UA74404C2 - pyrazolopyridine pyridine substituted derivatives - Google Patents

pyrazolopyridine pyridine substituted derivatives

Info

Publication number
UA74404C2
UA74404C2 UA2003065752A UA200365752A UA74404C2 UA 74404 C2 UA74404 C2 UA 74404C2 UA 2003065752 A UA2003065752 A UA 2003065752A UA 200365752 A UA200365752 A UA 200365752A UA 74404 C2 UA74404 C2 UA 74404C2
Authority
UA
Ukraine
Prior art keywords
pyrazolopyridine
substituted derivatives
pyridine substituted
diseases
treating
Prior art date
Application number
UA2003065752A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Йоханнес-Петер Шташ
Ахім Фойрер
Ахим Фойрер
Штефан Вайганд
Ельке Шталь
Дітмар Флубахер
Крістіна Алонсо-Алія
Франк Вундер
Дітер Ланг
Дитер Ланг
Клаус ДЕМБОВСКИ
Александер Штрауб
Елізабет Перзборн
Элизабет Перзборн
Original Assignee
Баєр Акціенгезельшафт
Байер Акциенгезелльшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Баєр Акціенгезельшафт, Байер Акциенгезелльшафт filed Critical Баєр Акціенгезельшафт
Priority claimed from PCT/EP2001/012969 external-priority patent/WO2002042301A1/en
Publication of UA74404C2 publication Critical patent/UA74404C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to novel pyrazolopyridine derivatives of the formula (I), wherein R1 represents 4-pyridinyi or 3-pyridinyl; R2 represents H, NH2 or halogen, and to the salts, isomers and hydrates thereof as stimulators of the soluble guanylate cyclase and for the use as agents for treating cardiovascular diseases, hypertonia, thromboembolic diseases and ischemias, sexual dysfunction or inflammations and for treating diseases of the central nervous system.  
UA2003065752A 2000-11-22 2001-11-09 pyrazolopyridine pyridine substituted derivatives UA74404C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10057753 2000-11-22
DE10131987A DE10131987A1 (en) 2000-11-22 2001-07-02 New pyridinyl-substituted pyrazolo (3,4-b) pyridine derivatives, are soluble guanylate cyclase stimulants useful e.g. for treating cardiovascular or central nervous system diseases, sexual dysfunction or inflammation
PCT/EP2001/012969 WO2002042301A1 (en) 2000-11-22 2001-11-09 Novel pyridine-substituted pyrazolopyridine derivatives

Publications (1)

Publication Number Publication Date
UA74404C2 true UA74404C2 (en) 2005-12-15

Family

ID=7664122

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2003065752A UA74404C2 (en) 2000-11-22 2001-11-09 pyrazolopyridine pyridine substituted derivatives

Country Status (12)

Country Link
KR (1) KR20030065519A (en)
DE (2) DE10131987A1 (en)
DO (1) DOP2001000291A (en)
EC (1) ECSP034616A (en)
GT (1) GT200100235A (en)
HN (1) HN2001000261A (en)
MY (1) MY127212A (en)
PE (1) PE20020581A1 (en)
RU (1) RU2003118584A (en)
SV (1) SV2003000743A (en)
UA (1) UA74404C2 (en)
ZA (1) ZA200303887B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102485724B (en) * 2010-12-06 2015-08-12 中国人民解放军军事医学科学院毒物药物研究所 Substituted thiophene base pyrazolo-pyridines and medicinal use thereof
ES2864009T3 (en) 2011-11-25 2021-10-13 Adverio Pharma Gmbh 5-Fluoro-1H-pyrazolopyridines substituted in crystalline form
US10918639B2 (en) * 2016-10-11 2021-02-16 Bayer Pharma Aktiengesellschaft Combination containing SGC stimulators and mineralocorticoid receptor antagonists

Also Published As

Publication number Publication date
GT200100235A (en) 2002-06-25
HN2001000261A (en) 2002-01-30
PE20020581A1 (en) 2002-07-13
RU2003118584A (en) 2004-12-20
KR20030065519A (en) 2003-08-06
DOP2001000291A (en) 2002-12-15
SV2003000743A (en) 2003-01-13
DE50106655D1 (en) 2005-08-04
MY127212A (en) 2006-11-30
DE10131987A1 (en) 2002-05-23
ZA200303887B (en) 2004-06-21
ECSP034616A (en) 2003-06-25

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