RU2635373C1 - Biologically active additive for increasing general working ability - Google Patents

Abstract

FIELD: food industry.

SUBSTANCE: biologically active additive (BAA) includes arginine alpha-ketoglutarate, taurine, vitamin P, vitamin PP and water-alcohol extract from Echinacea purpurea herb and roots, containing 5% of echinacosides, at a given ratio of components. The invention allows to improve microcirculation, biochemical blood composition, energy metabolism in the body, nutrition and growth of muscle tissue, to slow down aging processes, to stimulate regeneration processes. The BAA has immunostimulating activity, antioxidant defense of the heart, bronchi, eyes, low allergic activity, and has the hypocholesterolemic effect.

EFFECT: increasing the general working ability and the endurance to physical activity in athletes, preventing the development of cardiovascular and acute infectious diseases among the population.

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Description

The invention relates to the pharmaceutical and food industries, namely to biologically active nutritional supplements with a general strengthening effect, and can be used to increase the overall performance and physical endurance of athletes, as well as to prevent the development of cardiovascular and acute infectious diseases among the population.

A known method of restoring sexual desire (libido) in men by applying a biologically active food supplement to restore sexual desire (libido) in men. To do this, a biologically active additive (BAA) is introduced containing L-arginine, pollen or pollen, drone brood, a substance containing zinc, vitamin B6, as well as one to three plant components selected from goryanka, real or false ginseng root, and leuzea or sickle crowned, in effective amounts. This complex of biologically active components provides the restoration of libido by increasing the level of androgens in the blood in combination with anti-stress and psychostabilizing effects (RU 2496491, IPC A61K 31/198, A61K 31/315, A61K 31/4415, A61K 36/258, A61P 15 / 10, publ. 10/27/2013).

The disadvantages of the known biologically active additives are a multi-component composition, a narrow scope (recommended for use in impotence, erectile dysfunction), a small form of release (4 capsules) and high cost.

Known biologically active additive Vita Taurine Vitaline containing taurine, pyroxine hydrochloride, cyanocobalamin, folic acid, lipoic acid, lactose, talc and calcium stearate (state registration certificate No. RU.77.99.11.003.E.023711.06.11 of 06/10/2011 g ., manufacturer NOWFoods, USA).

A disadvantage of the known additives is the high cost, the taurine content in it (0.5 g) is greater than the daily requirement of the body (0.4 g). When taking this dietary supplement, allergic reactions often occur, in connection with the content of B vitamins.

Known biologically active food supplement with hepatoprotective and immunostimulating properties, which includes oxidized dextran with an average molecular weight (mm) of 40-70 kDa as the main active ingredient, and as an additional component that synergistically enhances the biological properties of the claimed composition, includes a component of plant origin containing bioflavonoids selected from the group: fruits of milk thistle (mainly silymarin), grass of hodgepodge, Rabbi and / or roots of Echinacea purpurea. As components of plant origin, mainly dry extracts of the above plants are used (RU 2516932, IPC A61K 31/721, A61K 36/185, A61K 36/28, A61K 47/38, A61P 1/16, A61P 37/04, publ. 20.05. 2014).

A disadvantage of the known food supplement is the lack of an effect of improving microcirculation, lipid-lowering and immunostimulating effects, in addition, it does not fully meet the requirements necessary for use as an additional product for sports nutrition.

A well-known protein-vitamin product for nutrition of athletes, including cedar nut cake, pumpkin seed flour, ground wheat germ and crushed kernel of sunflower seed, dried fruit and berry mixture, ascorbic acid and fructose. The fruit and berry mixture contains dried and crushed: rose hips, cranberries and lingonberries, taken in a ratio of 2.5: 1: 1, respectively (RU 2468609, IPC A23L 1/30, A23L 1/302, A23L 1/305, A23L 1/36, published on December 10, 2012).

The known solution allows you to get a natural protein-vitamin product with high energy and chemical potential, containing a natural vitamin-mineral complex in combination with valuable protein, lipid and carbohydrate components, a balanced combination of which ensures its high efficiency when included in the diet of athletes. However, the disadvantages of the known product is the multicomponent composition, the complexity of the preparation and the low accuracy of the dosage of the components. Also known product is intended only for nutrition of athletes.

The closest in technical essence to the proposed technical solution is a nutritional composition containing an effective amount of α-hydroxyisocaproic acid and an effective amount of α-ketoglutarate (ornithine-α-ketoglutarate, arginine-α-ketoglutarate), a source of ω-3 fatty acids, a nucleide, phyto supplement (carotenoid, plant sterols, quercetin, etc.), protein source, prebiotic, probiotic, amino acid (taurine, arginine, asparagine, etc.), antioxidant, vitamins (A, B1, B2, B3, B5, B6, B7 , B9, B12, C, D, E, K, K1, K2), mineral, L-ka Rnitin (RU 2013151087, IPC A23L 1/30, publ. 05.27.2015).

A disadvantage of the known composition is that the nutritional composition belongs to the group of highly allergenic components, in addition, it has a multicomponent composition.

The technical result consists in improving microcirculation, biochemical composition of blood, energy metabolism in the body, nutrition and growth of muscle tissue, slowing down the aging process, stimulating regeneration processes, reducing the complexity of manufacturing additives through the use of a chemical synthesis method, which results in higher dosing accuracy of components , the supplement also has immunostimulating activity, antioxidant protection of the heart, bronchi, eyes, low allergic ac ivnostyu and has a cholesterol-lowering effect.

The essence of the invention lies in the fact that a biologically active additive to increase overall performance includes arginine alpha-ketoglutarate, taurine, vitamin P, vitamin PP and a water-alcohol extract from the herb and roots of purple coneflower containing 5% echinacosides, in the following ratio of components, wt. . %:

Arginine Alpha Ketoglutarate 87-92 Taurine 3-4 Vitamin P one Vitamin PP 0.02 Hydroalcoholic extract from grass and roots echinacea purpurea containing 5% echinacosides Rest

Arginine alpha-ketoglutarate (AAKG) is a salt of the amino acid arginine and alpha-ketoglutaric acid. As a result of biochemical processes, AAKG is converted into arginine, the most important amino acid, during which the content of blood nitric oxide increases: in urology it is used to improve spermatogenesis (the process of formation of male sex hormones), in addition, it stimulates vasodilation and prevents blood clots. It also stimulates the secretion of growth hormone, so taking at bedtime is necessary (the production of somatropic hormone from 23.00-02.00). Arginine alpha-ketoglutarate is safe and to some extent helps to increase strength in the bench press, as well as peak power, but it does not affect muscle mass, as well as maximum aerobic performance. The daily requirement for arginine alpha-ketoglutarate is 6.1 g, the maximum dosage is 9.0 g.

Taurine is a sulfonic acid formed in the body from the amino acid cysteine. Taurine forms conjugates with bile acids in the liver (acylating at the amino group), the resulting conjugates (for example, taurocholic and taurodeoxycholic acids) are part of bile and contribute to the emulsification of fats in the intestines. In the brain, taurine plays the role of a neurotransmitter amino acid that inhibits synaptic transmission, has anticonvulsant activity, and also has a cardiotropic effect. Taurine helps improve energy processes, stimulates healing processes in dystrophic diseases and processes accompanied by a significant violation of the metabolism of the eye tissue, regulates cell volume, sensitivity to insulin and is an antioxidant, maintains blood sugar levels, affects the action of insulin, reduces oxidative stress and improves general indicators of training, helps to improve energy metabolism in the body, stimulates regeneration processes, improves and restores muscle function, the nervous system, reduces blood cholesterol, which prevents the development of atherosclerosis, provides antioxidant protection for the heart, bronchi, eyes, prevents damage to muscle cells after intense exercise (training) by free radicals, improves their nutrition.

Indications for use: increased endurance to physical activity. The daily need for taurine is 0.4 g.

Vitamin P is involved in redox processes, and also inhibits the action of hyalorunidase. The concentration of hyaluronic acid increases, which increases the elasticity of capillaries and reduces their permeability. In addition, it has antioxidant properties, reduces blood coagulation and increases the elasticity of red blood cells. The daily requirement for vitamin P is 0.025-0.05 mg, for athletes - 0.06-0.1 g, the maximum dosage is 0.4 g.

Vitamin PP (nicotinic acid) in the body turns into nicotinamide, which binds to coenzymes of codehydrogenase I and II (nicotinamide and nicotinamide diphosphoric acid), which carry hydrogen, is involved in the metabolism of fats, proteins, amino acids, purines, tissue respiration, glycogenolysis, and biosynthesis processes. Normalizes the concentration of blood lipoproteins; in large doses (3-4 g / day) reduces the concentration of total cholesterol, low density lipoproteins, reduces the cholesterol / phospholipids index, increases the content of high density lipoproteins with antiatherogenic effect. Hypocholesterolemic effect manifests itself in a few days, a decrease in triglycerides - a few hours after administration. However, clinical trials of statin therapy in combination with high doses of nicotinic acid, conducted by NationalHeart, Lung, andBloodInstitute, showed that although patients taking nicotinic acid with statin showed an increase in high density lipoproteins and a decrease in triglycerides compared to in patients taking only statin, the frequency of heart attacks in both groups did not differ. Vitamin PP dilates small blood vessels (including the brain), improves microcirculation, has a weak anticoagulant effect, increasing fibrinolytic activity of the blood. It has detoxification properties. Nicotinamide, unlike nicotinic acid, does not have a pronounced vasodilating effect, and with its use, there is no reddening of the skin and a feeling of a rush of blood to the head. The daily requirement for vitamin PP is 0.0015 g.

Echinacea purpurea contains polysaccharides (heteroxylans, arabinoramnogalactans), essential oils (0.15-0.50%), flavonoids, hydroxycinnamic (chicory, ferulic, coumaric, caffeic) acids, tannins, saponins, polyamines, echinacin (amide) , echinolone (unsaturated ketoalcohol), echinacoside (glycoside containing caffeic acid and pyrocatechol), organic acids, resins, phytosterols; rhizomes and roots - inulin (up to 6%), glucose (7%), essential and fatty oils, phenolcarboxylic acids, betaine, resins. All parts of the plant contain enzymes, macro- (potassium, calcium) and trace elements (selenium, cobalt, silver, molybdenum, zinc, manganese, etc.). Echinacea preparations have a therapeutic, antimicrobial and immunostimulating effect, have antioxidant regenerative, anti-inflammatory, antitumor and adaptogenic properties. The proposed solution uses echinacea purpurea extract, which is a fine powder from yellow-brown to greenish-brown in color with a grassy odor.

Example. A method of obtaining a biologically active additive consists in sequential mixing of metered substances obtained by chemical synthesis, arginine alpha-ketoglutarate (6.09-6.44 g), vitamin P (0.07 g), vitamin PP (0.0014 g), taurine (0.21-0.28 g), an extract from the herb and roots of purple coneflower containing 5% echinacosides (0.21-0.63 g). Echinacea purpurea extract is obtained from grass and roots by the method of water-alcohol extraction with further concentration and drying of the amount of extractive substances. The obtained biologically active additive is an odorless white powder for preparing a drink, which is packaged in bags (doy pack) and packaged with instructions.

Studies on the effectiveness of biologically active additives. Athletics were divided into 2 groups: 1st group (65 people) - athletes training without taking a dietary supplement, 2nd group (65 people) - athletes taking a dietary supplement once a day per hour before training for three weeks. Athletics measured speed (Table 1) and endurance (Table 2). The speed and endurance of athletes in the experimental group increased by 10% and 15% than in the control group, respectively. Power sports athletes were divided into 2 groups: group 1 (35 people) - athletes training without taking a dietary supplement, group 2 (34 people) - athletes taking a dietary supplement once a day for an hour before training for six weeks. The athletes evaluated the dynamics of muscle mass (table. 3). Marked increase in muscle mass in the experimental group by 4% than in the control.

A dietary supplement can be effectively used as a functional food product in the athletes ’diet, ensuring the intake of substances necessary for maintaining the body’s energy balance under conditions of increased physical and emotional stress, for increasing muscle strength and endurance, for faster adaptation to physical stress and recovery of strength after training. With regular use, the supplement has a positive effect on the functional state of the cardiovascular, respiratory, autonomic systems, psychological and emotional state of a person.

A dietary supplement can also be recommended for a balanced diet of people seeking a healthy lifestyle, for therapeutic and prophylactic nutrition at the stages of rehabilitation after various diseases, for nutrition of children and adolescents.

Release form: a dietary supplement in the form of a powder is packaged in bags with a measured spoon (1 measured spoon contains: arginine alpha-ketoglutarate - 6.09-6.44 g, taurine - 0.21-0.28 g, vitamin P - 0 , 07 g, vitamin PP - 0.0014 g, extract from the herb and roots of purple coneflower, containing 5% echinacosides - 0.21-0.63 g); 1 package contains 227.145 g of powder (for 1 month).

Method of application: for persons over 14 years of age, 1 scoop, dissolved in 200 ml of water, an hour before training or in order to prevent the development of cardiovascular and acute infectious diseases among the population once a day during lunch for 60 days.

Compared with the known solution, the proposed one allows to improve microcirculation, biochemical composition of blood, energy metabolism in the body, nutrition and growth of muscle tissue, slow down the aging process, stimulate regeneration processes. The dietary supplement also has immunostimulating activity, antioxidant protection of the heart, bronchi, eyes, low allergic activity and has a hypocholesterolemic effect. In addition, the additive is less time-consuming to manufacture due to the application of the chemical synthesis method, which results in higher dosing accuracy of the components.

Claims (2)

A dietary supplement to increase overall performance, including arginine alpha-ketoglutarate, taurine, characterized in that it additionally includes vitamin P, vitamin PP and a water-alcohol extract from the herb and roots of purple coneflower, containing 5% echinacosides, in the following ratio of components, wt. . %: Arginine Alpha Ketoglutarate 87-92 Taurine 3-4 Vitamin P one Vitamin PP 0.02 Hydroalcoholic extract from grass and roots echinacea purpurea containing 5% echinacosides Rest