UA39922C2 - Фрагмент днк, що включає ген, який кодує карміноміцин-4-0-метилтрансферазу, вектор, штам escherichia coli, штам streptomyces lividans, клітинний екстракт, пептид, що має карміноміцин-4-0-метилтрансферазну активність, спосіб продукування поліпептиду, спосіб одержання даунорубіцину, спосіб перетворення карміноміцину на даунорубіцин. - Google Patents
Фрагмент днк, що включає ген, який кодує карміноміцин-4-0-метилтрансферазу, вектор, штам escherichia coli, штам streptomyces lividans, клітинний екстракт, пептид, що має карміноміцин-4-0-метилтрансферазну активність, спосіб продукування поліпептиду, спосіб одержання даунорубіцину, спосіб перетворення карміноміцину на даунорубіцин.Info
- Publication number
- UA39922C2 UA39922C2 UA93004588A UA93004588A UA39922C2 UA 39922 C2 UA39922 C2 UA 39922C2 UA 93004588 A UA93004588 A UA 93004588A UA 93004588 A UA93004588 A UA 93004588A UA 39922 C2 UA39922 C2 UA 39922C2
- Authority
- UA
- Ukraine
- Prior art keywords
- gold
- karminomitsyn
- daunorubicin
- producing
- reagent
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 8
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 title 2
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 title 2
- 229960000975 daunorubicin Drugs 0.000 title 2
- 108090000765 processed proteins & peptides Proteins 0.000 title 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 2
- 241000588724 Escherichia coli Species 0.000 title 1
- 241000187398 Streptomyces lividans Species 0.000 title 1
- 229930188550 carminomycin Natural products 0.000 title 1
- XREUEWVEMYWFFA-CSKJXFQVSA-N carminomycin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=C(O)C=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XREUEWVEMYWFFA-CSKJXFQVSA-N 0.000 title 1
- XREUEWVEMYWFFA-UHFFFAOYSA-N carminomycin I Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=C(O)C=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XREUEWVEMYWFFA-UHFFFAOYSA-N 0.000 title 1
- 229950001725 carubicin Drugs 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 239000000284 extract Substances 0.000 title 1
- 239000012634 fragment Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 abstract 13
- 239000010931 gold Substances 0.000 abstract 13
- 229910052737 gold Inorganic materials 0.000 abstract 13
- 239000003153 chemical reaction reagent Substances 0.000 abstract 7
- 239000012141 concentrate Substances 0.000 abstract 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Substances 0.000 abstract 3
- 239000002440 industrial waste Substances 0.000 abstract 3
- 239000000463 material Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- 238000002156 mixing Methods 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- 230000002411 adverse Effects 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000002386 leaching Methods 0.000 abstract 1
- 238000005065 mining Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000005498 polishing Methods 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/888—Streptomyces antibioticus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79387391A | 1991-11-18 | 1991-11-18 | |
| US07/959,941 US5364781A (en) | 1991-11-18 | 1992-10-09 | Process for preparing daunorubicin |
| PCT/US1992/009580 WO1993010223A1 (en) | 1991-11-18 | 1992-11-17 | Dna-sequence coding for carminomycin 4-o-methyltransferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA39922C2 true UA39922C2 (uk) | 2001-07-16 |
Family
ID=25161036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA93004588A UA39922C2 (uk) | 1991-11-18 | 1992-11-17 | Фрагмент днк, що включає ген, який кодує карміноміцин-4-0-метилтрансферазу, вектор, штам escherichia coli, штам streptomyces lividans, клітинний екстракт, пептид, що має карміноміцин-4-0-метилтрансферазну активність, спосіб продукування поліпептиду, спосіб одержання даунорубіцину, спосіб перетворення карміноміцину на даунорубіцин. |
Country Status (7)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ245124A (en) * | 1991-11-18 | 1994-06-27 | Erba Carlo Spa | Carminomycin 4-0-methyltransferase, dna encoding it, vectors and host cells; and also a process for producing daunorubicin |
| FI944556A0 (fi) * | 1994-09-30 | 1994-09-30 | Kristiina Ylihonko | Foerfarande foer producering av antracykliner och deras mellanprodukter |
| GB2302540B (en) * | 1995-06-23 | 1999-02-24 | Pharmacia Spa | Cofactor for transmethylation |
| US5652125A (en) * | 1996-06-10 | 1997-07-29 | Pharmacia S.P.A. | Process for preparing daunorubicin |
| DE19880405T1 (de) * | 1997-03-06 | 1999-11-11 | Pharmacia & Upjohn Spa | Verfahren zur Herstellung von Doxorubicin |
| EP1071746A4 (en) * | 1998-04-24 | 2003-04-23 | Pharmacia Italia Spa | METHOD FOR PRODUCING DOXORUBICIN |
| US6177262B1 (en) * | 1998-09-22 | 2001-01-23 | Kosan Biosciences, Inc. | Recombinant host cells for the production of polyketides |
| KR102080666B1 (ko) * | 2019-04-12 | 2020-02-24 | 박행제 | 수력발전장치용 임펠라 어셈블리 |
-
1992
- 1992-10-09 US US07/959,941 patent/US5364781A/en not_active Expired - Lifetime
- 1992-10-27 TW TW081108541A patent/TW227575B/zh active
- 1992-11-16 PT PT101065A patent/PT101065B/pt not_active IP Right Cessation
- 1992-11-17 UA UA93004588A patent/UA39922C2/uk unknown
- 1992-11-17 ZA ZA928865A patent/ZA928865B/xx unknown
- 1992-11-17 KR KR1019930702133A patent/KR100283826B1/ko not_active Expired - Fee Related
- 1992-11-17 RU RU95114535/13A patent/RU2155811C2/ru not_active IP Right Cessation
- 1992-11-17 RU RU93054774A patent/RU2115731C1/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100283826B1 (ko) | 2001-03-02 |
| ZA928865B (en) | 1993-05-13 |
| TW227575B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1994-08-01 |
| RU2115731C1 (ru) | 1998-07-20 |
| PT101065B (pt) | 1999-08-31 |
| RU2155811C2 (ru) | 2000-09-10 |
| PT101065A (pt) | 1994-02-28 |
| US5364781A (en) | 1994-11-15 |
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