PE20020581A1 - DERIVATIVES OF PYRAZOLPYRIDINES SUBSTITUTED WITH PYRIDIMIDINE AS STIMULATORS OF GUANILATE CYCLASE - Google Patents

DERIVATIVES OF PYRAZOLPYRIDINES SUBSTITUTED WITH PYRIDIMIDINE AS STIMULATORS OF GUANILATE CYCLASE

Info

Publication number
PE20020581A1
PE20020581A1 PE2001001161A PE2001001161A PE20020581A1 PE 20020581 A1 PE20020581 A1 PE 20020581A1 PE 2001001161 A PE2001001161 A PE 2001001161A PE 2001001161 A PE2001001161 A PE 2001001161A PE 20020581 A1 PE20020581 A1 PE 20020581A1
Authority
PE
Peru
Prior art keywords
pyridimidine
stimulators
refers
derivatives
substituted
Prior art date
Application number
PE2001001161A
Other languages
Spanish (es)
Inventor
Johannes-Peter Stasch
Achim Feurer
Stefan Weigand
Elke Stahl
Dietmar Flubacher
Cristina Alonso-Alija
Frank Wunder
Dieter Lang
Klaus Dembowsky
Alexander Straub
Elisabeth Perzborn
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20020581A1 publication Critical patent/PE20020581A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A DERIVADOS DE PIRAZOLPIRIDINA SUSTITUIDOS EN LA POSICION 3 CON PIRIDIMIDINA DE FORMULA I DONDE: R1 ES 4-PIRIDINILO, 3-PIRIDINILO; R2 ES H, NH2, HALOGENO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. TAMBIEN SE REFIERE A LA COMBINACION CON NITRATOS O DONADORES NO ORGANICOS, INHIBIDORES DE LA FORMACION DE GUANOSINMONOFOSFATO CICLICO, LOS COMPUESTOS SON ESTIMULADORES DE GUANOSINMONOFOSFATO CICLICO (cGMP) Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES CORONARIO-CIRCULATORIAS, HIPERTONIA, ENFERMEDADES TROMBOEMBOLICAS E ISQUEMIAS, DISFUNCION SEXUAL, ENFERMEDADES DEL SISTEMA NERVIOSO CENTRALREFERS TO PYRAZOLPYRIDINE DERIVATIVES SUBSTITUTED AT POSITION 3 WITH PYRIDIMIDINE OF FORMULA I WHERE: R1 IS 4-PYRIDINYL, 3-PYRIDINYL; R2 IS H, NH2, HALOGEN. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. Also refers to the combination with nitrates or DONORS nonorganic, INHIBITORS FORMATION guanosine monophosphate CICLICO, the compounds are stimulators of guanosine monophosphate CICLICO (cGMP) AND MAY BE USEFUL FOR THE TREATMENT OF DISEASES CORONARY-CIRCULATORY, hypertension, thromboembolic diseases and ischaemias , SEXUAL DYSFUNCTION, DISEASES OF THE CENTRAL NERVOUS SYSTEM

PE2001001161A 2000-11-22 2001-11-21 DERIVATIVES OF PYRAZOLPYRIDINES SUBSTITUTED WITH PYRIDIMIDINE AS STIMULATORS OF GUANILATE CYCLASE PE20020581A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10057753 2000-11-22
DE10131987A DE10131987A1 (en) 2000-11-22 2001-07-02 New pyridinyl-substituted pyrazolo (3,4-b) pyridine derivatives, are soluble guanylate cyclase stimulants useful e.g. for treating cardiovascular or central nervous system diseases, sexual dysfunction or inflammation

Publications (1)

Publication Number Publication Date
PE20020581A1 true PE20020581A1 (en) 2002-07-13

Family

ID=7664122

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001161A PE20020581A1 (en) 2000-11-22 2001-11-21 DERIVATIVES OF PYRAZOLPYRIDINES SUBSTITUTED WITH PYRIDIMIDINE AS STIMULATORS OF GUANILATE CYCLASE

Country Status (12)

Country Link
KR (1) KR20030065519A (en)
DE (2) DE10131987A1 (en)
DO (1) DOP2001000291A (en)
EC (1) ECSP034616A (en)
GT (1) GT200100235A (en)
HN (1) HN2001000261A (en)
MY (1) MY127212A (en)
PE (1) PE20020581A1 (en)
RU (1) RU2003118584A (en)
SV (1) SV2003000743A (en)
UA (1) UA74404C2 (en)
ZA (1) ZA200303887B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102485724B (en) * 2010-12-06 2015-08-12 中国人民解放军军事医学科学院毒物药物研究所 Substituted thiophene base pyrazolo-pyridines and medicinal use thereof
DK2896617T3 (en) 2011-11-25 2016-12-12 Adverio Pharma Gmbh Method for preparing substituted (Z) -alpha-fluoro-beta-amino-ACRYLALDEHYDER
EP3525779A1 (en) * 2016-10-11 2019-08-21 Bayer Pharma Aktiengesellschaft Combination containing sgc stimulators and mineralocorticoid receptor antagonists

Also Published As

Publication number Publication date
RU2003118584A (en) 2004-12-20
KR20030065519A (en) 2003-08-06
ZA200303887B (en) 2004-06-21
UA74404C2 (en) 2005-12-15
HN2001000261A (en) 2002-01-30
MY127212A (en) 2006-11-30
DOP2001000291A (en) 2002-12-15
DE10131987A1 (en) 2002-05-23
ECSP034616A (en) 2003-06-25
GT200100235A (en) 2002-06-25
DE50106655D1 (en) 2005-08-04
SV2003000743A (en) 2003-01-13

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed