UA35028C2 - Средство на основе бетаметазона для лечения дерматозов - Google Patents
Средство на основе бетаметазона для лечения дерматозов Download PDFInfo
- Publication number
- UA35028C2 UA35028C2 UA99074409A UA99074409A UA35028C2 UA 35028 C2 UA35028 C2 UA 35028C2 UA 99074409 A UA99074409 A UA 99074409A UA 99074409 A UA99074409 A UA 99074409A UA 35028 C2 UA35028 C2 UA 35028C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cetylpyridinium chloride
- metason
- betamethasone valerate
- propylene glycol
- treatment
- Prior art date
Links
- 208000017520 skin disease Diseases 0.000 title claims abstract description 16
- 239000000203 mixture Substances 0.000 title abstract description 11
- 206010048768 Dermatosis Diseases 0.000 title abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000013543 active substance Substances 0.000 claims abstract description 15
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims abstract description 15
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims abstract description 15
- 239000008213 purified water Substances 0.000 claims abstract description 11
- 150000001298 alcohols Chemical class 0.000 claims abstract description 5
- SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 claims description 23
- 229960004311 betamethasone valerate Drugs 0.000 claims description 21
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 11
- 239000003995 emulsifying agent Substances 0.000 claims description 9
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 8
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 claims description 8
- 239000003755 preservative agent Substances 0.000 claims description 8
- 235000019271 petrolatum Nutrition 0.000 claims description 7
- 150000003138 primary alcohols Chemical class 0.000 claims description 6
- 229960002537 betamethasone Drugs 0.000 claims description 4
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 229940099259 vaseline Drugs 0.000 abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940070710 valerate Drugs 0.000 abstract 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 description 18
- 239000006071 cream Substances 0.000 description 15
- 230000000694 effects Effects 0.000 description 13
- 239000003921 oil Substances 0.000 description 10
- 208000010668 atopic eczema Diseases 0.000 description 9
- 238000010438 heat treatment Methods 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 201000004681 Psoriasis Diseases 0.000 description 7
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 5
- 239000002674 ointment Substances 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- 239000003871 white petrolatum Substances 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 229950009789 cetomacrogol 1000 Drugs 0.000 description 3
- 229960002242 chlorocresol Drugs 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 230000002322 anti-exudative effect Effects 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 201000011486 lichen planus Diseases 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 2
- RDEIXVOBVLKYNT-VQBXQJRRSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]o Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)C(C)N)N)[C@@H](N)C[C@H]1N.O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-VQBXQJRRSA-N 0.000 description 1
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- YJFSKTXFJSLNKF-UHFFFAOYSA-N 3-hexadecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCC1=CC=C[NH+]=C1 YJFSKTXFJSLNKF-UHFFFAOYSA-N 0.000 description 1
- 206010003645 Atopy Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 206010012455 Dermatitis exfoliative Diseases 0.000 description 1
- 208000006926 Discoid Lupus Erythematosus Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 201000009053 Neurodermatitis Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 201000002463 atopic dermatitis 2 Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- VQODGRNSFPNSQE-DVTGEIKXSA-N betamethasone phosphate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COP(O)(O)=O)(O)[C@@]1(C)C[C@@H]2O VQODGRNSFPNSQE-DVTGEIKXSA-N 0.000 description 1
- 229950006991 betamethasone phosphate Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 208000004921 cutaneous lupus erythematosus Diseases 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 229940124624 oral corticosteroid Drugs 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229960004838 phosphoric acid Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к лекарственному средству на основе бетаметазона для лечения дерматозов. Средство содержит в качестве активных веществ бетаметазона валерат и цетилпиридиния хлорид, а также масло вазелиновое, спирты синтетические первичные высшие фракции С16-С20 или цетостеариловый спирт, пропиленгликоль и воду очищенную.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UA99074409A UA35028C2 (ru) | 1999-07-30 | 1999-07-30 | Средство на основе бетаметазона для лечения дерматозов |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UA99074409A UA35028C2 (ru) | 1999-07-30 | 1999-07-30 | Средство на основе бетаметазона для лечения дерматозов |
Publications (1)
Publication Number | Publication Date |
---|---|
UA35028C2 true UA35028C2 (ru) | 2003-06-16 |
Family
ID=74204696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA99074409A UA35028C2 (ru) | 1999-07-30 | 1999-07-30 | Средство на основе бетаметазона для лечения дерматозов |
Country Status (1)
Country | Link |
---|---|
UA (1) | UA35028C2 (ru) |
-
1999
- 1999-07-30 UA UA99074409A patent/UA35028C2/ru unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69825495T2 (de) | Verbesserte formulierung zur topischen, nichtinvasiven anwendung in vivo | |
RU2470645C2 (ru) | Фармацевтическая композиция для местного применения, содержащая комбинацию фузидовой кислоты и кортикостероида | |
DE69926843T2 (de) | Aktives vitamin-d3 enthaltende lotionen in form von emulsionen | |
CN109044915B (zh) | 一种婴幼儿护臀膏及其制备工艺 | |
EP2395973B1 (de) | In situ haft-gelbildende zubereitungen, insbesondere zur topischen anwendung auf befeuchtete haut/schleimhaut | |
US9833461B2 (en) | Therapeutic compositions comprising cannabidiol and corticosteroids | |
CA2910206C (en) | Novel therapeutic composition | |
CN103402510A (zh) | 用于治疗皮肤病症的组合物 | |
EA023983B1 (ru) | Применение содержащего тритерпены олеогеля для заживления ран | |
EP0504403A1 (en) | Topical therapeutic preparation | |
US9820996B2 (en) | Preparation method for antithyroid ointment for external application | |
JP3504279B2 (ja) | 皮膚の萎縮軽減剤、およびその使用法 | |
EA029494B1 (ru) | Способ и стероидная композиция для местного применения | |
DE69723725T2 (de) | Verfahren zur herstellung von konzentrierten lösungen von fibronectin ohne puffer | |
US8758836B2 (en) | Method and formulation for treating dry ear inflammation with cortisone | |
RU2361594C2 (ru) | Фармацевтические композиции, включающие комбинацию кальцитриола и клобетазола пропионат | |
US9173940B1 (en) | Mixture of betamethasone and tranilast with a transdermal gel for scar treatment | |
RU2157214C2 (ru) | Противовоспалительное и антимикробное лекарственное средство для местного применения | |
UA35028C2 (ru) | Средство на основе бетаметазона для лечения дерматозов | |
Ricciatti-Sibbald et al. | Dermatologic vehicles | |
RU2482852C2 (ru) | Фармацевтическая композиция для лечения дерматозов, поддающихся глюкокортикостероидной терапии, и способ ее получения | |
EP0099074A2 (de) | Mittel zur Behandlung von Wunden | |
CN115624520B (zh) | 一种地奥司明乳膏剂和应用 | |
SHAIKH et al. | Traditional remedies for wound healing: a review | |
RU2440108C2 (ru) | Фармацевтическая композиция для лечения аллергических и воспалительных заболеваний кожи |