DOP2001000291A - NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE - Google Patents

NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE

Info

Publication number
DOP2001000291A
DOP2001000291A DO2001000291A DO2001000291A DOP2001000291A DO P2001000291 A DOP2001000291 A DO P2001000291A DO 2001000291 A DO2001000291 A DO 2001000291A DO 2001000291 A DO2001000291 A DO 2001000291A DO P2001000291 A DOP2001000291 A DO P2001000291A
Authority
DO
Dominican Republic
Prior art keywords
pirazolpiridina
piridine
substituted
new derivatives
diseases
Prior art date
Application number
DO2001000291A
Other languages
Spanish (es)
Inventor
Dieter Lang
Frank Wunder
Cristina Alonso-Alija
Elke Stahl
Stefan Weigand
Alexander Straub
Johannes-Peter Stasch
Achim Feurer
Dietmar Flubacher
Kalus Dembowsky
Elizabeth Perzborn
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DOP2001000291A publication Critical patent/DOP2001000291A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a nuevos derivados de pirazolpiridina de formula. En la que R1 representa 4-piridinilo o 3-piridinilo; R2 representa H,HN2 o halógeno; así como sales, isomeros e hidratos de los mismos como estimuladores de la guanilato ciclasa soluble y para la utilización como agentes para el tratamiento de enfermedades coronario-circulatorias, hipertonia, enfermedades tromboembólicas e isquemias, disfunción sexual o inflamaciones así como para el tratamiento de enfermedades de sistema nervioso central.The present invention relates to novel pyrazolpyridine derivatives of the formula. Wherein R1 represents 4-pyridinyl or 3-pyridinyl; R2 represents H, HN2 or halogen; as well as salts, isomers and hydrates thereof as stimulators of soluble guanylate cyclase and for use as agents for the treatment of coronary-circulatory diseases, hypertonia, thromboembolic diseases and ischemia, sexual dysfunction or inflammation as well as for the treatment of diseases of central nervous system.

DO2001000291A 2000-11-22 2001-11-20 NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE DOP2001000291A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10057753 2000-11-22
DE10131987A DE10131987A1 (en) 2000-11-22 2001-07-02 New pyridinyl-substituted pyrazolo (3,4-b) pyridine derivatives, are soluble guanylate cyclase stimulants useful e.g. for treating cardiovascular or central nervous system diseases, sexual dysfunction or inflammation

Publications (1)

Publication Number Publication Date
DOP2001000291A true DOP2001000291A (en) 2002-12-15

Family

ID=7664122

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2001000291A DOP2001000291A (en) 2000-11-22 2001-11-20 NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE

Country Status (12)

Country Link
KR (1) KR20030065519A (en)
DE (2) DE10131987A1 (en)
DO (1) DOP2001000291A (en)
EC (1) ECSP034616A (en)
GT (1) GT200100235A (en)
HN (1) HN2001000261A (en)
MY (1) MY127212A (en)
PE (1) PE20020581A1 (en)
RU (1) RU2003118584A (en)
SV (1) SV2003000743A (en)
UA (1) UA74404C2 (en)
ZA (1) ZA200303887B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102485724B (en) * 2010-12-06 2015-08-12 中国人民解放军军事医学科学院毒物药物研究所 Substituted thiophene base pyrazolo-pyridines and medicinal use thereof
DK2782914T3 (en) 2011-11-25 2018-11-26 Adverio Pharma Gmbh PROCEDURE FOR PREPARING SUBSTITUTED 5-FLUOR-1H-PYRAZOLOPYRIDINES
US10918639B2 (en) * 2016-10-11 2021-02-16 Bayer Pharma Aktiengesellschaft Combination containing SGC stimulators and mineralocorticoid receptor antagonists

Also Published As

Publication number Publication date
GT200100235A (en) 2002-06-25
RU2003118584A (en) 2004-12-20
HN2001000261A (en) 2002-01-30
SV2003000743A (en) 2003-01-13
ZA200303887B (en) 2004-06-21
MY127212A (en) 2006-11-30
UA74404C2 (en) 2005-12-15
ECSP034616A (en) 2003-06-25
DE10131987A1 (en) 2002-05-23
DE50106655D1 (en) 2005-08-04
PE20020581A1 (en) 2002-07-13
KR20030065519A (en) 2003-08-06

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