RU2751190C1 - Anti-stress drink - Google Patents

Abstract

FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to an anti-stress drink. Disclosed is an anti-stress drink including a 50% aqueous solution of plasmolysate obtained from brewer’s yeast enriched with extracts of eleutherococcus, in terms of eleutheroside B, milk thistle, in terms of silymarin, and licorice root, in terms of glyceram, glycine, L-carnitine, magnesium chelate and selenium in 2-valent form in the form of Selecor Maxi, drinking water taken in certain quantities per 1 liter of the drink.EFFECT: above-described drink has anti-stress activity.1 cl, 4 tbl, 2 ex

Description

The invention relates to restorative medicine, namely to means that reduce the harmful effect on the parenchymal organs of a person of excess stress hormones that arise when working in hazardous and particularly harmful industrial conditions, as well as due to everyday stress: driving a car, emotional outbursts, etc. ...

Special studies have found that workers who are constantly under conditions of industrial stress accumulate an excess amount of stress hormones in the blood, hundreds of times higher than the concentration of hormones of the adrenal cortex and adrenal system in "normal people" [Gerasimov E.M., Abelmasova E.E. ., Shumskaya N.E. Working conditions and health of workers in the gas industry (Special research). R-l 2.3. Quantitative Assessment of the Impact of Occupational Stress P.-335-337. Conclusion p. 339 - 344. Orenburg, volume 2, 2004. 375]. An excess of stress hormones (up to 150 norms of norepinephrine, dopamine and serotonin have been registered) leads to a spasm of small vessels with a breakdown of connective tissue (control of collagen exchange) in tissues and organs with inevitable tissue hypoxia, which provokes a sharp exacerbation of the preexisting prednosology of internal organs (control of liver function , kidney and heart) and an immediate response of the immune system (control of the concentrations of circulating immune complexes and immunoglobulins).

All these harmful effects of excessive industrial stress can be tried to neutralize (counteract) the regular use of herbal preparations [RF Patent No. 2475257. Tretyak L.N., Gerasimov E.M., Means for increasing the body's adaptability to extreme conditions. Declared 06/22/11, No. 2011125924/15, publ. 02/20/2013 BI No. 5].

Eleutherococcus tincture . It is known that the extract of Eleutherococcus not only improves cerebral blood supply by positively affecting the state of carbohydrate-phosphorus metabolism in the brain tissue, but under its influence the diameter of the vessels and the exchange surface of the capillary bed of the heart increase; at the same time, there is an increase in muscle performance due to lower consumption of carbohydrate energy sources and earlier mobilization of lipids, coupled with phosphorylation and better preservation of ATP balance in working muscles. [Sokolov S.Ya., Zamotaev I.P. Handbook of Medicinal Plants (Phytotherapy), ed. 3. - M .: Metallurgy, 1990, - P.36-37],

Eleutherosides are organic compounds that are composed of 6 groups of individual elements. Their main purpose is to quickly utilize carbohydrates and prevent the growth of adipose tissue. The rhizomes and roots of Eleutherococcus senticosus (Rupr. Et Maxim.) Maxim are a valuable raw material for obtaining adaptogenic, tonic and immunomodulatory drugs. It was also found that eleutherosides use fats and fatty acids as a fast source of glucose, and also stimulate the production of endomorphins [Yandex. Health ›Eleutherococcus extract. Instructions for use, healthportal.com.ua zdorovoe-pitanie / eleuterokokk, alerguya.ru jeleuterokokk; proven antidepressant activity of the extract from the underground part and eleutherosides [Eleutherococcus senticosus (araliaceae). Kurkin V.A., Zaitseva E.N., Dubishchev A.V., Pravdivtseva O.E., Bazitova A.A. (https://elibrary.ru/item.asp?id=29159875); Perevozkina, M.G. Antioxidant properties of eleutherococcus and ascorbic acid / M.G. Perevozkina, BN Beketov / VI International Conference "Bioantioxidant" April 16-19, 2002, Moscow): Abstracts. M. - S. 453-455].

It is also known a tool with adaptive activity, in which the crushed roots of Eleutherococcus are combined with other adaptogens [RF patent No. 2506090: A tool with adaptogenic activity. Authors Kohan S.T. and others, application: 2012154527/15, 12/14/2012. publ .: 10.02.2014. bul. No. 4 - access mode: https://fips.ru/registers-doc-view/fips_servlet].

Milk thistle extract ( active principle silymarin). The properties of milk thistle are known as a powerful antioxidant that prevents liver damage and simulates the regeneration of damaged hepatocytes; the antitoxic effect of the drugs is associated with the regeneration of glutathione reserves, which is necessary for detoxification processes from free radicals and lipid peroxidation products. [Nile. Wertheimer (editor). Medicines and dietary supplements. - Reader's Digest. Italy. 2005. - S. 444-445]. It is known to use milk thistle seed oil as an agent with wound healing and hepatoprotective action [RF Patent No. 2014840. A drug that has a wound healing and hepatoprotective effect. Authors: Lebedev A.A., Simerzina L.V., Lebedev P.A. Application: 5043755/14, app. 03/30/1992; publ. June 30, 1994].

Licorice root bare . Licorice root extract, which contains about 40 components (glycyrrhizic, glycyrrhetic acids, etc.) and has a wide range of medicinal properties, including antitoxic action. Studied the effect of licorice root extract on the level of GABA (γ-aminobutyric acid) as a way to prevent and arrest unwanted changes in the level of these neurotransmitters, the emergence of which is possible when exposed to a harmful chemical factor [Kerimov SA, Kasumov G.Yu. Influence of licorice root extract and tetrachlorethylene vapor on the level of some mediators of the amino acid structure of the brain of young animals / Experi. and clinics. pharmacol., 1998. - T. 61. - No. 3. - S. 54-56].

The main active ingredient: Glycyrramum (glyceram - monoammonium salt of glycyrrhizic acid from licorice roots) retains the expectorant, anti-inflammatory and anti-allergic effect of glycyrrhizin - Glycyrrhiza glabra [Sokolov S.Ya., Zamotaev I.P. Handbook of Medicinal Plants (Phytotherapy), ed. 3. - M .: Metallurgy, 1990. - S. 189-192].

Glycyrrhizin of licorice root (the main bioactive component of licorice roots (Glycyrrhiza glabra L.) and Ural (Gl. Uralensis Fisher), has neuroprotective properties, as a gamma drug, and is an anticoagulant, exhibiting a synergistic effect with acetylsalicylic acid A. ., Litvinenko V.I., Popova T.P. Use of licorice in world practice. Review of patent sources // review, information on chemical and pharmaceutical production / State Research Institute of Economic Medical Industry. - 1998 . - No. 1. - P. 1-9, 83.]; [Baltina J1.A., Sakhautdinova G.M., Zarudiy F.S., Lazareva D.N., Tolstikov G.A., Davydova V. A. Synthesis of glycopeptides of glycyrrhizic acid and their immunomodulatory properties // Chem.-Pharm. Journal - 1990. - T. 24. - No. 2. - P. 119-121.].

Anti-aggregate properties of licorice root . The main biologically active substances of licorice roots are triterpene glycosides and flavonoids. The triterpene (water-soluble) fraction of licorice root is represented by glycyrrhizin (6-12%), containing glycyrrhizic acid salts, glycyrrhizic acid and its derivatives. The antiaggregatory (antiplatelet) activity of licorice triterpenoids was established back in 1983. It was later found that glycyrrhizin is a thrombin inhibitor. The importance of the antithrombin action is determined not only by the fact that thrombin is the central enzyme of blood coagulation, but also by the fact that, under conditions of hemostasis activation, it is a direct inducer of lipid peroxidation (LPO). Its effect on LPO is realized through blood cells, platelets and erythrocytes. Modern anticoagulants with direct antithrombin action (ximelagatran, etc.) are considered the most promising for the prevention of strokes and heart attacks, they are used to prevent and treat venous thrombosis. There are two main mechanisms of action of licorice roots: suppression of inactivation of hormones of the adrenal cortex, glucocorticoids in the liver and suppression of the formation of free oxygen radicals in neutrophils [Georgievsky VP, Dmitruk S.Ye. Biologically active substances of medicinal plants, Novosibirsk, Nauka, 1990, p. 330; Teelucking S. "Liquorica" - Lancet, 1991, v. 337, N8756, p. 1549. Teelucking S. "Liquorica" - Lancet, 1991, v. 337, N8756, p. 1549]; [RF patent No. 2241483. Composition "ANGIONORM", which has antiaggregatory, capillary-protective, venotonic action. Authors: Kolkhir V.K., Voskoboinikova I.V. Appl .: 2003117111/15, 10.06.2003; publ .: 10.12.2004 bul. No. 34].

Thus, licorice is a natural synergist of the antithrombotic action of acetylsalicylic acid. Glycyrrhizin, glycyrrhizic acid and GABA preparations are used as: antiplatelet agent [Ammosov AS, Litvinenko VI, Popova ETC. SE "State Scientific Center for Medicines and Medical Products", Kharkov. Licorice: application in world practice (a review of the materials of title of protection for the period from 1901 to 2019 http://farmacomua.narod.ru/licorice_patent/article.html].

Known adaptogens of plant and animal origin have the ability to introduce the body into a state of nonspecifically increased resistance by regulating the course of stress reactions, increasing the resistance of cells and the body to the damaging action of harmful factors [K.V. Yaremenko. The teachings of N.V. Lazarev on CNPCs and adaptogens as a basic theory of preventive medicine. // Psychopharmacology and biological narcology. 2005. - Vol.5. - No. 4. S.1086-1092].

In model experiments on animals and in studies on young male volunteers, the adaptogenic properties of licorice were first established [Study of the effect of licorice extract on the processes of adaptation of the body. dissertation in the direction of the Higher Attestation Commission of the Russian Federation 03.00.13, Cand. biol. Rezenkova, O.V. / content / izuchenie-vliyaniya-ekstrakta-solodki-goloi-na-protsessy-adaptatsii-organizma].

It is also known a tool with adaptogenic activity, which contains the roots of Eleutherococcus prickly , roots of Rhodiola rosea, roots of Ural licorice, shoots of blueberries, creeping thyme herb [RF patent No. 2506090. An agent with adaptogenic activity. Authors: Kokhan S.T., Pateyuk A.V., Shantanova L.N. app. 2012154527/15, 12/14/2012; publ .: 10.02.2014, bul. No. 4].

Glycine . To relieve stressful nervous tension, sedatives are used, among which tranquilizers of the benzodiazepine series are most often used, as well as derivatives of gamma-aminobutyric acid (GABA) - phenibut, baclofen, lyoresal, which simultaneously have a nootropic effect [M.D. Mashkovsky. Medicines, 1988, part 1, M .: Medicine, S. 70-79, 122-123]. However, benzodiazepine tranquilizers and these GABA derivatives have serious side effects. Their reception is accompanied by the phenomena of drowsiness, lethargy, dizziness, decreased psychomotor reactions, impaired gait, menstrual cycle, libido and is contraindicated for persons whose behavior requires a quick and accurate mental and motor response. In addition, prolonged use of tranquisitors reduces mental performance, forms substance abuse.

Glycine is widely known and is used as nootropic agents of a number of GABA derivatives, however, the latter do not have anti-stress or stress-protective effects [M.D. Mashkovsky. Medicines, 1988, part 1, M .: Medicine, S. 117, S. 123].

Glycine is a natural aminoacetic acid in our body that improves metabolism in the brain. It is a classic neuroprotective agent that improves nutrition and oxygen supply to the brain. By removing free radicals and rejuvenating neurons, it increases efficiency, reduces psycho-emotional fatigue.

It is known to use glycine in the composition of the preparation Mega 3 Vitamins / Minerals from Ortho Biotics, used in stressful conditions and to increase intellectual performance [Professional Ortho-Biotics, Catalog 1989, CH, 1203 Geneve, Pharmacie Des Charmilles, p. 18]. However, along with glycine, this preparation contains more than 34 different components, including vitamins that have an allergenic effect. It also contains tryptophan, which is currently banned by the EDA in pharmaceuticals and nutritional supplements (December 1989).

To date, the neuroprotective effect of the amino acid glycine or its pharmaceutically acceptable salt has been proven [RF patent No. 2025124 "Antistress, stress-protective, nootropic agent, a method for the prevention and treatment of stressful conditions and a method for increasing mental performance": Application: 92004569/14, 11.12.1992; Publ. 12/30/1994, Applicant Komissarova I.A. et al. ].

Magnesium Only organic salts (citrate, lactate, di-L-asparaginate) work. Magnesium plays an essential role in regulating body functions. Magnesium ions activate more than 300 enzymes in the body, including sodium-potassium-ATPase. Magnesium is a physiological calcium antagonist and can inhibit spontaneous contractions of isolated smooth and transverse muscles. Magnesium ions are involved in the processes of energy intake and expenditure, normalize membrane permeability, neuromuscular conduction [RF patent No. 2336076. Oral drug for replenishing magnesium deficiency in the body. Authors: Voronin S.P. et al. Appl. 2006122160/15, 22.06.2006; Published: 20.10.2008. Bul. No. 29]. Magnesium not only increases the contractility of the heart muscle, but has antioxidant and neuroprotective effects [RF patent №2385722 Pharmaceutical neuroprotective, antioxidant, antihypoxant, antiapoptotic and membrane protective composition and method of treatment. Authors: Kozhoka T.G. and others. Appl .: 2008126624/15, 02.07.2008; Publ. 10.04.2010 B.I. No. 10].

Selenium is one of the main nutrients [Wendel, A .; Phosphorus, Sulfur Silicon Relat Elem .; 1992; 67, 1-4, 405-415], since it participates in the form of L (+) - selenocysteine or L (+) - selenomethionine [Muller, S. et al .; Arch. Microbiol 1997; 168; 421] in the biosynthesis of selenoproteins such as glutathione peroxidase, thioredoxin reductase and selenoprotein P. A daily selenium supplement of 200 μg is considered reliable and adequate for an average weight adult [Schrauzer, GN, J. Am. Col. Nutr .; 2001; twenty; 1-14].

Selenium is found in nature in two forms: organic and inorganic. Inorganic compounds are most often salts of inorganic acids such as selenite or sodium selenate. These compounds are very toxic to humans and most animals. Organic compounds (organoselenium compounds) are presented in living organisms by amino acids: L (+) - selenomethionine; L (+) - methylselenocysteine; L (+) - selenocysteine.

L (+) - selenomethionine is the main source of organic selenium in humans and animals. The food supplement in the form of L (+) - selenomethionine was proven to be much less toxic and had a higher bioavailability compared to sodium selenite [Mony, MC et al .; J. of Trace Elem. Exp. Med .; 2000; 13; 367-380].

You can find an acceptable intake of selenium in the form of organic selenium in higher plants (wheat, corn, soybeans), in which more than 80% of selenium is represented by L (+) - selenomethionine [Schrauzer, G.N .; J. Am. Coll. Nutrit., 2001. 20, 1. P. 1-4]. Meanwhile, the concentration of selenium in these plants is insufficient for easy preparation of nutritional supplements at the lowest cost.

Were prepared probiotic mixtures, consisting of yeast and lactobacilli, designed to strengthen the immune system and disease resistance [Huang Kehe Qin, patent CN 1283171C from 08.11.2006]. Moreover, in all these preparations, selenium-enriched microorganisms were prepared only on the basis of inorganic selenium. Thus, the most commonly used source of selenium is sodium selenite or sodium selenate dissolved in culture media for microorganisms. Often, microorganisms enriched in this way, despite the fact that they synthesized a sufficient amount of organic selenium, assimilated by the human body, contain an increased amount of residual inorganic selenium that has not undergone transformation, which can be dangerous for the consumer. Moreover, bacteria of the genus Lactobacillus convert this inorganic selenium mainly into selenocysteine and not into selenomethionine.

Plasmolyzate of waste brewer's yeast . The composition of micronutrients found in plasmolyzate samples showed the presence of a wide variety of beneficial ions, including those that help neutralize the harmful effects of stress hormones such as magnesium, selenium, iron and zinc [RF patent No. 2475257. Tretyak L.N., Gerasimov E.M., Means for increasing the body's adaptability to extreme conditions. Declared 06/22/11, No. 2011125924/15, publ. 02/20/2013 BI No. 5]. However, the concentrations of these beneficial ions were clearly insufficient to demonstrate an obvious therapeutic effect. At the same time, there was no concern about the presence of a negative effect from the presence of by-products.

Thus, both the ions of magnesium and organic selenium, which are part of the plasmolyzate of spent brewer's yeast, have obvious advantages over the consumption of drugs grown on artificial media. In addition, from the presented review it follows that only complexes of drugs of predominantly plant origin can counteract the damaging effect of stress on human organs, which, due to their biological characteristics, stimulate certain physiological systems of the body.

The closest prototype is an agent that increases efficiency, tolerance of extreme loads, adaptability to extreme conditions, containing brewer's yeast and plant extracts, it is a 50% aqueous solution of plasmolyzate obtained from brewer's yeast, spent during the main fermentation, which is enriched with extracts eleutherococcus, milk thistle (in terms of silymarin) and licorice root (in terms of glycers), taken in a ratio of 2: 0.8: 5: 2.4, respectively. [RF patent No. 2475257. Tretyak L.N., Gerasimov E.M., Means for increasing the body's adaptability to extreme conditions. Declared 06/22/11, No. 2011125924/15, publ. 02/20/2013 BI No. 5].

The disadvantage of means that increase efficiency, tolerance of extreme loads, adaptability to extreme conditions is the absence of pronounced nootropic properties that enhance myocardial contractility, improve its blood supply, increase antioxidant activity and physical performance of a person.

The aim of the invention is to increase the effectiveness of agents that protect the human body from the negative effects of excess stress hormones. This goal is solved by introducing components (glycine, L-carnitine, organic compounds of magnesium and selenium) into the anti-stress drink, which have nootropic properties, enhance myocardial contractility, improve its blood supply, increase antioxidant activity and physical performance of a person.

The technical result of the proposed method is the creation of an anti-stress drink, created on the basis of an agent that increases efficiency, tolerance of extreme loads, adaptability to extreme conditions and containing a 50% aqueous solution of plasmolysate obtained from brewer's yeast enriched with extracts of Eleutherococcus, milk thistle (in terms of silymarin ) and licorice root (in terms of glycers), taken in a ratio of 2: 0.8: 5: 2.4, respectively.

The task is solved by the fact that an anti-stress drink, created on the basis of a means to increase the body's adaptability to extreme conditions, contains the amino acid glycine, L-carnitine, organic compounds of magnesium and selenium, taken in doses (mg / dm ³ ) 300: 300: 300: 0 , 2, respectively.

The additionally introduced components provide comprehensive protection of the human body systems from an excess of stress hormones.

Examples of specific applications

Example 1: The composition of the drink is represented by the extracts of the main components (ml)

Table 1 - Composition of an anti-stress drink (in ml) for an adult man weighing 70 kg (per 1 liter)

Ingredient Dose Manufacturer one Eleutherococcus extract 40.0 ml CJSC "VIFITECH" 2 Milk thistle extract
1050.0 ml JSC "Evalar" (license of the Ministry of Health of the Russian Federation No. 99-04-000027 dated February 24, 2005) complies with
MS GMP 3 Licorice root extract 1400.0 ml CJSC "VIFITECH 4 Glycine (dietary supplement) 300.0 mg Vneshtorg Pharma LLC five Magnesium chelate 300.0 mg JSC "Evalar" 6 Selenium in bivalent form (Selekor maxi) 0.2 mg LLC "Selekor" 7 L-carnitine
(TU 9197-015-42873073-14) 7.5 ml Olifen Corporation eight Drinking water 500.0 ml in accordance with the requirements of SanPiN 2.1.4.1074-01
"Drinking water" nine 50% aqueous solution of spent brewer's yeast plasmolyzate up to 1000.0 ml plasmolyzate of spent brewer's yeast (race 34) stabilized with sodium citrate 5.5-aqueous
(CHDA,
GOST 22280-76)

Example 2: The composition of the drink is represented by the active principles of the extracts (mg) of the main components

Table 2 - Composition of an anti-stress drink for an adult man weighing 70 kg (per 1 liter)

Ingredient Dose Manufacturer one Eleutheroside B 3.0 mg Eleuteroside B, Syringosid,
(CAS No. 118-34-3) (supplier Fitopanacea LLC, Moscow) 2 Silymarin 2800.0 mg JSC "Evalar" (license of the Ministry of Health of the Russian Federation No. 99-04-000027 dated February 24, 2005) complies with MS GMP 3 glycers 140.0 mg CJSC "VIFITECH 4 Glycine (dietary supplement) 300.0 mg Vneshtorg Pharma LLC five Magnesium chelate, 300.0 mg JSC "Evalar" 6 Selenium in bivalent form (Selekor maxi) 0.2 mg LLC "Selekor" 7 L-carnitine
(TU 9197-015-42873073-14) 300 mg Olifen Corporation eight Drinking water 500.0 ml In accordance with the requirements of SanPiN 2.1.4.1074-01. "Drinking water" nine 50% aqueous solution of spent brewer's yeast plasmolyzate before
1000.0 ml Plasmolyzate of spent brewer's yeast (race 34), stabilized with sodium citrate 5.5-aqueous
(ChDA, GOST 22280-76)

The mineral composition of the spent brewer's yeast plasmolysate makes it possible to make certain adjustments to the dosage of the mineral ingredients of the claimed drink. The mineral composition of the plasmolyzate (dry matter, μg / g) was obtained by atomic emission and mass spectrometry (AES-ICP and MS-ICP) in the accredited testing laboratory of ANO Center for Biotic Medicine, Moscow (accreditation certificate - GSEN. RU.ЦОА.311, registration number in the state register - Russian RU 0001.513118 dated May 29, 2003; Registration Certificate of ISO 9001: 2000, Number 4017-5.04.06). The results are shown in Table 3.

Table 3 - The content of minerals in the plasmolyzate of spent brewer's yeast (μg / g ash residue)

Mineral Waste yeast content in plasmolysate Mineral Waste yeast content in plasmolysate one 2 one 2 Ca 666.0 Cr 0.0244 Mg 272.0 Mn 1.18 P 2619.0 As 0.013 Si 8.88 B 0.13 Na 75.62 Cd 0.01848 K 1564.0 Co 0.03748 Li 0.007 Hg 0.00054 Al 0.16 Ni 0.28 Fe 12.1 Pb 0.00485 J 0.03 Sn 0.01231 Zn 26.26 Sr 1.55 Se 0.0536 V 0.0024 Cu 1.56 Σ 5248.92 μg / g

The content of magnesium and selenium ions in the plasmolyzate, along with other bioelements, contributes to the anti-stress effect of the claimed formula of the anti-stress drink. The essential content of B vitamins (table 4) also promotes the regeneration of nerve structures and favorably distinguishes the claimed anti-stress drink from analogues.

Table 4 - Content of vitamins (mg / 100 ml) in plasmolysate

Vitamin Concentration Vitamin Concentration B ₁ 0.165 T ₆ 0.25 AT ₂ 19.5 B ₈ (inositol) 279.0 B ₃ (RR) 6.0 B ₁₂ 7.2 μg B ₄ (choline) 69.0 Folate 220.0 μg B ₅ (pantothenic acid) 1.78 Biotin 12.0 μg

The production of a new type of functional beverage does not require special equipment or special sanitary conditions, other than those usually required for the production of food drinks or fruit juices. Marketing research has shown that all suppliers of the beverage's ingredients provide sterile certified products. However, to increase safety, before bottling, we propose to disinfect the drink by passing it through an in-line microwave sterilizer. The recipe of the drink does not contain carbohydrates, and the flavoring bouquet is created by the use of flavoring additives. In particular, the extract of licorice root creates a sweet taste (glycers are 250 times sweeter than sugar). In the proposed drink options, we recommend using a lemon or non-alcoholic beer flavor (1% crystal malt extract).

When developing mechanisms for counteracting chronic stress, experimental studies were carried out using international methods. The results are published by the leading magazines in the country: [The effect of anti-stress sports drinks on the recovery of performance after muscle overload. Gerasimov E.M. and others: Bulletin of Restorative Medicine. - 2011. –№5 С.16-20]; Composition and concentration of electrolytes in multifunctional drinks: Tretyak L.N., Gerasimov E. M .: Beverage Industry. - 2011. - No. 2. - P.22-29; Ingredient composition of multifunctional food drinks. Methodological guide for coaches and athletes of the highest qualification. Gerasimov E.M. and others Orenburg. - 2010. - 70 s.].

The main beneficial effect of drinking a drink, in addition to rehydration of the body, is the direct protective protection of the consumer's health from stressful heart attacks or strokes with a daily intake of at least one liter of the drink. As part of the mechanism of protective protection of the organism of the drink consumer, the fight against the so-called "brain fatigue" is distinguished by activating phosphorus metabolism in the cells of the brain, which ensures a quick restoration of the functions of the central nervous system; prevention of angina pectoris consequences of hyperstress, contributing to the expansion of the entire capillary bed of the myocardium; and, also, protection of hepatocytes from excess of catecholamines and free radicals is provided; at the same time, long-term endogenous energy supply of working muscles is provided without exogenous carbohydrate feeding by stimulating gluconeogenesis and glycogenoneogenesis. At the same time, the presence of glyceram makes it possible not only to correct the taste of the composition for sweetness, but also leads to an increase in the drainage function of the bronchopulmonary system, as is known, overloaded due to hyperventilation of the lungs, which is inevitable during stress muscle overload. Under natural conditions, the L-carnitine molecule is required for the transport of activated fatty acids across the double membrane of mitochondria - organelles responsible for energy production in the cell, increasing physical endurance. Studies show that L-carnitine helps control hypoglycemia, strengthens the heart muscle and reduces the risk of myocardial infarction [Instructions for the use of L-carnitine: access mode https://www.eapteka.ru/goods/id213341 - date of access. 08/29/2020].

Claims (2)

An anti-stress drink containing a 50% aqueous solution of plasmolyzate obtained from brewer's yeast enriched with eleutherococcus extracts, in terms of eleutheroside B, milk thistle, in terms of silymarin, and licorice root, in terms of glycers, glycine, L-carnitine, magnesium chelate and selenium in bivalent form in the form of selector maxi, taken in the following quantities per 1 liter of drink: Eleutheroside B 3.0 mg Silymarin 2800.0 mg Glycers 140.0 mg Glycine 300.0 mg Magnesium chelate 300.0 mg Selekor maxi 0.2 mg L-carnitine 300 mg Drinking water 500.0 ml 50% aqueous solution of spent brewer's yeast plasmolyzate up to 1000.0 ml