UA75828C2 - Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity, pharmaceutical composition based thereon and method for treatment of disorder or disease (variants) - Google Patents

Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity, pharmaceutical composition based thereon and method for treatment of disorder or disease (variants) Download PDF

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Publication number
UA75828C2
UA75828C2 UA20041109704A UA20041109704A UA75828C2 UA 75828 C2 UA75828 C2 UA 75828C2 UA 20041109704 A UA20041109704 A UA 20041109704A UA 20041109704 A UA20041109704 A UA 20041109704A UA 75828 C2 UA75828 C2 UA 75828C2
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Ukraine
Prior art keywords
compound
compound according
solution
compounds
stage
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UA20041109704A
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English (en)
Ukrainian (uk)
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Merck & Co Inc
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Merck & Co Inc, Merck Sharp & Dohme filed Critical Merck & Co Inc
Publication of UA75828C2 publication Critical patent/UA75828C2/uk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
UA20041109704A 2002-04-29 2003-04-25 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity, pharmaceutical composition based thereon and method for treatment of disorder or disease (variants) UA75828C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37629102P 2002-04-29 2002-04-29
PCT/US2003/013042 WO2003093266A1 (en) 2002-04-29 2003-04-25 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
UA75828C2 true UA75828C2 (en) 2006-05-15

Family

ID=29401326

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20041109704A UA75828C2 (en) 2002-04-29 2003-04-25 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity, pharmaceutical composition based thereon and method for treatment of disorder or disease (variants)

Country Status (23)

Country Link
US (1) US7786305B2 (is)
KR (1) KR100754760B1 (is)
CN (1) CN1310917C (is)
AR (1) AR039489A1 (is)
AU (1) AU2003234251A1 (is)
BR (1) BR0309650A (is)
DO (1) DOP2003000638A (is)
EC (1) ECSP045392A (is)
HK (1) HK1081967A1 (is)
HR (1) HRP20041023A2 (is)
IL (1) IL164909A (is)
IS (1) IS7512A (is)
JO (1) JO2479B1 (is)
MA (1) MA27119A1 (is)
MX (1) MXPA04010702A (is)
MY (1) MY129850A (is)
NO (1) NO20045235L (is)
PE (1) PE20040598A1 (is)
PL (1) PL373401A1 (is)
RU (1) RU2285004C2 (is)
TW (1) TWI262077B (is)
UA (1) UA75828C2 (is)
WO (1) WO2003093266A1 (is)

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US7576089B2 (en) 2003-12-18 2009-08-18 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
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BRPI0512634A (pt) * 2004-06-28 2008-03-25 Incyte Corp 3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas
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US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US7977358B2 (en) 2007-07-26 2011-07-12 Hoffmann-La Roche Inc. Pyrazol derivatives
JP5108153B2 (ja) * 2008-11-26 2012-12-26 ファイザー・インク ケモカイン受容体モジュレーターとしての3−アミノシクロペンタンカルボキサミド
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI471321B (zh) * 2009-06-08 2015-02-01 Abbott Gmbh & Co Kg Bcl-2族群抑制劑之口服醫藥劑型
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
WO2011079127A1 (en) * 2009-12-22 2011-06-30 Abbott Laboratories Abt-263 capsule
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
KR102095698B1 (ko) 2010-10-29 2020-04-01 애브비 인코포레이티드 아폽토시스―유도제를 포함하는 고체 분산체
ES2603129T3 (es) 2010-11-23 2017-02-23 Abbvie Ireland Unlimited Company Métodos de tratamiento utilizando inhibidores selectivos de Bcl-2
DK2643322T3 (en) 2010-11-23 2017-12-11 Abbvie Inc SALTS AND CRYSTAL FORMS OF AN APOPTOSIS-INducing Agent
TW201249846A (en) 2011-03-17 2012-12-16 Bristol Myers Squibb Co Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
WO2012125663A2 (en) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
AU2013290418B2 (en) 2012-07-19 2017-08-03 Chaozhong Cai Octahydro-cyclopentapyrrolyl antagonists of CCR2
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CN108135168B (zh) 2015-05-21 2021-07-20 凯莫森特里克斯股份有限公司 Ccr2调节剂
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JP7442141B2 (ja) 2018-01-08 2024-03-04 ケモセントリックス,インコーポレイティド Ccr2アンタゴニストによる固形腫瘍の治療方法
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Also Published As

Publication number Publication date
AU2003234251A8 (en) 2003-11-17
HRP20041023A2 (en) 2005-02-28
US20050101628A1 (en) 2005-05-12
RU2285004C2 (ru) 2006-10-10
CN1310917C (zh) 2007-04-18
DOP2003000638A (es) 2003-11-30
MY129850A (en) 2007-05-31
US7786305B2 (en) 2010-08-31
IS7512A (is) 2004-10-18
BR0309650A (pt) 2005-04-26
HK1081967A1 (en) 2006-05-26
PL373401A1 (en) 2005-08-22
KR20050000413A (ko) 2005-01-03
NO20045235L (no) 2004-11-29
TW200307543A (en) 2003-12-16
PE20040598A1 (es) 2004-10-05
ECSP045392A (es) 2005-01-03
IL164909A (en) 2010-04-15
JO2479B1 (en) 2009-01-20
MA27119A1 (fr) 2004-12-20
AU2003234251A1 (en) 2003-11-17
KR100754760B1 (ko) 2007-09-04
IL164909A0 (en) 2005-12-18
WO2003093266A1 (en) 2003-11-13
AR039489A1 (es) 2005-02-23
MXPA04010702A (es) 2005-02-17
RU2004134604A (ru) 2005-05-27
TWI262077B (en) 2006-09-21
CN1662532A (zh) 2005-08-31

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