UA75828C2 - Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity, pharmaceutical composition based thereon and method for treatment of disorder or disease (variants) - Google Patents
Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity, pharmaceutical composition based thereon and method for treatment of disorder or disease (variants) Download PDFInfo
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- UA75828C2 UA75828C2 UA20041109704A UA20041109704A UA75828C2 UA 75828 C2 UA75828 C2 UA 75828C2 UA 20041109704 A UA20041109704 A UA 20041109704A UA 20041109704 A UA20041109704 A UA 20041109704A UA 75828 C2 UA75828 C2 UA 75828C2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US37629102P | 2002-04-29 | 2002-04-29 | |
PCT/US2003/013042 WO2003093266A1 (en) | 2002-04-29 | 2003-04-25 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
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UA75828C2 true UA75828C2 (en) | 2006-05-15 |
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UA20041109704A UA75828C2 (en) | 2002-04-29 | 2003-04-25 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity, pharmaceutical composition based thereon and method for treatment of disorder or disease (variants) |
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US (1) | US7786305B2 (is) |
KR (1) | KR100754760B1 (is) |
CN (1) | CN1310917C (is) |
AR (1) | AR039489A1 (is) |
AU (1) | AU2003234251A1 (is) |
BR (1) | BR0309650A (is) |
DO (1) | DOP2003000638A (is) |
EC (1) | ECSP045392A (is) |
HK (1) | HK1081967A1 (is) |
HR (1) | HRP20041023A2 (is) |
IL (1) | IL164909A (is) |
IS (1) | IS7512A (is) |
JO (1) | JO2479B1 (is) |
MA (1) | MA27119A1 (is) |
MX (1) | MXPA04010702A (is) |
MY (1) | MY129850A (is) |
NO (1) | NO20045235L (is) |
PE (1) | PE20040598A1 (is) |
PL (1) | PL373401A1 (is) |
RU (1) | RU2285004C2 (is) |
TW (1) | TWI262077B (is) |
UA (1) | UA75828C2 (is) |
WO (1) | WO2003093266A1 (is) |
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TWI262077B (en) | 2002-04-29 | 2006-09-21 | Merck & Co Inc | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
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US20060205761A1 (en) * | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
NZ546447A (en) * | 2003-10-27 | 2009-02-28 | Merck & Co Inc | ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine succinate |
US7576089B2 (en) | 2003-12-18 | 2009-08-18 | Incyte Corporation | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors |
EP1701724A4 (en) * | 2004-01-02 | 2007-11-14 | Merck & Co Inc | CYCLOPENTYL AMIDE MODULATORS OF ALKYLAMINO, ARYLAMINO AND SULFONAMIDO OF CHEMOKINE RECEPTOR ACTIVITY |
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CN101103027A (zh) * | 2004-04-28 | 2008-01-09 | 默克公司 | 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂 |
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BRPI0512634A (pt) * | 2004-06-28 | 2008-03-25 | Incyte Corp | 3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas |
KR100856156B1 (ko) | 2004-06-28 | 2008-09-03 | 인사이트 코포레이션 | 케모카인 수용체의 조절자로서의3-아미노사이클로펜탄카복스아마이드 |
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US8067415B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
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US7977358B2 (en) | 2007-07-26 | 2011-07-12 | Hoffmann-La Roche Inc. | Pyrazol derivatives |
JP5108153B2 (ja) * | 2008-11-26 | 2012-12-26 | ファイザー・インク | ケモカイン受容体モジュレーターとしての3−アミノシクロペンタンカルボキサミド |
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TWI471321B (zh) * | 2009-06-08 | 2015-02-01 | Abbott Gmbh & Co Kg | Bcl-2族群抑制劑之口服醫藥劑型 |
TWI532484B (zh) * | 2009-06-08 | 2016-05-11 | 艾伯維有限公司 | 包含凋亡促進劑之固態分散劑 |
WO2011079127A1 (en) * | 2009-12-22 | 2011-06-30 | Abbott Laboratories | Abt-263 capsule |
UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
KR102095698B1 (ko) | 2010-10-29 | 2020-04-01 | 애브비 인코포레이티드 | 아폽토시스―유도제를 포함하는 고체 분산체 |
ES2603129T3 (es) | 2010-11-23 | 2017-02-23 | Abbvie Ireland Unlimited Company | Métodos de tratamiento utilizando inhibidores selectivos de Bcl-2 |
DK2643322T3 (en) | 2010-11-23 | 2017-12-11 | Abbvie Inc | SALTS AND CRYSTAL FORMS OF AN APOPTOSIS-INducing Agent |
TW201249846A (en) | 2011-03-17 | 2012-12-16 | Bristol Myers Squibb Co | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases |
WO2012125663A2 (en) * | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists |
US8822460B2 (en) * | 2012-04-06 | 2014-09-02 | Janssen Pharmaceutica Nv | Fused cyclopentyl antagonists of CCR2 |
AU2013290418B2 (en) | 2012-07-19 | 2017-08-03 | Chaozhong Cai | Octahydro-cyclopentapyrrolyl antagonists of CCR2 |
US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
CN108135168B (zh) | 2015-05-21 | 2021-07-20 | 凯莫森特里克斯股份有限公司 | Ccr2调节剂 |
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CN101103027A (zh) | 2004-04-28 | 2008-01-09 | 默克公司 | 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂 |
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- 2003-04-25 WO PCT/US2003/013042 patent/WO2003093266A1/en not_active Application Discontinuation
- 2003-04-25 CN CNB038150417A patent/CN1310917C/zh not_active Expired - Fee Related
- 2003-04-25 KR KR1020047017373A patent/KR100754760B1/ko not_active IP Right Cessation
- 2003-04-25 BR BR0309650-5A patent/BR0309650A/pt not_active Application Discontinuation
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- 2003-04-25 PE PE2003000418A patent/PE20040598A1/es not_active Application Discontinuation
- 2003-04-25 MX MXPA04010702A patent/MXPA04010702A/es active IP Right Grant
- 2003-04-25 AU AU2003234251A patent/AU2003234251A1/en not_active Abandoned
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- 2004-11-17 MA MA27955A patent/MA27119A1/fr unknown
- 2004-11-29 NO NO20045235A patent/NO20045235L/no not_active Application Discontinuation
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2006
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Also Published As
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AU2003234251A8 (en) | 2003-11-17 |
HRP20041023A2 (en) | 2005-02-28 |
US20050101628A1 (en) | 2005-05-12 |
RU2285004C2 (ru) | 2006-10-10 |
CN1310917C (zh) | 2007-04-18 |
DOP2003000638A (es) | 2003-11-30 |
MY129850A (en) | 2007-05-31 |
US7786305B2 (en) | 2010-08-31 |
IS7512A (is) | 2004-10-18 |
BR0309650A (pt) | 2005-04-26 |
HK1081967A1 (en) | 2006-05-26 |
PL373401A1 (en) | 2005-08-22 |
KR20050000413A (ko) | 2005-01-03 |
NO20045235L (no) | 2004-11-29 |
TW200307543A (en) | 2003-12-16 |
PE20040598A1 (es) | 2004-10-05 |
ECSP045392A (es) | 2005-01-03 |
IL164909A (en) | 2010-04-15 |
JO2479B1 (en) | 2009-01-20 |
MA27119A1 (fr) | 2004-12-20 |
AU2003234251A1 (en) | 2003-11-17 |
KR100754760B1 (ko) | 2007-09-04 |
IL164909A0 (en) | 2005-12-18 |
WO2003093266A1 (en) | 2003-11-13 |
AR039489A1 (es) | 2005-02-23 |
MXPA04010702A (es) | 2005-02-17 |
RU2004134604A (ru) | 2005-05-27 |
TWI262077B (en) | 2006-09-21 |
CN1662532A (zh) | 2005-08-31 |
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