UA70347C2 - ІЗОБЕНЗОФУРАНИ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЛІКУВАННЯ РОЗЛАДУ АБО ЗАХВОРЮВАННЯ, ЧУТЛИВОГО ДО ДІЇ 5-НТ<sub>1А</sub> - Google Patents
ІЗОБЕНЗОФУРАНИ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЛІКУВАННЯ РОЗЛАДУ АБО ЗАХВОРЮВАННЯ, ЧУТЛИВОГО ДО ДІЇ 5-НТ<sub>1А</sub> Download PDFInfo
- Publication number
- UA70347C2 UA70347C2 UA2001064499A UA01064499A UA70347C2 UA 70347 C2 UA70347 C2 UA 70347C2 UA 2001064499 A UA2001064499 A UA 2001064499A UA 01064499 A UA01064499 A UA 01064499A UA 70347 C2 UA70347 C2 UA 70347C2
- Authority
- UA
- Ukraine
- Prior art keywords
- propyl
- dihydroisobenzofuran
- fluorophenyl
- indol
- carbonitrile
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 45
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- 230000009471 action Effects 0.000 title claims description 6
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- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 17
- 239000002253 acid Substances 0.000 claims abstract description 14
- 239000001257 hydrogen Substances 0.000 claims abstract description 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 181
- -1 hydroxy, formyl Chemical group 0.000 claims description 126
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 88
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 43
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 27
- 125000001424 substituent group Chemical group 0.000 claims description 21
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000000862 serotonergic effect Effects 0.000 description 1
- 239000004001 serotonin 1D antagonist Substances 0.000 description 1
- 239000000952 serotonin receptor agonist Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11136098P | 1998-12-08 | 1998-12-08 | |
PCT/DK1999/000676 WO2000034263A1 (en) | 1998-12-08 | 1999-12-03 | Benzofuran derivatives, their preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
UA70347C2 true UA70347C2 (uk) | 2004-10-15 |
Family
ID=22338076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2001064499A UA70347C2 (uk) | 1998-12-08 | 1999-03-12 | ІЗОБЕНЗОФУРАНИ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЛІКУВАННЯ РОЗЛАДУ АБО ЗАХВОРЮВАННЯ, ЧУТЛИВОГО ДО ДІЇ 5-НТ<sub>1А</sub> |
Country Status (11)
Country | Link |
---|---|
CN (1) | CN1198813C (pl) |
BR (1) | BR9916873A (pl) |
EA (1) | EA003781B1 (pl) |
HK (1) | HK1043121B (pl) |
ID (1) | ID30330A (pl) |
NZ (1) | NZ511751A (pl) |
PL (1) | PL201171B1 (pl) |
SK (1) | SK286524B6 (pl) |
TR (1) | TR200101605T2 (pl) |
UA (1) | UA70347C2 (pl) |
ZA (1) | ZA200103987B (pl) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110627757B (zh) * | 2018-06-25 | 2022-01-14 | 北京安博睿达医药科技有限公司 | 依地普仑衍生物及其制备方法和用途 |
-
1999
- 1999-03-12 UA UA2001064499A patent/UA70347C2/uk unknown
- 1999-12-03 EA EA200100633A patent/EA003781B1/ru not_active IP Right Cessation
- 1999-12-03 BR BR9916873-1A patent/BR9916873A/pt not_active Application Discontinuation
- 1999-12-03 NZ NZ511751A patent/NZ511751A/en unknown
- 1999-12-03 ID IDW00200101458A patent/ID30330A/id unknown
- 1999-12-03 TR TR2001/01605T patent/TR200101605T2/xx unknown
- 1999-12-03 SK SK776-2001A patent/SK286524B6/sk not_active IP Right Cessation
- 1999-12-03 PL PL347934A patent/PL201171B1/pl not_active IP Right Cessation
- 1999-12-03 CN CNB998142077A patent/CN1198813C/zh not_active Expired - Fee Related
-
2001
- 2001-05-16 ZA ZA200103987A patent/ZA200103987B/xx unknown
-
2002
- 2002-06-19 HK HK02104563.7A patent/HK1043121B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1329605A (zh) | 2002-01-02 |
SK286524B6 (sk) | 2008-12-05 |
EA003781B1 (ru) | 2003-08-28 |
TR200101605T2 (tr) | 2001-10-22 |
CN1198813C (zh) | 2005-04-27 |
HK1043121A1 (en) | 2002-09-06 |
NZ511751A (en) | 2003-09-26 |
PL201171B1 (pl) | 2009-03-31 |
SK7762001A3 (en) | 2001-11-06 |
ID30330A (id) | 2001-11-22 |
HK1043121B (zh) | 2005-12-16 |
BR9916873A (pt) | 2001-08-21 |
EA200100633A1 (ru) | 2001-10-22 |
ZA200103987B (en) | 2002-05-16 |
PL347934A1 (en) | 2002-04-22 |
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