UA45358C2 - Похідні 2,3-бензодіазепіну, спосіб їх одержання, проміжні сполуки та фармацевтична композиція - Google Patents
Похідні 2,3-бензодіазепіну, спосіб їх одержання, проміжні сполуки та фармацевтична композиція Download PDFInfo
- Publication number
- UA45358C2 UA45358C2 UA97041584A UA97041584A UA45358C2 UA 45358 C2 UA45358 C2 UA 45358C2 UA 97041584 A UA97041584 A UA 97041584A UA 97041584 A UA97041584 A UA 97041584A UA 45358 C2 UA45358 C2 UA 45358C2
- Authority
- UA
- Ukraine
- Prior art keywords
- group
- benzodiazepine
- hydrogen
- methyl
- dihydro
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретение относится к неконкурентным АМРА антагонистическим соединениям формулы I, в которой R1 и R2 представляют, независимо, водородную, галогенную, C1-4 алкильную группы, C1-4 алкокси- группу, нитрогруппу, трифторметильную группу или группу формулы -NR8R9, в которой R8 и R9 являются, независимо, водородной, C1-4 алкильной группой или группой формулы -COR10, в которой R10 является водородной, C1-6 алкильной группами, которые могут быть заменены, С6-10 арильной группой, C1-4 алкокси- группой, С3-5 циклоалкильной группой, С2-6 алкенильной группой, С3-5 циклоалкокси- группой или группой формулы -NR11R12, в которой R11 и R12 означают, независимо, водородную, C1-4 алкильную группы, С3-5 циклоалкильную группу или С6-10 арильную группу, R3 представляет C1-4 алкильную группу, С3-5 циклоалкильную группу или группу формулы -CO-R13, в которой R13 имеет те же самые определения, данные в отношении R10, R4 и R5 означают, независимо, водородную или C1-3 алкильную группы, R6 и R7 являются, независимо, водородом, хлором или бромом, с положением, что если один из R6 и R7 является, независимо, водородом, другой отличается от водорода, также как их изомеры и соли соединений, полученные после добавления кислоты, или изомеры, в дальнейшем фармацевтические составы, приготовленные из любых перечисленных соединений. Изобретение также относится к стартовым соединениям формулы II, в которой R1, R2, R4, R5, R6 и R7 таковы, как указано относительно формулы I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9600871A HU9600871D0 (en) | 1996-04-04 | 1996-04-04 | New 2,3-benzodiazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA45358C2 true UA45358C2 (uk) | 2002-04-15 |
Family
ID=89993864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA97041584A UA45358C2 (uk) | 1996-04-04 | 1997-04-03 | Похідні 2,3-бензодіазепіну, спосіб їх одержання, проміжні сполуки та фармацевтична композиція |
Country Status (11)
| Country | Link |
|---|---|
| KR (1) | KR970069997A (ru) |
| AT (1) | ATE254608T1 (ru) |
| AU (1) | AU720745B2 (ru) |
| BE (1) | BE1010962A4 (ru) |
| DE (1) | DE59711013D1 (ru) |
| ES (1) | ES2127699B1 (ru) |
| IT (1) | IT1290453B1 (ru) |
| NZ (1) | NZ314517A (ru) |
| UA (1) | UA45358C2 (ru) |
| YU (1) | YU13197A (ru) |
| ZA (1) | ZA972746B (ru) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU179018B (en) * | 1978-10-19 | 1982-08-28 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivatives |
| HU186760B (en) * | 1981-03-12 | 1985-09-30 | Gyogyszerkutato Intezet | Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives |
| HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
| HU208429B (en) * | 1991-05-03 | 1993-10-28 | Gyogyszerkutato Intezet | Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity |
| WO1996006606A1 (en) * | 1994-08-31 | 1996-03-07 | Eli Lilly And Company | Dihydro-2,3-benzodiazepine derivatives |
-
1997
- 1997-04-01 ZA ZA972746A patent/ZA972746B/xx unknown
- 1997-04-03 BE BE9700308A patent/BE1010962A4/fr not_active IP Right Cessation
- 1997-04-03 KR KR1019970012301A patent/KR970069997A/ko not_active Application Discontinuation
- 1997-04-03 UA UA97041584A patent/UA45358C2/uk unknown
- 1997-04-03 YU YU13197A patent/YU13197A/sh unknown
- 1997-04-03 NZ NZ314517A patent/NZ314517A/xx unknown
- 1997-04-04 AU AU17734/97A patent/AU720745B2/en not_active Ceased
- 1997-04-04 DE DE59711013T patent/DE59711013D1/de not_active Expired - Fee Related
- 1997-04-04 IT IT000776 patent/IT1290453B1/it active IP Right Grant
- 1997-04-04 AT AT97105591T patent/ATE254608T1/de not_active IP Right Cessation
- 1997-04-04 ES ES009700703A patent/ES2127699B1/es not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BE1010962A4 (fr) | 1999-03-02 |
| DE59711013D1 (de) | 2003-12-24 |
| NZ314517A (en) | 2000-03-27 |
| ES2127699B1 (es) | 2000-01-16 |
| ATE254608T1 (de) | 2003-12-15 |
| YU13197A (sh) | 1999-09-27 |
| ES2127699A1 (es) | 1999-04-16 |
| IT1290453B1 (it) | 1998-12-03 |
| AU720745B2 (en) | 2000-06-08 |
| KR970069997A (ko) | 1997-11-07 |
| ZA972746B (en) | 1998-10-09 |
| AU1773497A (en) | 1997-10-09 |
| ITMI970776A1 (it) | 1998-10-04 |
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