouinard Richard J. Wrap device to facilitate handling of stacked slides or other stackable flat objects
US20100220162A1 (en) * 2006-01-20 2010-09-02 Phoenix Contact Gmbh & Co. Kg Method and apparatus for printing objects, in particular plastic parts
US8303100B2 (en) 2006-01-20 2012-11-06 Phoenix Contact Gmbh & Co. Kg Method and apparatus for printing objects, in particular plastic parts
US20150241325A1 (en) * 2014-02-26 2015-08-27 CellPath Ltd. Histology cassette stack
US10288536B2 (en) * 2014-02-26 2019-05-14 CellPath Ltd. Histology cassette stack
WO2017136401A1 (en) * 2016-02-01 2017-08-10 Bioventures, Llc Dual-purpose biopsy collection container and tissue processing cassette

Also Published As

Publication number Publication date
EP1238706A3 (de) 2003-11-26
CN1254311C (zh) 2006-05-03
CA2375593A1 (en) 2002-09-09
ES2229055T3 (es) 2005-04-16
JP4031653B2 (ja) 2008-01-09
DE20104158U1 (de) 2001-08-02
JP2002357513A (ja) 2002-12-13
EP1238706A2 (de) 2002-09-11
CN1374234A (zh) 2002-10-16
DE50201060D1 (de) 2004-10-28
ATE276831T1 (de) 2004-10-15
EP1238706B1 (de) 2004-09-22

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Legal Events

Date Code Title Description
AS Assignment

Owner name: LEICA MICROSYSTEMS NUSSLOCH GMBH, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:LAUDAT, ANDREAS;REEL/FRAME:012682/0635

Effective date: 20020307

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION