UA89353C2 - Четвертичные хелидониновые и алкалоидные производные, способ их получения и их применение в производстве лекарственных средств - Google Patents
Четвертичные хелидониновые и алкалоидные производные, способ их получения и их применение в производстве лекарственных средств Download PDFInfo
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/564—Three-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
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Abstract
Изобретение касается продуктов реакции алкалоидов, которые получаются способом, при котором алкалоиды приводят во взаимодействие с алкилирующим агентом, преимущественно тиотепа, после чего алкилирующий агент, который не прореагировал, и другие водорастворимые соединения удаляют из реакционной смеси промыванием водой или соответствующим водным растворителем, потом реакционную смесь подвергают обработке сильной кислотой, преимущественно хлористым водородом (НС1), чтобы осадить водорастворимую соль продуктов реакции. Осажденные продукты реакции содержат, по меньшей мере, одно четвертичное алкалоидное производное и пригодны как лекарственные средства для профилактического или терапевтического применения, особенно для лечения иммунологических или метаболических дисфункций и рака.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03006015A EP1459753A1 (en) | 2003-03-18 | 2003-03-18 | Quaternary chelidonine and alkaloid derivatives, process for their preparation and their use in the manufacture of medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA89353C2 true UA89353C2 (ru) | 2010-01-25 |
Family
ID=32798820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200509763A UA89353C2 (ru) | 2003-03-18 | 2004-12-03 | Четвертичные хелидониновые и алкалоидные производные, способ их получения и их применение в производстве лекарственных средств |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US7795434B2 (ru) |
| EP (2) | EP1459753A1 (ru) |
| JP (1) | JP5303719B2 (ru) |
| KR (1) | KR101020680B1 (ru) |
| CN (1) | CN1532198A (ru) |
| AR (1) | AR043629A1 (ru) |
| AT (1) | ATE469651T1 (ru) |
| AU (1) | AU2004222661B2 (ru) |
| BR (1) | BRPI0408386A (ru) |
| CA (1) | CA2517769C (ru) |
| CL (2) | CL2004000552A1 (ru) |
| CY (1) | CY1112598T1 (ru) |
| DE (1) | DE602004027496D1 (ru) |
| DK (1) | DK1644012T3 (ru) |
| EA (1) | EA009049B1 (ru) |
| ES (1) | ES2346216T3 (ru) |
| GE (1) | GEP20084501B (ru) |
| GT (1) | GT200400046A (ru) |
| HR (1) | HRP20050987B1 (ru) |
| IL (1) | IL170505A (ru) |
| MA (1) | MA27833A1 (ru) |
| MX (1) | MXPA05009919A (ru) |
| MY (1) | MY141779A (ru) |
| NO (1) | NO333672B1 (ru) |
| NZ (1) | NZ542151A (ru) |
| PA (1) | PA8598201A1 (ru) |
| PE (1) | PE20050351A1 (ru) |
| PL (1) | PL1644012T3 (ru) |
| PT (1) | PT1644012E (ru) |
| SG (1) | SG158748A1 (ru) |
| SI (1) | SI1644012T1 (ru) |
| TN (1) | TNSN05230A1 (ru) |
| TW (1) | TWI347939B (ru) |
| UA (1) | UA89353C2 (ru) |
| WO (1) | WO2004082698A1 (ru) |
| ZA (1) | ZA200507020B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20080284A1 (it) * | 2008-02-22 | 2009-08-23 | Indena Spa | Agenti antitumorali a struttura benzofenantridinica e formulazioni che li contengono |
| WO2009148623A2 (en) | 2008-06-05 | 2009-12-10 | Stc.Unm | Methods and related compositions for the treatment of cancer |
| CN102552264A (zh) * | 2012-02-28 | 2012-07-11 | 苏州大学 | 血根碱在制备电离辐射防护剂中的应用 |
| CA3154468A1 (en) * | 2019-10-17 | 2021-04-22 | Chengdu Anticancer Bioscience, Ltd. | Benzophenanthridine alkaloids and their methods of use |
| CN113372355B (zh) * | 2021-05-13 | 2023-02-17 | 山东大学 | 六氢苯并菲啶类生物碱及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU368254A1 (ru) | 1969-06-16 | 1973-01-26 | А. И. Потопальский , В. М. Новицкий Львовский государственный медицинский институт | Способ получения соединений тиофосфамида с алкалоидами чистотела большого |
| US3865830A (en) * | 1969-06-16 | 1975-02-11 | Nikolai Mikhailovich Turkevich | Thiophosphamide derivatives of isoquinoline alkaloids, method of producing and application thereof |
| AT354644B (de) | 1975-12-19 | 1980-01-25 | Nowicky Wassili | Verfahren zur herstellung von neuen salzen von alkaloidderivaten von thiophosphorsaeure |
| AT377988B (de) | 1976-06-28 | 1985-05-28 | Nowicky Wassili | Verfahren zur herstellung von neuen phosphorderivaten von alkaloiden |
| DE3128018A1 (de) | 1981-07-13 | 1983-04-07 | Wassyl 1060 Wien Nowicky | "verfahren zum diagnostizieren und fuer die therapeutische behandlung von tumoren und/oder infektioesen krankheiten verschiedenster art unter praeparativem einsatz von alkaloid-verbindungen bzw. deren salze" |
| US4970212A (en) | 1982-05-18 | 1990-11-13 | Nowicky Wassili | Method of treating human illnesses which compromise the ability to mount an effective immunological response |
| AT407833B (de) | 1995-06-01 | 2001-06-25 | Nowicky Wassyl Dr | Mittel zur behandlung von strahlenschäden |
| AT408719B (de) | 2000-03-22 | 2002-02-25 | Nowicky Wassili | Mittel zur behandlung von hepatitis c |
| CH695417A5 (de) | 2001-11-15 | 2006-05-15 | Ddr Wassyl Nowicky Dipl Ing | Verfahren zur Umsetzung von Alkaloiden. |
-
2003
- 2003-03-18 EP EP03006015A patent/EP1459753A1/en not_active Withdrawn
- 2003-06-19 CN CNA031373550A patent/CN1532198A/zh active Pending
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2004
- 2004-03-12 ZA ZA200507020A patent/ZA200507020B/en unknown
- 2004-03-12 NZ NZ542151A patent/NZ542151A/en not_active IP Right Cessation
- 2004-03-12 DK DK04719983.1T patent/DK1644012T3/da active
- 2004-03-12 CA CA2517769A patent/CA2517769C/en not_active Expired - Fee Related
- 2004-03-12 SG SG200706589-9A patent/SG158748A1/en unknown
- 2004-03-12 US US10/549,433 patent/US7795434B2/en not_active Expired - Fee Related
- 2004-03-12 BR BRPI0408386-5A patent/BRPI0408386A/pt not_active IP Right Cessation
- 2004-03-12 JP JP2006504683A patent/JP5303719B2/ja not_active Expired - Fee Related
- 2004-03-12 DE DE602004027496T patent/DE602004027496D1/de not_active Expired - Lifetime
- 2004-03-12 WO PCT/EP2004/002637 patent/WO2004082698A1/en active Search and Examination
- 2004-03-12 AU AU2004222661A patent/AU2004222661B2/en not_active Ceased
- 2004-03-12 EP EP04719983A patent/EP1644012B1/en not_active Expired - Lifetime
- 2004-03-12 PT PT04719983T patent/PT1644012E/pt unknown
- 2004-03-12 PL PL04719983T patent/PL1644012T3/pl unknown
- 2004-03-12 MX MXPA05009919A patent/MXPA05009919A/es active IP Right Grant
- 2004-03-12 SI SI200431489T patent/SI1644012T1/sl unknown
- 2004-03-12 GE GEAP20048963A patent/GEP20084501B/en unknown
- 2004-03-12 KR KR1020057017086A patent/KR101020680B1/ko not_active IP Right Cessation
- 2004-03-12 AT AT04719983T patent/ATE469651T1/de active
- 2004-03-12 EA EA200501473A patent/EA009049B1/ru not_active IP Right Cessation
- 2004-03-12 ES ES04719983T patent/ES2346216T3/es not_active Expired - Lifetime
- 2004-03-16 MY MYPI20040919A patent/MY141779A/en unknown
- 2004-03-17 PE PE2004000281A patent/PE20050351A1/es not_active Application Discontinuation
- 2004-03-17 CL CL200400552A patent/CL2004000552A1/es unknown
- 2004-03-17 AR ARP040100877A patent/AR043629A1/es not_active Application Discontinuation
- 2004-03-18 TW TW093107196A patent/TWI347939B/zh not_active IP Right Cessation
- 2004-03-18 PA PA20048598201A patent/PA8598201A1/es unknown
- 2004-03-18 GT GT200400046A patent/GT200400046A/es unknown
- 2004-12-03 UA UAA200509763A patent/UA89353C2/ru unknown
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2005
- 2005-08-25 IL IL170505A patent/IL170505A/en not_active IP Right Cessation
- 2005-09-06 NO NO20054130A patent/NO333672B1/no not_active IP Right Cessation
- 2005-09-16 TN TNP2005000230A patent/TNSN05230A1/en unknown
- 2005-10-17 MA MA28556A patent/MA27833A1/fr unknown
- 2005-12-08 HR HRP20050987AA patent/HRP20050987B1/hr not_active IP Right Cessation
-
2008
- 2008-08-08 CL CL2008002345A patent/CL2008002345A1/es unknown
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2010
- 2010-08-20 CY CY20101100773T patent/CY1112598T1/el unknown
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