UA92917C2 - Похідні 5-піридиніл-1-азабіцикло[3.2.1]октану, їх одержання і їх застосування у терапії - Google Patents

Похідні 5-піридиніл-1-азабіцикло[3.2.1]октану, їх одержання і їх застосування у терапії

Info

Publication number
UA92917C2
UA92917C2 UAA200802988A UAA200802988A UA92917C2 UA 92917 C2 UA92917 C2 UA 92917C2 UA A200802988 A UAA200802988 A UA A200802988A UA A200802988 A UAA200802988 A UA A200802988A UA 92917 C2 UA92917 C2 UA 92917C2
Authority
UA
Ukraine
Prior art keywords
therapeutics
same
azabicyclo
pyridinyl
octane
Prior art date
Application number
UAA200802988A
Other languages
English (en)
Russian (ru)
Inventor
Фредерік Галлі
Оділь Леклерк
Алістер Локхед
Жюльєн Ваше
Original Assignee
Санофі-Авентіс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36273387&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA92917(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Санофі-Авентіс filed Critical Санофі-Авентіс
Publication of UA92917C2 publication Critical patent/UA92917C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Винахід стосується сполуки загальної формули (І), в якій R означає групу, вибрану з піразолілу, імідазолілу, триазолілу, оксазолілу, оксадіазолілу, тіазолілу, ізотіазолілу, тіадіазолілу, тетразолілу, причому вказана група, необов’язково заміщена однією або декількома групами, вибраними з галогенів, (С1-С6)алкілу, (С1-С6)алкокси, трифторметокси, трифторметилу, нітро, ціано, гідрокси, аміно, (С1-С6)алкіламіно або ді(С1-С6)алкіламіно; зв'язок вуглець-вуглець між положеннями 3 і 4 азабіциклооктанового кільця є простим або подвійним; у вигляді основи або адитивної солі з кислотою, а також у вигляді гідрату або сольвату. Спосіб одержання і застосування у терапії.
UAA200802988A 2005-08-12 2006-07-08 Похідні 5-піридиніл-1-азабіцикло[3.2.1]октану, їх одержання і їх застосування у терапії UA92917C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0508528A FR2889701B1 (fr) 2005-08-12 2005-08-12 Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique.
PCT/FR2006/001912 WO2007020344A1 (fr) 2005-08-12 2006-08-07 DÉRIVÉS DE δ-PYRIDINYL-i-AZABICYCLO[3.2.1]OCTANE, A LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE

Publications (1)

Publication Number Publication Date
UA92917C2 true UA92917C2 (uk) 2010-12-27

Family

ID=36273387

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200802988A UA92917C2 (uk) 2005-08-12 2006-07-08 Похідні 5-піридиніл-1-азабіцикло[3.2.1]октану, їх одержання і їх застосування у терапії

Country Status (41)

Country Link
US (2) US7863290B2 (uk)
EP (1) EP1915375B1 (uk)
JP (1) JP5164841B2 (uk)
KR (1) KR101299339B1 (uk)
CN (1) CN101238125B (uk)
AT (1) ATE444964T1 (uk)
AU (1) AU2006281341B2 (uk)
BR (1) BRPI0614623A2 (uk)
CA (1) CA2617828C (uk)
CR (1) CR9625A (uk)
CY (1) CY1109717T1 (uk)
DE (1) DE602006009668D1 (uk)
DK (1) DK1915375T3 (uk)
DO (1) DOP2006000180A (uk)
EA (1) EA014023B1 (uk)
EC (1) ECSP088170A (uk)
ES (1) ES2332472T3 (uk)
FR (1) FR2889701B1 (uk)
GT (1) GT200600368A (uk)
HK (1) HK1120788A1 (uk)
HN (1) HN2008000090A (uk)
HR (1) HRP20090677T1 (uk)
IL (1) IL188796A (uk)
JO (1) JO2583B1 (uk)
MA (1) MA30200B1 (uk)
ME (1) ME01750B (uk)
MX (1) MX2008001968A (uk)
MY (1) MY147846A (uk)
NO (1) NO20081151L (uk)
NZ (1) NZ565149A (uk)
PE (1) PE20070339A1 (uk)
PL (1) PL1915375T3 (uk)
PT (1) PT1915375E (uk)
RS (1) RS51068B (uk)
SI (1) SI1915375T1 (uk)
TN (1) TNSN07472A1 (uk)
TW (1) TWI324158B (uk)
UA (1) UA92917C2 (uk)
UY (1) UY29744A1 (uk)
WO (1) WO2007020344A1 (uk)
ZA (1) ZA200800958B (uk)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2912404B1 (fr) * 2007-02-09 2009-04-10 Sanofi Aventis Sa Derives d'azabicycloalkane,leur preparation et leur application en therapeutique.
GB0817424D0 (en) 2008-09-24 2008-10-29 Medivir Ab Protease inhibitors
JP2017114765A (ja) * 2014-04-25 2017-06-29 大正製薬株式会社 トリアゾリルで置換されたヘテロアリール化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
EP0664293A1 (en) * 1993-12-24 1995-07-26 Duphar International Research B.V 2-Phenyl-7-azabicycloheptanes and 6-phenyl-8-azabicyclo
KR100589872B1 (ko) * 1997-05-30 2006-06-15 뉴로서치 에이/에스 8-아자비사이클로(3,2,1)옥트-2-엔 유도체 및 이의 제조방법
FR2834511B1 (fr) 2002-01-07 2004-02-13 Sanofi Synthelabo Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
SI1915375T1 (sl) 2010-01-29
HN2008000090A (es) 2010-08-19
ZA200800958B (en) 2009-04-29
US20080146608A1 (en) 2008-06-19
BRPI0614623A2 (pt) 2011-04-12
US8541440B2 (en) 2013-09-24
AU2006281341A1 (en) 2007-02-22
CN101238125B (zh) 2012-07-04
IL188796A0 (en) 2008-08-07
CR9625A (es) 2008-04-10
JP5164841B2 (ja) 2013-03-21
TW200740810A (en) 2007-11-01
DK1915375T3 (da) 2010-02-15
MA30200B1 (fr) 2009-02-02
HK1120788A1 (uk) 2009-04-09
EP1915375B1 (fr) 2009-10-07
EA014023B1 (ru) 2010-08-30
HRP20090677T1 (hr) 2010-01-31
NZ565149A (en) 2011-05-27
MX2008001968A (es) 2008-03-26
EA200800575A1 (ru) 2008-06-30
EP1915375A1 (fr) 2008-04-30
US7863290B2 (en) 2011-01-04
WO2007020344A1 (fr) 2007-02-22
CN101238125A (zh) 2008-08-06
ECSP088170A (es) 2008-03-26
CY1109717T1 (el) 2014-08-13
JP2009505971A (ja) 2009-02-12
FR2889701B1 (fr) 2007-10-05
CA2617828A1 (fr) 2007-02-22
KR20080033378A (ko) 2008-04-16
DOP2006000180A (es) 2007-02-28
PL1915375T3 (pl) 2010-03-31
US20110077264A1 (en) 2011-03-31
PT1915375E (pt) 2009-11-26
JO2583B1 (en) 2011-02-27
NO20081151L (no) 2008-05-13
TNSN07472A1 (en) 2009-03-17
IL188796A (en) 2012-09-24
TWI324158B (en) 2010-05-01
CA2617828C (fr) 2014-03-11
MY147846A (en) 2013-01-31
FR2889701A1 (fr) 2007-02-16
PE20070339A1 (es) 2007-04-18
GT200600368A (es) 2007-07-06
ES2332472T3 (es) 2010-02-05
RS51068B (sr) 2010-10-31
ATE444964T1 (de) 2009-10-15
KR101299339B1 (ko) 2013-08-26
ME01750B (me) 2010-10-31
UY29744A1 (es) 2007-03-30
DE602006009668D1 (de) 2009-11-19
AU2006281341B2 (en) 2012-04-19

Similar Documents

Publication Publication Date Title
WO2008003854A3 (fr) Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique
WO2007090141A3 (en) Pyrrolo [2, 3, b] pyridine derivatives useful as raf kinase inhibitors
WO2006134317A8 (en) Oxadiazole derivatives as dgat inhibitors
MY130622A (en) Naphthyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors
TWI339659B (en) Aqueous composition comprising thiazole derivative
TW200607808A (en) Pyrido-pyrimidine derivatives, preparation thereof and application thereof
WO2007134827A8 (en) 5-phenyl-thiaz0l-2-yl-urea derivatives and use as pi3 kinase inhibitors
UA96759C2 (en) 2-ARYLINDOLE DERIVATIVES AS mPGES-I INHIBITORS
MX2011012057A (es) Derivados de ciclopenta [c] pirrolilalquilcarbamatos de heterociclos de 5 miembros, su preparación y su uso en terapéutica.
UA92007C2 (uk) Похідні 4-феніл-5-оксо-1,4,5,6,7,8-гексагідрохіноліну для лікування безплідності
UA92917C2 (uk) Похідні 5-піридиніл-1-азабіцикло[3.2.1]октану, їх одержання і їх застосування у терапії
MX2011009746A (es) Derivados de n-[(6-aza-biciclo[3.2.1]oct-5-il)-abril-metil]-hetero benzamida, su prepracion y su uso en terapeutica.
TNSN08026A1 (en) Derivatives of 5-pyridazinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics
MX2010007348A (es) Derivados de n-fenil-imidazo[1,2-a]piridin-2-carboxamidas, su preparacion y su aplicacion terapeutica.
IL197640A0 (en) Fluorinated catharanthine derivatives, their preparation and their utilisation as vinca dimeric alkaloid precursors
ZA200203570B (en) beta-D-5-thioxylose derivatives, preparation method and therapeutic use.
MX2011011246A (es) Derivados de 1-h-pirazolo [4,3-c] isoquinoleinas, su preparacion y su uso en terapeutica.
MX2009001168A (es) Nuevo procedimiento de preparacion.
MY152978A (en) Derivatives of morphine-6-glucuronide, preparation method thereof and use of same in therapeutics
GB0114699D0 (en) Organic compounds
TW200942538A (en) 2-benzoylimidazo[1,2-a]pyridine derivatives, preparation thereof and therapeutic use thereof
UA84603C2 (uk) Похідні тетрагідронафтиридину і спосіб їх одержання
MX2010007350A (es) Derivados de 2-heteroaroil-imidazol[1,2-a]piridina, su preparacion y aplicacion terapeutica.
TH65335A (th) สารประกอบพรัยโรโล [2,3d] ไพริมิดิน