EP1071746A4 - Process for preparing doxorubicin - Google Patents

Process for preparing doxorubicin

Info

Publication number
EP1071746A4
EP1071746A4 EP99919767A EP99919767A EP1071746A4 EP 1071746 A4 EP1071746 A4 EP 1071746A4 EP 99919767 A EP99919767 A EP 99919767A EP 99919767 A EP99919767 A EP 99919767A EP 1071746 A4 EP1071746 A4 EP 1071746A4
Authority
EP
European Patent Office
Prior art keywords
preparing doxorubicin
doxorubicin
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99919767A
Other languages
German (de)
French (fr)
Other versions
EP1071746A2 (en
Inventor
Augusto Inventi Solari
Giovanna Zanuso
Silvia Filippini
Francesca Torti
Sharee Otten
Anna Luisa Colombo
Charles R Hutchinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Publication of EP1071746A2 publication Critical patent/EP1071746A2/en
Publication of EP1071746A4 publication Critical patent/EP1071746A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
EP99919767A 1998-04-24 1999-04-22 Process for preparing doxorubicin Withdrawn EP1071746A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6560698A 1998-04-24 1998-04-24
US65606 1998-04-24
PCT/US1999/007016 WO1999055829A2 (en) 1998-04-24 1999-04-22 Process for preparing doxorubicin

Publications (2)

Publication Number Publication Date
EP1071746A2 EP1071746A2 (en) 2001-01-31
EP1071746A4 true EP1071746A4 (en) 2003-04-23

Family

ID=22063870

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99919767A Withdrawn EP1071746A4 (en) 1998-04-24 1999-04-22 Process for preparing doxorubicin

Country Status (5)

Country Link
EP (1) EP1071746A4 (en)
JP (1) JP2002512784A (en)
CN (1) CN1198930C (en)
CA (1) CA2326500A1 (en)
WO (1) WO1999055829A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006111561A1 (en) * 2005-04-21 2006-10-26 Dsm Ip Assets B.V. Improved microbial production of anthracyclins
CN1962869B (en) * 2005-11-09 2010-08-11 上海医药工业研究院 Regulation protein SnpR and its gene and application
CN101016533B (en) * 2005-11-09 2010-05-19 上海医药工业研究院 Engineering bacterium capable of producing anthracene ring antibiotics and application of the same
EP2192171B1 (en) * 2007-09-14 2014-03-05 Meiji Seika Kaisha Ltd. Method for production of non-natural antibiotic
CN102229906B (en) * 2011-03-09 2013-04-10 北京赛诺百奥生物技术有限公司 Daunorubicin and adriamycin producing engineered pseudomonas
CN104059892A (en) * 2013-03-18 2014-09-24 江苏禾昌生物科技有限公司 Daunorubicin C-14 hydroxylase mutant and production method of genetically engineered bacteria thereof
CN111187746B (en) * 2018-11-15 2022-11-22 上海医药工业研究院 Genetically engineered bacterium and preparation method and application thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665564A (en) * 1988-05-27 1997-09-09 Pharmacia & Upjohn S.P.A. Isolation and characterisation of genes resistant to anthracycline antibiotics
US5364781A (en) * 1991-11-18 1994-11-15 Farmitalia Carlo Erba S.R.L Process for preparing daunorubicin
US5695966A (en) * 1995-02-27 1997-12-09 Pharmacia & Upjohn S.P.A. DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
US5801032A (en) * 1995-08-03 1998-09-01 Abbott Laboratories Vectors and process for producing high purity 6,12-dideoxyerythromycin A by fermentation
US5976830A (en) * 1996-05-24 1999-11-02 The Ohio State University Research Foundation Methods of producing doxorubicin
US5652125A (en) * 1996-06-10 1997-07-29 Pharmacia S.P.A. Process for preparing daunorubicin

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9955829A3 *

Also Published As

Publication number Publication date
JP2002512784A (en) 2002-05-08
CN1198930C (en) 2005-04-27
WO1999055829A3 (en) 1999-12-23
CA2326500A1 (en) 1999-11-04
CN1298453A (en) 2001-06-06
WO1999055829A2 (en) 1999-11-04
EP1071746A2 (en) 2001-01-31

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20001027

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 12P 19/56 A, 7C 12N 15/31 B, 7C 12N 15/53 B, 7C 12N 15/63 B, 7C 12N 15/74 B, 7C 12N 15/76 B

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: PHARMACIA ITALIA S.P.A.

A4 Supplementary search report drawn up and despatched

Effective date: 20030306

RIC1 Information provided on ipc code assigned before grant

Ipc: 7C 12N 9/02 B

Ipc: 7C 12N 15/76 B

Ipc: 7C 12N 15/74 B

Ipc: 7C 12N 15/63 B

Ipc: 7C 12N 15/53 B

Ipc: 7C 12N 15/31 B

Ipc: 7C 12P 19/56 A

17Q First examination report despatched

Effective date: 20040607

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: PFIZER ITALIA S.R.L.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20071101