UA94579C2 - Анетолдитиолтион и другие дитиолтионы для лечения состояний, связанных с дисфункцией нейротрансмисии моноамина - Google Patents

Анетолдитиолтион и другие дитиолтионы для лечения состояний, связанных с дисфункцией нейротрансмисии моноамина

Info

Publication number
UA94579C2
UA94579C2 UAA200710593A UAA200710593A UA94579C2 UA 94579 C2 UA94579 C2 UA 94579C2 UA A200710593 A UAA200710593 A UA A200710593A UA A200710593 A UAA200710593 A UA A200710593A UA 94579 C2 UA94579 C2 UA 94579C2
Authority
UA
Ukraine
Prior art keywords
dithiolethiones
dysfunction
treatment
conditions associated
compounds
Prior art date
Application number
UAA200710593A
Other languages
English (en)
Ukrainian (uk)
Inventor
Бенджамин Друкарч
Антон Н.М. Шоффельмеер
Рулоф В. Фенстра
Мари-одиль Кристен
Жан-луиз Бюрго
Марилен Шолле
Баккер Воутер И. Ивема
Флит Бернард Ж. ван
Мартинус Т.М. Тульп
Original Assignee
Эббот Хелскеа Продактс Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эббот Хелскеа Продактс Б.В. filed Critical Эббот Хелскеа Продактс Б.В.
Publication of UA94579C2 publication Critical patent/UA94579C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Изобретение касается производных дитиолтионов как ингибиторов моноаминоксидазы, в частности ингибиторов В, способов получения этих соединений и новых промежуточных соединений, пригодных для синтеза указанных производных дитиолтионов.Изобретение также касается применения соединений согласно изобретению для получения лекарственных средств, которые дают целебный эффект.В вариантах осуществления изобретения отдельно указанные соединения используют для изготовления лекарства, пригодных для лечения, облегчения или профилактики состояний, связанных с дисфункцией нейротрансмисии моноамина.Соединения имеют общую формулу (1), (1)где радикалы имеют значения, приведенные в описании.
UAA200710593A 2005-02-24 2006-02-17 Анетолдитиолтион и другие дитиолтионы для лечения состояний, связанных с дисфункцией нейротрансмисии моноамина UA94579C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05101405 2005-02-24

Publications (1)

Publication Number Publication Date
UA94579C2 true UA94579C2 (ru) 2011-05-25

Family

ID=34938805

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200710593A UA94579C2 (ru) 2005-02-24 2006-02-17 Анетолдитиолтион и другие дитиолтионы для лечения состояний, связанных с дисфункцией нейротрансмисии моноамина

Country Status (14)

Country Link
EP (1) EP1858875A2 (ru)
JP (1) JP2008531519A (ru)
KR (1) KR20070117607A (ru)
CN (1) CN101107240B (ru)
AR (1) AR055862A1 (ru)
AU (1) AU2006218012A1 (ru)
BR (1) BRPI0609043A2 (ru)
CA (1) CA2594165A1 (ru)
MX (1) MX2007010380A (ru)
RU (1) RU2402543C2 (ru)
SA (1) SA06270023B1 (ru)
TW (1) TW200640898A (ru)
UA (1) UA94579C2 (ru)
WO (1) WO2006089861A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0704718D0 (en) * 2007-03-12 2007-04-18 Prendergast Patrick T Compounds and methods for preventing and treating mucositis
CN102807557B (zh) * 2012-08-21 2015-02-04 苏州大学 3h-1,2-二硫环戊烯-3-硫酮类化合物及其应用
KR101438415B1 (ko) * 2013-07-25 2014-09-17 동국대학교 경주캠퍼스 산학협력단 기억력 손상의 예방 또는 개선을 위한 조구등 추출물
CN104788440B (zh) * 2015-04-03 2017-12-26 苏州大学 烟酸衍生物及其应用
FR3063640B1 (fr) * 2017-03-07 2020-10-09 Elodie Petitjean Traitement de la fibrose pulmonaire a l'aide d'un inhibiteur selectif de la production d'especes reactives de l'oxygene d'origine mitochondriale
CN110662535A (zh) 2017-03-07 2020-01-07 Op2药品公司 用于治疗与线粒体活性氧(ros)产生相关的疾病的去甲基茴三硫衍生物
AU2019341666A1 (en) * 2018-09-18 2021-05-13 St Ip Holding Ag Rotomeric isomers of 4-alkyl-5-heteroaryl-3H-1,2- dithiole-3-thiones

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1442450A (fr) * 1964-05-05 1966-06-17 Monsanto Chemicals Nouveaux composés hétérocycliques contenant du soufre
JPH089611B2 (ja) * 1988-06-20 1996-01-31 三井東圧化学株式会社 新規１，２−ジチオール−３−チオン誘導体およびそれを有効成分とする免疫調節剤
WO1998027970A2 (en) * 1996-12-24 1998-07-02 National Research Council Of Canada Treatment of diseases or prevention of cellular damage caused by oxygen-containing free radicals
AU6462500A (en) * 1999-07-29 2001-02-19 Patrick T. Prendergast Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement

Also Published As

Publication number Publication date
TW200640898A (en) 2006-12-01
MX2007010380A (es) 2007-09-25
CA2594165A1 (en) 2006-08-31
WO2006089861A2 (en) 2006-08-31
KR20070117607A (ko) 2007-12-12
CN101107240A (zh) 2008-01-16
RU2007135184A (ru) 2009-03-27
AR055862A1 (es) 2007-09-12
RU2402543C2 (ru) 2010-10-27
CN101107240B (zh) 2011-02-09
AU2006218012A1 (en) 2006-08-31
BRPI0609043A2 (pt) 2010-11-16
WO2006089861A3 (en) 2006-10-26
EP1858875A2 (en) 2007-11-28
SA06270023B1 (ar) 2010-10-12
SA06270023A (ar) 2005-12-03
JP2008531519A (ja) 2008-08-14

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