UA85567C2 - Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate - Google Patents

Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate

Info

Publication number
UA85567C2
UA85567C2 UAA200604501A UAA200604501A UA85567C2 UA 85567 C2 UA85567 C2 UA 85567C2 UA A200604501 A UAA200604501 A UA A200604501A UA A200604501 A UAA200604501 A UA A200604501A UA 85567 C2 UA85567 C2 UA 85567C2
Authority
UA
Ukraine
Prior art keywords
amino
isobutyl
hexahydrofuro
aminophenyl
furan
Prior art date
Application number
UAA200604501A
Other languages
English (en)
Inventor
Николаас Марта Феликс Гойваэртс
Пит Том Берт Пауль Вигеринк
Хартмут Бургхард Зинсер
Биргит М. Эберт
Original Assignee
Тиботек Фармасьютикелз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43827001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA85567(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Тиботек Фармасьютикелз Лтд. filed Critical Тиботек Фармасьютикелз Лтд.
Publication of UA85567C2 publication Critical patent/UA85567C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Furan Compounds (AREA)
UAA200604501A 2003-12-23 2004-12-23 Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate UA85567C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03104949 2003-12-23

Publications (1)

Publication Number Publication Date
UA85567C2 true UA85567C2 (en) 2009-02-10

Family

ID=43827001

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200604501A UA85567C2 (en) 2003-12-23 2004-12-23 Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate

Country Status (5)

Country Link
US (1) US7772411B2 (ru)
JP (1) JP4818124B2 (ru)
ME (1) ME01059B (ru)
RS (1) RS51073B (ru)
UA (1) UA85567C2 (ru)

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TWI482775B (zh) * 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
US20110257111A1 (en) * 2008-10-24 2011-10-20 Harbeson Scott L Hydroxyethlamino Sulfonamide Derivatives
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
WO2010127272A2 (en) * 2009-04-30 2010-11-04 Concert Pharmaceuticals, Inc. Hydroxyethylamino sulfonamide derivatives
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WO2011017395A1 (en) * 2009-08-04 2011-02-10 Glaxosmithkline Llc Chemical compounds
AU2010313085A1 (en) 2009-10-30 2012-05-31 Lupin Limited A novel process for preparation of darunavir and darunavir ethanolate of fine particle size
PL2528923T3 (pl) 2010-01-28 2015-01-30 Mapi Pharma Ltd Sposób wytwarzania darunawiru i pochodnych darunawiru
WO2012107889A1 (en) 2011-02-10 2012-08-16 Ranbaxy Laboratories Limited Process for the preparation of amorphous darunavir
WO2013011485A1 (en) 2011-07-20 2013-01-24 Ranbaxy Laboratories Limited Process for the preparation of sulfonamides useful as retroviral protease inhibitors
WO2013108105A2 (en) 2012-01-18 2013-07-25 Aurobindo Pharma Limited Novel solvates of darunavir
JP2015521635A (ja) * 2012-07-02 2015-07-30 ファーマシェン エス．エー． ソリフェナシン又はその塩の調製方法
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US20160075643A1 (en) 2014-09-16 2016-03-17 Zcl Chemicals Limited Novel process to prepare intermediates of hiv-protease inhibitors thereof
JP6435907B2 (ja) * 2015-02-16 2018-12-12 住友化学株式会社 ヘキサヒドロフロフラノール誘導体の製造方法
EP3303343A1 (en) 2015-06-05 2018-04-11 Amneal Pharmaceuticals Company GmbH Process for the preparation of darunavir
US20180085387A1 (en) 2016-09-27 2018-03-29 Gilead Sciences, Inc. Therapeutic compositions for treatment of human immunodeficiency virus
EP3532478B1 (en) 2016-10-27 2021-05-26 Gilead Sciences, Inc. Crystalline form of darunavir free base
KR102506813B1 (ko) * 2016-11-17 2023-03-06 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 간소화된 다루나비르 제조 절차
CN113896658A (zh) * 2021-09-24 2022-01-07 上药康丽（常州）药业有限公司 一种利用微通道反应器合成地瑞那韦中间体的方法

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Also Published As

Publication number Publication date
ME01059B (me) 2012-10-20
US20070060642A1 (en) 2007-03-15
US7772411B2 (en) 2010-08-10
JP2007520468A (ja) 2007-07-26
JP4818124B2 (ja) 2011-11-16
RS51073B (sr) 2010-10-31

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