US20020054920A1

US20020054920A1 - Antistress composition for a stress prevention and treatment

Info

Publication number: US20020054920A1
Application number: US09/730,993
Authority: US
Inventors: Byung Choi; Gyung Park
Original assignee: BYUNG HAK CHOI
Current assignee: BYUNG HAK CHOI; BYUNG HAG CHOI
Priority date: 2000-09-20
Filing date: 2000-12-06
Publication date: 2002-05-09
Anticipated expiration: 2020-12-06
Also published as: KR20020022342A; US6416795B1; KR100373501B1

Abstract

The present invention provides antistress compositions contaning various medicinal herbs which are composed of one or more of medicinal herb 2.0˜40.0 g of fructus hordel germintus, messa medicata fermentata, frucutus amomi and fructus crataegei; hone or more of medicinal herb 2.0˜40.0 g of radix polygalae, semen zizyphi spinosae and rhizoma acori graminei; one or more of medicinal herb 2.0˜40.0 g selected from the group of poria holen and poria, one or more of medicinal herb 2.0˜40.0 g of folium phyllostachyos, calus in taein phyllostachos, succus phyllostachos and radix scutellariae; one or more of medicinal herb 2.0˜40.0 g of legumonosae, fructus amomicardamomi, semen glycine and semen lablab; one or more of medicinal herb 2.0˜40.0 g of rhizoma zingiberis, radix asari, rhizoma zingiberis siccatum and radix aconiti; one or more of medicinal herb 2.0˜40.0 g of bulbos allii fistulosi, herba ephedrae and folium perillae; and one or more of medicinal herb 2.0˜40.0 g of red pepper and radix platycodi as the effective ingredients that relieve stress and represse of a memory failure that releive stress and repress of a memory failure.

Description

FIELD OF THE INVENTION

The present invention relates to an antistress compositions contaning various medical herbs as effective ingredients that relieve stress and repress a memory failure.

Particularly, the present invention relates to the antistress compositions containing mixture Which is composed of one or more of medicinal herb 2.0˜40.0 g selected from the group of fructus hordel germintus, messa medicata fermentata, frucutus amomi and fructus crataegei; one or more of medicinal herb 2.0˜40.0 g selected from the group of radix polygalae, semen zizyphi spinosae and rhizoma acori graminei; one or more of medicinal herb 2.0˜40.0 g selected from the group of poria holen and poria; one or more of medicinal herb 2.0˜40.0 g selected from the group of folium phyllostachyos, culus in taein phyllostachos, succus phyllostachos and radix scutellariae; one or more of medicinal herb 2.0˜40.0 g selected from the group of legumonosae, fructus amomicardamomi, semen glycine and semen lablab; one or more of medicinal herb 2.0˜40.0 g selected from the group of rhizoma zingiberis. radix asari, rhizoma zingiberis siccatum and radix aconiti; one or more of medicinal herb 2.0˜40.0 g selected from the group of bulbos allii fistulosi, herba ephedrae and folium perillae; and one or more of medicinal herb 2.0˜40.0 g selected from the group of red pepper and radix platycodi as the effective ingredients.

The antistress compositions of the present invention are so effective for the stress relief and the memory failure by the excessive stress that they can be useful not only for stress prevention and treatment but also for the health food.

BACKGROUND

Generally, when a stimulus to a living body become over the certain level, it injures the living body. At this time, the living body shows a general adaptive syndrome as a reaction to the certain threat irrelevant the kind of stimulus, and this phenomena has defined as a stress (Selye, H: The stress of life, Toronto, Longnans Green and Co., pp.1-50, 1958).

This reaction is represented as the various phenomena in the body, which develop strain headache, migraine, hypertension, dyspepsia, fatigue, pain, climacteric suffering, hair growing and rough skin. If these phenomena continue chronically, all kinds of neuropathy and stomach ulcer are caused and physiological activity and immune response are reduced. It also threatens the health considerably since the breakage of homeostasis in the body weakens resistance, and then causes other disease. In addition, it shrinks psychological activity and induces abnormal behavior because of instable emotion. Particularly, the stress is raised as a very important problem since it is excessively occurred in the modern society.

The stress which is called as the root of modern diseases is induced by the various causes and is roughly classified as follows.

1) Physical factor—overexertion, lack of sleep, external wound, addiction, etc.

2) External factor—natural environment, cultural state, human relationship in the home or in the office, etc.

3) Internal factor—personality, mental conflict in the real life, mental injury in the childhood, etc.

The effect of this stress to the human body is so various that it induces nervousness, headache, hypertension, etc, and if the stress is continued, other secondary disease develops since the function of the body decreases. As the above-mentioned, the cause of the stress is various according to the method which inflicts injury to the body, but it is commonly said that all the following reactions are mediated by accelerating the function of HPA, sympathetic nervous system, which induces hormone secretion. In short, these reactions are as follows. Adrenal gland which is stimulated by adrenal corticotropic hormone increases its weight and decreases the lipid, and the spleen considerably decreases its weight because of the decline of immune function. On the other hand, adrenal gland increases cholesterol, blood sugar, alkaline phosphatase (ALP), lactate dehydrogenase (LDH), aspartate aminotransferase(AST or GOT), alanine aminotransferase(ALT or GPT) by secreting other steroid hormone and induces the decrease of neutral lipid in case of serious state. These variations in the living body are reported as the middle step of external symptoms which are above-mentioned. Therefore, to prevent or cure the stress, it is desirable to recover diverse physiological variations in the human body occurred by the stress.

The variations which are induced by the stress are very diverse and if these states are continued, it becomes the root of many diseases. So it is urgently necessary to repress the stress. However, only the physical treatment methods like sports, sleeping and relaxation have been suggested. The methods which stimulate recovery of physiological variations induced by the stress have not be enoughly suggested. Therefore, it has been suggested the necessity of development of the medicine which has the preventive and curing effect to the stress.

As part of these research, antistress components which have the effects of the stress prevention and treatment using cholic acids have been deveolped(Korea patent No.95-6225). The antistress agents including cholic acids are widely used as the solublizing agent of gallstone. since the antistress agents have the activity of choleretic function, liver detoxification, improvement of liver blood stream, stimulating function of lipid absorption and waste excretion through fine biliary duct, they are marketted as the gallstone solublizer, ursodeoxycholic acid which has the effects of liver function improvement in chronical liver disease, general malaise by the liver function disturbance, dyspepsia, anorexia and body fatigue. And they include tauroursodeoxycholic acid effective for liver lipid treatment(JP No.4-235918) which is reported that it improves liver function and decreasing the amount of liver lipid in case of oral administration, andchenodeoxycholic acid and dihydrocholic acid that are on sale as the solublizing agent of gallstone.

However, antistress compositions using the cholic acids only have proved that they have the preventive effects for weight increase of adrenal gland and shrink of spleen and the repressive effects for ascorbiac acid content variation of adrenal gland and blood biochemical variation which are general symptoms induced by the stress. So it is not mentioned at all about the effect which represses or recovers memory failure induced by the stress.

Moreover, various forms of medicines principally made from ginseng, Eucommiaceae ulmoides, brekman that are reported as having useful effects to the stress as amedicinal herb or a folk remedy, are developed(Korea patent No.96-8230). The nutrition tonic containing ginseng as a principal ingrdient is widely marketted, and the nutrition tonic containing Eucommiaceae ulmoides as a pricipal ingrdient is marketted. In addition, the nutrition tonic comprised of various compounds like honey, vitamin and the like is marketted. However, though it is reported that the medicinal herbs like ginseng, brekhman (Pharmacological investigation of glycosides from Ginseng and Eleutherococcus, Loydia, Vol.32, No.1, pp.46-51, 1969), ocimum sanctum Linn, tinosporamalabarica(Sen, P., Maiti, PC and Ray, A. Mechanism of anti-stress activity of Linn, eugenol and in exprimental animals, Indian J. Exp Biol., 30, 592-596, 1992) and biological materials like melatonin have the antistress function, they have the effect to induced by the stress or have a little effect. In addtion, they have no unique characteristic in the point of using the medicinal herb extracts which have been used as traditional oriental material and generally, they have only the purpose using the nutrition tonic or commonly known effect.

In this real condition, it is asked for the development of desirable antistress agents which have the repressive effects to the various symptoms induced by the stress, wherein the stress is big problem in modern society. Especially, it is urgently required for the development of desirable antistress agents cause using relevant combination of medicinal herb extracts which have the preventive or curing effects to the various symptoms induced by the stress which is induced by the various.

In order to develop new antistress agents which have exellent effect and have not been used in combination so far, the present invention has developed antistress compositions containing fructus hordel germintus, radix polygalae, poria holen folium phyllostachyos, leguminosae, rhizoma zingiberis, bulbus allii fistulosi and red pepper of the medicinal herbs as effective ingrdients, and verified that the antistress compositions have wide and exellent effect to the prevention and cure of the stress and repression of the memory failure.

SUMMARY OF THE INVENTION

It is an object of this invention to provide antistress compositions containing various medicinal herbs as effective ingredients to relieve stress and repress a memory failure.

It as afurther object of this invention to provide the antistress compositions containing mixture composed of fructus hordel germintus, radix polygalae, poria holen, folium phyllostachyos, leguminosae, rhizoma zingiberis, bulbus allii fistulosi and red pepper of the medicinal herbs which have the effects for the prevention and cure of the stress in order to releive the stress and repress memory failure induced by excessive stress.

In accordance with the present invention, the foregoing objects and advantages are readily obtained.

The present invention provides the antistress compositions containing mixture which is composed of one or more of medicinal herb 2.0˜40.0 g selected from the group of fructus hordel germintus, messa medicata fermentata, frucutus amomi and fructus crataegei; one or more of medicinal herb 2.0˜40.0 g selected from the group of radix polygalae, semen zizyphi spinosae and rhizoma acori graminei; one or more of medicinal herb 2.0˜40.0 g selected from the group of poria holen and poria; one or more of medicinal herb 2.0˜40.0 g selected from the group of folium phyllostachyos, calus in taein phyllostachos, succus phyllostachos and radix scutell ariae; one or more of medicinal herb 2.0˜40.0 g selected from the group of legumonosae, fructus amomicardamomi, semen glycine and semen lablab; one or more of medicinal herb 2.0˜40.0 g selected from the group of rhizoma zingiberis, radix asari, rhizoma zingiberis siccatum and radix aconiti; one or more of medicinal herb 2.0˜40.0 g selected from the group of bulbos allii fistulosi, herba ephedrae and folium perillae; and one or more of medicinal herb 2.0˜40.0 g selected from the group of red pepper and radix platycodi as the effective components.

This invention also providesthe pharmaceutical compositions containing the antistress compositions as the effective ingredients which have preventive and curing effects of the stress.

In addition, the present invention provides if health food containing the antistress components as the effective components which have preventive and curing effects of the stress.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows weight variation in proportion to administration period after the emdicinal herb extracts of antistress compositions of the present invention are administered to experimental animals, wherein [0023]
Control group;the group which are not administered with the medicinal herb tea extracts of antistress compositions of the present invention [0024]
Experimental group;the group which are administered with the medicinal herb tea extracts of antistress compositions of the present invention [0025]
♦; the control group which are not given with stress [0026]
▪; the control group which are given with stress [0027]
▴; the experimental group which are not given with stress [0028]
*; the experimental group which are given with stress[0029]

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

Hereinafter, the present invention is described in detail. [0030]
The present invention provides antistress compositions contaning various medical herbs as effective ingrdients that relieve stress and repress memory failure. [0031]
The antistress compositions of the present invention contains mixture which is composed of one or more of medicinal herb 2.0˜40.0 g selected from the group of [0032] fructus hordel germintus, messa medicata fermentata, frucutus amomi and fructus crataegei; one or more of medicinal herb 2.0˜40.0 g selected from the group of radix polygalae, semen zizyphi spinosae and rhizoma acori graminei; one or more of medicinal herb 2.0˜40.0 g selected from the group of poria holen and poria, one or more of medicinal herb 2.0˜40.0 g selected from the group of folium phyllostachyos, calus in taein phyllostachos, succus phyllostachos and radix scutellariae; one or more of medicinal herb 2.0˜40.0 g selected from the group of legumonosae, fructus amomicardamomi, semen glycine and semen lablab; one or more of medicinal herb 2.0˜40.0 g selected from the group of rhizoma zingiberis, radix asari, rhizoma zingiberis siccatum and radix aconiti; one or more of medicinal herb 2.0˜40.0 g selected from the group of bulbos allii fistulosi, herba ephedrae and folium perillae; and one or more of medicinal herb 2.0˜40.0 g selected from the group of red pepper and radix platycodi as the effective components.
[0033] Fructus hordel germintus is acquired by sprouting annual medicinal herb, barley, easily regarded as Korean traditional food which is called as malt, but it is the enzyme acquired from the nature and used universally. Fructus hordel germintus is the bud which is germinated by relevant watering and at regular temperature, and it contains a lot of amylase. Using the function of amylase, it is used to manufacture fermented rice punch, rice nectar, glutinous starch syrup, taffy, beer and the like. Well-made Fructus hordel germintus contains protease, invertase, oxidative enzyme, phytase other than amylase. Of the amylase, it is the α-amylase that is comprised a lot in Fructus hordel germintus but the β-amylase that is not almost comprised. In addition, the protease of Fructus hordel germintus has the effect which makes the flavor, the taste and the foam better by degrading the protein.
[0034] Fructus hordel germintus is used as follows. Fructus hordel germintus is soaked in water, is taken out of water, is put in a roub basket and the top is weaved by a cattail, in the state of covering with a buddle, is frequently watered and germinated below 60° C. and is collected and dried under the sun when the length of the bud becoms about 3-5 cm.
[0035] Fructus hordel germintus has the effect to the cure of acute and chronic hepatitis, stimulates an appetite, represses an intestinal convulsion and cures dyspepsia, vomiting, diarrhea and the like. It is preferable that the antistress components of the present invention to contain 2.0˜40.0 g of fructus hordel germintus.
As the alternative medicinal herb of [0036] fructus hordel germintus, messa medicata fermentata, fructus amomi and fructus crataegai can be used.
[0037] Radix polygalae is the part of root of the perennial medicinal herb which is belong to radix polygalae family. The part of the root contains a lot of saponin, and saponin is hydrolyzed to crystal of tenuiginin A and tenuiginin B. In addition, it contains polygalitol, N-acetylglycosamine, alkaloid tenuidine, vegetable fat, resin and the like. Since plant saponin which is comprised in radix polygalae induces light vomiting by stimulating stomach mucosa, it has the effects of discharging phlegm by increasing an exudate in bronchus and RBC hydrolysis. It has been reported that the herb tea of radix polygalae induces exciting effect for guinea pig, rabbit, unpregnented dog and the removed womb of pregnented dog.
[0038] Radix polygalae is used as follows. The root of radix polygalae is collected in spring and summer, the pith of the inner part is removed, is soaked in the water of boil-down licorite root for about 15-20 min water of boil-down licorite root for about 15-20 min and is dried in the shade.
[0039] Radix polygalae has the effects which stablize the mental, make brain clear, discharge phlegm and congestion of blood. In addition, it has the functions which increase wisdom, make the health and eyesight better and reinforce memory. It is preferable that the antistress components of the present invention contain 2.0 g˜40.0 g of radix polygalae.
As the alternative medicinal herb of [0040] radix polygalae, semen zizyphi spinosae and rhizoma acori graminei can be used.
[0041] Poria holen is the white part which contains naturally pine root in the middle of stem and the part of the root of the plant which is belong to Polyporaceae family. Poria holen tastes sweet and flat, has ordinary property and it has been reported that poria holen generally stabilizes mental, excrets water and treats worry susceptibility to fright, amnesia, insomnia, epilepsy, urine handicap and the like. If poria holen has been injected to the intestine of experimental animal which is excited state by taking caffein, experimental animal is stabilized to the state of dozing but dosen't show sleeping phenomena.
[0042] Poria holen is collected in spring or summer, dried in the shade and used as medicinal herb. It is present invention contain 2.0 g˜40.0 g of poria holen.
As the alternative medicine of [0043] poria holen, poria can be used.
[0044] Folium phyllostachuos is the leaflet of the black bamboo which is belong to rice family, contains arundoin, cylindrin, taraxelrol and fridelin, which are triterpenoid compound, and in addition, contains phenol-based lipid, amino acid, organic acid, saccharide and the like. Folium phyllostachuos tastes sweet and flat, has cold property, cures symptoms of swollen and painful gingiva, gets rid of the thirst of a fever, discharges urine well and makes mental refreshing. In addition, folium phyllostachuos discharges phlegm, makes eyes bright and temperature go down and has the effect of detoxification. In case of oral administration to the rat which is artificially developed fever, it has been reported that it shows exellent alleviatin of a fever and has urination function by increasing chloride execretion.
[0045] Folium phyllostachuos is collected as the leaflet of the black bamboo in May-June before blooming, is dried in the sun and is used as medicinal herb. Folium phyllostachuos alleviates fever, makes urination better, makes eyes bright and treats symptoms of swollen and painful gingiva and mouth inflammation. It is preferable that the antistress components of the present invention contain 2.0˜40.0 g of folium phyllostachuos.
As the alternative medicinal herb of [0046] folium phyllostachuos, calcus in taein phyllostachyos, succus phyllostachyos and radix scutellarial can be used.
Leguminosae is germinated black soybean which is belong to the pulse family and generally means bean sprouts. Although bean sprouts is the food which is made of germinated soybean, it is better rather to ingest bean sprouts than ingest soybean and has the effects for cure and prevention of the various adult diseases. The remarkable thing in the bean sprouts is that it produces vitamin C, vitamin B[0047] ₂, niacin and vitamin K which are absent in black soybean. In addition, it is estimated as the important source of vitamins and minerals in North Europe since it contains a lot of minerals like potassium and calcium and food fibers. The digestive absorption rate of soybean itself is low, but soybean sprouts has high digestive absorption rate since it contains digestive enzymes such as amylase, invertase and the like and comprises lysin, tryptophan, methionin and the like as vegetable protein. In addtion, green-bean sprouts and mung bean sprouts have a lot of phosphorous and vitamin B₂, but since the components are easily soluble in water, they should be eaten by roasting in oil. Soybean sprouts which has low calorie and large volume is very popular for diet food and is reported that they promote health by intaking food fiber if they are cooked with other vegetables.
Leguminosae is that domestic yellow soybean for the use of soybean sprouts is germinated by soaking in water, is grown at ambient temperature for about 5 days, is completely dried in the cold place and is used as medicinal herb. [0048]
Leguminosae vitalizes the body mentally and physically and cures lingering intoxification, headache and stomachache which are induced by a cold, diarrhea, skin disease. It is preferable that the antistress components of the present invention contain 2.0-40.0 g of leguminosae. [0049]
As the alternative medicinal herb, [0050] fructus amomi cardamomi, semen glycine and semen lablab can be used.
[0051] Rhizoma zingiberis is perennial medicinal herb which is belong to ginger family, is used as a source without asking irrespective of the East and the West and has the big effect not only to the flavor but also to the health. Particularly, rhizoma zingiberis shows the effect of the resistance to the ulcer and contains the same components of the gastric ulcer drug which is marketted now. The mixture of 6-gingetol and 26-gingetol which are oil components of the pungent taste of rhizoma zingiberis increases bile secretion which stimulates digestive absorption of lipid at about 1.3 fold. In addition, rhizoma zingiberis represses sickening and vomiting, is helpful to prevent constipation by increasing the intestinal activity, makes intestine clean and stops diarrhea. On the other way, it has been reported that rhizoma zingiberis alleviates pain, shows cough remedy, and sterilizes
which is parasitic in sashimi and shakes intestine violently. Rhizoma zingiberis is the natural medicinal herb which has strong antioxidative function such as vitamin E, vitamin C, betacarotene, green tea shows that the effect of each component, in the view of experiment, is the same as or stronger than synthetic drug and may show synergy effect with other component and has no side effect.
[0052] Rhizoma zingiberis is picked in spring and is used as medicinal herb after rhizoma zingiberis removed of stem, leaf and hair root is washed clean. Rhizoma zingiberis acts on digestive system, stops vomiting, discharges phlegm, induces excitement function to the center of blood vein activity and respiration and has the effects of antibacteria and antiprotozoan. It is preferable that the antistress components of the present invention contain 2.0-40.0 g of rhizoma zingiberis.
As the alternative medicinal herb, radix asari, [0053] rhizoma zingiberis siccatum and radix aconiti can be used.
[0054] Bulbus allii fistulosi is the perennial medicinal herb, the leek, which is belong to a lily family and is reported as panacea of tonsils, headache, kidney disease, cold, nervous breakdown, insomnia, fever and diarrhea. In our country, the leek is used only as food source but it has been developed as medicine in Chinease, America, Japanease and Europe.
The pungent component of the leek is allyl sulfide, which exists glyciside form in the organism and which is produced by the enzyme of disrupted cell and is evaporated by heat. The leek contains a lot of water but it contains a lot of amino acids in dried state which contain 30% alanine that degrades lipid, recovers fatigue and increases mental power and 30% glutamine that helps lipid metabolism, detoxificates harmful material and stimulates brain development. So the leek has been analyzed to have the effect not only for food but also for circulatory system disease like cerebral apoplexy as a medicine. [0055]
[0056] Bulbus allii fistulosi is used as medicinal herb which is dried in the shade after washing the leek which is removed of soil. Bulbus allii fistulosi cures heat and cold, headache, stomachache, bad urination and defecation, dysntery, swell and cleans the large and small intestinal convulsion and beriberi. It is preferable that the antistress components of the present invention contain 2.0-40.0 g of bulbus allii fistulosi.
As the alternative medicinal herb, [0057] herba ephedrae and folium perillae can be used.
Red pepper which contains capsacin tastes pungent, contains carotene of pigment component, which oxidizes to capsanthin when green pepper matures and becomes red pepper of deep red. If capsacin is ingested relavantly, it has the effects of promotion of appetite, keeping warmth and sterilization of intestine. The people who lives in hot weather eat red pepper as the source of power and the people who lives in cold weather eat red pepper for the purpose of making the body warm. [0058]
In oreiental medicine, red pepper has the function of making eyesight better, helps digestion by activating stomache, is introduced as folk remedy which helps blood stream by retaining heat, releives the pain of neuralgia or arthritis by cauterizing with powdered red pepper in folk remedy and cures gout or arthritis. In addition, red pepper has the functions of removal of pain and promotion of metabolism. [0059]
Red pepper is collected in autumn when it ripes and used as medicinal herb after it is dried in the sun and is cleaned with dried towel. It is preferable that the antistress components of the present invention contain 2.0-40.0 g of red pepper. [0060]
As the alternative medicinal herb, [0061] rhizoma zingiberis and radix platycodi can be used.
In addition, the present invention provides the pharmaceutical compositions which comprise the antistress compounds as the effective ingrdients and have the effects for a stress prevention and treatment. [0062]
The preparing method of the antistress components of the present invention can be performed by customary method which is known in this field and can be made to the type of herb tea(infusion), pill, tablet, soft capsule, liquid, powder and granule. [0063]
In general, the herb tea is called as whole medicinal decoction and is the type of liquid medicine. In other words, the medicinal herb is soaked in water, heated for a certain time, discarded of dregs and used as drug of extracted water. The herb tea is widely used type of oriental medicine and has the good points of easy absorption, rapid treatment and simple preparation. It is desirable to use the utensil of porcelin or enamel which is made of soil. This is for the protection of bad effect to medicinal effect by inducing variation reaction of medicinal herb which comprises tanin and organic acid, so it is undesirable to use the utensil of iron or copper. [0064]
In addition, it is desirable to use white cotton cloth as the herb tea pocket which is used when the medicinal herb is boiled down in the extracter, since it dosen't make chemical reaction and filters fine dregs well comparatively. [0065]
Like this, the liquid component of the herb tea extracts which is boiled-down in the extracter is packed vaccumly by using automatic package machine in order to drink easily by the amount of one time. [0066]
On the basis of the customary preparing method, the preparing method of the antistress components in the present invention is composed of the following steps; [0067]
1)soaking the rest medicinal herb except red pepper and [0068] bulbus allii fistulosi in water after weighing medicinal herbs of the prescription on the balancer
2)extracting herb tea by putting the soaked medicinal herbs of the [0069] step 1 into the pocket, adding red pepper and bulbus allii fistulosi for the amount and boiling in the preheated extracter
3)moving the extracted herb tea of the step 2 to the automatic package machine and packing by the amount for one time. [0070]
It is proper to soak the medicinal herb of the [0071] step 1 for about 30 min or 1 hour, which makes the effective ingredients of medicinal herb solublized easily.
It is desirable to use white cotton cloth for the pocket in the step 2 and the herb tea is extracted by boiling for about one and a half hour after adding water 4000 cc per dried medicinal herb 500 g. [0072]
In the step 3, after the pressure of extracter is increased suddenly, the extracted herb tea is moved to the package machine by opening valve and the dregs is left in the extracter. [0073]
Pills are the types of various granules which are made by adding paster to the fine powder of medicinal herb and [0074]
,
,
are generally used in clinic. Pills have the effects of simple intaking, gentle absorption, long continuance and convinient carry and store.
The preparing method of the pills of the antistress components in the present invention is composed of the following step; [0075]
1)prepariong the mixture of medicinal herbs by mixing and powdering after weighing all the medicinal herbs on the balancer for the amount; [0076]
2)continuesly heating honey with weak fire until it becomes yellow after heating and filtering honey for several times; [0077]
3)If the step 2 is completed, adding the mixture of medicinal herb of the [0078] step 1 to the hot honey and kneading into dough;
4)molding the dough of the step 3 into pill of regular size using artificial or pill machine; [0079]
5) sealing up and storing the pill of the step 4 in the shaded and cold place after drying in the cold and dried place [0080]
In the [0081] step 1, after powdering all the components of medicinal herbs, they are all added and pulverized repeatedly in the blender for several times in order to mix each medicinal herb evenly.
In the step 2, honey is prepared for 250 cc per pulverized medicinal herb 500 g and water, wallnut oil and vinegar can be used instead of the honey. The honey is heated until it is sticky and has yellow fiber when picked and rubbed with finger and it isn't sticky in the palm. [0082]
The capsule of the antistress components in the present invention is prepared by putting appropriate amount into the capsule after lyophilizing the herb tea which is made by the preparing method of the present. [0083]
On the other hand, the pharmaceutical compositions of the present invention are prepared to the customary drug type by adding one or more of ordinary carrier which is permissible pharmaceutically and one or more of ordinary additive to the effective amount of the antistress components. [0084]
Carrier can be selected from one or more of diluent, glosser, combinator, vehicle, sweetening, stabilizer and antiseptic and additive can be selected from one or more of spice, vitamins and antioxidizer. The formulations pharmaceutically permissible of the present invention can be prepared in the type of herb tea, pill, tablet, capsule, soft capsule, liquid, granule and powder and orally administered. [0085]
In the present invention, all the carrier and additive which are pharmaceutically permissible can be used. Particularly, diluent can be selected from the group of lactose monohydrate, cornstarch, soybean oil, microcrystalline cellulose and D-mannitol. Glosser is preferable to be selected from magnesium stearate or talc, and combinator from polyvinylpyrrolidone(PVP) or hydroxypropylcellulose(HPC). In addtion, it is desirable to select carboxymethylcellulose caicium, sodium starch glycolate, polacrylin potassium or cross-linked polyvinylpyrrolidone as the vehicle, white sugar, fructose, sorbitol or aspartam as the sweetenings, carboxymethylcellulose sodium(Na-CMC), beta-cyclodextrin, white bee's wax or xanthan gum as the stabilizer, methylparaben, propylparaben or potassium sorbate as the antiseptic. [0086]
In the pharmaceutical compositions of the present invention except the main components above, mineral compounds of vitamin B, C, E or beta-carotene, Ca, Mg, Zn or phosphlipid like lecitin or maltol and amino acids compounds can be used as the auxiliary component and it is preferable to use the mixture of 2-3 components of vitamin C, E or beta-carotene, maltol because of increasing or reinforcing biological activity effect of organism. [0087]
In addition to the preceded components, as the known additive, the natural spices or natural juices like Japanease apricot, lemon, pineapple or herb; natural pigments of chlorophyllin and flavonoid; sweetening components of fructose, honey, sugar alcohol, sugar; and souring components like citric acid and sodium citric acid can be used in order to promote appitite. [0088]
In order to obtain the preventive and curing effects of the stress in the medicine, the antistress compositions of the rpesent invention as the effective ingrdients are desirable to freely, orally administer to be 30-120 g/day of total amount, preferably 40-60 g/day of total amount to the standard of 60 kg adult in the type of herb tea, pill, tablet, capsule, soft capsule, liquid, granule or powder. [0089]
Since the antistress compositions of the present invention contain the medicinal herbs widely used in the oriental medicine as the effective components and their components and toxicity data are well-known, acute toxicity test doesn't be performed. [0090]
In addition, the present invention provides the health food which has preventive and curing effect for stress by comprising the antistress compositions as the effective ingredients. [0091]
The health foods comprising the antistress components of the present invention are folk remedies of tea, jelly, juice and drink containing the medicinal berbs as the effective ingredients for the purpose of prevention of stress and repression of memory failure. [0092]
The present inventors have conformed the effects of prevention of stress and repression of memory failure of the antistress compositions in the present invention by the animal test as follows. The herb tea extracts of the antistress compositions of the present invention were administered and the stress was given to the experimental animals which was educated by Morris water maze test. The time to get to the objective place and the variation of a time to find out the point were measured. As a result, in the normal state, the experimental animals memorized the objective place where they were educated for 20 times after 6 weeks, but their educated memory was declined very much because of the external physical stress. However, these phenomena of memory failure were repressed by the herb tea which was injected with the external physical stress. So, it was confirmed that the herb tea extracts of the antistress compositions in the present invention had the effects of preventing the memory failure and recovering the memory power. [0093]
To put together the results, it has been demonstrated that the herb tea extracts of the present invention, which are administered to the experimental animals, have the effects of preventing the failure of education ability and memory power and recovering the memory power since the antistress compositions of the present invention have the synergy effect by comprising main effective ingredients. [0094]

EXAMPLES

Practical and presently preferred embodiments of the present invention are illustrative as shown in the following Examples. [0095]
However, it will be appreciated that those skilled in the art, on consideration of this disclosure, may make modifications and improvements within the spirit and scope of the present invention. [0096]

Example 1

Preparation of Pharmaceutical Compositions of Antistress Agents; Herb Tea [0097]
<1-1>[0098]
In order to prepare pharmaceutical compositions comprising the antistress components of the present invention as the effective ingredients for herb tea, after weighing [0099] fructus hordel germintus 5.0 g, radix polygalae 3.0 g, poria holen 3.0 g, folium phyllostachos 3.0 g, legumonosae 3.0 g, rhizoma zingiberis 2.0 g, bulbos allii fistulosi 2.0 g and red pepper 2.0 g on the balancer for the amount, the rest medicinal herbs except red pepper and bulbos allii fistulosi were soaked in water to decoct the effective ingredients of the medicinal herbs for about 30 min or 1 hour.
After the medicinal herbs soaked in water were collected in the pocket and red pepper and [0100] bulbos allii fistulosi were added, the herb tea were extracted by boiling down in the preheated herb tea extracter. At this time, it was preferable to use the pocket made of white cotton cloth. The herb tea were extracted by adding water 4000 cc to dried medicinal herbs 500 g and boiling for about one and a half hour.
In order to move the extracted herb tea like the preceded method, after the pressure of the extracter was suddenly increased, the extracted herb tea was moved to package machine by opening the valve for automatic package machine and prerared by packaging for the dosage of one time and the dregs were left in the extracter. [0101]
<1-2>[0102]
The herb tea was prepared by using [0103] fructus hordel germintus 20.0 g, radix polygalae 16.0 g, poria holen 16.0 g, folium phyllostachos 16.0 g, legumonosae 15.0 g, rhizoma zingiberis 10.0 g, bulbos allii fistulosi 10.0 g and red pepper 8.0 g as the medicinal herbs of antistress componenets via the procedure described in the Example <1-1>.
<1-3>[0104]
The herb tea was prepared by using [0105] hordel germintus 20.0 g, semen zizyphi spinosae 16.0 g, poria holen 16.0 g, calcus in taein phyllostachos 16.0 g, legumonosae 15.0 g, radix asari 10.0 g, bulbos allii fistulosi and radix platycodi 8.0 g as the medicinal herbs of antistress componenets via the procedure described in the Example <1-1>.
<1-4>[0106]
The herb tea was prepared by the preceded (step 1) and the medicinal herbs of antistress components were [0107] messa medicata fermentata 20.0 g, radix polygalae 16.0 g, poria 16.0 g, folium phyllostachyos 16.0 g, fructus amomicardamomi 15.0 g, rhizoma zingiberis 10.0 g, herba ephedrae 10.0 g and red pepper 8.0 g.
<1-5>[0108]
The herb tea was prepared by using [0109] messa medicata 20.0 g, semen zizyphi spinosae 16.0 g, poria 16.0 g, calcus in taein phyllostachos 16.0 g, fructus amomicardamomi 15.0 g, radix asari 10.0 g g, herba ephedrae 10.0 g and radix platicodi 8.0 g as the medicinal herbs of antistress components via the procedure described in the Example <1-1>.
<1-6>[0110]
The herb tea was prepared by using [0111] fructus amomi 20.0 g, rhizoma acori graminei 16.0 g, poria 16.0 g, succus phyllostachos 16.0 g, semen glycine 15.0 g, rhizoma zingiberis siccatum 10.0 g, folium perillac 10.0 g and radix platycodi 8.0 g as the medicinal herbs of antistress components via the procedure described in the Example <1-1>.
<1-7>[0112]
The herb tea was prepared by using [0113] fructus crataegei 20.0 g, semen zizyphi spinosae 16.0 g, poria holen 16.0 g, radix phyllostachos 16.0 g, semen lablab 15.0 g, radix aconiti 10.0 g, folium perillae 10.0 g and radix platycodi 8.0 g as the medicinal herbs of antistress components via the procedure described in the Example <1-1>.

Example 2

Preparation of Pharmaceutical Compositions of Antistress agents; Tablet [0114]
<2-1>[0115]
In order to prepare pharmaceutical compositions comprising the antistress component s of the present invention as the effective ingredients for tablet, after weighing [0116] fructus hordel germintus 5.0 g, radix polygalae 3.0 g, poria holen 3.0 g, folium phyllostachos 3.0 g, legumonosae 3.0 g, rhizoma zingiberis 2.0 g, bulbos allii fistulosi 2.0 g and red pepper 2.0 g on the balancer for the amount, the mixture of medicinal herbs were prepared by pulverizing each medicinal herb finely and mixing evenly. At this time, after pulverizing the each component of medicinal herb, each medicinal herb was evenly mixed by repeating pulverization of all the powder in the blender for several times.
After repeatedly heating and filtering of the honey which was prepared for 250 cc per pulverized medicinal herb 500 g three or four times, it was heated until the honey was sticky, had yellow fiber when picked and rubbed with finger and wasn't sticky in the palm. Water, wallnut oil and vinegar could be used instead of the honey. After kneading the mixture of the medicinal herbs by adding the hot honey which was prepaed like this, the pill was prepared by molding the kneading into the regular size using artificial or pill machine. The pill was sealed up and stored in the shaded and cold place after drying in the cold and dried place. [0117]
<2-2>[0118]
The pill was prepared by using [0119] fructus hordel germintus 20.0 g, radix polygalae 16.0 g, poria holen 16.0 g, folium phyllostachos 16.0 g, legumonosae 15.0 g, rhizoma zingiberis 10.0 g, bulbos allii fistulosi 10.0 g and red pepper 8.0 g as the medicinal herbs of antistress components via the procedure described in the Example <2-1>.
<2-3>[0120]
The pill was prepared by using [0121] hordel germintus 20.0 g, semen zizyphi spinosac 16.0 g, poria holen 16.0 g, calcus in taein phyllostachos 16.0 g, legumonosac 15.0 g radix asari 10.0 g, bulbos allii fistulosi and radix platycodi 8.0 g as the medicinal herbs of antistress components via the procedure described in the Example <2-1>.
<2-4>[0122]
The pill was prepared by using [0123] messa medicata fermentata 20.0 g, radix polygalae 16.0 g, poria 16.0 g, folium phyllostachyos 16.0 g, fructus amomicardamomi 15.0 g, rhizoma zingiberis 10.0 g, herba ephedrae 10.0 g and red pepper 8.0 g as the medicinal herbs of antistress compnents via the procedure described in the Example <2-1>.
<2-5>[0124]
The pill was prepared by using [0125] messa medicata 20.0 g, semen zizyphi spinosae 16.0 g, poria 16.0 g, calcus in taein phyllostachos 16.0 g, fructus amomicardamomi 15.0 g, radix asari 10.0 g, herba ephedrae 10.0 g and radix platicodi 8.0 g as the medicinal herbs of antistress components via the procedure described in the Example <2-1>.
<2-6>[0126]
The pill was prepared by using [0127] fructus amomi 20.0 g, rhizoma acori graminei 16.0 g, poria 16.0 g, succus phyllostachos 16.0 g, semen glycine 15.0 g, rhizoma zingiberis siccatum 10.0 g, folium perillae 10.0 g and radix platycodi 8.0 g as the medicinal herbs of antistress components via the procedure described in the Example <2-1>.
<2-7>[0128]
The pill was prepared by using [0129] fructus crataegei 20.0 g, semen zizyphi spinosae 16.0 g, poria holen 16.0 g, radix phyllostachos 16.0 g, semen lablab 15.0 g, radix aconiti 10.0 g, folium perillae 10.0 g and radix platycodi 8.0 g as the medicinal herbs of antistress components via the procedure described in the Example <2-1>.

Example 3

Preparation of the Pharmaceutical Compositions of Antistress Agents; Capsule [0130]
After lyophilizing the herb tea which was prepared by the Example <1-1> to <1-7>, the capsule of the antistress compositions in the present invention was prepared by customary method of adding vehicle to the lyophilized herb tea and adjusting the weight of the capsule to 222 mg per one capsule. [0131]

Example 4

Preparation of the Pharmaceutical Compositions of Antistress Agents; Soft Capsule [0132]
After lyophilizing the herb tea which was prepared by the Example <1-1> to <1-7>, the soft capsule of the antistress compositions in the present invention was prepared by customary method of adding vehicle to the lyophilized herb tea and the weight of the capsule was 324.3 mg per one capsule. [0133]

Example 5

Preparation of the Pharmaceutical Compositions of Antistress Agents; Liquid Formulation [0134]
After solublizing the herb tea which was prepared by the Example <1-1> to <1-7> by adding vehicle, the liquid formulation of the antistress compositions in the present invention was prepared by adding purified water to the final volume 10 l as the customary method of liquid formulation. [0135]

Example 6

Preparation of the Pharmaceutical Compositions of Antistress Agents; Powders [0136]
After drying the herb tea which was prepared by the Example <1-1> to <1-7> by adding vehicle, the powders of the antistress compositions in the present invention was prepared by the customary method of powder and adjusting the weight of powder to 1,000 mg for one pack. [0137]

Experimental Example 1

Preparation of Experimental Animal, Injection of Medicinal Herb and Appliance of Stress [0138]
Well-educated organisms were selected and used after performing Morris water maze test(Redish, A. D. and Touretzky, D. S., The role of the hippocampus in solving the Morris water maze. [0139] Neural computation, 10: 73-111, 19998; Moriguchi, T., Saito, H., and Nishiyama, N., Aged garlic extract prolongs longevity and Omproves spatial memory deficitin sequence-accelerated mouse. Bio. Pham. Bull., 19:305-307, 1996) to 7-weeks ICR male mouse (Korean experimental animal) and the experiments were performed as following 4 groups after they were separated to the control groups, which were not administered, and the experimental groups, which were administered with the herb tea extracts of the Example <1-1> to <1-7> and they were separated again to groups which were given stress or groups which were not given stress.
1)Control groups which were not administered with the herb tea extracts and were not given stress(Cont-Not), [0140]
2)Control groups which were not administered with the herb tea extracts and were given stress(Cont-Stress), [0141]
3)Experimental groups which were administered with the herb tea extracts and were not given stress(Treat-Not), [0142]
4)Experimental groups which were administered with the herb tea extracts and were given stress(Treat-Stress). [0143]
10-12 mouses were used for each group and the herb tea extracts prepared by the Example <1-1> to <1-7> were orally administered by the dose of 8 g/kg/day per dried medicinal herb. The herb tea extracts were administered by storing solution in a freezer and equal amount of water was orally administered to the control group. For giving the stress, experimental animals were confined in the trays which were so small that experimental animals could barely enter and the stress were given by 15 min/day for 6 weeks. Administering the herb tea extracts and giving stress were performed in the same period, and 6 weeks later, all the animals were anesthetized with ether and the various intestinal organs were removed from the body after the whole blood was collected with heparin-treated syrige in the rear vein. The collected blood was used for CBC count(complete blood cell count) and cetrifuged to separate blood plasma at 10,000 rpm at 4° C. for 10 min(eppendorf 5402 centrifuge). The removed intestinal organs and the separated blood plasma were stored at −70° C. [0144]

Experimental Example 2

Education of Experimental Animals [0145]
In order to verify the memory power of experimental animals, they were educated by Morris water maze test. The cylindrical water tank of the diameter 120 cm was filled with water which sinks destination below the water level at about 5 mm, and milk 6 l was added not to show the destination. The sense of direction by eyesight was excluded by intercepting external light and using indirect illumination in the experimental room which had the water tank. The maximam swimming time was determined for 2 min 30 sec and if they couldn't find the destination for that time, they were educated to recognize the destination where was direct line in the sunk water tank by artificial landing for 5 sec. The education was performed for 20 times and the well-educated organisms were selected and used in animal experiment. After administering the herb tea extracts and giving stress for 6 weeks, the educated memory level before administering the herb tea extracts and giving stress was observed by performing Morris water maze test for 4 times. [0146]
The results were compared of the behaviour of final 4 times(17, 18, 19, 20) in the 20 times educations of well-educated organisms' with the behaviour 6 weeks later after administering herb tea extracts and giving stress. The time(sec) which was taken to arrive the destination and the frequency of finding the destination were compared. By performing t-test, ANOVA-test, Bonferroni multiple comparison and Fisher's least-significant-difference test of the each result, the difference of the each group or before/after administration was decided to have the meaning in case of p<0.05. [0147]

Experimental Example 3

Measurement of Weight Variation by Administration of Herb Tea Extracts and Appliance of Stress [0148]

After experimental animals were educated by Morris water maze test for 20 times, the weight of each group was measured weekly for 6 weeks before/after giving stress by administering the herb tea extracts of the Example <1-1>.

TABLE 1


Weight variation of each group in proportion
to administration period

Adminitration		Cont-		Treat-
period (week)	Cont-Not	Stress	Treat-Not	Stress

0	37.76 ±	35.82 ±	36.95 ±	36.09 ±
	1.13	0.73	0.48	0.72
1	37.11 ±	36.28 ±	37.60 ±	35.98 ±
	1.08	0.87	0.46	0.56
2	37.73 ±	36.01 ±	38.08 ±	35.78 ±
	0.87	0.75	0.40	0.63
3	38.79 ±	36.69 ±	38.80 ±	36.03 ±
	1.16	0.95	0.46	0.63
4	40.32 ±	35.44 ±	39.63 ±	35.78 ±
	1.15	0.64#	0.86*	0.82#
5	41.27 ±	38.02 ±	39.75 ±	37.18 ±
	1.01*	0.95	0.49**	0.61##
6	41.19 ±	38.16 ±	39.83 ±	37.23 ±
	0.97*	0.91	0.45**	0.49##

Compared by Bonferroni multiple comparison, [0150]
Comparing with OW of each group *;p<0.05, **;p<0.01, [0151]
Comparing with Cont-Not in each week age #;p<0.05 [0152]
While weight increase which had meaning(p<0.05) was observed in 5 weeks in the group (Cont-Not) which were not given stress and weight increase which had meaning(p<0.05, p<0.01) was observed in 4 weeks after administering the herb tea extracts in the group (Treat-Not) by comparing before administration(0 week), the weight increase was not observed in the control group and experimental group(Cont-Stress and Treat-Stress) during the administration period of 6 weeks. These results showed that in normal state, the weight increased in proportion to week age and the administration of herb tea extracts didn't affect the weight increas in proportion to week age, and in stress-given state for 6 weeks, the weight increase was repressed in proportion to week age and the administration of herb tea didn't affect these repression phenomena. The herb tea extracts of the Example <1-2> to <1-7> showed the same results as the preceded results. [0153]

Experimental Example 4

Measurement of the Variation of Whole Blood Cell Number by Administering Herb Tea and Giving Stress [0154]

The abnormality of immune system and hematopoietic function was decided by measuring whole blood cells which were collected from all the experimental animals after administering the herb tea extracts and giving stress. The number of leucocytes, lymphocytes, monocytes, granulocytes and RBC was measured from the blood of experimental animals which were given stress and administered with the herb tea extracts or were administered only of the herb tea extracts without stress. The amount of hemoglobin and capacity of RBC were compared and the results were shown in table 2.

TABLE 2


The variation of whole blood cell number in
proportion to the administering herb tea extracts and
the giving stress

			Treat-
Cont-Not	Cont-Stress	Treat-Not	Stress

Leucocyte	4.00 ± 0.93	2.30 ± 0.47	2.77 ±	2.97 ±
			0.47	0.37
Lymphocyte	3.28 ± 0.75	1.38 ± 0.18	2.11 ±	2.20 ±
			0.36	0.27
Monocyte	0.40 ± 0.11	0.70 ± 0.43	0.51 ±	0.61 ±
			0.09	0.10
Granulocyte	0.30 ± 0.12	0.30 ± 0.16	0.16 ±	0.15 ±
			0.06	0.03
RBC	8.51 ± 0.23	8.55 ± 0.21	8.60 ±	8.93 ±
			0.12	0.20
Hemoglobin	14.56 ± 0.34	14.51 ± 0.28	14.26 ±	14.76 ±
			0.19	0.26
Capacity	42.12 ± 1.07	42.67 ± 0.74	42.43 ±	43.94 ±
ratio of RBC			0.51	0.80

As described in the table 2, the measurement results of whole blood cell number showed that the immune system function and hematopoietic function were not varied in proportion to the administering herb tea extracts and the giving stress, and the herb tea extracts of the Example <1-2> to <1-7> showed the same results. [0156]

Experimental Example 5

Measurement of the Variation of Arrival Time by Administering Herb Tea Extracts and Giving Stress [0157]

The present inventors showed the results of final 4 times in 20 times of Morris water maze test which were performed before administrating the herb tea extracts and 4 times of Morris water maze test which were performed 6 weeks later after administrating the herb tea extracts as time taken to arrive the destination in table 3 by using the herb tea extracts of the Example <1-1>.

TABLE 3


The variation of arrival time (sec) by
adminisering the herb tea extracts and giving stress

		6 weeks later after
	Before administering	administering herb
	herb tea extracts	tea extracts

Cont-not	75.24 ± 8.59	69.95 ± 8.53
Cont-stress	61.41 ± 7.59	97.43 ± 8.18**^$$
Treat-not	42.36 ± 6.02	49.55 ± 6.89^##&&
Treat-stress	49.30 ± 6.29	54.77 ± 7.12

Comparing one week with 6 weeks of each group in t-test **;p<0.01, [0159]
Comparing Cont-Stress with Treat-Stress in t-test ##; p<0.01, [0160]
Comparing one week with 6 weeks in ANOVA test $$; p<0.01, [0161]
Comparing Cont-Stress with Treat-Stress in ANOVA test &&; p<0.01. [0162]
The time taken to find destination was 75.24±8.59 sec and 69.95±8.53 sec in the control group without stress, which showed no difference between before and 6 weeks later after administering the herb tea extracts in the results of Morris water maze test, but the time taken to find destination between before and 6 weeks later after administering the herb tea extracts had been increased very much to 61.41±7.59 sec and 97.43±8.18 sec in the group which were given stress for 15 min every day (p<0.01). On the other hand, the time taken to find destination was 42.36±6.02 sec and 49.55±6.89 sec in the experimental group without stress, which showed no difference between before and after administering the herb tea extracs, and the time was 49.30±6.29 sec and 54.77±7.12 sec, which showed no meaningful difference in the group which were given stress. In other words, ICR mouse memorized the destination where they were educated for 20 times 6 weeks later in normal state, but the educated memory power decreased very much by the 6 week-continued external physical stress. However, since the herb tea extracts which were administered with external physical stress repressed the memory decline which was induced by the stress. So it was verified that the antistress compositions of the present invention had the repressive effect of the memory failure which was induced by the stress and the recovering effect of memory power. [0163]

Experimental Example 6

Measurement of Frequency to Find Destination by Administering Herb Tea Extracts and Giving Stress [0164]
Among the results of final 4 times of Morris water maze test which was performed for 20 times before administering the herb tea extracs and giving stress and the results of 4 times of Morris water maze test which was performed 6 weeks later after administering the herb tea extracts and giving stress, the frequencies of arriving the detination within 2 min 30 sec were showed in table 4. [0165]

TABLE 4

frequencies of arriving the destination by

each group before/after administering the herb tea

extracts

6 weeks later after

Before administering administering the

the herb tea extracts herb tea extracts

Cont-not 3.18 ± 0.26 3.46 ± 0.16

Cont-stress 3.42 ± 0.15 2.42 ± 0.38*

Treat-not 3.73 ± 0.14 3.55 ± 0.25

Treat-stress 3.70 ± 0.15 3.70 ± 0.15#
Comparing before administration with 6 weeks later after administration by t-test, *; p<0.05 [0166]
Comparing Cont-Stress with Treat-Stress by t-test, #; p<0.05 [0167]
In the results of measuring frequencies of arriving the destination of water tank within 2 min 30 sec which was standard time of Morris water maze test, the frequencies of finding the destination before and 6 weeks later after administering the herb tea extracts were not varied in the normal state, but in the stress group, the frequency of 3.42±0.15 before administering the herb tea extracts became the frequency of 2.42±0.38 6 weeks later after administering the herb tea extracts, which showed the frequencies of finding the destination decreased largely(p<0.05) On the other hand, in the experimental group, the frequencies of finding the destination before and after administering the herb tea extracts, which were same as that of normal state, were not varied in the group without stress, and the frequencies of finding the destination before and after administering the herb tea extracts were not varied in the group which were administered with the herb tea extracts and given stress, too. In addition, when the group (Cont-Stress) which was only given stress was compared with the group (Treat-Stress) which was administered with the herb tea extracts and given stress, the frequencies of finding the destination had no difference between the two groups before administering the herb tea extracts, but 6 weeks later after administering the herb tea extracts, the frequencies of finding the destination in the group which were administered with the herb tea extracts and given stress increased relative to the group which were only given stress(p<0.05). The herb tea extracts the Example <1-2> to <1-7> also showed same results. [0168]
Therefore, these results showed that the physical stress decreased the frequencies of finding the destination by declining the educated memory, but this memory failure could be normalized by administering the antistress compositions of the present invention. [0169]
As the results described in the above, it could be verified that experimental animals showed the decline of education power and memory power by the external physical stress, but the decline of education power and memory power was repressed by administering the antistress compositions of the present invention. [0170]

INDUSTRIAL APPLICABILITY

The present invention relates to an antistress compositions containing various medical herbs as effective ingredients that relieve stress and repress a memory failure. [0171]
Since the antistress compositions of the present invention represents effective repression of memory failure as well as exellent preventive and curing effect to stress, and they can be used not only for preventive and curing agents of stress but also for health food. [0172]
Those skilled in the art will appreciate that the conceptions and specific embodiments disclosed in the foregoing description may be readily utilized as a basis for modifying or designing other embodiments for carrying out the same purposes of the present invention. Those skilled in the art will also appreciate that such equivalent embodiments do not depart from the spirit and scope of the invention as set forth in the appended claims. [0173]

Claims

What is claimed is

1. Antietress compositions containing mixture which is composed of one or more of medicinal herb 2.0˜40.0 g selected from the group of fructus hordel germintus, messa medicata fermentata, frucutus amomi and fructus crataegei; one or more of medicinal herb 2.0˜40.0 g selected from the group of radix polygalae, semen zizyphi spinosae and rhizoma acori graminei; one or more of medicinal herb 2.0˜4.0 g selected from the group of poria holen and poria; one or more of medicinal herb 2.0˜40.0 g selected from the group of folium phyllostachyos, calus in taein phyllostachos, succus phyllostachos and radix scutellariae; one or more of medicinal herb 2.0˜40.0 g selected from the group of legumonosae, fructus amomicardamomi, semen glycine and semen lablab; one or more of medicinal herb 2.0˜40.0 g selected from the group of rhizoma zingiberis, radix asari, rhizoma zingiberis siccatum and radix aconiti; one or more of medicinal herb 2.0˜40.0 g selected from the group of bulbos allii fistulosi, herba ephedrae and folium perillae; and one or more of medicinal herb 2.0˜40.0 g selected from the group of red pepper and radix platycodi as the effective ingredients.

2. The antistress compositions according to claim 1, which contain the mixture composed of fructus hordel germintus 2.0-40.0 g, radix polygalae 2.0-40.0 g, poria holen 2.0-40.0 g, folium phyllostachos 2.0-40.0 g, legumonosae 2.0-40.0 g, rhizoma zingiberis 2.0-40.0 g, bulbos allii fistulosi 2.0-40.0 g and red pepper 2.0-40.0 g as the effective ingredients.

3. The antistress compositions according to claim 1, which contain the mixture composed of hordel germintus 2.0-40.0 g, semen zizyphi spinosae 2.0-40.0 g, poria holen 2.0-40.0 g, calcus in taein phyllostachos 2.0-40.0 g, legumonosae 2.0-40.0 g, radix asari 2.0-40.0 g, bulbos allii fistulosi 2.0-40.0 and radix platycodi 2.0-40.0 g as the effective ingredients.

4. The antistress compositions according to claim 1 which contain the mixture composed of messa medicata fermentata 2.0-40.0 g, radix polygalae 2.0-40.0 g, poria 2.0-40.0 g, folium phyllostachyos 2.0-40.0 g, fructus amomicardamomi 2.0-40.0 g, rhizoma zingiberis 2.0-40.0 g, herba ephedrae 2.0-40.0 and red pepper 2.0-40.0 g as the effective ingredients.

5. The antistress compositions according to claim 1, which contain the mixture composed of messa medicata 2.0-40.0 g, semen zizyphi spinosae 2.0-40.0 g, poria 2.0-40.0 g, calcus in taein phyllostachos 2.0-40.0 g, fructus amomicardamomi 2.0-40.0 g, radix asari 2.0-40.0 g, herba ephedrae 2.0-40.0 g and radix platicodi 2.0-40.0 g as the effective ingredients.

6. The antistress compositions according to claim 1, which contain the mixture composed of fructus amomi 2.0-40.0 g, rhizoma acori graminei 2.0-40.0 g, poria 2.0-40.0 g, succus phyllostachos 2.0-40.0 g, semen glycine 2.0-40.0 g, rhizoma zingiberis siccatum 2.0-40.0 g, folium perillae 2.0-40.0 g and radix platycodi 2.0-40.0 g as the effective ingredients.

7. The antistress compositions according to claim 1, which contain the mixture composed of fructus crataegei 2.0-40.0 g, semen zizyphi spinosae 2.0-40.0 g, poria holen 2.0-40.0 g, radix phyllostachos 2.0-40.0 g, semen lablab 2.0-40.0 g, radix aconiti 2.0-40.0 g, folium perillae 2.0-40.0 g and radix platycodi 2.0-40.0 g as the effective ingredients.

8. The antistress compositions according to claim 1, which is prepared in formulation selected from the group of herb tea, pill, tablet, capsule, soft capsule, liquid formulation, granule and powder.

9. The antistress compositions according to claim 8, wherein the herb tea is prepared by the following steps;

1)soaking the rest medicinal herb except red pepper and bulbus allii fistulosi in water after weighing medicinal herbs of the prescription on the balancer

2)extracting herb tea by putting the soaked medicinal herbs of the step 1 into the pocket, adding red pepper and bulbus allii fistulosi for the amount and boiling in the preheated extracter

3)moving the extracted herb tea of the step 2 to the automatic package machine and packing by the amount for one time.

10. The antistress compositions according to claim 8, wherein the pill is prepared by the following steps;

1)prepariong the mixture of medicinal herbs by mixing and powdering after weighing all the medicinal herbs on the balancer for the amount;

2)continuesly heating honey with weak fire until it becomes yellow after heating and filtering honey for several times;

3)If the step 2 is completed, adding the mixture of medicinal herb of the step 1 to the hot honey and kneading into dough;

4)molding the dough of the step 3 into pill of regular size using artificial or pill machine;

5) sealing up and storing the pill of the step 4 in the shaded and cold place after drying in the cold and dried place

11. The antistress compositions according to claim 10, wherein the step 2 uses water, wallnut oil or vinegar instead of honey

12. The antistress composistions according to claim 8, wherein the capsule is prepared by lyophilizing the herb tea of the antistress compositions and putting the proper amount into capsule.

13. Agents for stress prevention and treatment containing the antistress compositions of claim 1 as the effective ingredients.

14. Agents for memory failure prevention and treatment using the pharmaceutical compositions which contain the antistress compositions of claim 1 as the effective ingredients.

15. Health food effective for stress prevention and treatment containing the antistress compositions of claim 1 as the effective ingredients.

16. Health food effective for stress prevention and treatment containing the antistress compositions of claim 1 as the effective ingredients.