UA129400C2 - Застосування церебролізину для зменшення смертності в пацієнтів з cadasil - Google Patents

Застосування церебролізину для зменшення смертності в пацієнтів з cadasil Download PDF

Info

Publication number
UA129400C2
UA129400C2 UAA202001881A UAA202001881A UA129400C2 UA 129400 C2 UA129400 C2 UA 129400C2 UA A202001881 A UAA202001881 A UA A202001881A UA A202001881 A UAA202001881 A UA A202001881A UA 129400 C2 UA129400 C2 UA 129400C2
Authority
UA
Ukraine
Prior art keywords
cerebrolysin
use according
treated
patient
patients
Prior art date
Application number
UAA202001881A
Other languages
English (en)
Ukrainian (uk)
Inventor
Штефан Вінтер
Штефан ВИНТЕР
Герберт Мьослер
Original Assignee
Евер Нейро Фарма Гмбх
Эвер Нейро Фарма Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Евер Нейро Фарма Гмбх, Эвер Нейро Фарма Гмбх filed Critical Евер Нейро Фарма Гмбх
Publication of UA129400C2 publication Critical patent/UA129400C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/185Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/48Nerve growth factor [NGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
UAA202001881A 2017-08-28 2018-08-28 Застосування церебролізину для зменшення смертності в пацієнтів з cadasil UA129400C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17188180.8A EP3449931B1 (en) 2017-08-28 2017-08-28 Use of cerebrolysin
PCT/EP2018/073106 WO2019042983A1 (en) 2017-08-28 2018-08-28 USE OF CERBROLYSINE

Publications (1)

Publication Number Publication Date
UA129400C2 true UA129400C2 (uk) 2025-04-16

Family

ID=59745228

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA202001881A UA129400C2 (uk) 2017-08-28 2018-08-28 Застосування церебролізину для зменшення смертності в пацієнтів з cadasil

Country Status (15)

Country Link
US (1) US20200376040A1 (enExample)
EP (2) EP3449931B1 (enExample)
JP (1) JP7281450B2 (enExample)
KR (1) KR102676274B1 (enExample)
CN (1) CN111050780B (enExample)
AU (1) AU2018326339A1 (enExample)
CA (1) CA3073991A1 (enExample)
EA (1) EA202090108A1 (enExample)
ES (2) ES2767070T3 (enExample)
HR (1) HRP20200031T1 (enExample)
MX (1) MX2020002267A (enExample)
PH (1) PH12020500376A1 (enExample)
PL (2) PL3449931T3 (enExample)
UA (1) UA129400C2 (enExample)
WO (1) WO2019042983A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220168325A1 (en) * 2019-03-25 2022-06-02 The University Of Vermont Methods to promote cerebral blood flow in the brain
ES2964145T3 (es) 2020-07-13 2024-04-04 Ever Neuro Pharma Gmbh Método para producir un hidrolizado de proteína de cerebro de mamífero
EP4347634A1 (en) * 2021-06-02 2024-04-10 Regeneron Pharmaceuticals, Inc. Treatment of cerebrovascular disease with neurogenic locus notch homolog protein 3 (notch3) agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69126563T2 (de) 1990-04-12 1998-02-05 Ebewe Arzneimittel Verwendung einer Mischung von Peptiden and Aminosäuren für die Prophylaxis oder Behandlung von Dementia
JP2012501967A (ja) 2008-08-20 2012-01-26 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 調節放出型多粒子のホットメルト押出成形

Also Published As

Publication number Publication date
CN111050780A (zh) 2020-04-21
AU2018326339A1 (en) 2020-03-05
KR20200045503A (ko) 2020-05-04
PH12020500376A1 (en) 2020-12-07
JP2020531568A (ja) 2020-11-05
HRP20200031T1 (hr) 2020-03-20
US20200376040A1 (en) 2020-12-03
PL3449931T3 (pl) 2020-06-01
CN111050780B (zh) 2023-11-03
KR102676274B1 (ko) 2024-06-18
EA202090108A1 (ru) 2020-03-31
EP3449931A1 (en) 2019-03-06
ES2767070T3 (es) 2020-06-16
WO2019042983A1 (en) 2019-03-07
JP7281450B2 (ja) 2023-05-25
ES2901508T3 (es) 2022-03-22
EP3675879A1 (en) 2020-07-08
EP3675879B1 (en) 2021-09-15
EP3449931B1 (en) 2019-10-16
MX2020002267A (es) 2020-10-22
CA3073991A1 (en) 2019-03-07
PL3675879T3 (pl) 2022-02-14

Similar Documents

Publication Publication Date Title
Jana et al. Fibrillar amyloid-β peptides activate microglia via TLR2: implications for Alzheimer’s disease
JP7379615B2 (ja) 補体活性のモジュレーター
JP2000507828A (ja) アルツハイマー病の診断および治療法
JP2021505565A (ja) 補体活性のモジュレータ
Gulati et al. A Novel Neuroregenerative Approach Using ET B Receptor Agonist, IRL-1620, to Treat CNS Disorders.
UA129400C2 (uk) Застосування церебролізину для зменшення смертності в пацієнтів з cadasil
JP2024113090A (ja) 神経可塑性を誘導するための方法および組成物
AU2011314074B2 (en) ND2 peptides and methods of treating neurological disease
Kozin et al. Enalaprilat inhibits zinc-dependent oligomerization of metal-binding domain of amyloid-beta isoforms and protects human neuroblastoma cells from toxic action of these isoforms
US10174097B2 (en) Specific A-beta species-binding peptides for the therapy and/or diagnosis of Alzheimer's dementia
Dhapola et al. Exploring Retinal Neurodegeneration in Alzheimer’s Disease: A Molecular and Cellular Perspective
JP7419229B2 (ja) 方法
HK40026040B (en) Cerebrolysin for use in the treatment of cadasil
Zhang et al. Cholecystokinin B receptor agonists alleviates anterograde amnesia in CCK-deficient and aged Alzheimer's disease mice
EA040978B1 (ru) Применение церебролизина
Wang et al. Age-and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse
HRP20220370A1 (hr) Postupci liječenja cln2 bolesti kod pedijatrijskih subjekata
EP2746402A1 (en) Method of prognosis of Alzheimers disease and substrates for use therein
Lina Palaiodimou et al. FABRY DISEASE: CLINICAL CHARACTERISTICS, DIAGNOSIS AND MANAGEMENT
飯島圭哉 Transplanted microvascular endothelial cells promote oligodendrocyte precursor cell survival in ischemic demyelinating lesions.
Banfi et al. A CASE OF CHRONIC IMMUNE SENSORY POLIRADICU-LOPATHY (CISP) RESPONSIVE TO IMMUNE MODULATING TREATMENT
Oyesola et al. SLEEP DEPRIVATION AND COFFEE CONSUMPTION INDUCED CHANGES IN BMI, BLOOD PRESSURE AND BLOOD GLUCOSE IN MALE WISTAR ALBINO RATS
Obukhov et al. Joint analysis of electroencephalogram, electromyogram, and tremor in the early stage of Parkinson’s disease.
Morkūnienė et al. Antibodies dramatically increase the neurotoxicity of amyloid beta oligomers in primary neuronal-glial cultures by activating microglia
Chatzopoulou et al. Study on the role of TAG-1 in axono-glial and axono-axonal interactions in the embryonic optic nerve